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10. Corneal opacity due to infantile capillary hemangioma: A rare presentation

Author

Doctor, Mariya, Ramappa, Muralidhar, Dave, Tarjani, and Kalki, Swathi

Subjects
Hemangioma, Health
Abstract

Byline: Mariya. Doctor, Muralidhar. Ramappa, Tarjani. Dave, Swathi. Kalki Capillary hemangioma of the eyelid has a natural tendency to resolve with time; hence, it usually does not require any treatment. [...]

Published
2023

11. Grand Challenges in global eye health: a global prioritisation process using Delphi method

Author

Aghaji, Ada, Adewole, Adeyemi T, Csutak, Adrienne, Salam, Ahmad Shah, Paduca, Ala, Bron, Alain M, Denniston, Alastair K, Lazo Legua, Alberto, Halim, Aldiana, Tefera, Alemayehu Woldeyes, Mwangi, Alice, Jenkins, Alicia J, Davis, Amanda, Meddeb-Ouertani, Amel, Wali, Amina H, Palis, Ana G, Bastos de Carvalho, Ana, Joshi, Anagha, Kreis, Andreas J, Mueller, Andreas, Bastawrous, Andrew, Cooper, Andrew, Smith, Andrew F, Grzybowski, Andrzej, Arvind, Anitha, Karanu, Anne M, Orlina, Anne O, Burnett, Anthea, Yashadhana, Aryati, Abeydeera, Asela P, Abdurakhmanova, Aselia, Mohamed, Ashik, Bacchav, Ashish, Bernhisel, Ashlie, Webson, Aubrey Walton, Azuara-Blanco, Augusto, Hossain, Ava, Ilhan, Bayazit, Assumpta Lucienne, Bella, Tousignant, Benoit, Shamanna, Bindiganavale R, Wiafe, Boateng, Mueller, Brigitte, Caglar, Cagatay, Mpyet, Caleb, Abraham, Carl H, Cheung, Carol Y, Thiel, Cassandra L, Jan, Catherine L, Emedike, Chike, Chuluunkhuu, Chimgee, Chinyere, Chinomso, Henein, Christin, Gilbert, Clare E, Bascaran, Covadonga, Nitulescu, Cristina Elena, Patel, Daksha, Bachani, Damodar, Kiage, Daniel, Etya'ale, Daniel, Dahdal, David, Woo Lawson, Dawn, Godin, Denise, Nkanga, Dennis G, Ondeyo, Dennis M, O'Brien, Donna, Mutie, Dorothy M, Alalawi, Ebtisam S K, Mayorga, Eduardo, Bin Hashim, Effendy, Ashrafi, Elham, Kishiki, Elizabeth Andrew, Kurian, Elizabeth, D'Esposito, Fabrizio, Masila, Faith, Pena, Fernando Yaacov, Büsch, Fortunat, Topouzis, Fotis, Bandello, Francesco, Oyediji, Funmilayo J, Thumann, Gabriele, Ezz Elarab, Gamal, Kitema, Gatera Fiston, Schlenther, Gerhard, Fefoame, Gertrude Oforiwa, Cochrane, Gillian M, Laganovska, Guna, Awan, Haroon R, Ansari, Harris M, Philippin, Heiko, Burn, Helen, Dimaras, Helen, Filipe, Helena P, Monye, Henrietta I, Kandel, Himal, Randrianarisoa, Hoby Lalaina, Jones, Iain, Murdoch, Ian E, Fabian, Ido Didi, Khan, Imran A, Sharma, Indra P, Elbeih, Islam, Mactaggart, Islay, Pastor, J Carlos, Keunen, Jan E E, Ohuma, Jane A, Pithuwa Nirwoth, Jason, Hammou, Jaouad, Vianna, Jayme R, Biao, Jean-eudes, Burr, Jennifer M, Keenan, Jeremy D, Blijkers, Jess, Black, Joanna M, Barbosa Breda, Joao, Furtado, Joao M, Buchan, John C, Lawrenson, John G, Kempen, John H, Ehrlich, Joshua R, Stern, Judith, Zhang, Justine H, Keskinbora, Kadircan H, Knoll, Karin M, Blanchet, Karl, Schmid, Katrina L, Ono, Koichi, Ogundimu, Kolawole, Balo, Komi, Somda, Kussome Paulin, Yeboah, Kwame, Amissah-Arthur, Kwesi N, Nasehi, Leone, Øverland, Lene, Vijaya, Lingam, Keay, Lisa, Hamm, Lisa M, Mowatt, Lizette, Harrison-Williams, Lloyd C M, Silva, Lucia, Bilotto, Luigi, Mörchen, Manfred, Rabiu, Mansur, Zondervan, Marcia, Chagunda, Margarida, Sandinha, Maria Teresa, Yee Melgar, Mariano, Salas Vargas, Marisela, Daniell, Mark D, Katibeh, Marzieh, Broom, Matt, Collins, Megan E, Alp, Mehmet Numan, Kwarteng, Michael A, Belkin, Michael, Gichangi, Michael, Sylvanowicz, Michelle, Wu, Min, Cano, Miriam R, Shalaby, Mohammad, Duggal, Mona, Khairallah, Moncef, Batur, Muhammed, Bikbov, Mukharram M, Ramappa, Muralidhar, Pamarathi, Nagaraju, Khachatryan, Naira, Muhammad, Nasiru, Kennedy, Neil, Murray, Neil, Beare, Nicholas A V, Astbury, Nick, Carnt, Nicole A, St Rose, Nigel A, Barker, Nigel H, Pehere, Niranjan K, Uche, Nkechinyere J, Lois, Noemi, Awe, Oluwaseun O, Mujica, Oscar J, Okolo, Oteri E, Rani, Padmaja Kumari, Ruamviboonsuk, Paisan, Ndiaye, Papa Amadou, Dhakhwa, Parami, Rozsival, Pavel, Mbulawa, Pearl K, Keane, Pearse A, Jones, Pete R, Holland, Peter, Nukella, Phanindra Babu, Burgess, Philip I, O'Dwyer, Pinar Aydin, Piyasena, Prabhath, Bastola, Pradeep, Morjaria, Priya, Nasimee, Qais, Rambacal, Raizza A T, Das, Rajdeep, Khandekar, Rajiv B, Azad, Rajvardhan, Bashshur, Ramona, Sousa, Raúl A R C, Oenga, Rebecca, Gurung, Reeta, Geneau, Robert, Jacobs, Robert J, Finger, Robert P, Guymer, Robyn H, Sevciuc, Rodica, Khanna, Rohit C, George, Ronnie, Graham, Ronnie, Kawasaki, Ryo, Ho, S May, Mishra, Sailesh Kumar, Buttan, Sandeep, Block, Sandra S, Talero, Sandra, Yoon, Sangchul, Joseph, Sanil, Safi, Sare, Dodson, Sarity, Munoz, Sergio R, Bakayoko, Seydou, Mohammadi, Seyed Farzad, Muez, Shabir Ahmad, Pardhan, Shahina, Hopkins, Shelley, Sheu, Shwu-Jiuan, Coulibaly, Sidi Mohamed, Schellini, Silvana A, Arunga, Simon, Bush, Simon R, Sivaprasad, Sobha, Salomao, Solange R, Marmamula, Srinivas, Onwubiko, Stella N, Misra, Stuti L, Kuyyadiyil, Subeesh, Kulkarni, Sucheta, khanal, Sudarshan, Yasmin, Sumrana, Pavljasevic, Suzana Nikolic, Gilbert, Suzanne S, Braithwaite, Tasanee, Ghidirimschi, Tatiana, Ravilla, Thulasiraj, Fricke, Timothy R, Cogliati, Tiziana, Kassa, Tsehaynesh, Peto, Tunde, Dibb, Ute, Lansingh, Van C, Hu, Victor H, Sheffield, Victoria M, Mathenge, Wanjiku, Dean, William H, Nolan, Winifred, Hiratsuka, Yoshimune, Mahsood, Yousaf Jamal, Sapkota, Yuddha, Ramke, Jacqueline, Evans, Jennifer R, Habtamu, Esmael, Mwangi, Nyawira, Silva, Juan Carlos, Swenor, Bonnielin K, Congdon, Nathan, Faal, Hannah B, Foster, Allen, Friedman, David S, Gichuhi, Stephen, Jonas, Jost B, Khaw, Peng T, Kyari, Fatima, Murthy, Gudlavalleti V S, Wang, Ningli, Wong, Tien Y, Wormald, Richard, Yusufu, Mayinuer, Taylor, Hugh, Resnikoff, Serge, West, Sheila K, and Burton, Matthew J

Published
2022
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14. Clinical and demographic profile of herpes zoster ophthalmicus: A hospital-based study of 1752 Indian patients.

Author

Rathi, Anubha, Das, Anthony V., and Ramappa, Muralidhar

Subjects
OPHTHALMIC zoster, ELECTRONIC health records, VISION disorders, SOCIOECONOMIC status, BIG data, IRIDOCYCLITIS
Abstract

Purpose: To describe the clinical and demographic profile of herpes zoster ophthalmicus (HZO) in patients presenting to a multitier ophthalmology hospital network in India. Methods: Cross-sectional hospital-based study included 3,004,470 new patients between August 2010 and October 2021. Patients with a clinical diagnosis of HZO in at least one eye were included. Data were collected using an electronic medical record system. Results: In total, 1,752 (0.058%) patients were diagnosed with HZO. Nearly two-thirds were male (63.76%) in the seventh decade of life (339;19.35% patients) with unilateral (98.34%) affliction. Higher prevalence was seen in patients from higher socioeconomic status (0.059%) and metropolitan geography (0.062%). Most common ocular signs included eyelid edema (44.19%), conjunctival congestion (65.69%), punctate keratopathy (23.36%), and anterior uveitis (21.22%). Of the 1,781 eyes, mild/ no visual impairment was seen in 952 (53.45%) eyes, moderate in 258 (14.49%) eyes, and severe to blindness in 363 (20.39%) eyes. Oral antivirals were started within 72 h (Group A) in 361 (20.61%) patients and after 72 h in 1391 (79.39%) patients (Group B). Significantly lesser severity of ocular involvement was noted in Group A (P < 0.00001). Surgical intervention was required in 211 (11.85%) eyes. Conclusion: HZO more commonly affects males in the seventh decade of life and is predominantly unilateral. It more commonly affects those from higher socioeconomic strata and metropolitan regions. Half of the eyes have mild or no visual impairment, while others have moderate to severe impairment. Institution of antivirals within 72 h is associated with less severe involvement. Surgical intervention is warranted in a tenth of the eyes. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Band-shaped keratopathy in HNF4A-related Fanconi syndrome: a case report and review of the literature.

Author

Verma, Anshuman, Mishra, Dilip Kumar, Edward, Deepak P., and Ramappa, Muralidhar

Subjects
RENAL osteodystrophy, FANCONI syndrome, GENETIC testing, LITERATURE reviews, GENETIC variation
Abstract

Fanconi's syndrome (FS) is characterized by type-2 renal tubular acidosis, short stature, and renal rickets, along with glycosuria, aminoaciduria, hypophosphaturia, and urinary bicarbonate wasting. The genetic form of FS has been linked to HNF4A variants. Although additional clinical features such as hearing impairment have recently been associated with HNF4A-linked FS, its ocular manifestation has not been described. Presenting a case of a 5-year-old male child with bilateral progressive corneal opacification and the presence of bilateral greyish-white deposits in the interpalpebral region since infancy. A next-generation sequencing (NGS)-based genetic testing was performed for the child followed by parental genetic testing for the identified variant. Furthermore, relevant works of literature were reviewed related to this condition. Detailed corneal findings showed a bilateral band-shaped keratopathy (BSK) in the patient. Physical and systemic findings showed signs consistent with FS. Sequencing analysis revealed a novel heterozygous c.635C>T, (p.Pro212Leu) variant in the HNF4A gene in the proband and mother, while the father had a normal genotype. Our case highlights the occurrence of BSK in an exceptionally rare manifestation of hereditary FS linked to HNF4A gene variant. The variant exists both in proband and asymptomatic mother. Therefore, the variable penetrance which is known to exist in HNF4A is acknowledged in this context. This report suggests the first documented instance establishing a plausible connection between BSK and HNF4A-associated FS, characterized by the variable penetrance attributed to the HNF4A gene. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Ectopia Lentis: Clinical profiles in a large cohort of children from a Tertiary Eye Care network in India.

Author

Bhate, Manjushree, Das, Anthony Vipin, Kekunnaya, Ramesh, Sachdeva, Virender, Ramappa, Muralidhar, Warkad, Vivek, and Majhi, Debasmita

Abstract

PURPOSE: To study the clinical presentations, visual, and refractive profiles of children with congenital ectopia lentis in a large cohort of patients from a tertiary eye care network in India. MATERIALS AND METHODS: A retrospective review of electronic medical records from December 2012 to December 2020 was conducted. Two hundred and ninety‑seven consecutive children ≤18 years of age at presentation were identified and analyzed for demographic details, patient distribution, lens subluxation, visual, and refractive profiles before and after the interventions. RESULTS: Five hundred and ninety‑four eyes of 297 (male 56%; n = 166) patients were analyzed. The mean age at presentation was 8.74 ± 3.89. Best‑corrected visual acuity (BCVA) at presentation ranged from 0.3 logMAR to 3.5 logMAR; (Snellen: 6/9 – close to face [CF]) (mean 0.89 ± 0.68). High myopia (n = 201; 33.83%) and mild astigmatism (n = 340; 57.23%) were more frequent. Temporal (n = 108; 18.18%) subluxation was most common followed by superior. Lensectomy with limited vitrectomy was performed in 243 eyes of 127 patients (40.90%). Median preoperative BCVA was 1.0 (range: 0.3–3.5 logMAR; 20/40 ‑ CF). Median postoperative BCVA was 0.5 logMAR (6/18) in the pseudophakic group and 0.6 logMAR (6/24) in the aphakic group. Spherical equivalent in myopic children reduced from −12.06 ± 6.84D to −1.57D (−0.25D to − 5.5D) in the pseudophakic group and +9.3D (+5.5D to 15.5D) in the aphakic group. CONCLUSION: This study is a large cohort of children presenting with ectopia lentis. Following intervention, an improvement in the median BCVA and refractive correction was noted in the entire cohort. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Updates on congenital hereditary endothelial dystrophy

Author

Mehta, Neet, primary, Verma, Anshuman, additional, Achanta, Divya Sree, additional, Kannabiran, Chitra, additional, Roy, Sanhita, additional, Mishra, Dilip Kumar, additional, Chaurasia, Sunita, additional, Edward, Deepak Paul, additional, and Ramappa, Muralidhar, additional

Published
2023
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20. Objectively measuring anterior segment alterations in the eyes of mucopolysaccharidoses: Its utility in early diagnosis of glaucoma

Author

Achanta, Divya Ramya, Mohamed, Ashik, Chaurasia, Sunita, Senthil, Sirisha, Mandal, Anil, Takkar, Brijesh, Mishra, Dilip, Edward, Deepak, and Ramappa, Muralidhar

Subjects
Mucopolysaccharidosis -- Diagnosis -- Complications and side effects, Glaucoma -- Risk factors -- Diagnosis, Health
Abstract

Byline: Divya. Ramya Achanta, Ashik. Mohamed, Sunita. Chaurasia, Sirisha. Senthil, Anil. Mandal, Brijesh. Takkar, Dilip. Mishra, Deepak. Edward, Muralidhar. Ramappa Purpose: Our study aimed to evaluate the utility of the [...]

Published
2022

22. Neurotization of the human cornea - A comprehensive review and an interim report

Author

Rathi, Anubha, Bothra, Nandini, Priyadarshini, Smruti, Achanta, Divya, Fernandes, Merle, Murthy, Somasheila, Kapoor, Anasua, Dave, Tarjani, Rath, Suryasnata, Yellinedi, Rajesh, Nuvvula, Rambabu, Dendukuri, Gautam, Naik, Milind, and Ramappa, Muralidhar

Subjects
Corneal diseases -- Risk factors -- Diagnosis -- Care and treatment, Nerve growth factor -- Analysis, Confocal microscopy -- Methods, Health
Abstract

Byline: Anubha. Rathi, Nandini. Bothra, Smruti. Priyadarshini, Divya. Achanta, Merle. Fernandes, Somasheila. Murthy, Anasua. Kapoor, Tarjani. Dave, Suryasnata. Rath, Rajesh. Yellinedi, Rambabu. Nuvvula, Gautam. Dendukuri, Milind. Naik, Muralidhar. Ramappa We [...]

Published
2022

24. Secondary developmental glaucoma in eyes with congenital aphakia

Author

Badakere, Swathi, Aulakh, Simranjeet, Achanta, Divya, Chary, Raghava, Senthil, Sirisha, Chaurasia, Sunita, Ramappa, Muralidhar, and Edward, Deepak

Subjects
Aphakia -- Risk factors -- Diagnosis -- Care and treatment, Genetic disorders -- Risk factors -- Diagnosis -- Care and treatment, Glaucoma -- Risk factors -- Diagnosis -- Care and treatment, Pediatric research, Health
Abstract

Byline: Swathi. Badakere, Simranjeet. Aulakh, Divya. Achanta, Raghava. Chary, Sirisha. Senthil, Sunita. Chaurasia, Muralidhar. Ramappa, Deepak. Edward Purpose: To describe the clinical spectrum and management of glaucoma in congenital aphakia. [...]

Published
2022

25. Toric intraocular lenses: Expanding indications and preoperative and surgical considerations to improve outcomes

Author

Singh, Vivek, Ramappa, Muralidhar, Murthy, Somasheila, and Rostov, Audrey

Subjects
Corneal diseases -- Care and treatment, Astigmatism -- Care and treatment, Cataract -- Surgery, Intraocular lenses -- Usage, Health
Abstract

Byline: Vivek. Singh, Muralidhar. Ramappa, Somasheila. Murthy, Audrey. Rostov Since the introduction of the first toric intraocular lens (IOLs) in the early 1990s, these lenses have become the preferred choice [...]

Published
2022

27. Axenfeld–Rieger syndrome in the pediatric population: A review.

Author

Khandwala, Nikhila, Ramappa, Muralidhar, Edward, Deepak, and Mocan, Mehmet

Abstract

Axenfeld–Rieger syndrome (ARS) is a rare autosomal-dominant neurocristopathy that presents with a variety of classical ocular and systemic findings. The pathophysiology of the disease involves anterior segment dysgenesis, and patients may present with ophthalmic complications early in life, including secondary glaucoma, high refractive errors, amblyopia, and permanent visual damage. There are a limited number of studies in the literature that focus primarily on pediatric patients with ARS. The purpose of this article was to review the current literature on clinical presentation, genetic associations, diagnosis, secondary complications, and treatment of ARS in pediatric patients. Evaluating the essential clinical aspects of the disease in children may allow for earlier diagnosis and treatment and prevent visual morbidity from amblyopia and secondary glaucoma that may result in permanent visual damage. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Unusual corneal epitheliopathy: An unfamiliar adverse effect of topical retinoids

Author

Tanna, Vishakha, Chaurasia, Sunita, and Ramappa, Muralidhar

Subjects
Tetracycline -- Complications and side effects, Tetracyclines -- Complications and side effects, Retinoids, Health
Abstract

Byline: Vishakha. Tanna, Sunita. Chaurasia, Muralidhar. Ramappa Case Report We describe a 19-year-old female who presented to the cornea clinic with a chief complaint of gradual diminution of vision in [...]

Published
2021

40. Quantitative corneal neural imaging using in vivo confocal microscopy in cases of congenital corneal anesthesia: A prospective analysis and clinical correlation

Author

Gopal, Madhumita, Ramappa, Muralidhar, Mohamed, Ashik, Dhakal, Rohit, and Chaurasia, Sunita

Subjects
Corneal diseases -- Diagnosis, Confocal microscopy -- Methods, Neuroimaging -- Methods, Pediatric research, Health
Abstract

Byline: Madhumita. Gopal, Muralidhar. Ramappa, Ashik. Mohamed, Rohit. Dhakal, Sunita. Chaurasia Purpose: Congenital corneal anesthesia (CCA) is a rare clinical entity that poses a diagnostic dilemma, particularly in the pediatric [...]

Published
2021

41. Commentary: A perspective on pediatric keratoconus: One size does not fit all

Author

Ramappa, Muralidhar

Subjects
Children -- Diseases, Lasers in surgery -- Methods, Keratoconus -- Diagnosis -- Care and treatment, Pediatric research, Health
Abstract

Byline: Muralidhar. Ramappa Everyone knows ' one-size-fits-all ' is often a lie. Solutions might fit most, but the fit is usually really, poor for the few outliers. Pediatric keratoconus is [...]

Published
2021

42. Unusual 'fish bone pattern' epitheliopathy

Author

Rajarajan, Mugundhan, Muthukumar, Bhavatharini, Kapoor, Rajat, and Ramappa, Muralidhar

Subjects
Epithelium -- Case studies -- Health aspects, Corneal diseases -- Case studies -- Diagnosis, Autonomic neuropathies -- Case studies -- Diagnosis, Health
Abstract

Byline: Mugundhan. Rajarajan, Bhavatharini. Muthukumar, Rajat. Kapoor, Muralidhar. Ramappa A 13-year-old female presented with the history of whitish discoloration and decreased vision in both eyes since 3 years, more-so in [...]

Published
2021

45. Bilateral retinal detachment in Goldenhar syndrome

Author

Dorji, Phuntsho, Ramappa, Muralidhar, and Takkar, Brijesh

Subjects
Retinal detachment -- Case studies -- Development and progression -- Care and treatment, Genetic disorders -- Case studies -- Complications and side effects -- Care and treatment, Health
Abstract

Byline: Phuntsho. Dorji, Muralidhar. Ramappa, Brijesh. Takkar The ocular features of Goldenhar syndrome (GS) are typically external, like surface dermoids and lid coloboma. Retinal detachment (RD) is rare and has [...]

Published
2020

46. Acute endophthalmitis after penetrating and endothelial keratoplasty at a tertiary eye care center over a 13-year period

Author

Das, Shilpa, Ramappa, Muralidhar, Mohamed, Ashik, Chaurasia, Sunita, Sharma, Savitri, and Das, Taraprasad

Subjects
Corneal transplantation -- Complications and side effects, Gram-negative bacterial infections -- Development and progression -- Care and treatment, Endophthalmitis -- Development and progression -- Care and treatment, Health
Abstract

Byline: Shilpa. Das, Muralidhar. Ramappa, Ashik. Mohamed, Sunita. Chaurasia, Savitri. Sharma, Taraprasad. Das Purpose: To evaluate the clinico-microbiological profile, donor cornea risk factors, and outcomes of postkeratoplasty endophthalmitis at a [...]

Published
2020

47. Anterior segment alterations in congenital primary aphakia--a clinicopathologic report of five cases

Author

Chaurasia, Sunita, Jakati, Saumya, Ramappa, Muralidhar, Mishra, Dilip, and Edward, Deepak

Subjects
Cornea -- Medical examination -- Physiological aspects, Aphakia -- Physiological aspects, Genetic disorders -- Physiological aspects, Health
Abstract

Byline: Sunita. Chaurasia, Saumya. Jakati, Muralidhar. Ramappa, Dilip. Mishra, Deepak. Edward Purpose: To report the clinicopathological features of corneal buttons in patients with congenital primary aphakia. Methods: Five corneal specimens [...]

Published
2020

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