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3. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial

Author

Mart, Matthew F, Boehm, Leanne M, Kiehl, Amy L, Gong, Michelle N, Malhotra, Atul, Owens, Robert L, Khan, Babar A, Pisani, Margaret A, Schmidt, Gregory A, Hite, R Duncan, Exline, Matthew C, Carson, Shannon S, Hough, Catherine L, Rock, Peter, Douglas, Ivor S, Feinstein, Daniel J, Hyzy, Robert C, Schweickert, William D, Bowton, David L, Masica, Andrew, Orun, Onur M, Raman, Rameela, Pun, Brenda T, Strength, Cayce, Rolfsen, Mark L, Pandharipande, Pratik P, Brummel, Nathan E, Hughes, Christopher G, Patel, Mayur B, Stollings, Joanna L, Ely, E Wesley, Jackson, James C, and Girard, Timothy D

Published
2024
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11. Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults

Author

Han, Jin H., Ginde, Adit A., Brown, Samuel M., Baughman, Adrienne, Collar, Erin M., Ely, E. Wesley, Gong, Michelle N., Hope, Aluko A., Hou, Peter C., Hough, Catherine L., Iwashyna, Theodore J., Jackson, James C., Khan, Akram, Orun, Onur M., Patel, Mayur B., Raman, Rameela, Rice, Todd W., Ringwood, Nancy, Semler, Matthew W., Shapiro, Nathan I., Talmor, Daniel S., and Self, Wesley H.

Published
2021
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13. Reporting of Child Maltreatment During the COVID-19 Pandemic in a Southern State in the United States

Author

Diamond-Welch, Bridget, Finigan-Carr, Nadine, Decker, Michele R., Chon, Katherine Y., Thome, Julia C., Gracey, Kathy, Epstein, Richard A., Cull, Michael J., Kuhn, Tarah, and Raman, Rameela

Abstract

Objectives: COVID-19–related stay-at-home orders (SAHOs) created an immediate physical barrier between children and professionals such as pediatricians and teachers, who are often first to identify and report signs of child maltreatment. Our objective was to determine how the SAHO in a southern state was associated with reports of child maltreatment and whether this association was modified by sociodemographic characteristics.Methods: We linked data on reports of child maltreatment from a southern state in the United States from October 1, 2018, through September 30, 2020, to data from the US Census Bureau to obtain data on county-level socioeconomic characteristics. We fit a segmented regression model to evaluate changes in reports before and after the SAHO, March 20, 2020. We evaluated potential disparities by child age, case and allegation severity, and socioeconomic characteristics.Results: Of 374 885 hotline calls, 276 878 (73.9%) were made before the SAHO and 98 007 (26.1%) after it. Although an immediate decrease in reports of child maltreatment occurred on the day of the SAHO, the rates of reporting within socioeconomic groups started increasing thereafter. While we found no significant change in the overall rate of change in hotline calls after versus before the SAHO (0.23; 95% CI, −0.11 to 0.58), stratified analyses indicate that the rates at which reporting increased varied by education level, health insurance coverage, median annual household income, and unemployment.Conclusions: Evaluating these trends is important for policy makers and practitioners to understand how policies enforced during the pandemic influence child maltreatment reporting and how these policies may affect reporting differently across socioeconomic groups.

Published
2025
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14. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Author

Creteur, Jacques, Bogossian, Elisa Govea, Peluso, Lorenzo, González-Seguel, Felipe, Hidalgo-Calibin, Viviane, Carreño-Montenegro, Pablo, Rojas, Verónica, Tobar, Eduardo, Ramírez-Palma, Antonio, Herrera-Davis, Karen, Ferré, Alexis, Legriel, Stéphane, Godet, Thomas, Fraisse, Ugo, Gonçalves, Bruno, Mazeraud, Aurélien, Tzimou, Myrto, Rasulo, Frank, Beretta, Silvia, Marchesi, Mattia, Robba, Chiara, Battaglini, Denise, Pelosi, Paolo, Mazzeo, Anna Teresa, Noto, Alberto, Servillo, Giuseppe, Marra, Annachiara, Cutuli, Salvatore Lucio, Pintaudi, Gabriele, Stival, Eleonora, Tanzarella, Eloisa Sofia, Roman-Pognuz, Erik, Concetta Massaro, Chiara Maria, Elhadi, Muhammed, Smit, Lisa, Olasveengen, Theresa, Pereira, Isabel Jesus, Teixeira, Carla Margarida, Santos, Alice, Valente, Miguel, Granja, Cristina, Pereia, Rita, Silva, João, Furquet, Blanca, García Simón, Mónica, Godoy Torres, Daniel A, Monleón, Berta, Morcillo, Esteban, Romero, Nekane, Serrano, Ainhoa, Torrico Sánchez, Sara, Pérez Caballero, Francisco Luis, Peña Luna, Isabel, Baeza Gómez, Ignacio, Calizaya Vargas, Milagros, Morillas Pérez, Jordi, Carrasco Gómez, Genís, Molina Latorre, Ricard, Moya Gutiérrez, Sheila, Barón Barrera, Irene Patricia, Delgado Palacios, Cristina, García Góngora, Beatriz, Labrador Romero, Laura, Galarza, Laura, Catalán-Monzón, Ignacio, Rodriguez-Martínez, Enver, Murcia Gubianas, Cristina, Bellès, Ariadna, Rodriguez Delgado, María Esther, Caballero, Jesús, Morales, Dulce, Pujol, Andrés, Rubio, Jorge, Álvarez Torres, Eva, Carvajal Revuelta, Estefanía, de la Calle Gil, Isabel, Fernández Tomás, Blanca, Gallego Rodríguez, Berta, González Serrano, Matilde, LaTorre Andreu, Paloma, Pérez Lucendo, Aris, Abril Palomares, Elena, González González, Elena, Martín Delgado, María Cruz, Muñoz De Cabo, Carlos, Aznar, Pablo T., Calvo, Carlos A., Garutti, Ignacio, Higuero, Fernando, Martínez-Gascueña, David, Maseda, Emilio, Insausti, Itziar, Montero Feijoo, Ana, Suarez-de-la-Rica, Alejandro, Del Moral Barbudo, Beatriz, García Blanco-Traba, Yago, Giménez Santamarina, Maria Claudia, Gonzalo Millán, Alba, Llorente Damas, Sergio, Pestaña Lagunas, David, Reyes García, Isabel, Ruiz Perea, Alejandro, Ortega Guerrero, Álvaro, Mármol Cubillo, María Jesús, Díaz Muñoz, David, García de Castrillón i Ramal, Silvia, Andorrà Sunyer, Xavier, Noci Moreno, María de las Nieves, Pérez Manrique, Rosa María, del Campo Molina, Emilio, Martínez Quintana, María Elena, Fernandez-Gonzalo, Sol, Gomà Fernández, Gemma, Navarra-Ventura, Guillem, Baró Serra, Anna, Fuster, Cristina, Plans Galván, Oriol, Gil-Castillejos, Diana, Dalorzo González, Mario, Morán Gallego, Francisco Javier, Paredes Borrachero, Irene, Rodríguez Villamizar, Patricia, Romeu Prieto, Juan, Sánchez Carretero, María José, Gallardo Sánchez, Susana, Bustos Molina, Filadelfo, García Pérez, María Luisa, Castello-Mora, Paula, Puig, Jaume, Sanchis-Martin, María Rosa, Sanchis-Veryser, Carmen Andrea, Vicente-Fernández, María Pilar, Zaragoza, Rafael, Lizama, Laura, Torres, Irene, Álvarez, Cristina, Ramírez, Paula, Martin Cerezuela, Meri, Montero, María Jesús, García Cantos, Jose, Valls, Paola, Aretxabala Cortajarena, Nerea, García Domelo, Pablo, González Cubillo, Laura, Martín Martínez, Marta, Pérez Francisco, Inés, Poveda Hernández, Yolanda, Quintano Rodero, Amaia, Rodriguez Nuñez, César, Siegemund, Martin, Estermann, Anna, Zellweger, Núria, Ben Saida, Imen, Boussarsar, Mohamed, Esen, Figen, Ergin Özcan, Perihan, Berkey, Christopher, Harb, Christine, Tandy, Morgan H., Morgan, Ellis, Shephard, Karen, Hyzy, Robert C, Kenes, Michael, Nelson, Kristine, Hosse, Robert E., Vance, Katie M., Austin, C. Adrian, Lerner, Aaron, Sanders, Emily, Balk, Robert A, Bennett, David A, Vogel, Andrew R., Chowdhury, Lucia, Devulapally, Kiran, Woodham, Michelle, Cohen, Sarah, Patel, Nihal, Kuza, Catherine M., Sing, Mandeep, Roberson, Spencer, Drumright, Kelly, Sehgal, Sameep, LaHue, Sara C., Douglas, Vanja C., Sarwal, Aarti, Pun, Brenda T, Badenes, Rafael, Heras La Calle, Gabriel, Orun, Onur M, Chen, Wencong, Raman, Rameela, Simpson, Beata-Gabriela K, Wilson-Linville, Stephanie, Hinojal Olmedillo, Borja, Vallejo de la Cueva, Ana, van der Jagt, Mathieu, Navarro Casado, Rosalía, Leal Sanz, Pilar, Orhun, Günseli, Ferrer Gómez, Carolina, Núñez Vázquez, Karla, Piñeiro Otero, Patricia, Taccone, Fabio Silvio, Gallego Curto, Elena, Caricato, Anselmo, Woien, Hilde, Lacave, Guillaume, O'Neal, Hollis R, Jr, Peterson, Sarah J, Brummel, Nathan E, Girard, Timothy D, Ely, E Wesley, and Pandharipande, Pratik P

Published
2021
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23. Antipsychotics and the QTc Interval During Delirium in the Intensive Care Unit

Author

Stollings, Joanna L., primary, Boncyk, Christina S., additional, Birdrow, Caroline I., additional, Chen, Wencong, additional, Raman, Rameela, additional, Gupta, Deepak K., additional, Roden, Dan M., additional, Rivera, Erika L., additional, Maiga, Amelia W., additional, Rakhit, Shayan, additional, Pandharipande, Pratik P., additional, Ely, E. Wesley, additional, Girard, Timothy D., additional, and Patel, Mayur B., additional

Published
2024
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30. Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer

Author

Shinall, Myrick C., primary, Martin, Sara F., additional, Karlekar, Mohana, additional, Hoskins, Aimee, additional, Morgan, Ellis, additional, Kiehl, Amy, additional, Bryant, Patsy, additional, Orun, Onur M., additional, Raman, Rameela, additional, Tillman, Benjamin F., additional, Hawkins, Alexander T., additional, Brown, Alaina J., additional, Bailey, Christina E., additional, Idrees, Kamran, additional, Chang, Sam S., additional, Smith, Joseph A., additional, Tan, Marcus C. B., additional, Magge, Deepa, additional, Penson, David, additional, and Ely, E. Wesley, additional

Published
2023
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34. Modifiable in‐hospital factors for 12‐month global cognition, post‐traumatic stress disorder symptoms, and depression symptoms in adults hospitalized with COVID‐19.

Author

Han, Jin H., Jackson, James C., Orun, Onur M., Brown, Samuel M., Casey, Jonathan D., Clark, Lindsay, Collins, Sean P., Cordero, Kemberlyne, Ginde, Adit A., Gong, Michelle N., Hough, Catherine L., Iwashyna, Theodore J., Kiehl, Amy L., Lauck, Alana, Leither, Lindsay M., Lindsell, Christopher J., Patel, Mayur B., Raman, Rameela, Rice, Todd W., and Ringwood, Nancy J.

Subjects
POST-traumatic stress disorder, MENTAL depression, COVID-19, SYMPTOMS, COGNITION, CHILD patients, REFUGEE children
Abstract

Background: We sought to identify potentially modifiable in‐hospital factors associated with global cognition, post‐traumatic stress disorder (PTSD) symptoms, and depression symptoms at 12 months. Methods: This was a multi‐center prospective cohort study in adult hospitalized patients with acute COVID‐19. The following in‐hospital factors were assessed: delirium; frequency of in‐person and virtual visits by friends and family; and hydroxychloroquine, corticosteroid, and remdesivir administration. Twelve‐month global cognition was characterized by the MOCA‐Blind. Twelve‐month PTSD and depression were characterized using the PTSD Checklist for the DSM‐V and Hospital Anxiety Depression Scale, respectively. Findings: Two hundred three patients completed the 12‐month follow‐up assessments. Remdesivir use was associated with significantly higher cognition at 12 months based on the MOCA‐Blind (adjusted odds ratio [aOR] = 1.98, 95% CI: 1.06, 3.70). Delirium was associated with worsening 12‐month PTSD (aOR = 3.44, 95% CI: 1.89, 6.28) and depression (aOR = 2.18, 95% CI: 1.23, 3.84) symptoms. Multiple virtual visits per day during hospitalization was associated with lower 12‐month depression symptoms compared to those with less than daily virtual visits (aOR = 0.40, 95% CI: 0.19, 0.85). Conclusion: Potentially modifiable factors associated with better long‐term outcomes included remdesivir use (associated with better cognitive function), avoidance of delirium (associated with less PTSD and depression symptoms), and increased virtual interactions with friends and family (associated with less depression symptoms). [ABSTRACT FROM AUTHOR]

Published
2023
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35. Dynamic predictors of in-hospital and 3-year mortality after traumatic brain injury: A retrospective cohort study

Author

Wilson, Laura D., primary, Maiga, Amelia W., additional, Lombardo, Sarah, additional, Nordness, Mina F., additional, Haddad, Diane N., additional, Rakhit, Shayan, additional, Smith, Laney F., additional, Rivera, Erika L., additional, Cook, Madison R., additional, Thompson, Jennifer L., additional, Raman, Rameela, additional, and Patel, Mayur B., additional

Published
2022
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36. Where to Find It

Author

Thompson, Jennifer, Ely, E., Raman, Rameela, and Girard, Timothy

Subjects
health care facilities, manpower, and services, education, health care economics and organizations
Abstract

Internal list of where to find various study documents.

Published
2022
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37. Statistical Analysis Plan

Author

Raman, Rameela, Orun, Onur, Chen, Wencong, and Pun, Brenda

Subjects
genetic structures, Medicine and Health Sciences, eye diseases
Abstract

SAP for the COVID-D Study

Published
2022
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38. Analyses

Author

Thompson, Jennifer, Raman, Rameela, Girard, Timothy, and Ely, E.

Abstract

Documents and code related to statistical analysis for the MIND-USA randomized clinical trial.

Published
2022
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39. MIND-USA In-Hospital Outcomes

Author

Thompson, Jennifer, Raman, Rameela, Girard, Timothy, and Ely, E.

Subjects
mental disorders, behavioral disciplines and activities, nervous system diseases
Abstract

In-hospital outcomes for clinical trial aiming to define the role of antipsychotics in the management of delirium in critically ill patients. clinicaltrials.gov: NCT01211522

Published
2022
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41. Data

Author

Thompson, Jennifer, Raman, Rameela, Girard, Timothy, and Ely, E.

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Documents and code related to analysis datasets for this project.

Published
2022
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42. Delirium, depression, and long-term cognition.

Author

Andrews, Patricia S., Thompson, Jennifer, Raman, Rameela, Rick, Chelsea, Kiehl, Amy, Pandharipande, Pratik, Jackson, James C., Taylor, Warren D., Ely, E. W., and Wilson, Jo E.

Abstract

Objectives: We examined whether preadmission history of depression is associated with less delirium/coma-free (DCF) days, worse 1-year depression severity and cognitive impairment. Design and measurements: A health proxy reported history of depression. Separate models examined the effect of preadmission history of depression on: (a) intensive care unit (ICU) course, measured as DCF days; (b) depression symptom severity at 3 and 12 months, measured by the Beck Depression Inventory-II (BDI-II); and (c) cognitive performance at 3 and 12 months, measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) global score. Setting and participants: Patients admitted to the medical/surgical ICU services were eligible. Results: Of 821 subjects eligible at enrollment, 261 (33%) had preadmission history of depression. After adjusting for covariates, preadmission history of depression was not associated with less DCF days (OR 0.78, 95% CI, 0.59–1.03 p = 0.077). A prior history of depression was associated with higher BDI-II scores at 3 and 12 months (3 months OR 2.15, 95% CI, 1.42–3.24 p = <0.001; 12 months OR 1.89, 95% CI, 1.24–2.87 p = 0.003). We did not observe an association between preadmission history of depression and cognitive performance at either 3 or 12 months (3 months beta coefficient −0.04, 95% CI, −2.70–2.62 p = 0.97; 12 months 1.5, 95% CI, −1.26–4.26 p = 0.28). Conclusion: Patients with a depression history prior to ICU stay exhibit a greater severity of depressive symptoms in the year after hospitalization. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Reporting of Child Maltreatment During the COVID-19 Pandemic in a Southern State in the United States.

Author

Thome, Julia C., Gracey, Kathy, Epstein, Richard A., Cull, Michael J., Kuhn, Tarah, and Raman, Rameela

Subjects
INSURANCE, INCOME, CHILD abuse, UNEMPLOYMENT, STAY-at-home orders, SOCIODEMOGRAPHIC factors, CONFIDENCE intervals, COVID-19 pandemic, EDUCATIONAL attainment
Abstract

Objectives: COVID-19–related stay-at-home orders (SAHOs) created an immediate physical barrier between children and professionals such as pediatricians and teachers, who are often first to identify and report signs of child maltreatment. Our objective was to determine how the SAHO in a southern state was associated with reports of child maltreatment and whether this association was modified by sociodemographic characteristics. Methods: We linked data on reports of child maltreatment from a southern state in the United States from October 1, 2018, through September 30, 2020, to data from the US Census Bureau to obtain data on county-level socioeconomic characteristics. We fit a segmented regression model to evaluate changes in reports before and after the SAHO, March 20, 2020. We evaluated potential disparities by child age, case and allegation severity, and socioeconomic characteristics. Results: Of 374 885 hotline calls, 276 878 (73.9%) were made before the SAHO and 98 007 (26.1%) after it. Although an immediate decrease in reports of child maltreatment occurred on the day of the SAHO, the rates of reporting within socioeconomic groups started increasing thereafter. While we found no significant change in the overall rate of change in hotline calls after versus before the SAHO (0.23; 95% CI, −0.11 to 0.58), stratified analyses indicate that the rates at which reporting increased varied by education level, health insurance coverage, median annual household income, and unemployment. Conclusions: Evaluating these trends is important for policy makers and practitioners to understand how policies enforced during the pandemic influence child maltreatment reporting and how these policies may affect reporting differently across socioeconomic groups. [ABSTRACT FROM AUTHOR]

Published
2025
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47. Delirium, depression, and long-term cognition

Author

Andrews, Patricia S., primary, Thompson, Jennifer, additional, Raman, Rameela, additional, Rick, Chelsea, additional, Kiehl, Amy, additional, Pandharipande, Pratik, additional, Jackson, James C., additional, Taylor, Warren D., additional, Ely, E. W., additional, and Wilson, Jo E., additional

Published
2021
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49. Prospective Validation of the Preschool Confusion Assessment Method for the ICU to Screen for Delirium in Infants Less Than 6 Months Old

Author

Canter, Marguerite O., primary, Tanguturi, Yasas C., additional, Ellen Wilson, Jo, additional, Williams, Stacey R., additional, Exum, Sylvia A., additional, Umrania, Hiren M., additional, Betters, Kristina A., additional, Raman, Rameela, additional, Ely, E. Wesley, additional, Pandharipande, Pratik P., additional, Fuchs, D. Catherine, additional, and Smith, Heidi A. B., additional

Published
2021
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50. Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis

Author

Hughes, Christopher G., primary, Mailloux, Patrick T., additional, Devlin, John W., additional, Swan, Joshua T., additional, Sanders, Robert D., additional, Anzueto, Antonio, additional, Jackson, James C., additional, Hoskins, Aimee S., additional, Pun, Brenda T., additional, Orun, Onur M., additional, Raman, Rameela, additional, Stollings, Joanna L., additional, Kiehl, Amy L., additional, Duprey, Matthew S., additional, Bui, Lan N., additional, O’Neal, Hollis R., additional, Snyder, Allison, additional, Gropper, Michael A., additional, Guntupalli, Kalpalatha K., additional, Stashenko, Gregg J., additional, Patel, Mayur B., additional, Brummel, Nathan E., additional, Girard, Timothy D., additional, Dittus, Robert S., additional, Bernard, Gordon R., additional, Ely, E. Wesley, additional, and Pandharipande, Pratik P., additional

Published
2021
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