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1. Immuno-PET Monitoring of CD8+ T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a 89Zr Anti-CD8+ Mouse Minibody in EMT6 Syngeneic Tumor Mouse

Author

Alsaid, Hasan, Cheng, Shih-Hsun, Bi, Meixia, Xie, Fang, Rambo, Mary, Skedzielewski, Tinamarie, Hoang, Bao, Mohanan, Sunish, Comroe, Debra, Gehman, Andrew, Hsu, Chih-Yang, Farhangi, Kamyar, Tran, Hoang, Sherina, Valeriia, Doan, Minh, Groseclose, M. Reid, Hopson, Christopher B., Brett, Sara, Wilson, Ian A., Nicholls, Andrew, Ballas, Marc, Waight, Jeremy D., and Jucker, Beat M.

Published
2023
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3. MRI/PET multimodal imaging of the innate immune response in skeletal muscle and draining lymph node post vaccination in rats

Author

Madi, Saaussan, primary, Xie, Fang, additional, Farhangi, Kamyar, additional, Hsu, Chih-Yang, additional, Cheng, Shih-Hsun, additional, Aweda, Tolulope, additional, Radaram, Bhasker, additional, Slania, Stephanie, additional, Lambert, Tammy, additional, Rambo, Mary, additional, Skedzielewski, Tina, additional, Cole, Austin, additional, Sherina, Valeriia, additional, McKearnan, Shannon, additional, Tran, Hoang, additional, Alsaid, Hasan, additional, Doan, Minh, additional, Stokes, Alan H., additional, O’Hagan, Derek T., additional, Maruggi, Giulietta, additional, Bertholet, Sylvie, additional, Temmerman, Stéphane T., additional, Johnson, Russell, additional, and Jucker, Beat M., additional

Published
2023
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4. Immuno-PET Monitoring of CD8+ T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a 89Zr Anti-CD8+ Mouse Minibody in EMT6 Syngeneic Tumor Mouse

Author

Alsaid, Hasan, primary, Cheng, Shih-Hsun, additional, Bi, Meixia, additional, Xie, Fang, additional, Rambo, Mary, additional, Skedzielewski, Tinamarie, additional, Hoang, Bao, additional, Mohanan, Sunish, additional, Comroe, Debra, additional, Gehman, Andrew, additional, Hsu, Chih-Yang, additional, Farhangi, Kamyar, additional, Tran, Hoang, additional, Sherina, Valeriia, additional, Doan, Minh, additional, Groseclose, M. Reid, additional, Hopson, Christopher B., additional, Brett, Sara, additional, Wilson, Ian A., additional, Nicholls, Andrew, additional, Ballas, Marc, additional, Waight, Jeremy D., additional, and Jucker, Beat M., additional

Published
2022
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5. Immuno-PET Monitoring of CD8+ T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a 89Zr Anti-CD8+ Mouse Minibody in EMT6 Syngeneic Tumor Mouse.

Author

Alsaid, Hasan, Cheng, Shih-Hsun, Bi, Meixia, Xie, Fang, Rambo, Mary, Skedzielewski, Tinamarie, Hoang, Bao, Mohanan, Sunish, Comroe, Debra, Gehman, Andrew, Hsu, Chih-Yang, Farhangi, Kamyar, Tran, Hoang, Sherina, Valeriia, Doan, Minh, Groseclose, M. Reid, Hopson, Christopher B., Brett, Sara, Wilson, Ian A., and Nicholls, Andrew

Subjects
ANIMAL rescue, PROGRAMMED cell death 1 receptors, T cells, CYTOTOXIC T cells, LYMPHOID tissue, FEATURE extraction, POSITRON emission tomography, IMMUNOGLOBULINS
Abstract

Purpose: The presence and functional competence of intratumoral CD8+ T cells is often a barometer for successful immunotherapeutic responses in cancer. Despite this understanding and the extensive number of clinical-stage immunotherapies focused on potentiation (co-stimulation) or rescue (checkpoint blockade) of CD8+ T cell antitumor activity, dynamic biomarker strategies are often lacking. To help fill this gap, immuno-PET nuclear imaging has emerged as a powerful tool for in vivo molecular imaging of antibody targeting. Here, we took advantage of immuno-PET imaging using 89Zr-IAB42M1-14, anti-mouse CD8 minibody, to characterize CD8+ T-cell tumor infiltration dynamics following ICOS (inducible T-cell co-stimulator) agonist antibody treatment alone and in combination with PD-1 blocking antibody in a model of mammary carcinoma. Procedures. Female BALB/c mice with established EMT6 tumors received 10 µg, IP of either IgG control antibodies, ICOS agonist monotherapy, or ICOS/PD-1 combination therapy on days 0, 3, 5, 7, 9, 10, or 14. Imaging was performed at 24 and 48 h post IV dose of 89Zr IAB42M1-14. In addition to 89Zr-IAB42M1-14 uptake in tumor and tumor-draining lymph node (TDLN), 3D radiomic features were extracted from PET/CT images to identify treatment effects. Imaging mass cytometry (IMC) and immunohistochemistry (IHC) was performed at end of study. Results: 89Zr-IAB42M1-14 uptake in the tumor was observed by day 11 and was preceded by an increase in the TDLN as early as day 4. The spatial distribution of 89Zr-IAB42M1-14 was more uniform in the drug treated vs. control tumors, which had spatially distinct tracer uptake in the periphery relative to the core of the tumor. IMC analysis showed an increased percentage of cytotoxic T cells in the ICOS monotherapy and ICOS/PD-1 combination group compared to IgG controls. Additionally, temporal radiomics analysis demonstrated early predictiveness of imaging features. Conclusion: To our knowledge, this is the first detailed description of the use of a novel immune-PET imaging technique to assess the kinetics of CD8+ T-cell infiltration into tumor and lymphoid tissues following ICOS agonist and PD-1 blocking antibody therapy. By demonstrating the capacity for increased spatial and temporal resolution of CD8+ T-cell infiltration across tumors and lymphoid tissues, these observations underscore the widespread potential clinical utility of non-invasive PET imaging for T-cell-based immunotherapy in cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Abstract 2816: Immuno-PET monitoring of CD8+ T cell infiltration post anti-ICOS agonist antibody treatment alone and in combination with PD-1 blocking antibody using a 89Zr anti-CD8+ mouse minibody in EMT 6 syngeneic tumor mouse

Author

Alsaid, Hasan, primary, Cheng, Shih-Hsun, additional, Bi, Meixia, additional, Rambo, Mary V., additional, Skedzielewski, Tinamarie, additional, Hoang, Bao, additional, Mohanan, Sunish, additional, Gehman, Andrew, additional, Hsu, Chih-Yang, additional, Doan, Minh, additional, Xie, Fang, additional, Groseclose, M. Reid, additional, Hopson, Christopher, additional, Brett, Sara, additional, Wilson, Ian A., additional, Nicholls, Andrew, additional, Ballas, Marc, additional, Waight, Jeremy D., additional, Jucker, Beat M., additional, and Hoos, Axel, additional

Published
2021
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8. In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice

Author

Lenhard, Stephen C., primary, McAlexander, Allen, additional, Virtue, Anthony, additional, Fieles, William, additional, Skedzielewski, Tina, additional, Rambo, Mary, additional, Trinh, Han, additional, Cheng, Shih-Hsun, additional, Hong, Hyundae, additional, Isidro-Llobet, Albert, additional, Nadin, Alan, additional, Geske, Robert, additional, Klein, Jean-Louis, additional, Lee, Dennis, additional, Jucker, Beat M., additional, and Hu, Erding, additional

Published
2019
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9. Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice

Author

Alsaid, Hasan, primary, Skedzielewski, Tinamarie, additional, Rambo, Mary V., additional, Hunsinger, Kristen, additional, Hoang, Bao, additional, Fieles, William, additional, Long, Edward R., additional, Tunstead, James, additional, Vugts, Danielle J., additional, Cleveland, Matthew, additional, Clarke, Neil, additional, Matheny, Christopher, additional, and Jucker, Beat M., additional

Published
2017
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11. Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction

Author

Alsaid, Hasan, primary, Bao, Weike, additional, Rambo, Mary V., additional, Logan, Gregory A., additional, Figueroa, David J., additional, Lenhard, Stephen C., additional, Kotzer, Charles J., additional, Burgert, Mark E., additional, Willette, Robert N., additional, Ferrari, Victor A., additional, and Jucker, Beat M., additional

Published
2011
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