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127 results on '"Ramirez, Giuseppe Alvise"'

2. Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency

Author

Damanti, Sarah, Ramirez, Giuseppe Alvise, Bozzolo, Enrica Paola, Da Prat, Valentina, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Marinosci, Alessandro, Scotti, Raffaella, Strada, Silvia, Scarpellini, Paolo, Castiglioni, Barbara, Oltolini, Chiara, Ripa, Marco, Din, Chiara Tassan, Centurioni, Clarissa Elisabeth, Di Scala, Flavia, Gobbi, Agnese, Alba, Ada Carla, Casiraghi, Giuseppina Maria, Morgillo, Anna, and Tresoldi, Moreno

Published
2022
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3. P34 Lung involvement in patients with systemic lupus erythematosus: multicenter study

Author

Argolini, Lorenza Maria, primary, Scotti, Isabella, additional, Artusi, Carolina, additional, Pellico, Maria Rosa, additional, Ramirez, Giuseppe Alvise, additional, Moroni, Luca, additional, Bozzolo, Enrica, additional, Cavallo, Ludovica, additional, Bellocchi, Chiara, additional, Beretta, Lorenza, additional, Dagna, Lorenzo, additional, Caporali, Roberto, additional, and Gerosa, Maria, additional

Published
2024
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9. Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology

Author

Nettis, Eustachio, Foti, Caterina, Ambrifi, Marina, Baiardini, Ilaria, Bianchi, Leonardo, Borghi, Alessandro, Caminati, Marco, Canonica, Giorgio Walter, Casciaro, Marco, Colli, Laura, Colombo, Giselda, Corazza, Monica, Cristaudo, Antonio, De Feo, Giulia, De Pita’, Ornella, Di Gioacchino, Mario, Di Leo, Elisabetta, Fassio, Filippo, Gangemi, Sebastiano, Gatta, Alessia, Hansel, Katharina, Heffler, Enrico, Incorvaia, Cristoforo, Napolitano, Maddalena, Patruno, Cataldo, Peveri, Silvia, Pigatto, Paolo Daniele, Quecchia, Cristina, Radice, Anna, Ramirez, Giuseppe Alvise, Romita, Paolo, Rongioletti, Franco, Rossi, Oliviero, Savi, Eleonora, Senna, Gianenrico, Triggiani, Massimo, Zucca, Myriam, Maggi, Enrico, and Stingeni, Luca

Published
2020
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10. Efficacy of Siltuximab and 1,927 nm Fractional Laser for the Treatment of Cutaneous Manifestations in Castleman's Disease: The Role of Dermoscopy and Reflectance Confocal Microscopy for Lesion Evaluation.

Author

Paolino, Giovanni, Ardigò, Marco, Della-Torre, Emanuel, Moroni, Luca, Rizzo, Nathalie, Nicola, Matteo Riccardo Di, Bianchi, Vittoria Giulia, Dagna, Lorenzo, Ramirez, Giuseppe Alvise, and Mercuri, Santo Raffaele

Subjects
CASTLEMAN'S disease, CUTANEOUS manifestations of general diseases, CONFOCAL microscopy, DERMOSCOPY, REFLECTANCE
Abstract

Introduction: Multicentric Castleman's disease (MCD) with cutaneous involvement has rarely been discussed in dermatologic literature, with few reports. Cutaneous lesions in MCD may induce deep scars, causing a significant impact in the daily life of the patients. The treatment of Castleman's disease (CD) is usually a challenge, especially in case of cutaneous involvement. Case Presentation: We report the case of a 35-year-old Caucasian man with a 3-year-old history of MCD with cutaneous involvement that we treated with a combined therapy characterized by siltuximab and 1,927 nm fractional laser. The patient showed a therapeutic response, characterized by a reduction of systemic symptoms and cutaneous manifestations. Conclusion: We believe that the combination of siltuximab and 1,927 nm fractional laser might have a synergistic beneficial role in patients with cutaneous iMCD and maximize esthetic outcomes. Anyway, additional evidence is needed to validate our findings. [ABSTRACT FROM AUTHOR]

Published
2024
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11. ERN ReCONNET points to consider for treating patients living with autoimmune rheumatic diseases with antiviral therapies and anti-SARS-CoV-2 antibody products

Author

Talarico, Rosaria, primary, Ramirez, Giuseppe Alvise, additional, Barreira, Sofia C., additional, Cardamone, Chiara, additional, Triggianese, Paola, additional, Aguilera, Silvia, additional, Andersen, Jeanette, additional, Avcin, Tadej, additional, Benistan, Karelle, additional, Bertsias, George, additional, Bortoluzzi, Alessandra, additional, Bouillot, Coralie, additional, Bulina, Inita, additional, Burmester, Gerd R., additional, Callens, Steven, additional, Carreira, Patricia E., additional, Cervera, Ricard, additional, Cutolo, Maurizio, additional, Damian, Laura, additional, Della-Torre, Emanuel, additional, Faria, Raquel, additional, Fonseca, João E., additional, Galetti, Ilaria, additional, Hachulla, Eric, additional, Iaccarino, Luca, additional, Jacobsen, Søren, additional, Khmelinskii, Nikita, additional, Limper, Maarten, additional, Marinello, Diana, additional, Meyer, Alain, additional, Moroncini, Gianluca, additional, Nagy, Gyorgy, additional, Olesinska, Marzena, additional, Pamfil, Cristina, additional, Pileckyte, Margarita, additional, Pistello, Mauro, additional, Rednic, Simona, additional, Richez, Christophe, additional, Romão, Vasco C., additional, Schneider, Matthias, additional, Sciascia, Savino, additional, Scirè, Carlo Alberto, additional, Simonini, Gabriele, additional, Smith, Vanessa, additional, Sulli, Alberto, additional, Tani, Chiara, additional, Tas, Sander W., additional, Tincani, Angela, additional, Vonk, Madelon C., additional, Tektonidou, Maria, additional, and Mosca, Marta, additional

Published
2023
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12. Heart Rate Variability in Subjects with Severe Allergic Background Undergoing COVID-19 Vaccination

Author

Cilona, Maria Bernadette, primary, D’Amico, Filippo, additional, Asperti, Chiara, additional, Ramirez, Giuseppe Alvise, additional, Turi, Stefano, additional, Benanti, Giovanni, additional, Bohane, Shai Marc, additional, Nannipieri, Serena, additional, Labanca, Rosa, additional, Gervasini, Matteo, additional, Russetti, Federica, additional, Viapiana, Naomi, additional, Lezzi, Martina, additional, Landoni, Giovanni, additional, Dagna, Lorenzo, additional, and Yacoub, Mona-Rita, additional

Published
2023
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13. High Risk of Secondary Infections Following Thrombotic Complications in Patients With COVID-19

Author

Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, Seghi, Federico, Ripa, Marco, Galli, Laura, D’Angelo, Armando, Apruzzi, Luca, Palumbo, Diego, Campochiaro, Corrado, Tassan Din, Chiara, Danise, Anna, Da Prat, Valentina, Vitali, Giordano, Brugliera, Luigia, Poli, Andrea, Monardo, Roberta, Monti, Giacomo, Baccellieri, Domenico, De Cobelli, Francesco, Clementi, Massimo, Iannaccone, Sandro, Dagna, Lorenzo, Rovere-Querini, Patrizia, Ciceri, Fabio, Tresoldi, Moreno, Zangrillo, Alberto, Scarpellini, Paolo, Castagna, Antonella, Andolina, Andrea, Bigoloni, Alba, Bossolasco, Simona, Bruzzesi, Elena, Canetti, Diana, Castiglioni, Barbara, Cernuschi, Massimo, Chiurlo, Matteo, Cinque, Paola, Dell’Acqua, Raffaele, Della Torre, Liviana, Gianotti, Nicola, Guffanti, Monica, Hasson, Hamid, Messina, Emanuela, Morsica, Giulia, Nozza, Silvia, Ranzenigo, Martina, Uberti-Foppa, Caterina, Vinci, Concetta, Badalucco Ciotta, Flavia, Bottanelli, Martina, Clemente, Tommaso, Mainardi, Ilaria, Mori, Giovanni, Papaioannu Borjesson, Rebecka, Ponta, Giacomo, Muccini, Camilla, Mastrangelo, Andrea, Oltolini, Chiara, Spagnuolo, Vincenzo, Benassi, Luca, Bigai, Giorgia, Bozzolo, Enrica, Borio, Giorgia, Bussolari, Cecilia, Calvisi, Stefania, Canti, Valentina, Castellani, Jacopo, Cavallo, Ludovica, Cilla, Marta, Cinel, Elena, Compagnone, Nicola, D’Aliberti, Teresa, Damanti, Sarah, De Lorenzo, Rebecca, Di Lucca, Giuseppe, Di Terlizzi, Gaetano, Dumea, Iulia, Farolfi, Federica, Ferrante, Marica, Frangi, Claudia, Gallina, Gabriele, Germinario Bruno, Nicolò, Lanzillotta, Marco, Li Voti, Raffaele, Marinosci, Alessandro, Martinenghi, Sabina, Memoli, Massimo, Montagna, Marco, Pascali, Maria, Patrizi, Alessandro, Pomaranzi, Chiara, Scotti, Raffaella, Strada, Silvia, Boffini, Nicola, Cavalli, Giulio, Della Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Moroni, Luca, Ramirez Giuseppe, Alvise, Tomelleri, Alessandro, Azzolini Maria, Luisa, Baiardo Redaelli, Martina, Calabrò Maria, Grazia, Casiraghi Giuseppina, Maria, Dell’Acqua, Antonio, Fresilli, Stefano, Guzzo, Francesca, Landoni, Giovanni, Lombardi, Gaetano, Maimeri, Nicolò, Moizo, Elena, Nisi Francesco, Giuseppe, Oriani, Alessandro, Ortalda, Alessandro, Pasculli, Nicola, Pieri, Marina, Turi, Stefano, Bertoglio, Luca, Bilman, Victor, Carletti, Silvia, Gona, Floriana, Mancini, Nicasio, Della Valle, Patrizia, Molinari, Chiara, Poloniato, Antonella, Lalla, Francesca, Prestifilippo, Dario, Sapienza, Jacopo, and Seghi, Federico

Subjects
pulmonary embolism, Infectious Diseases, Oncology, bacteria, coronavirus, infections, thrombosis
Abstract

BackgroundThis study’s primary aim was to evaluate the impact of thrombotic complications on the development of secondary infections. The secondary aim was to compare the etiology of secondary infections in patients with and without thrombotic complications.MethodsThis was a cohort study (NCT04318366) of coronavirus disease 2019 (COVID-19) patients hospitalized at IRCCS San Raffaele Hospital between February 25 and June 30, 2020. Incidence rates (IRs) were calculated by univariable Poisson regression as the number of cases per 1000 person-days of follow-up (PDFU) with 95% confidence intervals. The cumulative incidence functions of secondary infections according to thrombotic complications were compared with Gray's method accounting for competing risk of death. A multivariable Fine-Gray model was applied to assess factors associated with risk of secondary infections.ResultsOverall, 109/904 patients had 176 secondary infections (IR, 10.0; 95% CI, 8.8–11.5; per 1000-PDFU). The IRs of secondary infections among patients with or without thrombotic complications were 15.0 (95% CI, 10.7–21.0) and 9.3 (95% CI, 7.9–11.0) per 1000-PDFU, respectively (P = .017). At multivariable analysis, thrombotic complications were associated with the development of secondary infections (subdistribution hazard ratio, 1.788; 95% CI, 1.018–3.140; P = .043). The etiology of secondary infections was similar in patients with and without thrombotic complications.ConclusionsIn patients with COVID-19, thrombotic complications were associated with a high risk of secondary infections.

Published
2022

18. Predictors and outcomes of delirium in the emergency department during the first wave of the COVID-19 pandemic in Milan

Author

Damanti, Sarah, primary, Bozzolo, Enrica, additional, Franchini, Stefano, additional, Frangi, Claudia, additional, Ramirez, Giuseppe Alvise, additional, Pedroso, Carla, additional, Di Lucca, Giuseppe, additional, Scotti, Raffaella, additional, Valsecchi, Davide, additional, Cilla, Marta, additional, Cinel, Elena, additional, Santini, Chiara, additional, Castellani, Jacopo, additional, Manzo, Emanuela, additional, Vadruccio, Stefania, additional, Spessot, Marzia, additional, Borghi, Giovanni, additional, Monti, Giacomo, additional, Landoni, Giovanni, additional, Rovere-Querini, Patrizia, additional, Yacoub, Mona-Rita, additional, and Tresoldi, Moreno, additional

Published
2022
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19. Post-traumatic stress disorder in patients with systemic lupus erythematosus heavily affects quality of life. A cross-sectional web survey-based study

Author

Moroni, Luca, primary, Mazzetti, Martina, additional, Ramirez, Giuseppe Alvise, additional, Zuffada, Simone, additional, Ciancio, Anna, additional, Gallina, Gabriele, additional, Farina, Nicola, additional, Bozzolo, Enrica, additional, Di Mattei, Valentina, additional, and Dagna, Lorenzo, additional

Published
2022
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20. Influence of reduced muscle mass and quality on ventilator weaning and complications during intensive care unit stay in COVID-19 patients

Author

Damanti, Sarah, primary, Cristel, Giulia, additional, Ramirez, Giuseppe Alvise, additional, Bozzolo, Enrica Paola, additional, Da Prat, Valentina, additional, Gobbi, Agnese, additional, Centurioni, Clarissa, additional, Di Gaeta, Ettore, additional, Del Prete, Andrea, additional, Calabrò, Maria Grazia, additional, Calvi, Maria Rosa, additional, Borghi, Giovanni, additional, Zangrillo, Alberto, additional, De Cobelli, Francesco, additional, Landoni, Giovanni, additional, and Tresoldi, Moreno, additional

Published
2022
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21. Evidence for charge-based mimicry in anti dsDNA antibody generation

Author

Bruschi, Maurizio, primary, Angeletti, Andrea, additional, Kajana, Xhuliana, additional, Moroni, Gabriella, additional, Sinico, Renato Alberto, additional, Fredi, Micaela, additional, Vaglio, Augusto, additional, Cavagna, Lorenzo, additional, Pratesi, Federico, additional, Migliorini, Paola, additional, Locatelli, Francesco, additional, Pazzola, Giulia, additional, Pesce, Giampaola, additional, Bagnasco, Marcello, additional, Manfredi, Angelo, additional, Ramirez, Giuseppe Alvise, additional, Esposito, Pasquale, additional, Negrini, Simone, additional, Bui, Federica, additional, Trezzi, Barbara, additional, Emmi, Giacomo, additional, Cavazzana, Ilaria, additional, Binda, Valentina, additional, Fenaroli, Paride, additional, Pisani, Isabella, additional, Montecucco, Carlomaurizio, additional, Santoro, Domenico, additional, Scolari, Francesco, additional, Volpi, Stefano, additional, Mosca, Marta, additional, Tincani, Angela, additional, Candiano, Giovanni, additional, Verrina, Enrico, additional, Franceschini, Franco, additional, Ravelli, Angelo, additional, Prunotto, Marco, additional, Meroni, Pier Luigi, additional, and Ghiggeri, Gian Marco, additional

Published
2022
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22. Quantitative measurement of 18F-FDG PET/CT uptake reflects the expansion of circulating plasmablasts in IgG4-related disease

Author

Berti, Alvise, Della-Torre, Emanuel, Gallivanone, Francesca, Canevari, Carla, Milani, Raffaella, Lanzillotta, Marco, Campochiaro, Corrado, Ramirez, Giuseppe Alvise, Bozzalla Cassione, Emanuele, Bozzolo, Enrica, Pedica, Federica, Castiglioni, Isabella, Arcidiacono, Paolo Giorgio, Balzano, Gianpaolo, Falconi, Massimo, Gianolli, Luigi, and Dagna, Lorenzo

Published
2017
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25. Long-Term Clinical Outcome in Systemic Lupus Erythematosus Patients Followed for More Than 20 Years: The Milan Systemic Lupus Erythematosus Consortium (SMiLE) Cohort

Author

Gerosa, Maria, primary, Beretta, Lorenzo, additional, Ramirez, Giuseppe Alvise, additional, Bozzolo, Enrica, additional, Cornalba, Martina, additional, Bellocchi, Chiara, additional, Argolini, Lorenza Maria, additional, Moroni, Luca, additional, Farina, Nicola, additional, Segatto, Giulia, additional, Dagna, Lorenzo, additional, and Caporali, Roberto, additional

Published
2022
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26. Evidence for charge-based mimicry in anti dsDNA antibody generation

Author

Bruschi, M, Angeletti, A, Kajana, X, Moroni, G, Sinico, R, Fredi, M, Vaglio, A, Cavagna, L, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Negrini, S, Bui, F, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Verrina, E, Franceschini, F, Ravelli, A, Prunotto, M, Meroni, P, Ghiggeri, G, Bruschi, Maurizio, Angeletti, Andrea, Kajana, Xhuliana, Moroni, Gabriella, Sinico, Renato Alberto, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe Alvise, Esposito, Pasquale, Negrini, Simone, Bui, Federica, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Verrina, Enrico, Franceschini, Franco, Ravelli, Angelo, Prunotto, Marco, Meroni, Pier Luigi, Ghiggeri, Gian Marco, Bruschi, M, Angeletti, A, Kajana, X, Moroni, G, Sinico, R, Fredi, M, Vaglio, A, Cavagna, L, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Negrini, S, Bui, F, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Verrina, E, Franceschini, F, Ravelli, A, Prunotto, M, Meroni, P, Ghiggeri, G, Bruschi, Maurizio, Angeletti, Andrea, Kajana, Xhuliana, Moroni, Gabriella, Sinico, Renato Alberto, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe Alvise, Esposito, Pasquale, Negrini, Simone, Bui, Federica, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Verrina, Enrico, Franceschini, Franco, Ravelli, Angelo, Prunotto, Marco, Meroni, Pier Luigi, and Ghiggeri, Gian Marco

Abstract

Mechanisms for the generation of anti-dsDNA autoantibodies are still not completely elucidated. One theory states that dsDNA interacts for mimicry with antibodies raised versus other antigens but molecular features for mimicry are unknown. Here we show that, at physiological acid-base balance, anti-Annexin A1 binds IgG2 dsDNA in a competitive and dose-dependent way with Annexin A1 and that the competition between the two molecules is null at pH 9. On the other hand, these findings also show that dsDNA and Annexin A1 interact with their respective antibodies on a strictly pH-dependent basis: in both cases, the binding was minimal at pH 4 and maximal at pH9-10. The anionic charge of dsDNA is mainly conferred by the numerous phosphatidic residues. The epitope binding site of Annexin A1 for anti-Annexin A1 IgG2 was here characterized as a string of 34 amino acids at the NH2 terminus, 10 of which are anionic. Circulating levels of anti-dsDNA and anti-Annexin A1 IgG2 antibodies were strongly correlated in patients with systemic lupus erythematosus (n 496) and lupus nephritis (n 425) stratified for age, sex, etc. These results show that dsDNA competes with Annexin A1 for the binding with anti-Annexin A1 IgG2 on a dose and charged mediated base, being able to display an inhibition up to 75%. This study provides the first demonstration that dsDNA may interact with antibodies raised versus other anionic molecules (anti-Annexin A1 IgG2) because of charge mimicry and this interaction may contribute to anti-dsDNA antibodies generation.

Published
2022

27. Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis (EGPA): a European multicenter observational study

Author

Bettiol, A, Urban, M, Dagna, L, Cottin, V, Franceschini, F, Del Giacco, S, Schiavon, F, Neumann, T, Lopalco, G, Novikov, P, Baldini, C, Lombardi, C, Berti, A, Alberici, F, Folci, M, Negrini, S, Sinico, R, Quartuccio, L, Lunardi, C, Parronchi, P, Moosig, F, Espígol-Frigolé, G, Schroeder, J, Kernder, A, Monti, S, Silvagni, E, Crimi, C, Cinetto, F, Fraticelli, P, Roccatello, D, Vacca, A, Mohammad, A, Hellmich, B, Samson, M, Bargagli, E, Cohen Tervaert, J, Ribi, C, Fiori, D, Bello, F, Fagni, F, Moroni, L, Ramirez, G, Nasser, M, Marvisi, C, Toniati, P, Firinu, D, Padoan, R, Egan, A, Seeliger, B, Iannone, F, Salvarani, C, Jayne, D, Prisco, D, Vaglio, A, Emmi, G, Bettiol, Alessandra, Urban, Maria Letizia, Dagna, Lorenzo, Cottin, Vincent, Franceschini, Franco, Del Giacco, Stefano, Schiavon, Franco, Neumann, Thomas, Lopalco, Giuseppe, Novikov, Pavel, Baldini, Chiara, Lombardi, Carlo, Berti, Alvise, Alberici, Federico, Folci, Marco, Negrini, Simone, Sinico, Renato Alberto, Quartuccio, Luca, Lunardi, Claudio, Parronchi, Paola, Moosig, Frank, Espígol-Frigolé, Georgina, Schroeder, Jan, Kernder, Anna Luise, Monti, Sara, Silvagni, Ettore, Crimi, Claudia, Cinetto, Francesco, Fraticelli, Paolo, Roccatello, Dario, Vacca, Angelo, Mohammad, Aladdin J, Hellmich, Bernhard, Samson, Maxime, Bargagli, Elena, Cohen Tervaert, Jan Willem, Ribi, Camillo, Fiori, Davide, Bello, Federica, Fagni, Filippo, Moroni, Luca, Ramirez, Giuseppe Alvise, Nasser, Mouhamad, Marvisi, Chiara, Toniati, Paola, Firinu, Davide, Padoan, Roberto, Egan, Allyson, Seeliger, Benjamin, Iannone, Florenzo, Salvarani, Carlo, Jayne, David, Prisco, Domenico, Vaglio, Augusto, Emmi, Giacomo, Bettiol, A, Urban, M, Dagna, L, Cottin, V, Franceschini, F, Del Giacco, S, Schiavon, F, Neumann, T, Lopalco, G, Novikov, P, Baldini, C, Lombardi, C, Berti, A, Alberici, F, Folci, M, Negrini, S, Sinico, R, Quartuccio, L, Lunardi, C, Parronchi, P, Moosig, F, Espígol-Frigolé, G, Schroeder, J, Kernder, A, Monti, S, Silvagni, E, Crimi, C, Cinetto, F, Fraticelli, P, Roccatello, D, Vacca, A, Mohammad, A, Hellmich, B, Samson, M, Bargagli, E, Cohen Tervaert, J, Ribi, C, Fiori, D, Bello, F, Fagni, F, Moroni, L, Ramirez, G, Nasser, M, Marvisi, C, Toniati, P, Firinu, D, Padoan, R, Egan, A, Seeliger, B, Iannone, F, Salvarani, C, Jayne, D, Prisco, D, Vaglio, A, Emmi, G, Bettiol, Alessandra, Urban, Maria Letizia, Dagna, Lorenzo, Cottin, Vincent, Franceschini, Franco, Del Giacco, Stefano, Schiavon, Franco, Neumann, Thomas, Lopalco, Giuseppe, Novikov, Pavel, Baldini, Chiara, Lombardi, Carlo, Berti, Alvise, Alberici, Federico, Folci, Marco, Negrini, Simone, Sinico, Renato Alberto, Quartuccio, Luca, Lunardi, Claudio, Parronchi, Paola, Moosig, Frank, Espígol-Frigolé, Georgina, Schroeder, Jan, Kernder, Anna Luise, Monti, Sara, Silvagni, Ettore, Crimi, Claudia, Cinetto, Francesco, Fraticelli, Paolo, Roccatello, Dario, Vacca, Angelo, Mohammad, Aladdin J, Hellmich, Bernhard, Samson, Maxime, Bargagli, Elena, Cohen Tervaert, Jan Willem, Ribi, Camillo, Fiori, Davide, Bello, Federica, Fagni, Filippo, Moroni, Luca, Ramirez, Giuseppe Alvise, Nasser, Mouhamad, Marvisi, Chiara, Toniati, Paola, Firinu, Davide, Padoan, Roberto, Egan, Allyson, Seeliger, Benjamin, Iannone, Florenzo, Salvarani, Carlo, Jayne, David, Prisco, Domenico, Vaglio, Augusto, and Emmi, Giacomo

Abstract

Objective: Mepolizumab proved efficacious for eosinophilic granulomatosis with polyangiitis (EGPA, former Churg-Strauss) at the dosage of 300mg/4 weeks in the randomized controlled MIRRA trial. Few successful real-life experiences with the dosage approved for severe eosinophilic asthma (100mg/4 weeks) were recently reported. We retrospectively assessed the effectiveness and safety of mepolizumab 100 and 300mg/4 weeks in a large European EGPA cohort. Methods: We included all EGPA patients treated with mepolizumab at the recruiting centres in 2015-2020. Treatment response was evaluated from month 3 through 24 (T3-T24) after mepolizumab starting. Complete response (CR) was defined as no disease activity (Birmingham Vasculitis Activity Score, BVAS=0) and a prednisone dose ≤4mg/day. Respiratory outcomes included asthma and ear-nose-throat (ENT) exacerbations. Results: We included 203 patients, of whom 191 at stable dosage (158 mepolizumab 100mg/4 weeks, 33 300mg/4 weeks). At T3, 25 patients (12.3%) had a CR. CR rates increased to 30.4% and 35.7% at T12 and T24 and were comparable between mepolizumab 100 and 300mg/4 weeks. Mepolizumab led to a significant reduction in BVAS, prednisone dose, eosinophil counts from T3 through T24, with no significant differences between 100 and 300 mg/4weeks. Eighty-two patients (40.4%) experienced asthma exacerbations [57/158 (36%) on 100mg/4 weeks; 17/33 (52%) on 300mg/4 weeks]. Thirty-one (15.3%) experienced ENT exacerbations. Forty-four patients (21.7%) experienced adverse events, most being non-serious (38/44). Conclusion: Mepolizumab both at 100 and 300mg/4 weeks is effective for EGPA. The two dosages should be compared in the setting of a controlled trial.

Published
2022

28. The Impact of Anti-SARS-CoV-2 Vaccine in Patients with Systemic Lupus Erythematosus: A Multicentre Cohort Study

Author

Gerosa, M, Schioppo, T, Argolini, L, Sciascia, S, Ramirez, G, Moroni, G, Sinico, R, Bonelli, G, Alberici, F, Mescia, F, Moroni, L, Tamborini, F, Miraglia, P, Bellocchi, C, Beretta, L, Roccatello, D, Dagna, L, Bozzolo, E, Caporali, R, Gerosa, Maria, Schioppo, Tommaso, Argolini, Lorenza Maria, Sciascia, Savino, Ramirez, Giuseppe Alvise, Moroni, Gabriella, Sinico, Renato Alberto, Bonelli, Grazia, Alberici, Federico, Mescia, Federica, Moroni, Luca, Tamborini, Francesco, Miraglia, Paolo, Bellocchi, Chiara, Beretta, Lorenzo, Roccatello, Dario, Dagna, Lorenzo, Bozzolo, Enrica, Caporali, Roberto, Gerosa, M, Schioppo, T, Argolini, L, Sciascia, S, Ramirez, G, Moroni, G, Sinico, R, Bonelli, G, Alberici, F, Mescia, F, Moroni, L, Tamborini, F, Miraglia, P, Bellocchi, C, Beretta, L, Roccatello, D, Dagna, L, Bozzolo, E, Caporali, R, Gerosa, Maria, Schioppo, Tommaso, Argolini, Lorenza Maria, Sciascia, Savino, Ramirez, Giuseppe Alvise, Moroni, Gabriella, Sinico, Renato Alberto, Bonelli, Grazia, Alberici, Federico, Mescia, Federica, Moroni, Luca, Tamborini, Francesco, Miraglia, Paolo, Bellocchi, Chiara, Beretta, Lorenzo, Roccatello, Dario, Dagna, Lorenzo, Bozzolo, Enrica, and Caporali, Roberto

Abstract

Vulnerable subjects, including systemic lupus erythematosus (SLE) patients, have been prioritised to receive anti-SARS-CoV-2 vaccines. Few data about the safety of these vaccines in SLE are available. The aim of our study is to investigate the safety of anti-SARS-CoV-2 vaccines in SLE. We included 452 SLE patients, referring to seven tertiary centres, who were immunised. A total of 119 (26%) reported side effects (SE) after the first and/or the second shot (the most frequent SE were fever, local reaction, fatigue, and arthralgia). Patients with constitutional symptoms and those on an immunosuppressive regimen (especially belimumab) showed more SE. In addition, 19 (4%) had a flare after the immunisation (flares classified by organ involvement: six musculoskeletal with constitutional symptoms, four renal, three cardio-respiratory, three haematological, two mucocutaneous). None of the patients needed hospitalisation and none died. Moreover, 15 required a transient increase in corticosteroids and four were treated with steroid pulses. One patient required an additional rituximab course. Anti-dsDNA, moderate/high DAS before vaccine, and belimumab were found more frequently in patients with disease flare. Anti-SARS-CoV-2 vaccines are safe in SLE patients, and they should be recommended in these patients, as the potential benefits widely outweigh the risk of SE. Treatment adjustment might be considered with the aim of minimising SE risk and flare.

Published
2022

29. Predictors and outcomes of delirium in the emergency department during the first wave of the COVID-19 pandemic in Milan.

Author

Damanti, Sarah, Bozzolo, Enrica, Franchini, Stefano, Frangi, Claudia, Ramirez, Giuseppe Alvise, Pedroso, Carla, Di Lucca, Giuseppe, Scotti, Raffaella, Valsecchi, Davide, Cilla, Marta, Cinel, Elena, Santini, Chiara, Castellani, Jacopo, Manzo, Emanuela, Vadruccio, Stefania, Spessot, Marzia, Borghi, Giovanni, Monti, Giacomo, Landoni, Giovanni, and Rovere-Querini, Patrizia

Published
2023
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30. The Impact of Anti-SARS-CoV-2 Vaccine in Patients with Systemic Lupus Erythematosus: A Multicentre Cohort Study

Author

Gerosa, Maria, primary, Schioppo, Tommaso, additional, Argolini, Lorenza Maria, additional, Sciascia, Savino, additional, Ramirez, Giuseppe Alvise, additional, Moroni, Gabriella, additional, Sinico, Renato Alberto, additional, Bonelli, Grazia, additional, Alberici, Federico, additional, Mescia, Federica, additional, Moroni, Luca, additional, Tamborini, Francesco, additional, Miraglia, Paolo, additional, Bellocchi, Chiara, additional, Beretta, Lorenzo, additional, Roccatello, Dario, additional, Dagna, Lorenzo, additional, Bozzolo, Enrica, additional, and Caporali, Roberto, additional

Published
2022
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32. Supplemental Material - Post-traumatic stress disorder in patients with systemic lupus erythematosus heavily affects quality of life. A cross-sectional web survey-based study

Author

Moroni, Luca, Mazzetti, Martina, Ramirez, Giuseppe Alvise, Zuffada, Simone, Ciancio, Anna, Gallina, Gabriele, Farina, Nicola, Bozzolo, Enrica, Di Mattei, Valentina, and Dagna, Lorenzo

Subjects
111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental Material for Post-traumatic stress disorder in patients with systemic lupus erythematosus heavily affects quality of life. A cross-sectional web survey-based study by Luca Moroni, Martina Mazzetti, Giuseppe Alvise Ramirez, Simone Zuffada, Anna Ciancio, Gabriele Gallina, Nicola Farina, Enrica Bozzolo, Valentina Di Mattei and Lorenzo Dagna in Lupus

Published
2022
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34. Post-traumatic stress disorder in patients with systemic lupus erythematosus heavily affects quality of life. A cross-sectional web survey-based study.

Author

Moroni, Luca, Mazzetti, Martina, Ramirez, Giuseppe Alvise, Zuffada, Simone, Ciancio, Anna, Gallina, Gabriele, Farina, Nicola, Bozzolo, Enrica, Di Mattei, Valentina, and Dagna, Lorenzo

Subjects
POST-traumatic stress disorder, LUPUS nephritis, QUALITY of life, SYSTEMIC lupus erythematosus, SELF-evaluation, FATIGUE (Physiology), DISEASE prevalence
Abstract

Objectives: Neuropsychiatric symptoms develop in up to 20% of the patients with Systemic Lupus Erythematosus (SLE). Growing evidence is accruing on the association of SLE with Post-traumatic Stress Disorder (PTSD), but little is known about its contribution on patient-reported outcomes. This study focuses on PTSD prevalence in our SLE cohort and on its impact on quality of life. Methods: Trauma and Loss Spectrum – Self Reported (TALS-SR) and Lupus Quality of Life (Lupus QoL) questionnaires were administered via web to the patients with SLE in our cohort, along with questions on demographical and disease-related aspects. Results: Among 99 patients who completed the questionnaire, fatigue prevalence was 75% and 31% scored TALS-SR test consistently with PTSD. Patients with PTSD achieved lower scores compared to those without PTSD in three Lupus QoL domains: planning (83.3 vs. 100, p =.035), body image (85.0 vs. 95.0, p =.031) and fatigue (66.7 vs. 91.7, p =.001). An inverse correlation was found between TALS-SR domains and Lupus QoL scores, particularly regarding fatigue with reaction to losses or upsetting events (ρ -0.458, p <.001). Conclusions: PTSD is possibly far more frequent in patients with SLE than in general population and exerts a detrimental influence on quality of life. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Six‐month respiratory outcomes and exercise capacity of COVID‐19 acute respiratory failure patients treated with continuous positive airway pressure

Author

Damanti, Sarah, primary, Ramirez, Giuseppe Alvise, additional, Bozzolo, Enrica Paola, additional, Rovere‐Querini, Patrizia, additional, De Lorenzo, Rebecca, additional, Magnaghi, Cristiano, additional, Scotti, Raffaella, additional, Di Lucca, Giuseppe, additional, Marinosci, Alessandro, additional, Strada, Silvia, additional, Di Terlizzi, Gaetano, additional, Vitali, Giordano, additional, Martinenghi, Sabina, additional, Compagnone, Nicola, additional, Landoni, Giovanni, additional, and Tresoldi, Moreno, additional

Published
2021
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38. Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19

Author

Spagnuolo, V., Guffanti, M., Galli, L., Poli, A., Querini, P. Rovere, Ripa, M., Clementi, M., Scarpellini, P., Lazzarin, A., Tresoldi, Moreno, Dagna, L., Zangrillo, A., Ciceri, F., Castagna, A., Andolina, A., Redaelli, M. Baiardo, Baldissera, E., Bigai, G., Bigoloni, A., Boffini, N., Borio, G., Bossolasco, S., Bruzzesi, E., Calabrò, M. G., Calvisi, S., Campochiaro, C., Canetti, D., Canti, V., Castellani, J., Castiglioni, B., Cavalli, G., Cavallo, L., Cernuschi, M., Chiurlo, M., Cilla, M., Cinel, E., Cinque, P., Conte, C., Da Prat, V., Danise, A., De Lorenzo, R., De Luca, G., Dell’Acqua, A., Dell’Acqua, R., Torre, E. Della, Torre, L. Della, Di Terlizzi, G., Dumea, I., Farolfi, F., Ferrante, M., Frangi, C., Fumagalli, L., Gallina, G., Germinario, B., Gianotti, Nicola, Hasson, H., Lalla, F., LANDONI, Giovanni, Lanzillotta, M., Voti, R. Li, Mastrangelo, A., Messina, E., Moizo, E., Montagna, M., Monti, G., Morsica, G., Muccini, C., Nozza, S., Oltolini, C., Pascali, M., Patrizi, A., Pieri, M., Prestifilippo, D., Ramirez, Giuseppe Alvise, Ranzenigo, M., Sapienza, J., Sartorelli, S., Seghi, F., Tambussi, G., Din, C. Tassan, Tomelleri, A., Turi, S., Uberti-Foppa, C., Vinci, C., COVID-BioB study group, Spagnuolo, V., Guffanti, M., Galli, L., Poli, A., Querini, P. R., Ripa, M., Clementi, M., Scarpellini, P., Lazzarin, A., Tresoldi, M., Dagna, L., Zangrillo, A., Ciceri, F., Castagna, A., Andolina, A., Redaelli, M. B., Baldissera, E., Bigai, G., Bigoloni, A., Boffini, N., Borio, G., Bossolasco, S., Bruzzesi, E., Calabro, M. G., Calvisi, S., Campochiaro, C., Canetti, D., Canti, V., Castellani, J., Castiglioni, B., Cavalli, G., Cavallo, L., Cernuschi, M., Chiurlo, M., Cilla, M., Cinel, E., Cinque, P., Conte, C., Da Prat, V., Danise, A., De Lorenzo, R., De Luca, G., Dell'Acqua, A., Dell'Acqua, R., Torre, E. D., Torre, L. D., Di Terlizzi, G., Dumea, I., Farolfi, F., Ferrante, M., Frangi, C., Fumagalli, L., Gallina, G., Germinario, B., Gianotti, N., Hasson, H., Lalla, F., Landoni, G., Lanzillotta, M., Voti, R. L., Mastrangelo, A., Messina, E., Moizo, E., Montagna, M., Monti, G., Morsica, G., Muccini, C., Nozza, S., Oltolini, C., Pascali, M., Patrizi, A., Pieri, M., Prestifilippo, D., Ramirez, G., Ranzenigo, M., Sapienza, J., Sartorelli, S., Seghi, F., Tambussi, G., Din, C. T., Tomelleri, A., Turi, S., Uberti-Foppa, C., and Vinci, C.

Subjects
Male, medicine.medical_specialty, Time Factors, Coronavirus disease 2019 (COVID-19), Lymphocyte, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Corticosteroid treatment, Severe disease, Diseases, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Adrenal Cortex Hormones, Internal medicine, medicine, Humans, In patient, 030212 general & internal medicine, Pandemics, Aged, Retrospective Studies, Multidisciplinary, business.industry, Proportional hazards model, Age Factors, COVID-19, Retrospective cohort study, Middle Aged, Viral Load, Publisher Correction, COVID-19 Drug Treatment, Hospitalization, Treatment Outcome, Infectious diseases, Viral infection, medicine.anatomical_structure, Italy, Female, business
Abstract

The aim of this study was to evaluate the impact of early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis on patients admitted to the San Raffaele Hospital (Milan, Italy) with moderate/severe COVID-19 and availability of at least two nasopharyngeal swabs. The primary outcome was the time to nasopharyngeal swab negativization. A multivariable Cox model was fitted to determine factors associated with nasopharyngeal swab negativization. Of 280 patients included, 59 (21.1%) patients were treated with steroids. Differences observed between steroid users and non-users included the proportion of patients with a baseline PaO2/FiO2 ≤ 200 mmHg (45.8% vs 34.4% in steroids and non-steroids users, respectively; p = 0.023) or ≤ 100 mmHg (16.9% vs 12.7%; p = 0.027), and length of hospitalization (20 vs 14 days; p 2/FiO2 > 200 mmHg, and a lymphocyte count at admission > 1.0 × 109/L. SARS-CoV-2 clearance was not associated with corticosteroid use. Our study shows that delayed SARS-CoV-2 clearance in moderate/severe COVID-19 is associated with older age and a more severe disease, but not with an early use of corticosteroids.

Published
2020

41. Baseline characteristics of systemic lupus erythematosus patients included in the Lupus Italian Registry of the Italian Society for Rheumatology

Author

Sebastiani, Gian Domenico, primary, Spinelli, Francesca Romana, additional, Bartoloni, Elena, additional, Bortoluzzi, Alessandra, additional, Bozzolo, Enrica, additional, Canofari, Claudia, additional, Canti, Valentina, additional, Conigliaro, Paola, additional, Ditto, Maria Chiara, additional, Emmi, Giacomo, additional, Franceschini, Franco, additional, Frassi, Micol, additional, Iaccarino, Luca, additional, Iuliano, Annamaria, additional, Manfredi, Angelo, additional, Pacucci, Viviana, additional, Parisi, Simone, additional, Pazzola, Giulia, additional, Perricone, Roberto, additional, Prevete, Immacolata, additional, Ramirez, Giuseppe Alvise, additional, Scarpato, Salvatore, additional, Scirocco, Chiara, additional, Silvagni, Ettore, additional, Zen, Margherita, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Conti, Fabrizio, additional, and Doria, Andrea, additional

Published
2021
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47. Calreticulin as a novel B-cell receptor antigen in chronic lymphocytic leukemia

Author

Hacken, Elisa ten, primary, Gounari, Maria, additional, Back, Jaap Willem, additional, Shimanovskaya, Ekaterina, additional, Scarfò, Lydia, additional, Kim, Ekaterina, additional, Burks, Jared, additional, Ponzoni, Maurilio, additional, Ramirez, Giuseppe Alvise, additional, Wierda, William G., additional, Estrov, Zeev, additional, Keating, Michael J., additional, Ferrajoli, Alessandra, additional, Stamatopoulos, Kostas, additional, Ghia, Paolo, additional, and Burger, Jan A., additional

Published
2017
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48. Drug induced exfoliative dermatitis: state of the art

Author

Yacoub, Mona-Rita, primary, Berti, Alvise, additional, Campochiaro, Corrado, additional, Tombetti, Enrico, additional, Ramirez, Giuseppe Alvise, additional, Nico, Andrea, additional, Di Leo, Elisabetta, additional, Fantini, Paola, additional, Sabbadini, Maria Grazia, additional, Nettis, Eustachio, additional, and Colombo, Giselda, additional

Published
2016
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49. Quantitative measurement of 18F-FDG PET/CT uptake reflects the expansion of circulating plasmablasts in IgG4-related disease.

Author

Berti, Alvise, Della-Torre, Emanuel, Gallivanone, Francesca, Canevari, Carla, Milani, Raffaella, Lanzillotta, Marco, Campochiaro, Corrado, Ramirez, Giuseppe Alvise, Cassione, Emanuele Bozzalla, Bozzolo, Enrica, Pedica, Federica, Castiglioni, Isabella, Arcidiacono, Paolo Giorgio, Balzano, Gianpaolo, Falconi, Massimo, Gianolli, Luigi, and Dagna, Lorenzo

Subjects
AUTOIMMUNE disease diagnosis, IMMUNOSUPPRESSIVE agents, FIBROSIS, BLOOD sedimentation, C-reactive protein, COMPUTED tomography, IMMUNOGLOBULINS, LIVER, PROBABILITY theory, RADIOPHARMACEUTICALS, POSITRON emission tomography, DESCRIPTIVE statistics, DIAGNOSIS
Abstract

Objective [18F]Fluorodeoxyglucose (18F-FDG) PET/CT is increasingly used to assess organ involvement and response to treatment in IgG4-related disease (IgG4-RD), but clear correlations between 18F-FDG uptake and disease activity have not been established yet. We aimed to correlate the intensity and distribution of 18F-FDG uptake with validated clinical, serological and immunological parameters of IgG4-RD activity. Methods Twenty patients with active IgG4-RD underwent a baseline 18F-FDG PET/CT. Ten patients repeated 18F-FDG PET/CT after immunosuppressive treatments. 18F-FDG tissue uptake was measured using the standardized uptake value corrected for the partial volume effect (PVC-SUV) and the total lesion glycolysis (TLG) with (TLGtot+ln) and without (TLGtot-ln) lymph nodes. Disease activity was assessed by means of clinical parameters [IgG4-RD Responder Index (RI)], serological (ESR and CRP) and immunological (serum IgG4 and circulating plasmablasts) biomarkers. The enhanced liver fibrosis score was exploited as a biomarker for fibroblast activation. Results Thirteen (65%) patients had two or more organs affected by IgG4-RD. All patients had active IgG4-RD as defined by a median IgG4-RD RI value of 9 (range 6--15; normal < 3). Serum IgG4 and plasmablasts were elevated in 85% of patients. Circulating plasmablasts positively correlated with PVC-SUV (P = 0.027), inversely correlated with TLGtot-ln (P = 0.023) and did not correlate with TLGtot+ln (P > 0.05). No statistically significant correlation was found between PVC-SUV or TLG and IgG4-RD RI, ESR, CRP, serum IgG4 or enhanced liver fibrosis score (P > 0.05). Clinical response to immunosuppressive therapies was associated with a consensual reduction of circulating plasmablasts, PVC-SUV, TLGtot+ln and TLGtot-ln values (P < 0.05 for all comparisons). Conclusions 18F-FDG uptake of IgG4-RD lesions reflects immunological perturbations of the B cell compartment rather than fibroblast activation and extracellular matrix deposition. Conventional biomarkers of disease activity, namely IgG4-RD RI, ESR, CRP and serum IgG4 levels, do not appear to correlate with the radiometabolic activity of IgG4-RD lesions. In light of our results PET/CT represents a reliable instrument for assessing IgG4-RD activity, although lymph-node uptake deserves careful interpretation. [ABSTRACT FROM AUTHOR]

Published
2017
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50. Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps?

Author

Yacoub, Mona-Rita, primary, Trimarchi, Matteo, additional, Cremona, George, additional, Dal Farra, Sara, additional, Ramirez, Giuseppe Alvise, additional, Canti, Valentina, additional, Della Torre, Emanuel, additional, Baldini, Mattia, additional, Pignatti, Patrizia, additional, Bussi, Mario, additional, Sabbadini, Maria Grazia, additional, Manfredi, Angelo A, additional, and Colombo, Giselda, additional

Published
2015
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