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1. Cardiac Troponin and Treatment Effects of Omecamtiv Mecarbil: Results From the GALACTIC-HF Study

Author

Felker, G. Michael, Solomon, Scott D., Metra, Marco, Mcmurray, John J.V., Diaz, Rafael, Claggett, Brian, Lanfear, David E., Vandekerckhove, Hans, Biering-Sørensen, Tor, Lopes, Renato D., Arias-Mendoza, Alexandra, Momomura, Shin-Ichi, Corbalan, Ramon, Ramires, Felix J.A., Zannad, Faiez, Heitner, Stephen B., Divanji, Punag H., Kupfer, Stuart, Malik, Fady I., and Teerlink, John R.

Published
2024
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2. Omecamtiv Mecarbil in Black Patients With Heart Failure and Reduced Ejection Fraction: Insights From GALACTIC-HF

Author

Lanfear, David E., Njoroge, Joyce N., Adams, Kirkwood F., Anand, Inder, Fang, James C., Ramires, Felix, Sliwa-Hahnle, Karen, Badat, Aysha, Burgess, Lesley, Gorodeski, Eiran Z., Williams, Celeste, Diaz, Rafael, Felker, Gary M., McMurray, John J.V., Metra, Marco, Solomon, Scott, Miao, Zi Michael, Claggett, Brian L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., and Teerlink, John R.

Published
2023
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4. Sacubitril/Valsartan Versus Enalapril in Chronic Chagas Cardiomyopathy

Author

Bocchi, Edimar Alcides, Echeverria, Luis E., Demacq, Caroline, de Barros e Silva, Pedro Gabriel Melo, Mazza Barbosa, Lilian, Chiang, Lu-May, Damiani, Lucas, Morillo, Carlos A., Kevorkian, Ruben, Ramires, Felix, Bahit, M. Cecilia, Ferrari, Ariana, Chavez-Mendoza, Adolfo, Magaña-Serrano, Jose Antonio, McMurray, John J.V., Gimpelewicz, Claudio, and Lopes, Renato D.

Abstract

Chronic Chagas cardiomyopathy (CCC) has unique pathogenic and clinical features with worse prognosis than other causes of heart failure (HF), despite the fact that patients with CCC are often younger and have fewer comorbidities. Patients with CCC were not adequately represented in any of the landmark HF studies that support current treatment guidelines. PARACHUTE-HF (Prevention And Reduction of Adverse outcomes in Chagasic Heart failUre Trial Evaluation) is an active-controlled, randomized, phase IV trial designed to evaluate the effect of sacubitril/valsartan 200 mg twice daily vs enalapril 10 mg twice daily added to standard of care treatment for HF. The study aims to enroll approximately 900 patients with CCC and reduced ejection fraction at around 100 sites in Latin America. The primary outcome is a hierarchical composite of time from randomization to cardiovascular death, first HF hospitalization, or relative change from baseline to week 12 in NT-proBNP levels. PARACHUTE-HF will provide new data on the treatment of this high-risk population. (Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC [PARACHUTE-HF]; NCT04023227)

Published
2024
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5. Effect of exercise training on cardiovascular autonomic and muscular function in subclinical Chagas cardiomyopathy: a randomized controlled trial

Author

Sarmento, Adriana Oliveira, Antunes-Correa, Ligia M., Alves, Maria J. N. N., Bacurau, Aline V. N., Fonseca, Keila C. B., Pessoa, Fernanda G., Lobo, Denise M. L., Moreira, Leila D. P., Trombetta, Ivani C., Rondon, Maria U. P. B., Rondon, Eduardo, Vieira, Marcelo L. C., Ramires, Felix J. A., do Brasileiro-Santos, Maria Socorro, Brum, Patricia C., Mady, Charles, Negrao, Carlos E., Thomas, Scott, and Ianni, Barbara M.

Published
2021
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6. Dysregulation of insulin levels in Chagas heart disease is associated with altered adipocytokine levels

Author

Dabarian, Andre Luiz, Mady, Charles, Barbosa-Ferreira, Joao Marcos, Ianni, Barbara Maria, Hotta, Viviane Tiemi, Ramires, Felix Jose Alvarez, Lopes, Heno Ferreira, Buck, Paula de Cassia, Pessoa, Fernanda Gallinaro, Fonseca, Keila Cardoso Barbosa, Nogueira, Adriana Ramos, and Fernandes, Fabio

Subjects
Chagas disease -- Physiological aspects, Insulin -- Physiological aspects, Cytokines -- Physiological aspects, Heart diseases -- Physiological aspects, Cardiac patients, Myocardial diseases, Interleukins, Etiology (Medicine), Congestive cardiomyopathy, Tumors, Cholesterol, Necrosis, Heart rate, Cardiovascular diseases, Tumor necrosis factor, Leptin, Patient monitoring equipment, Heart, Heart failure, Diabetes therapy, Glucose, Biological sciences
Abstract

Metabolic, inflammatory, and autonomic nervous system (ANS) dysfunction are present in patients with heart failure. However, whether these changes are due to left ventricular dysfunction or heart failure etiology is unknown. We evaluated metabolism and inflammatory activity in patients with idiopathic dilated cardiomyopathy (IDC) and Chagas cardiomyopathy (CHG) and their correlation with the ANS. Forty-six patients were divided into 3 groups: IDC, CHG, and control. We evaluated adiponectin, leptin, insulin, interleukin-6, and tumor necrosis factor-alpha. ANS were analyzed by heart rate variability in time and frequency domains on a 24-hour Holter monitor. Levels of glucose, cholesterol, leptin, and adiponectin did not show differences between groups. Insulin levels were lower in CHG group (5.4 [+ or -] 3.3 [micro]U/mL) when compared with control (8.0 [+ or -] 4.9 [micro]U/mL) and IDC (9.9 [+ or -] 5.0 [micro]U/mL) groups (p = 0.007). Insulin was positively associated with LFr/HFr ratio (r = 0.562; p = 0.029) and with the LFr component (r = 0.562; p = 0.029) and negatively associated with adiponectin (r = -0.603; p = 0.017) in CHG group. The addition of an adiponectin unit reduced average insulin by 0.332 [micro]g/mL. Insulin levels were decreased in the CHG group when compared with the IDC group and were associated with ANS indexes and adiponectin levels.Key words: adipocytokine, insulin levels, Chagas heart disease.Les systemes metabolique, inflammatoire et nerveux autonome presentent des dysfonctionnements chez les patients atteints d'insuffisance cardiaque. Cependant, on ne sait pas si l'etiologie de ces modifications est liee au dysfonctionnement du ventricule gauche ou a l'insuffisance cardiaque. Nous avons evalue le metabolisme et l'activite inflammatoire chez des patients atteints de cardiomyopathie dilatee idiopathique (CDI) ou de cardiomyopathie de Chagas (CCH), ainsi que leur correlation avec le systeme nerveux autonome (SNA). Nous avons reparti 46 patients dans 3 groupes : CDI, CCH et temoin (GT). Nous avons evalue les taux d'adiponectine, de leptine, d'insuline, d'interleukine 6 et du facteur de necrose tumorale alpha. Le SNA a ete evalue par la variabilite de la frequence cardiaque dans le temps et les domaines de frequence a l'aide d'une surveillance de 24 heures par Holter. Les taux de glucose, de cholesterol, de leptine et d'adiponectine ne se sont pas reveles differents entre les groupes. Les taux d'insuline etaient moins eleves dans le groupe CCH (5,4 [+ or -] 3,3 [micro]U/mL) que dans les groupes GT (8,0 [+ or -] 4,9 [micro]U/mL) et CDI (9,9 [+ or -] 5,0 [micro]U/mL) (p = 0,007). Dans le groupe CCH, les taux d'insuline etaient directement proportionnels au ratio LFr/HFr (basses frequences sur hautes frequences; r = 0,562; p = 0,029) et a la composante LFr (r = 0,562; p = 0,029), ainsi qu'inversement proportionnels aux taux d'adiponectine (r = -0,603; p = 0,017). L'ajout d'une unite d'adiponectine entrainait une diminution des taux d'insuline moyens de 0,332 [micro]g/mL. Les taux d'insuline etaient plus bas dans le groupe CCH que dans le groupe CDI et associes aux indices du SNA et aux taux d'adiponectine. [Traduit par la Redaction]Mots-cles : adipocytokine, taux d'insuline, maladie cardiaque de Chagas., IntroductionChagas disease occurs from the southern United States to Patagonia and affects around 8 million people in Latin America and is the main cause of cardiomyopathy in these endemic areas [...]

Published
2019
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7. Multifaceted Strategy Based on Automated Text Messaging After a Recent Heart Failure Admission: The MESSAGE-HF Randomized Clinical Trial

Author

Rohde, Luis E., Rover, Marciane M., Hoffmann Filho, Conrado R., Rabelo-Silva, Eneida Rejane, Silvestre, Odilson M., Martins, Silvia M., Passos, Luiz C. S., de Figueiredo Neto, José A., Danzmann, Luiz C., Silveira, Fábio S., Mesas, Cezar Eumann, Hernandes, Mauro E., Moura, Lidia Z., Simões, Marcus V., Ritt, Luiz E. F., Nishijuka, Fábio Akio, Bertoldi, Eduardo G., Dall Orto, Frederico T. C., Magedanz, Ellen Hettwer, Mourilhe-Rocha, Ricardo, Fernandes-Silva, Miguel M., Ferraz, Almir Sergio, Schwartzmann, Pedro, de Castilho, Fábio M., Pereira Barretto, Antonio Carlos, dos Santos Júnior, Edval Gomes, Nogueira, Paulo Roberto, Canesin, Manoel, Beck-da-Silva, Luis, de Carvalho Silva, Maísa, Adolfi Júnior, Mario Sergio, Santos, Renato H. N., Ferreira, Amanda, Pereira, Danielle, López Pedraza, Leticia, Kojima, Flávia C. S., Campos, Viviane, de Barros e Silva, Pedro G. M., Blacher, Mariana, Cavalcanti, Alexandre B., and Ramires, Felix

Abstract

IMPORTANCE: Readmissions after an index heart failure (HF) hospitalization are a major contemporary health care problem. OBJECTIVE: To evaluate the feasibility and efficacy of an intensive telemonitoring strategy in the vulnerable period after an HF hospitalization. DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial was conducted in 30 HF clinics in Brazil. Patients with left ventricular ejection fraction less than 40% and access to mobile phones were enrolled up to 30 days after an HF admission. Data were collected from July 2019 to July 2022. INTERVENTION: Participants were randomly assigned to a telemonitoring strategy or standard care. The telemonitoring group received 4 daily short message service text messages to optimize self-care, active engagement, and early intervention. Red flags based on feedback messages triggered automatic diuretic adjustment and/or a telephone call from the health care team. MAIN OUTCOMES AND MEASURES: The primary end point was change in N-terminal pro–brain natriuretic peptide (NT-proBNP) from baseline to 180 days. A hierarchical win-ratio analysis incorporating blindly adjudicated clinical events (cardiovascular deaths and HF hospitalization) and variation in NT-proBNP was also performed. RESULTS: Of 699 included patients, 460 (65.8%) were male, and the mean (SD) age was 61.2 (14.5) years. A total of 352 patients were randomly assigned to the telemonitoring strategy and 347 to standard care. Satisfaction with the telemonitoring strategy was excellent (net promoting score at 180 days, 78.5). HF self-care increased significantly in the telemonitoring group compared with the standard care group (score difference at 30 days, −2.21; 95% CI, −3.67 to −0.74; P = .001; score difference at 180 days, −2.08; 95% CI, −3.59 to −0.57; P = .004). Variation of NT-proBNP was similar in the telemonitoring group compared with the standard care group (telemonitoring: baseline, 2593 pg/mL; 95% CI, 2314-2923; 180 days, 1313 pg/mL; 95% CI, 1117-1543; standard care: baseline, 2396 pg/mL; 95% CI, 2122-2721; 180 days, 1319 pg/mL; 95% CI, 1114-1564; ratio of change, 0.92; 95% CI, 0.77-1.11; P = .39). Hierarchical analysis of the composite outcome demonstrated a similar number of wins in both groups (telemonitoring, 49 883 of 122 144 comparisons [40.8%]; standard care, 48 034 of 122 144 comparisons [39.3%]; win ratio, 1.04; 95% CI, 0.86-1.26). CONCLUSIONS AND RELEVANCE: An intensive telemonitoring strategy applied in the vulnerable period after an HF admission was feasible, well-accepted, and increased scores of HF self-care but did not translate to reductions in NT-proBNP levels nor improvement in a composite hierarchical clinical outcome. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04062461

Published
2024
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8. Detection of Early Diffuse Myocardial Fibrosis and Inflammation in Chagas Cardiomyopathy with T1 Mapping and Extracellular Volume

Author

Melo, Rodrigo J. L., Assunção, Antonildes N., Morais, Thamara C., Nomura, Cesar H., Scanavacca, Mauricio I., Martinelli-Filho, Martino, Ramires, Felix J. A., Fernandes, Fabio, Ianni, Barbara M., Mady, Charles, and Rochitte, Carlos E.

Subjects
Original Research
Abstract

PURPOSE: To evaluate myocardial T1 mapping and extracellular volume (ECV) parameters in different stages of Chagas cardiomyopathy and determine whether they are predictive of disease severity and prognosis. MATERIALS AND METHODS: Prospectively enrolled participants (July 2013 to September 2016) underwent cine and late gadolinium enhancement (LGE) cardiac MRI and T1 mapping with a precontrast (native) or postcontrast modified Look-Locker sequence. The native T1 and ECV values were measured among subgroups that were based on disease severity (indeterminate, Chagas cardiomyopathy with preserved ejection fraction [CCpEF], Chagas cardiomyopathy with midrange ejection fraction [CCmrEF], and Chagas cardiomyopathy with reduced ejection fraction [CCrEF]). Cox proportional hazards regression and the Akaike information criterion were used to determine predictors of major cardiovascular events (cardioverter defibrillator implant, heart transplant, or death). RESULTS: In 107 participants (90 participants with Chagas disease [mean age ± SD, 55 years ± 11; 49 men] and 17 age- and sex-matched control participants), the left ventricular (LV) ejection fraction and the extent of focal and diffuse or interstitial fibrosis were correlated with disease severity. Participants with CCmrEF and participants with CCrEF showed significantly higher global native T1 and ECV values than participants in the indeterminate, CCpEF, and control groups (T1: 1072 msec ± 34 and 1073 msec ± 63 vs 1010 msec ± 41, 1005 msec ± 69, and 999 msec ± 46; ECV: 35.5% ± 3.6 and 35.0% ± 5.4 vs 25.3% ± 3.5, 28.2% ± 4.9, and 25.2% ± 2.2; both P < .001). Remote (LGE-negative areas) native T1 and ECV values were also higher (T1: 1056 msec ± 32 and 1071 msec ± 55 vs 1008 msec ± 41, 989 msec ± 96, and 999 msec ± 46; ECV: 30.2% ± 4.7 and 30.8% ± 7.4 vs 25.1% ± 3.5, 25.1% ± 3.7, and 25.0% ± 2.2; both P < .001). Abnormal remote ECV values (>30%) occurred in 12% of participants in the indeterminate group, which increased with disease severity. Nineteen combined outcomes were observed (median follow-up time: 43 months), and a remote native T1 value greater than 1100 msec was independently predictive of combined outcomes (hazard ratio, 12 [95% CI: 4.1, 34.2]; P < .001). CONCLUSION: Myocardial native T1 and ECV values were correlated with Chagas disease severity and may serve as markers of myocardial involvement in Chagas cardiomyopathy that precede LGE and LV dysfunction. Keywords: MRI, Cardiac, Heart, Imaging Sequences, Chagas Cardiomyopathy Supplemental material is available for this article. © RSNA, 2023

Published
2023

9. Erythropoietin reduces collagen deposition after myocardial infarction but does not improve cardiac function

Author

Pessoa, Fernanda Gallinaro, Mady, Charles, Fonseca, Keila Cardoso Barbosa, de Oliveira-Fonoff, Adriana Morgan, Salemi, Vera Maria Cury, Jordao, Mauncio Rodrigues, Fernandes, Fabio, and Ramires, Felix Jose Alvarez

Subjects
Heart attack -- Physiological aspects, Collagen -- Physiological aspects, Erythropoietin -- Physiological aspects, Biological sciences
Abstract

Myocardial remodeling includes inappropriate collagen deposition in the interstitium. Erythropoietin (EPO) may have cardioprotective effects. We aimed to assess the role of EPO on myocardial remodeling during the chronic phase. We studied 60 Wistar rats divided into the following groups: control (CT), control + EPO (CT + EPO), myocardial infarction + EPO (MI + EPO), and myocardial infarction (MI). The interstitial collagen volume fraction (ICVF) was quantified and echocardiography was performed. We quantified asymmetric dimethylarginine and glutathione by ELISA, and used real-time PCR to assess apoptosis and inflammation. Western blotting was used to evaluate inflammatory proteins and tissue inhibitors of metalloproteinases (TIMPs), and TUNEL staining was used to detect apoptosis. For matrix metalloproteinases (MMPs), we performed zymography. Parametric and nonparametric analyses were performed according to normality testing. ICVF was greater in MI groups (p < 0.001) and was attenuated by EPO (p = 0.05). The MMP-2 did not show any difference between groups. The TIMP-1 and TIMP-2 did not have difference between groups. The MI groups had worse fraction shortening (p < 0.001), without EPO protection (p = 0.666). The MI groups had increased left ventricle diastolic dimension (p < 0.001) without EPO attenuation (p = 0.79). EPO did not act on oxidative stress. Apoptosis and inflammation were not modulated by EPO. We concluded that EPO attenuated interstitial collagen accumulation, but did not protect from heart dilation or dysfunction. Key words: erythropoietin, ventricular remodeling, fibrosis, myocardial infarction, inflammation, oxidative stress. Resume : Le remodelage du myocarde comprend le depot inapproprie de collagene dans le tissu interstitiel. Par ailleurs, l'erythropoietine (EPO) pourrait avoir des effets cardioprotecteurs. Nous visions a evaluer le role de l'EPO sur le remodelage du myocarde pendant la phase chronique. Nous avons etudie 60 rats Wistar repartis dans les groupes suivants: temoin (T), temoin + EPO (T + EPO), infarctus du myocarde + EPO (IM + EPO) et infarctus du myocarde (IM). Nous avons quantifie la fraction volumique du collagene interstitiel (FVCI) et effectue une echocardiographie. En vue d'evaluer l'apoptose et l'inflammation, nous avons quantifie les taux de dymethylarginine asymetrique et de glutathion a l'aide des techniques d'ELISA et de PCR en temps reel. Nous avons utilise l'immunobuvardage de Western pour evaluer les taux de proteines inflammatoires et d'inhibiteurs des metalloproteinases tissulaires (TIMP), ainsi que la technique de marquage TUNEL pour deceler l'apoptose. Pour les metalloproteinases matricielles (MMP), nous avons effectue une zymographie. Nous avons enfin effectue des analyses parametriques et non parametriques en fonction de tests de distribution normale. La FVCI etait plus elevee dans les groupes IM (p < 0,001) et diminuait avec l'EPO (p = 0,05). Les taux de MMP-2 ne se sont pas reveles differents entre les groupes. L'activite de TIMP-1 et de TIMP-2 n'etait pas differente entre les groupes non plus. En fait, la fraction de raccourcissement etait moins avantageuse dans les groupes IM (p < 0,001), sans protection liee a l'EPO (p = 0,666). Et la dimension du ventricule gauche en diastole etait plus elevee dans les groupes IM (p < 0,001), sans attenuation liee a l'EPO non plus (p = 0,79). Enfin, l'EPO n'avait aucun effet sur le stress oxydatif et elle ne participait pas a la modulation de l'apoptose ni de l'inflammation. Nous en sommes arrives a la conclusion que l'EPO permettait de diminuer l'accumulation de collagene dans le tissu interstitiel, mais qu'elle n'entramait pas de protection contre la dilatation du creur ni contre son dysfonctionnement. [Traduit par la Redaction] Mots-cles: erythropoietine, remodelage des ventricules, fibrose, infarctus du myocarde, inflammation, stress oxydatif., Introduction Myocardial remodeling is responsible for cardiac dysfunction that results in heart failure. Interstitial collagen deposition into the myocardium has a pivotal role in this scenario. Inflammation, oxidative stress, and [...]

Published
2018
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10. Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023

Author

Marin-Neto, José Antonio, primary, Rassi, Anis, additional, Oliveira, Gláucia Maria Moraes, additional, Correia, Luís Claudio Lemos, additional, Ramos, Alberto Novaes, additional, Luquetti, Alejandro Ostermayer, additional, Hasslocher-Moreno, Alejandro Marcel, additional, Sousa, Andréa Silvestre de, additional, Paola, Angelo Amato Vincenzo de, additional, Sousa, Antônio Carlos Sobral, additional, Ribeiro, Antonio Luiz Pinho, additional, Correia, Dalmo, additional, Souza, Dilma do Socorro Moraes de, additional, Cunha-Neto, Edecio, additional, Ramires, Felix Jose Alvarez, additional, Bacal, Fernando, additional, Nunes, Maria do Carmo Pereira, additional, Martinelli, Martino, additional, Scanavacca, Maurício Ibrahim, additional, Saraiva, Roberto Magalhães, additional, Oliveira, Wilson Alves de, additional, Lorga-Filho, Adalberto Menezes, additional, Guimarães, Adriana de Jesus Benevides de Almeida, additional, Braga, Adriana Lopes Latado, additional, Oliveira, Adriana Sarmento de, additional, Sarabanda, Alvaro Valentim Lima, additional, Pinto, Ana Yecê das Neves, additional, Carmo, Andre Assis Lopes do, additional, Schmidt, Andre, additional, Costa, Andréa Rodrigues da, additional, Ianni, Barbara Maria, additional, Markman, Brivaldo, additional, Rochitte, Carlos Eduardo, additional, Macêdo, Carolina Thé, additional, Mady, Charles, additional, Chevillard, Christophe, additional, Virgens, Cláudio Marcelo Bittencourt das, additional, Castro, Cleudson Nery de, additional, Britto, Constança Felicia De Paoli de Carvalho, additional, Pisani, Cristiano, additional, Rassi, Daniela do Carmo, additional, Sobral, Dário Celestino, additional, Almeida, Dirceu Rodrigues de, additional, Bocchi, Edimar Alcides, additional, Mesquita, Evandro Tinoco, additional, Mendes, Fernanda de Souza Nogueira Sardinha, additional, Gondim, Francisca Tatiana Pereira, additional, Silva, Gilberto Marcelo Sperandio da, additional, Peixoto, Giselle de Lima, additional, Lima, Gustavo Glotz de, additional, Veloso, Henrique Horta, additional, Moreira, Henrique Turin, additional, Lopes, Hugo Bellotti, additional, Pinto, Ibraim Masciarelli Francisco, additional, Ferreira, João Marcos Bemfica Barbosa, additional, Nunes, João Paulo Silva, additional, Barreto-Filho, José Augusto Soares, additional, Saraiva, José Francisco Kerr, additional, Lannes-Vieira, Joseli, additional, Oliveira, Joselina Luzia Menezes, additional, Armaganijan, Luciana Vidal, additional, Martins, Luiz Cláudio, additional, Sangenis, Luiz Henrique Conde, additional, Barbosa, Marco Paulo Tomaz, additional, Almeida-Santos, Marcos Antonio, additional, Simões, Marcos Vinicius, additional, Yasuda, Maria Aparecida Shikanai, additional, Moreira, Maria da Consolação Vieira, additional, Higuchi, Maria de Lourdes, additional, Monteiro, Maria Rita de Cassia Costa, additional, Mediano, Mauro Felippe Felix, additional, Lima, Mayara Maia, additional, Oliveira, Maykon Tavares de, additional, Romano, Minna Moreira Dias, additional, Araujo, Nadjar Nitz Silva Lociks de, additional, Medeiros, Paulo de Tarso Jorge, additional, Alves, Renato Vieira, additional, Teixeira, Ricardo Alkmim, additional, Pedrosa, Roberto Coury, additional, Aras, Roque, additional, Torres, Rosalia Morais, additional, Povoa, Rui Manoel dos Santos, additional, Rassi, Sergio Gabriel, additional, Alves, Silvia Marinho Martins, additional, Tavares, Suelene Brito do Nascimento, additional, Palmeira, Swamy Lima, additional, Silva, Telêmaco Luiz da, additional, Rodrigues, Thiago da Rocha, additional, Madrini, Vagner, additional, Brant, Veruska Maia da Costa, additional, Dutra, Walderez Ornelas, additional, and Dias, João Carlos Pinto, additional

Published
2023
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11. Diretriz da Sociedade Brasileira de Cardiologia sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas

Author

Marin-Neto, José Antonio, primary, Rassi Jr., Anis, additional, Moraes Oliveira, Gláucia M., additional, Lemos Correia, Luís Claudio, additional, Novaes Ramos Jr., Alberto, additional, Hasslocher-Moreno, Alejandro Marcel, additional, Luquetti Ostermayer, Alejandro, additional, Sousa, Andréa Silvestre de, additional, Amato Vincenzo de Paola, Angelo, additional, Sobral de Sousa, Antonio Carlos, additional, Pinho Ribeiro, Antonio Luiz, additional, Correia Filho, Dalmo, additional, Moraes de Souza, Dilma do Socorro, additional, Cunha-Neto, Edecio, additional, J. A. Ramires, Felix, additional, Bacal, Fernando, additional, Pereira Nunes, Maria do Carmo, additional, Martinelli Filho, Martino, additional, Ibrahim Scanavacca, Maurício, additional, Magalhães Saraiva, Roberto, additional, Alves de Oliveira Júnior, Wilson, additional, M. Lorga-Filho, Adalberto, additional, De Jesus Benevides de Almeida Guimarães, Adriana, additional, Lopes Latado Braga, Adriana, additional, Sarmento de Oliveira, Adriana, additional, V. L. Sarabanda, Alvaro, additional, Yecê das Neves Pinto, Ana, additional, Assis Lopes do Carmo, André, additional, Schmidt, André, additional, Costa, Andréa Rodrigues da, additional, Ianni, Barbara Maria, additional, Markman Filho, Brivaldo, additional, Eduardo Rochitte, Carlos, additional, Thé Macedo, Carolina, additional, Mady, Charles, additional, Chevillard, Christophe, additional, Bittencourt das Virgens, Cláudio Marcelo, additional, Nery de Castro, Cleudson, additional, De Paoli de Carvalho Britto, Constança Felícia, additional, Pisani, Cristiano, additional, Do Carmo Rassi, Daniela, additional, C. Sobral Filho, Dario, additional, Rodrigues Almeida, Dirceu, additional, A. Bocchi, Edimar, additional, T. Mesquita, Evandro, additional, De Souza Nogueira Sardinha Mendes, Fernanda, additional, Pereira, Francisca Tatiana, additional, Sperandio da Silva, Gilberto Marcelo, additional, De Lima Peixoto, Giselle, additional, Glotz de Lima, Gustavo, additional, H. Veloso, Henrique, additional, Turin Moreira, Henrique, additional, Bellotti Lopes, Hugo, additional, Masciarelli Francisco Pinto, Ibraim, additional, Pinto Dias, João Carlos, additional, Bemfica, João Marcos, additional, Silva-Nunes, João Paulo, additional, Soares Barreto-Filho, José Augusto, additional, Kerr Saraiva, José Francisco, additional, Lannes-Vieira, Joseli, additional, Menezes Oliveira, Joselina Luzia, additional, V. Armaganijan, Luciana, additional, Martins, Luiz Cláudio, additional, C. Sangenis, Luiz Henrique, additional, Barbosa, Marco Paulo, additional, Almeida-Santos, Marcos Antônio, additional, Simões, Marcos Vinicius, additional, Shikanai-Yasuda, Maria Aparecida, additional, Vieira Moreira, Maria da Consolação, additional, Higuchi, Maria de Lourdes, additional, Costa Monteiro, Maria Rita de Cássia, additional, Felix Mediano, Mauro Felippe, additional, Maia Lima, Mayara, additional, T. Oliveira, Maykon, additional, Moreira Dias Romano, Minna, additional, Nitz, Nadjar, additional, De Tarso Jorge Medeiros, Paulo, additional, Vieira Alves, Renato, additional, Alkmim Teixeira, Ricardo, additional, Coury Pedrosa, Roberto, additional, Aras, Roque, additional, Morais Torres, Rosália, additional, Dos Santos Povoa, Rui Manoel, additional, Rassi, Sérgio Gabriel, additional, Salles Xavier, Sérgio, additional, Marinho Martins Alves, Silvia, additional, B. N. Tavares, Suelene, additional, Lima Palmeira, Swamy, additional, Da Silva Junior, Telêmaco Luiz, additional, Da Rocha Rodrigues, Thiago, additional, Madrini Junior, Vagner, additional, Maia da Costa, Veruska, additional, and Dutra, Walderez, additional

Published
2022
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12. Position Statement on Diagnosis and Treatment of Cardiac Amyloidosis – 2021

Author

Simões, Marcus V., Fernandes, Fabio, Marcondes-Braga, Fabiana G., Scheinberg, Philip, Correia, Edileide de Barros, Rohde, Luis Eduardo P., Bacal, Fernando, Alves, Silvia Marinho Martins, Mangini, Sandrigo, Biolo, Andréia, Beck-da-Silva, Luis, Szor, Roberta Shcolnik, Marques Junior, Wilson, Oliveira, Acary Souza Bulle, Cruz, Márcia Waddington, Bueno, Bruno Vaz Kerges, Hajjar, Ludhmila Abrahão, Issa, Aurora Felice Castro, Ramires, Felix José Alvarez, Coelho Filho, Otavio Rizzi, Schmidt, André, Pinto, Ibraim Masciarelli Francisco, Rochitte, Carlos Eduardo, Valicelli, Flávio Henrique, Vieira, Marcelo Luiz Campos, Mesquita, Cláudio Tinoco, Ramos, Celso Dario, Soares-Junior, José, Romano, Minna Moreira Dias, Mathias Junior, Wilson, Garcia Junior, Marcelo Iório, Montera, Marcelo Westerlund, Melo, Marcelo Dantas Tavares de, Silva, Sandra Marques e, Garibaldi, Pedro Manoel Marques, Alencar Neto, Aristóteles Comte de, Lopes, Renato Delascio, Ávila, Diane Xavier de, Viana, Denizar, Saraiva, José Francisco Kerr, Canesin, Manoel Fernandes, Oliveira, Glaucia Maria Moraes de, and Mesquita, Evandro Tinoco

Subjects
Gynecology, Position statement, medicine.medical_specialty, Cardiac amyloidosis, business.industry, RC666-701, medicine, Diseases of the circulatory (Cardiovascular) system, Posicionamento, Statement, Cardiology and Cardiovascular Medicine, business
Abstract

1. Introducao Nos ultimos anos, foram consolidados avancos expressivos no conhecimento de amiloidose cardiaca (AC), trazendo uma profunda reformulacao do seu significado clinico. Alem de haver evidencias convincentes de que AC seja uma causa relativamente comum de insuficiencia cardiaca com fracao de ejecao preservada (ICFEP), assistimos o surgimento de terapias especificas modificadoras do curso natural da doenca, capazes de prolongar a sobrevida dos pacientes acometidos. Em paralelo, relevantes progressos nas tecnicas de imagem cardiovascular tem contribuido grandemente para o reconhecimento [...]

Published
2021

13. Air Pollution’s Impact on Cardiac Remodeling in an Experimental Model of Chagas Cardiomyopathy

Author

Fonseca, Keila Cardoso Barbosa, primary, Pessoa, Fernanda Gallinaro, additional, Ribeiro, Orlando do Nascimento, additional, Hotta, Viviane Tiemi, additional, Ianni, Barbara Maria, additional, Fernandes, Fabio, additional, Ferreira Rivero, Dolores Helena Rodriguez, additional, Saldiva, Paulo Hilário Nascimento, additional, Mady, Charles, additional, and Ramires, Felix José Alvarez, additional

Published
2022
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14. Análise Crítica e Limitações do Diagnóstico de Insuficiência Cardíaca com Fração de Ejeção Preservada (ICFEp)

Author

Hotta, Viviane Tiemi, primary, Rassi, Daniela do Carmo, additional, Pena, José Luiz Barros, additional, Vieira, Marcelo Luiz Campos, additional, Rodrigues, Ana Clara Tude, additional, Cardoso, Juliano Novaes, additional, Ramires, Felix Jose Alvarez, additional, Nastari, Luciano, additional, Mady, Charles, additional, and Fernandes, Fábio, additional

Published
2022
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16. Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy

Author

Shen, Li, Ramires, Felix, Martinez, Felipe, Bodanese, Luiz Carlos, Echeverría, Luis Eduardo, Gómez, Efraín A., Abraham, William T., Dickstein, Kenneth, Køber, Lars, Packer, Milton, Rouleau, Jean L., Solomon, Scott D., Swedberg, Karl, Zile, Michael R., Jhund, Pardeep S., Gimpelewicz, Claudio R., and McMurray, John J.V.

Published
2017
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20. Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Author

Teerlink, John R., Diaz, Rafael, Felker, G. Michael, McMurray, John J.V., Metra, Marco, Solomon, Scott D., Adams, Kirkwood F., Anand, Inder, Arias‐Mendoza, Alexandra, Biering‐Sørensen, Tor, Böhm, Michael, Bonderman, Diana, Cleland, John G.F., Corbalan, Ramon, Crespo‐Leiro, Maria G., Dahlström, Ulf, Echeverria Correa, Luis E., Fang, James C., Filippatos, Gerasimos, Fonseca, Cândida, Goncalvesova, Eva, Goudev, Assen R., Howlett, Jonathan G., Lanfear, David E., Lund, Mayanna, Macdonald, Peter, Mareev, Vyacheslav, Momomura, Shin‐ichi, O'Meara, Eileen, Parkhomenko, Alexander, Ponikowski, Piotr, Ramires, Felix J. A., Serpytis, Pranas, Sliwa, Karen, Spinar, Jindrich, Suter, Thomas M., Tomcsanyi, Janos, Vandekerckhove, Hans, Vinereanu, Dragos, Voors, Adriaan A., Yilmaz, Mehmet B., Zannad, Faiez, Sharpsten, Lucie, Legg, Jason C., Abbasi, Siddique A., Varin, Claire, Malik, Fady I., Kurtz, Christopher E., Besada, Diego Alejandro, Majul, Claudio Rodolfo, Bruno, Marco Raul Litvak, Sassone, Sonia, Avaca, Horacio Alberto, Rasmussen, Mariela, Aiub, Jorge Roberto, Hominal, Miguel Angel, Perna, Eduardo, Duran, Ruben Omar Garcia, Schiavi, Lilia, Marquez, Lilia Luz Lobo, Vilamajo, Oscar Alberto Gomez, Mackinnon, Ignacio, Fuente, Ricardo Alfonso Leon, Montana, Oscar Romano, Novaretto, Leonardo, Guerrero, Rodolfo Andres Ahuad, Brasca, Daniela Garcia, Prado, Aldo, Garrido, Marcelo Alejandro, Luquez, Hugo, Martinez, Diego Felipe, Nicolosi, Liliana, Parody, Maria Leonor, Zaidman, Cesar, Berra, Fernando Colombo, Ibañez, Julio, Zapata, Gerardo, Caccavo, Alberto, Colque, Roberto, Diez, Mirta, Poy, Carlos, Salomone, Oscar Alejandro, Vogel, Daniel, Bordonava, Anselmo Paulino, Fernandez, Alberto, French, John, Atherton, John, Hamilton, Andrew, Begg, Alistair, Abhayaratna, Walter, Judkins, Christopher, De Pasquale, Carmine, McKenzie, Scott, Amerena, John, Szto, Gregory, Kearney, Leighton, Zimmet, Hendrik, Sverdlov, Aaron, Beltrame, John, Korczyk, Dariusz, Sindone, Andrew, Moertl, Deddo, Huber, Kurt, Huelsmann, Martin, Ablasser, Klemens, Ebner, Christian, Siostrzonek, Peter, Drexel, Heinz, Poelzl, Gerhard, Dujardin, Karl, Dupont, Matthias, Buysschaert, Ian, Lancellotti, Patrizio, Droogne, Walter, Chouchane, Iman, Silveira, Fabio, Rassi, Salvador, Reis, Gilmar, Filho, Pedro Pimentel, Simoes, Marcus Vinicius, Braga, Joao Carlos, Giorgeto, Flavio Eduardo, Ferraz, Almir, Jaeger, Cristiano Pederneiras, Saraiva, Jose Francisco, Tognon, Alexandre, Cardoso, Juliano, Greco, Oswaldo, Paiva, Maria Sanali, Paolino, Bruno, Filho, Otavio Coelho, Maia, Lilia Nigro, Silva, Rodrigo, Canesin, Manoel, Rossi, Paulo Roberto Ferreira, Fortes, Jose Augusto Ribas, Cerci, Rodrigo Julio, Manenti, Euler Roberto Fernandes, Leaes, Paulo Ernesto, Silva Neto, Luis Beck, Souza, Weimar Kunz Barroso, Bacal, Fernando, Chaves, Renato, Ramires, Felix, Vidotti, Maria Helena, Barros e Silva, Pedro Gabriel Melo, Piegas, Leopoldo Soares, Todorov, Georgi, Tzekova, Maria, Goudev, Assen, Mincheva, Valentina, Vasilev, Ivaylo, Tisheva‐ Gospodinova, Snezhanka, Petrov, Ivo, Postadzhiyan, Arman, Velikov, Chavdar, Dimov, Bojidar, Constance, Christian, Phaneuf, Denis‐Carl, Mielniczuk, Lisa, Pandey, A Shekhar, Senaratne, Manohara, Zieroth, Shelley, Savard, Daniel, Stewart, Robert, Huynh, Thao, Giannetti, Nadia, Moe, Gordon, Bourgeois, Ronald, Ezekowitz, Justin, Hartleib, Michael, Sussex, Bruce, Babapulle, Mohan, Chehayeb, Raja, Gaudet, Daniel, McKelvie, Robert, Nguyen, Viviane, Roth, Sherryn, Gupta, Milan, Pesant, Yves, Rupka, Dennis, Bhargava, Rakesh, Costa‐Vitali, Atilio, Proulx, Guy, Vega, Mario, Potthoff, Sergio, Cid, Maria Cristina Schnettler, Sepulveda, Alex Mauricio Villablanca, Zanetti, Fernando Tomas Lanas, Gajardo, Victor Areli Saavedra, Kindel, Carlos Conejeros, Jofre, Christian Paolo Pincetti, Segarra, Jorge Leonardo Cobos, Venegas, Manuel Eduardo Rodriguez, Hidalgo, Mario Yanez, Jalaf, Margarita Gertrudis Vejar, Li, Weimin, Zhang, Jinguo, Fu, Xin, Zhang, Xuelian, Li, Dongye, Wang, Zhifang, Qu, Yanling, Zheng, Zhe, Tang, Huifang, Yang, Ping, Zhang, Yuhui, Zheng, Yang, Mi, Yafei, Huang, He, Bu, Peili, Chen, Guoqin, Chen, Jiyan, Han, Yajun, Li, Zhangquan, Ma, Shumei, Yang, Xuming, Yuan, Zuyi, Dong, Yugang, Li, Zhaoping, Mahemuti, Ailiman, Niu, Wentang, Yang, Zhenyu, Zhang, Yuqing, Sun, Yuemin, Wu, Weiheng, Liu, Feng, Yan, Jing, Li, Yinjun, Wang, Yi, Zhang, Shouyan, Zhou, Changyong, Cui, Hanbin, Li, Jianjun, Li, Tianfa, Han, Qinghua, Wei, Yu, Correa, Luis Eduardo Echeverria, Mendoza, Jose Luis Accini, Jattin, Fernando Manzur, Osorio, Wilder Castaño, Luengas, Carlos Alberto, Arroyo, Julian Alonso Coronel, Corredor, Miguel Alfredo Moncada, Giraldo, Clara Ines Saldarriaga, Lopez, Rodrigo Botero, Salazar, Dora Ines Molina, Triana, Miguel Urina, Lopez, Luis Horacio Atehortua, Rojas, Pastor Olaya, Pelaez, Sebastian Velez, Pareja, Monica Lopez, Bonfanti, Alberto Cadena, Polasek, Rostislav, Monhart, Zdenek, Sochor, Karel, Motovska, Zuzana, Belohlavek, Jan, Busak, Ladislav, Krupicka, Jiri, Tyl, Petr, Jerabek, Ondrej, Podpera, Ivo, Skrobakova, Janka, Peterka, Karel, Spacek, Rudolf, Cech, Vladimir, Kellnerova, Ivana, Nechvatal, Libor, Pozdisek, Zbynek, Houra, Marek, Kryza, Radim, Machova, Vilma, Cepelak, Michal, Stepek, David, Zeman, Kamil, Klimsa, Zdenek, Koleckar, Pavel, Schee, Alexandr, Spinarova, Lenka, Coufal, Zdenek, Jeppesen, Jorgen, Vraa, Soren, Wiggers, Henrik, Nyvad, Ole, Nielsen, Tonny, Kaiser‐Nielsen, Peter, Videbaek, Lars, Galinier, Michel, Lefebvre, Jean‐Marie, Tartiere, Jean‐Michel, De Geeter, Guillaume, Roubille, Francois, Ricci, Jean Etienne, Salvat, Muriel, Gueffet, Jean‐Pierre, Decoulx, Eric, Berdague, Philippe, Jondeau, Guillaume, Ovize, Michel, Groote, Pascal De, Donal, Erwan, Isnard, Richard, Sabatier, Rémi, Trochu, Jean Noel, Damy, Thibaud, Georges, Jean‐Louis, Rosamel, Yann, Picard, François, Aboyans, Victor, Laperche, Thierry, Mitrovic, Veselin, Taggeselle, Jens, Störk, Stefan, Ebelt, Henning, Genth‐Zotz, Sabine, Rassaf, Tienush, Duengen, Hans‐Dirk, Mittag, Marcus, Menck, Niels, Zeymer, Uwe, Haehling, Stephan, Boehm, Michael, Frankenstein, Lutz, Killat, Holger, Bourhaial, Hakima, Beug, Daniel, Horacek, Thomas, Pfister, Roman, Sandri, Marcus, Westenfeld, Ralf, Kadel, Christoph, Karvounis, Haralambos, Patsilinakos, Sotirios, Mantas, Ioannis, Karavidas, Apostolos, Giamouzis, Grigorios, Tsioufis, Konstantinos, Naka, Katerina, Tziakas, Dimitrios, Parissis, John, Styliadis, Ioannis, Barbetseas, Ioannis, Manolis, Athanasios, Kochiadakis, George, Herczeg, Bela, Nagy, Laszlo, Nyolczas, Noemi, Toth, Kalman, Merkely, Bela, Laszlo, Zoltan, Mark, Laszlo, Szakal, Imre, Papp, Andras, Bezzegh, Katalin, Lakatos, Ferenc, Hajko, Erik, Papp, Aniko, Forster, Tamas, Lupkovics, Geza, Mohacsi, Attila, Salamon, Csaba, Aradi, Daniel, Andreka, Peter, Szasz, Gyula, Zilahi, Zsolt, Kazinczy, Rita, Margonato, Alberto, Agostoni, Piergiuseppe, Fucili, Alessandro, Piovaccari, Giancarlo, Senni, Michele, Carluccio, Erberto, Bilato, Claudio, Frigerio, Maria, Indolfi, Ciro, Sinagra, Gianfranco, Brunetti, Natale Daniele, Perna, Gianpiero, Pini, Daniela, Volterrani, Maurizio, Leonardi, Sergio, Mortara, Andrea, Friz, Hernan Emilio Francisco Polo, Rossini, Roberta, Tocchetti, Carlo Gabriele, Vincenzi, Antonella, Cavallini, Claudio, Floresta, Agata Marina, Zaca, Valerio, Giudici, Vittorio, Villani, Giovanni Quinto, Higashino, Yorihiko, Oishi, Shogo, Wada, Atsuyuki, Fukuzawa, Shigeru, Onoue, Kenji, Koike, Akihiro, Koizumi, Tomomi, Masuda, Seigo, Mitsuo, Kazuhisa, Takahashi, Natsuki, Takenaka, Takashi, Tanabe, Jun, Watanabe, Naoki, Yoshida, Takeshi, Amano, Tetsuya, Ishikawa, Masahiro, Kida, Keisuke, Kubota, Toru, Nakamura, Kentaro, Sakamoto, Tomohiro, Shimomura, Mitsuhiro, Yuge, Masaru, Doi, Masayuki, Domae, Hiroshi, Ebato, Mio, Fujii, Kenshi, Fujiwara, Wakaya, Gohara, Seiichiro, Hata, Yoshiki, Kanda, Junji, Kitaoka, Hiroaki, Matsumoto, Takashi, Michishita, Ichiro, Miura, Shinichiro, Miyazaki, Tetsuro, Nakamura, Akihiro, Ogawa, Tomohiro, Okumura, Takahiro, Okumura, Yasuo, Sakai, Tetsuo, Sato, Yukihito, Shimizu, Wataru, Sugino, Hiroshi, Suzuki, Masahiro, Takagi, Atsutoshi, Takaishi, Hiroshi, Tanaka, Takahiro, Terasaki, Toshiro, Tsujimoto, Mitsuru, Ueda, Yasunori, Ujino, Keiji, Usui, Makoto, Yamamoto, Mitsutaka, Yoshikawa, Masaki, Ando, Kenji, Asakura, Masanori, Asano, Hiroshi, Fujii, Shigeru, Hara, Hisao, Inomata, Takayuki, Isshiki, Takaaki, Kadokami, Toshiaki, Kai, Hisashi, Kasai, Toshio, Kawamitsu, Katsunori, Kawasaki, Tomohiro, Koga, Tokushi, Komiyama, Nobuyuki, Maejima, Yasuhiro, Manita, Mamoru, Miyamoto, Nobuhide, Node, Koichi, Numaguchi, Kotaro, Sakata, Yasushi, Serikawa, Takeshi, Takama, Noriaki, Tatebe, Shunsuke, Ueno, Hideki, Hidaka, Takayuki, Hiroi, Shitoshi, Iseki, Harukazu, Ito, Hiroshi, Kajinami, Kouji, Kawakami, Hideo, Momiyama, Yukihiko, Mori, Masuki, Morita, Yukiko, Okishige, Kaoru, Sakagami, Satoru, Takeishi, Yasuchika, Terasawa, Akihiro, Utsu, Noriaki, Badariene, Jolita, Celutkiene, Jelena, Slapikas, Rimvydas, Jarasuniene, Dalia, Castillo, Armando Garcia, De los Rios Ibarra, Manuel Odin, Lopez, Gabriel Arturo Ramos, Llamas, Edmundo Alfredo Bayram, Esperon, Guillermo Antonio Llamas, Vazquez, Eduardo Salcido, Gonzalez, Ricardo Garcia, Leon, Jose Luis Arenas, Gonzalez, Salvador Leon, Mendoza, Maria Alexandra Arias, Rodriguez, Alicia Contreras, Machado, Gustavo Francisco Mendez, Salazar, Melchor Alpizar, Ruiz, Alberto Esteban Bazzoni, Flores, Ana Maria De Leon, Carrasco, Jose Alfredo Pagola, Araiza, Raul Reyes, Römer, Tjeerd, Remmen, Johannes, Van Eck, Jacob, Elvan, Arif, Smilde, Tom, Voors, Adriaan, Wal, Ruud, Schaap, Jeroen, Sluis, Aize, Linssen, Gerardus, Magro, Michael, Willems, Frank, Hal, John, Zwaan, Coenraad, Beelen, Driek, Boswijk, Dirk, Hermans, Walter, Van Kesteren, Henricus, Scott, Russell, Hart, Hamish, Lund, Marianne, Szczasny, Marcin, Blicharski, Tomasz, Kafara, Mariusz, Stankiewicz, Anna, Skonieczny, Grzegorz, Zabowka, Maciej, Kania, Grzegorz, Kopaczewski, Jerzy, Pawlowicz, Lidia, Spyra, Janusz, Wlodarczyk, Aleksander, Sciborski, Ryszard, Balsam, Pawel, Drozdz, Jaroslaw, Sobkowicz, Bozena, Konieczynska, Malgorzata, Lelonek, Malgorzata, Bednarkiewicz, Zbigniew, Trebacz, Jaroslaw, Jankowski, Piotr, Sidor, Mateusz, Berkowski, Piotr, Chmielak, Zbigniew, Lenartowska, Lucyna, Nessler, Jadwiga, Straburzynska‐Migaj, Ewa, Kalarus, Zbigniew, Kowalski, Robert, Kalecinska‐Krystkiewicz, Ewa, Gola, Zbigniew, Pijanowski, Zbigniew, Wozakowska‐Kaplon, Beata, Cymerman, Krzysztof, Rynkiewicz, Andrzej, Miekus, Pawel, Monteiro, Pedro, Sarmento, Pedro Morais, Almeida, Filipa, Duarte, Tatiana, Fonseca, Candida, Oliveira, Luis, Santos, Luis, Brito, Dulce, Stanciulescu, Gabriela, Spiridon, Marilena Renata, Militaru, Constantin, Podoleanu, Cristian Gheorghe, Zdrenghea, Dumitru, Popescu, Mircea Ioachim, Macarie, Cezar‐Eugen, Giuca, Alina, Mitu, Florin, Voicu, Olga‐Cristina, Dorobantu, Maria, Lighezan, Daniel, Stamate, Sorin, Bykov, Alexander, Kobalava, Zhanna, Zrazhevskiy, Konstantin, Semenova, Irina, Vishnevsky, Alexander, Shutemova, Elena, Tereschenko, Sergey, Shvarts, Yury, Barbarash, Olga, Lukyanov, Yury, Voevoda, Mikhail, Dovgolis, Svetlana, Dronov, Dmitry, Goloshchekin, Boris, Sitnikova, Maria, Ezhov, Marat, Tarasov, Nikolay, Kotelnikov, Mikhail, Kostenko, Viktor, Solovev, Oleg, Goncharov, Ivan, Myasnikov, Roman, Rafalskiy, Vladimir, Ryabov, Vyacheslav, Kosmacheva, Elena, Motylev, Igor, Nosov, Vladimir, Osipova, Irina, Salukhov, Vladimir, Belenkiy, Dmitriy, Bolshakova, Olga, Pimenov, Leonid, Shilkina, Nataliya, Kulibaba, Elena, Repin, Alexey, Timofeev, Alexander, Mitrokhin, Vladislav, Sherenkov, Alexander, Arbolishvili, Georgy, Antalik, Lubomir, Dzupina, Andrej, Fulop, Peter, Majercak, Ivan, Gonsorcik, Jozef, Vinanska, Daniela, Lenner, Egon, Lukacova, Jana, Margoczy, Roman, Smik, Rudolf, Stevlik, Jan, Uhliar, Rudolf, Burgess, Lesley, Badat, Aysha, Klug, Eric, Van Zyl, Louis, Abelson, Mark, Moodley, Rajendran, Tsabedze, Nqoba, Fourie, Nyda, Bonet, Luis Almenar, Prado, Jose Maria Arizon, Oliveira Soares, Manue Martinez‐Selles D, Villota, Julio Eduardo Nuñez, Leiro, Maria Generosa Crespo, Juanatey, Jose Ramon Gonzalez, Figal, Domingo Andres Pascual, Palomas, Juan Luis Bonilla, Perez, Sonia Mirabet, Jimenez, Juan Francisco Delgado, Padron, Antonio Lara, Diaz, Victor Alfonso Jimenez, Cubero, Javier Segovia, Paya, Vicente Eduardo Climent, Mayoral, Alejandro Recio, Fuente Galan, Luis, Doblas, Juan Jose Gomez, Freire, Ramon Bover, Peiro, Maria Teresa Blasco, Molina, Beatriz Diaz, Martinez, Laura Jordan, Vilchez, Francisco Gonzalez, Boman, Kurt, Karlstrom, Patric, Berglund, Stefan, Szabo, Barna, Peterson, Magnus, Wodlin, Peter, Lindholm, Carl‐Johan, Moccetti, Tiziano, Mueller, Christian, Suter, Thomas, Hullin, Roger, Meyer, Philippe, Noll, Georg, Yigit, Zerrin, Turgut, Okan Onur, Bekar, Lutfu, Sahin, Tayfun, Koldas, Zehra Lale, Celik, Ahmet, Cavusoglu, Yuksel, Demir, Mesut, Onrat, Ersel, Duzenli, Mehmet, Cosansu, Kahraman, Muderrisoglu, Ibrahim Haldun, Tuncer, Mustafa, Badak, Ozer, Nalbantgil, Sanem, Kirma, Cevat, Okuyan, Ertugrul, Guray, Umit, Prokhorov, Oleksandr, Karpenko, Oleksandr, Vakaliuk, Igor, Yagensky, Andriy, Kracz, Igor, Stanislavchuk, Mykola, Kulynych, Oleksii, Rishko, Mykola, Stets, Roman, Tseluyko, Vira, Mishchenko, Larysa, Rudenko, Leonid, Rudyk, Iurii, Alieksieieva, Liudmyla, Korzh, Oleksii, Mostovoy, Yuriy, Parkhomenko, Oleksandr, Rasputina, Lesya, Voronkov, Leonid, Lymar, Yurii, Vasilyeva, Larysa, Keeling, Philip, Barr, Craig, Wong, Kenneth, Price, Dallas, Skaria, Binoy, Clark, Andrew, Chandrasekaran, Badrinathan, Trevelyan, Jasper, Gordon, Brian, Donnelly, Patrick, Glover, Jason, Ryding, Alisdair, Weir, Robin, Lang, Chim, Roy, Debashis, Adhya, Shaumik, Clifford, Piers, Ludman, Andrew, Kalra, Paul, Lynch, Mary, Mahmood, Shahid, Al Mohammad, Abdallah, Asubiaro, Joshua, Elmahi, Einas, Muthumala, Amal, Taylor, Justin, Gupta, Dinesh, Nadar, Venkatesh, Henderson, David, Zolty, Ronald, Sauer, Andrew, Adams, Kirkwood, Chandra, Lokesh, Jaffrani, Naseem, Grewal, Gurinder, Mancini, Donna, McLean, Dalton, Vasallo, Javier, Gottlieb, Stephen, Joseph, Susan, Barua, Rajat, Gorodeski, Eiran, Mouhaffel, Asad, Chung, Eugene, Desai, Pratik, Portnay, Edward, Rama, Bhola, Shandling, Adrian, Stahl, Llyod, Heilman, Karl, Jacob, Binu, Londono, Juan, Almousalli, Omar, Ashcom, Thomas, Bauerlein, Eugene Joseph, Koo, Charles, McGrew, Frank, Rajagopalan, Navin, Robinson, Shawn, Schultz, David, Starling, Randall, Ambardekar, Amrut, Bhagwat, Ravi, Boehmer, John, Bouza, Manuel, Farris, Neil, Feitell, Scott, Ganji, Jagadeesh, Geltman, Edward, Javier, Julian, Morrow, John Andrew, Pianko, Leonard, Smart, Frank, Adler, Alexander, Brinkley, Douglas, Cardona, Jose, Coletti, Andrew, Harris, John, Hunter, Vernon, Krantz, Mori, Lang, Christopher, Lovell, Charles, Murray, David, Pillutla, Priya, Shah, Amit, Bogaev, Roberta, Dauber, Ira, Franchi, Francesco, Fremont, Richard, Hart, Terence, Hattler, Brack, Janik, Matthew, Khalife, Wissam, Malhotra, Sanjay, Mamdani, Shafiq, Nelson, William, Orgera, Marisa, Ortiz, Aurelio, Rahko, Peter, Rennyson, Stephen, Shin, Jooyoung, Tsao, Lana, Uretsky, Barry, Wahid, Faisal, Wilkett, Matt, Amanullah, Aman, Baker, Mathue, Berk, Martin, Boccalandro, Fernando, Cruz, Kimberly, Doyle, Timothy, Gianfagna, Robert, Jones, Alonzo, King, Anthony, Lepor, Norman, Martinez‐Castrillon, Melvin, Pham, Michael, Radin, Michael, Radojevic, Joseph, Ramanathan, Kodangudi, Schmalfuss, Carsten, Schnitzler, Robert, Shah, Keyur, Takata, Theodore, Bertolet, Barry, Bostick, Brian, Civitello, Andrew, Collins, John, Dib, Nabil, Fang, James, Gilmore, Richard, Gray, Wayne, Grazette, Luanda, Haddad, Tariq, Hearne, Steven, Janmohamed, Munir, Katz, Richard, Kazemi, Navid, Llerena, Sara, Lohr, Nicole, Marzouka, George, Mignone, John, Ooi, Henry, Paszczuk, Anna, Pickett, Christopher, Sampognaro, Gregory, Sawyer, Douglas, Shayani, Steven, Treasure, Charles, Vaz, Garth, Vijay, Nampalli, Williams, Celeste, Yeoman, Gary, Zhang, Lily, Aaronson, Keith, Abo‐Auda, Wael, Alharethi, Rami, Anderson, William, Ariani, Mehrdad, Banerji, Sourin, Baweja, Paramdeep, Carson, Peter, Eberly, Arthur, Elliott, James, Fernando, Ronald, Fisher, Daniel, Forman, Steven, Gabriel, George, Gogia, Harinder, Hametz, Craig, Houston, Brian, Ibrahim, Hassan, Jadbabaie, Farid, Kassiotis, Christos, Krishnamoorthy, Arun, Kwan, Michael, Lupovitch, Steven, Macias, Leonardo, Malik, Adnan, Martinez, Luis, Miyamoto, Michael, Mody, Freny, Patel, Devesh, Peart, Brenda, Pisani, Barbara, Ramos, Mark, Rivero, Mariel, Shah, Anil, Sharma, Mukesh, Sichrovsky, Tina, Simon, Marc, Singh, Deovrat, Tallet, Julio, Vaccari, Christopher, Villoch, Mario, Wheeler, Matthew, Yousuf, Kabir, Abadier, Rafik, Abdullah, Shuaib, Arora, Raveen, Aslam, Shamaila, Buynak, Robert, Chang, David, Contreras, Johanna, Halpern, Stephen, Handel, Franklin, Heitner, John, Herzog, William, Jackson, Bruce, Kao, John, Kondo, Nicholas, Koren, Michael, LeWinter, Martin, Martindale, Jeffrey, Martinez‐Arraras, Joaquin, Olsen, Stephanie, Piatek, Marek, Ranadive, Nandkishore, Randall, William, Rao, Sunder, Rawitscher, David, Rider, James, Sokos, George, Strader, J Russell, Sulemanjee, Nasir, Tahirkheli, Naeem, Trichon, Benjamin, Vanhecke, Thomas, Whellan, David, Abuannadi, Mohammad, Aggarwala, Gaurav, Ahmad, Saad, Artis, Andre, Cheirif, Jorge, Cotarlan, Vladimir, Cox, Jeremy, Eaton, Charles, Florea, Viorel, Frank, Theodore, Friedman, Keith, Ganeshram, Vedampattu, Gass, Alan, Gemignani, Anthony, Hasni, Syed, Hedgepeth, Chester, Itchhaporia, Dipti, Kaluski, Edo, Karim, Amin, Kono, Alan, Lader, Ellis, Lakshminarayanan, Batlagundu, Lewis, Neil, Malhotra, Vinay, Mayer, Nolan, Mohapatra, Robert, Nair, Nandini, O'Brien, Terrence, Pauwaa, Sunil, Rowan, Christopher, Saxena, Sanjeev, Seto, Arnold, Shah, Nishant, Singh, Pradeep, Skopicki, Hal, Stoddard, Marcus, and Sweitzer, Nancy

Subjects
R1
Abstract

Aims:\ud The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.\ud \ud Methods and Results:\ud Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure

Published
2020

21. Posicionamento sobre Diagnóstico e Tratamento da Amiloidose Cardíaca – 2021

Author

Simões, Marcus V., primary, Fernandes, Fabio, additional, Marcondes-Braga, Fabiana G., additional, Scheinberg, Philip, additional, Correia, Edileide de Barros, additional, Rohde, Luis Eduardo P., additional, Bacal, Fernando, additional, Alves, Silvia Marinho Martins, additional, Mangini, Sandrigo, additional, Biolo, Andréia, additional, Beck-da-Silva, Luis, additional, Szor, Roberta Shcolnik, additional, Marques, Wilson, additional, Oliveira, Acary Souza Bulle, additional, Cruz, Márcia Waddington, additional, Bueno, Bruno Vaz Kerges, additional, Hajjar, Ludhmila Abrahão, additional, Issa, Aurora Felice Castro, additional, Ramires, Felix José Alvarez, additional, Coelho, Otavio Rizzi, additional, Schmidt, André, additional, Pinto, Ibraim Masciarelli Francisco, additional, Rochitte, Carlos Eduardo, additional, Vieira, Marcelo Luiz Campos, additional, Mesquita, Cláudio Tinoco, additional, Ramos, Celso Dario, additional, Soares-Junior, José, additional, Romano, Minna Moreira Dias, additional, Mathias, Wilson, additional, Garcia, Marcelo Iório, additional, Montera, Marcelo Westerlund, additional, Melo, Marcelo Dantas Tavares de, additional, Silva, Sandra Marques e, additional, Garibaldi, Pedro Manoel Marques, additional, Alencar, Aristóteles Comte de, additional, Lopes, Renato Delascio, additional, Ávila, Diane Xavier de, additional, Viana, Denizar, additional, Saraiva, José Francisco Kerr, additional, Canesin, Manoel Fernandes, additional, Oliveira, Glaucia Maria Moraes de, additional, and Mesquita, Evandro Tinoco, additional

Published
2021
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22. A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure

Author

McMurray, John, Packer, Milton, Desai, Akshay, Gong, Jianjian, Greenlaw, Nicola, Lefkowitz, Martin, Rizkala, Adel, Shi, Victor, Rouleau, Jean, Solomon, Scott, Swedberg, Karl, Zile, Michael R., Andersen, Karl, Arango, Juan Luis, Arnold, Malcolm, Belohlávek, Jan, Böhm, Michael, Boytsov, Sergey, Burgess, Lesley, Cabrera, Walter, Chen, Chen-Huan, Erglis, Andrejs, Fu, Michael, Gomez, Efrain, Gonzalez, Angel, Hagege, Albert-Alain, Katova, Tzvetana, Kiatchoosakun, Songsak, Kim, Kee-Sik, Bayram, Edmundo, Martinez, Felipe, Merkely, Bela, Mendoza, Iván, Mosterd, Arend, Negrusz-Kawecka, Marta, Peuhkurinen, Keijo, Ramires, Felix, Refsgaard, Jens, Senni, Michele, Sibulo, Antonio S., Jr, Silva-Cardoso, José, Squire, Iain, Starling, Randall C., Vinereanu, Dragos, Teerlink, John R., and Wong, Raymond

Published
2015
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23. Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca, 2021

Author

Marcondes-Braga, Fabiana G., Zytynski Moura, Lidia Ana, Issa, Victor Sarli, Vieira, Jefferson Luis, Rohde, Luis Eduardo, Simoes, Marcus Vinicius, Fernandes-Silva, Miguel Morita, Rassi, Salvador, Martins Alves, Silvia Marinho, de Albuquerque, Denilson Campos, de Almeida, Dirceu Rodrigues, Bocchi, Edimar Alcides, Alvarez Ramires, Felix Jose, Bacal, Fernando, Rossi Neto, Joao Manoel, Danzmann, Luiz Claudio, Montera, Marcelo Westerlund, de Oliveira Junior, Mucio Tavares, Clausell, Nadine, Silvestre, Odilson Marcos, Bestetti, Reinaldo Bulgarelli, Bernadez-Pereira, Sabrina, Freitas Jr, Aguinaldo F., Biolo, Andreia, Pereira Barretto, Antonio Carlos, Lagoeiro Jorge, Antonio Jose, Biselli, Bruno, Lucena Montenegro, Carlos Eduardo, Dos Santos Junior, Edval Gomes, Figueiredo, Estevao Lanna, Fernandes, Fabio, Silveira, Fabio Serra, Atik, Fernando Antibas, de Brito, Flavio Souza, Conceicao Souza, Germano Emilio, de Aguiar Ribeiro, Gustavo Calado, Villacorta, Humberto, de Souza Neto, Joao David, Goldraich, Livia Adams, Beck-da-Silva, Luis, Canesin, Manoel Fernandes, Bittencourt, Marcelo Imbroinise, Bonatto, Marcely Gimenes, Vieira Moreira, Maria da Consolacao, Avila, Monica Samuel, Coelho Filho, Otavio Rizzi, Schwartzmann, Pedro Vellosa, Mourilhe-Rocha, Ricardo, Mangini, Sandrigo, Ayub Ferreira, Silvia Moreira, de Figueiredo Neto, Jose Albuquerque, and Mesquita, Evandro Tinoco

Subjects
Human medicine
Published
2021

24. Air Pollution's Impact on Cardiac Remodeling in an Experimental Model of Chagas Cardiomyopathy.

Author

Barbosa Fonseca, Keila Cardoso, Gallinaro Pessoa, Fernanda, do Nascimento Ribeiro, Orlando, Tiemi Hotta, Viviane, Maria Ianni, Barbara, Fernandes, Fabio, Rodriguez Ferreira Rivero, Dolores Helena, Nascimento Saldiva, Paulo Hilário, Mady, Charles, and Alvarez Ramires, Felix José

Subjects
AIR pollution, CHAGAS' disease, STAINS & staining (Microscopy), CARDIOMYOPATHIES, REACTIVE oxygen species
Abstract

Background: Chagas disease is characterized by intense myocardial fibrosis stimulated by the exacerbated production of inflammatory cytokines, oxidative stress, and apoptosis. Air pollution is a serious public health problem and also follows this same path. Therefore, air pollution might amplify the inflammatory response of Chagas disease and increase myocardial fibrosis. Methods: We studied groups of Trypanosoma cruzi infected Sirius hamsters (Chagas=CH and Chagas exposed to pollution=CH+P) and 2 control groups (control healthy animals=CT and control exposed to pollution=CT+P). We evaluated acute phase (60 days post infection) and chronic phase (10 months). Echocardiograms were performed to assess left ventricular systolic and diastolic diameter, in addition to ejection fraction. Interstitial collagen was measured by morphometry in picrosirius red staining tissue. The evaluation of inflammation was performed by gene and protein expression of cytokines IL10, IFN-g, and TNF; oxidative stress was quantified by gene expression of NOX1, MnSOD, and iNOS and by analysis of reactive oxygen species; and apoptosis was performed by gene expression of BCL2 and Capsase3, in addition to TUNEL analysis. Results: Chagas groups had increased collagen deposition mainly in the acute phase, but air pollution did not increase this deposition. Also, Chagas groups had lower ejection fraction in the acute phase (p = 0.002) and again air pollution did not worsen ventricular function or dilation. The analysis of the inflammation and oxidative stress pathways were also not amplified by air pollution. Apoptosis analysis showed increased expression of BCL2 and Caspase3 genes in chagasic groups in the acute phase, with a marginal p of 0.054 in BCL2 expression among infected groups, and TUNEL technique showed amplified of apoptotic cells by pollution among infected groups. Conclusions: A possible modulation of the apoptotic pathway was observed, inferring interference from air pollution in this pathway. However, it was not enough to promote a greater collagen deposition, or worsening ventricular function or dilation caused by air pollution in this model of Chagas cardiomyopathy. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Afecções Pericárdicas em Pacientes com COVID-19: Uma Possível Causa de Deterioração Hemodinâmica

Author

Fernandes, Fábio, Ramires, Felix José Alvarez, Fernandes, Fábio Danziato, Simões, Marcus Vinicius, Mesquita, Evandro Tinoco, and Mady, Charles

Subjects
Pandemia, SARS-CoV-2, Betacoronavirus/complications, COVID-19, Keywords, Thrombosis, Complicações Cardiovasculares, Coronavirus-19, Inflamação Sistêmica, Systemic, Inflammation, Trombose, Cardiovascular Complications, Hipóxia, Hypoxia, Pandemics, Betacoronavirus/complicações
Published
2020

26. Galectina-3 Associada a Formas Graves e Mortalidade em Longo Prazo em Pacientes com Doença de Chagas

Author

Fernandes, Fábio, primary, Moreira, Carlos Henrique Valente, additional, Oliveira, Lea Campos, additional, Souza-Basqueira, Marcela, additional, Ianni, Barbara Maria, additional, Lorenzo, Claudia di, additional, Ramires, Felix José Alvarez, additional, Nastari, Luciano, additional, Cunha-Neto, Edecio, additional, Ribeiro, Antonio L., additional, Lopes, Renato Delascio, additional, Keating, Sheila M., additional, Sabino, Ester Cerdeira, additional, and Mady, Charles, additional

Published
2021
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27. Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

Author

Teerlink, John R., primary, Diaz, Rafael, additional, Felker, G. Michael, additional, McMurray, John J.V., additional, Metra, Marco, additional, Solomon, Scott D., additional, Adams, Kirkwood F., additional, Anand, Inder, additional, Arias-Mendoza, Alexandra, additional, Biering-Sørensen, Tor, additional, Böhm, Michael, additional, Bonderman, Diana, additional, Cleland, John G.F., additional, Corbalan, Ramon, additional, Crespo-Leiro, Maria G., additional, Dahlström, Ulf, additional, Echeverria, Luis E., additional, Fang, James C., additional, Filippatos, Gerasimos, additional, Fonseca, Cândida, additional, Goncalvesova, Eva, additional, Goudev, Assen R., additional, Howlett, Jonathan G., additional, Lanfear, David E., additional, Li, Jing, additional, Lund, Mayanna, additional, Macdonald, Peter, additional, Mareev, Viacheslav, additional, Momomura, Shin-ichi, additional, O’Meara, Eileen, additional, Parkhomenko, Alexander, additional, Ponikowski, Piotr, additional, Ramires, Felix J.A., additional, Serpytis, Pranas, additional, Sliwa, Karen, additional, Spinar, Jindrich, additional, Suter, Thomas M., additional, Tomcsanyi, Janos, additional, Vandekerckhove, Hans, additional, Vinereanu, Dragos, additional, Voors, Adriaan A., additional, Yilmaz, Mehmet B., additional, Zannad, Faiez, additional, Sharpsten, Lucie, additional, Legg, Jason C., additional, Varin, Claire, additional, Honarpour, Narimon, additional, Abbasi, Siddique A., additional, Malik, Fady I., additional, and Kurtz, Christopher E., additional

Published
2021
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28. Effects of sympathectomy on myocardium remodeling and function

Author

Jordão, Maurício Rodrigues, primary, Pessoa, Fernanda G., additional, Fonseca, Keila C.B., additional, Zanoni, Fernando, additional, Salemi, Vera M.C., additional, Souza, Leandro E., additional, Ribeiro, Orlando N., additional, Fernandes, Fábio, additional, Irigoyen, Maria Claudia, additional, Moreira, Luiz Felipe P., additional, Mady, Charles, additional, and Ramires, Felix Jose Alvarez, additional

Published
2021
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32. Effect of exercise training on cardiovascular autonomic and muscular function in subclinical Chagas cardiomyopathy: a randomized controlled trial

Author

Sarmento, Adriana Oliveira, primary, Antunes-Correa, Ligia M., additional, Alves, Maria J. N. N., additional, Bacurau, Aline V. N., additional, Fonseca, Keila C. B., additional, Pessoa, Fernanda G., additional, Lobo, Denise M. L., additional, Moreira, Leila D. P., additional, Trombetta, Ivani C., additional, Rondon, Maria U. P. B., additional, Rondon, Eduardo, additional, Vieira, Marcelo L. C., additional, Ramires, Felix J. A., additional, do Brasileiro-Santos, Maria Socorro, additional, Brum, Patricia C., additional, Mady, Charles, additional, Negrao, Carlos E., additional, Thomas, Scott, additional, and Ianni, Barbara M., additional

Published
2020
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35. Galectina-3 em Pacientes com Pericardite Constritiva Crônica

Author

Fernandes, Fábio, primary, Melo, Dirceu Thiago Pessoa de, additional, Ramires, Felix José Alvarez, additional, Sabino, Ester Cerdeira, additional, Moreira, Carlos Henrique Valente, additional, Benvenutti, Luiz Alberto, additional, Hotta, Viviane Tiemi, additional, Sayegh, Ana Luiza Carrari, additional, Souza, Francis Ribeiro de, additional, Dias, Ricardo Ribeiro, additional, and Mady, Charles, additional

Published
2020
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36. Influence of Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism in Progression of Chagas Heart Disease

Author

Alves, Silvia Marinho Martins, primary, Alvarado-Arnês, Lúcia Elena, additional, Cavalcanti, Maria da Glória Aureliano de Melo, additional, Carrazzone, Cristina de Fátima Velloso, additional, Pacheco, Antônio Guilherme Fonseca, additional, Sarteschi, Camila, additional, Moraes, Milton Ozorio, additional, Oliveira Junior, Wilson Alves de, additional, Medeiros, Carolina de Araújo, additional, Pessoa, Fernanda Gallinaro, additional, Mady, Charles, additional, Lannes-Vieira, Joseli, additional, and Ramires, Felix José Alvarez, additional

Published
2020
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39. Post hoc analyses of SHIFT and PARADIGM-HF highlight the importance of chronic Chagas' cardiomyopathy Comment on: 'Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: a post hoc analysis of the SHIFT trial' by Bocchi et al

Author

Ramires, Felix J.A., Martinez, Felipe, Gómez, Efraín A., Demacq, Caroline, Gimpelewicz, Claudio R., Rouleau, Jean L., Solomon, Scott D., Swedberg, Karl, Zile, Michael R., Packer, Milton, and McMurray, John J.V.

Abstract

No abstract available.

Published
2018

44. Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF

Author

Mogensen, Ulrik M., Køber, Lars, Jhund, Pardeep S., Desai, Akshay S., Senni, Michele, Kristensen, Søren L., Dukát, Andrej, Chen, Chen-Huan, Ramires, Felix, Lefkowitz, Martin P., Prescott, Margaret F., Shi, Victor C., Rouleau, Jean L., Solomon, Scott D., Swedberg, Karl, Packer, Milton, McMurray, John J.V., Mogensen, U, Køber, L, Jhund, P, Desai, A, Senni, M, Kristensen, S, Dukát, A, Chen, C, Ramires, F, Lefkowitz, M, Prescott, M, Shi, V, Rouleau, J, Solomon, S, Swedberg, K, Packer, M, and Mcmurray, J

Subjects
Male, Tetrazoles, Heart failure, Angiotensin Receptor Antagonists, Angiotensin, Double-Blind Method, Humans, Mortality, Heart Failure, Aminobutyrates, Biphenyl Compounds, Stroke Volume, Focus on Clinical Trials, Middle Aged, Prognosis, Uric Acid, Drug Combinations, Treatment Outcome, Valsartan, Female, Neprilysin, Co‐morbidities in Clinical Trials, Uric acid, Biomarkers, Follow-Up Studies, Glomerular Filtration Rate, Research Article
Abstract

Aims Elevated serum uric acid concentration (SUA) has been associated with an increased risk of cardiovascular disease, but this may be due to unmeasured confounders. We examined the association between SUA and outcomes as well as the effect of sacubitril/valsartan on SUA in patients with heart failure with reduced ejection fraction (HFrEF) in PARADIGM-HF. ..................................................................................................................................................................... Methods and results The association between SUA and the primary composite outcome of cardiovascular death or heart failure (HF) hospitalization, its components, and all-cause mortality was examined using Cox regression analyses among 8213 patients using quintiles (Q1–Q5) of SUA adjusted for baseline prognostic variables including estimated glomerular filtration rate (eGFR), diuretic dose, and log N-terminal pro-brain natriuretic peptide. Change in SUA from baseline over 12 months was also evaluated in each treatment group. Patients in Q5 (SUA ≥8.6 mg/dL) compared with Q1 ( < 5.4 mg/dL) were younger (62.8 vs. 64.2 years), more often male (88.7% vs. 63.1%), had lower systolic blood pressure (119 vs. 123 mmHg), lower eGFR (57.4 vs. 76.6 mL/min/1.73 m2), and greater diuretic use. Higher SUA was associated with a higher risk of the primary outcome (adjusted hazard ratios) Q5 vs. Q1=1.28 [95% confidence intervals (1.09–1.50), P =0.003], cardiovascular death [1.44 (1.11–1.77), P =0.001], HF hospitalization [1.37 (1.11–1.70), P =0.004], and all-cause mortality [1.36 (1.13–1.64), P =0.001]. Compared with enalapril, sacubitril/valsartan reduced SUA by 0.24 (0.17–0.32) mg/dL over 12 months (P < 0.0001). Sacubitril/valsartan improved outcomes, irrespective of SUA concentration. ..................................................................................................................................................................... Conclusion Serum uric acid concentration was an independent predictor of worse outcomes after multivariable adjustment in patients with HFrEF. Compared with enalapril, sacubitril/valsartan reduced SUA and improved outcomes irrespective of SUA.

Published
2018

49. Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda

Author

Rohde, Luis Eduardo Paim, primary, Montera, Marcelo Westerlund, additional, Bocchi, Edimar Alcides, additional, Clausell, Nadine Oliveira, additional, Albuquerque, Denilson Campos de, additional, Rassi, Salvador, additional, Colafranceschi, Alexandre Siciliano, additional, Freitas Junior, Aguinaldo Figueiredo de, additional, Ferraz, Almir Sergio, additional, Biolo, Andreia, additional, Barretto, Antonio C. Pereira, additional, Ribeiro, Antonio Luiz Pinho, additional, Polanczyk, Carisi Anne, additional, Gualandro, Danielle Menosi, additional, Almeida, Dirceu Rodrigues, additional, Silva, Eneida Rejane Rabelo da, additional, Figueiredo, Estêvão Lanna, additional, Mesquita, Evandro Tinoco, additional, Marcondes-Braga, Fabiana G., additional, Cruz, Fátima das Dores da, additional, Ramires, Felix José Alvarez, additional, Atik, Fernando Antibas, additional, Bacal, Fernando, additional, Souza, Germano Emilio Conceição, additional, Almeida Junior, Gustavo Luiz Gouvêa de, additional, Ribeiro, Gustavo Calado de Aguiar, additional, Villacorta Junior, Humberto, additional, Vieira, Jefferson Luís, additional, Souza Neto, João David de, additional, Rossi Neto, João Manoel, additional, Figueiredo Neto, Jose Albuquerque de, additional, Moura, Lidia Ana Zytynsky, additional, Goldraich, Livia Adams, additional, Beck-da-Silva, Luis, additional, Danzmann, Luiz Claudio, additional, Canesin, Manoel Fernandes, additional, Bittencourt, Marcelo Imbroinise, additional, Garcia, Marcelo Iorio, additional, Bonatto, Marcely Gimenes, additional, Simões, Marcus Vinícius, additional, Moreira, Maria da Consolação Vieira, additional, Silva, Miguel Morita Fernandes da, additional, Olivera Junior, Mucio Tavares de, additional, Silvestre, Odilson Marcos, additional, Schwartzmann, Pedro Vellosa, additional, Bestetti, Reinaldo Bulgarelli, additional, Rocha, Ricardo Mourilhe, additional, Simões, Ricardo, additional, Pereira, Sabrina Bernardez, additional, Mangini, Sandrigo, additional, Alves, Sílvia Marinho Martins, additional, Ferreira, Silvia Moreira Ayub, additional, Issa, Victor Sarli, additional, Barzilai, Vitor Salvatore, additional, and Martins, Wolney de Andrade, additional

Published
2018
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50. AIR POLLUTION IN MYOCARDIAL REMODELING

Author

Pessoa, Fernanda Gallinaro, primary, Fonseca, Keila, additional, Mady, Charles, additional, Ribeiro, Orlando N., additional, Oliveira-Fonoff, Adriana M., additional, Salemi, Vera, additional, Saldiva, Paulo, additional, Fernandes, Fabio, additional, and Ramires, Felix, additional

Published
2017
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