Search

Your search keyword '"Ramage, Gordon"' showing total 749 results
Start Over Author "Ramage, Gordon"
749 results on '"Ramage, Gordon"'

7. Dual nanocarrier of chlorhexidine and fluconazole: Physicochemical characterization and effects on microcosm biofilms and oral keratinocytes

Author

Araujo, Heitor Ceolin, Pessan, Juliano Pelim, Caldeirão, Anne Caroline Morais, Sampaio, Caio, Oliveira, Marcelo José dos Santos, Sales, Douglas Henrique, Teixeira, Silvio Rainho, Constantino, Carlos José Leopoldo, Delbem, Alberto Carlos Botazzo, Oliveira, Sandra Helena Penha, Ramage, Gordon, and Monteiro, Douglas Roberto

Published
2023
Full Text
View/download PDF

10. Clinical Management of Fungal Biofilm Infections

Author

Ramage, Gordon, Short, Bryn, McKloud, Emily, Alshanta, Om Alkhir, Butcher, Mark, McLean, William, Brown, Jason L., Rumbaugh, Kendra P., Series Editor, Coenye, Tom, Series Editor, Richter, Katharina, editor, and Kragh, Kasper Nørskov, editor

Published
2022
Full Text
View/download PDF

13. Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Author

Van Dijck, Patrick, Sjollema, Jelmer, Cammue, Bruno P, Lagrou, Katrien, Berman, Judith, d'Enfert, Christophe, Andes, David R, Arendrup, Maiken C, Brakhage, Axel A, Calderone, Richard, Cantón, Emilia, Coenye, Tom, Cos, Paul, Cowen, Leah E, Edgerton, Mira, Espinel-Ingroff, Ana, Filler, Scott G, Ghannoum, Mahmoud, Gow, Neil AR, Haas, Hubertus, Jabra-Rizk, Mary Ann, Johnson, Elizabeth M, Lockhart, Shawn R, Lopez-Ribot, Jose L, Maertens, Johan, Munro, Carol A, Nett, Jeniel E, Nobile, Clarissa J, Pfaller, Michael A, Ramage, Gordon, Sanglard, Dominique, Sanguinetti, Maurizio, Spriet, Isabel, Verweij, Paul E, Warris, Adilia, Wauters, Joost, Yeaman, Michael R, Zaat, Sebastian AJ, and Thevissen, Karin

Subjects
antibiofilm material coating, antifungal susceptibility testing, biofilm eradication, biofilm inhibition, in vivo models
Abstract

Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

Published
2018

14. Materials-driven fibronectin assembly on nanoscale topography enhances mesenchymal stem cell adhesion, protecting cells from bacterial virulence factors and preventing biofilm formation

Author

Damiati, Laila A., Tsimbouri, Monica P., Hernandez, Virginia-Llopis, Jayawarna, Vineetha, Ginty, Mark, Childs, Peter, Xiao, Yinbo, Burgess, Karl, Wells, Julia, Sprott, Mark R., Meek, R.M. Dominic, Li, Peifeng, Oreffo, Richard O.C., Nobbs, Angela, Ramage, Gordon, Su, Bo, Salmeron-Sanchez, Manuel, and Dalby, Matthew J.

Published
2022
Full Text
View/download PDF

17. Use of Nanoparticles to Manage Candida Biofilms

Author

Monteiro, Douglas Roberto, Arias, Laís Salomão, Araujo, Heitor Ceolin, Caldeirão, Anne Caroline Morais, Gulart, Bianca Fiorese, de Oliveira, Joseane, dos Santos, Marilene Batista, Ramage, Gordon, Pessan, Juliano Pelim, and Shukla, Ashutosh Kumar, editor

Published
2020
Full Text
View/download PDF

18. Study of the Structure of Hyperbranched Polyglycerol Coatings and Their Antibiofouling and Antithrombotic Applications.

Author

Moore, Eli, Robson, Alexander J., Crisp, Amy R., Cockshell, Michaelia P., Burzava, Anouck L. S., Ganesan, Raja, Robinson, Nirmal, Al‐Bataineh, Sameer, Nankivell, Victoria, Sandeman, Lauren, Tondl, Markus, Benveniste, Glen, Finnie, John W., Psaltis, Peter J., Martocq, Laurine, Quadrelli, Alessio, Jarvis, Samuel P., Williams, Craig, Ramage, Gordon, and Rehman, Ihtesham U.

Published
2024
Full Text
View/download PDF

25. Informed development of a multi‐species biofilm in chronic obstructive pulmonary disease.

Author

Short, Bryn, Delaney, Christopher, Johnston, William, Litherland, Gary J., Lockhart, John C., Williams, Craig, Mackay, William G., and Ramage, Gordon

Subjects
CHRONIC obstructive pulmonary disease, CANDIDA albicans, BIOFILMS
Abstract

Recent evidence indicates that microbial biofilm aggregates inhabit the lungs of COPD patients and actively contribute towards chronic colonization and repeat infections. However, there are no contextually relevant complex biofilm models for COPD research. In this study, a meta‐analysis of the lung microbiome in COPD was used to inform development of an optimized biofilm model composed of genera highly associated with COPD. Bioinformatic analysis showed that although diversity matrices of COPD microbiomes were similar to healthy controls, and internal compositions made it possible to accurately differentiate between these cohorts (AUC = 0.939). Genera that best defined these patients included Haemophilus, Moraxella and Streptococcus. Many studies fail to account for fungi; therefore, Candida albicans was included in the creation of an interkingdom biofilm model. These organisms formed a biofilm capable of tolerating high concentrations of antimicrobial therapies with no significant reductions in viability. However, combined therapies of antibiotics and an antifungal resulted in significant reductions in viable cells throughout the biofilm (p < 0.05). This biofilm model is representative of the COPD lung microbiome and results from in vitro antimicrobial challenge experiments indicate that targeting both bacteria and fungi in these interkingdom communities will be required for more positive clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

32. Fungal Biofilms in Human Disease

Author

Williams, Craig, Ramage, Gordon, Cohen, Irun R., Series editor, Lajtha, N.S. Abel, Series editor, Paoletti, Rodolfo, Series editor, Lambris, John D., Series editor, and Donelli, Gianfranco, editor

Published
2015
Full Text
View/download PDF

35. Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials

Author

Gaur, Nishtha, Patenall, Bethany L., Ghimire, Bhagirath, Thet, Naing T., Gardiner, Jordan E., Doare, Krystal E. Le, Ramage, Gordon, Short, Bryn, Heylen, Rachel A., Williams, Craig, Short, Robert D., Jenkins, Toby A., Gaur, Nishtha, Patenall, Bethany L., Ghimire, Bhagirath, Thet, Naing T., Gardiner, Jordan E., Doare, Krystal E. Le, Ramage, Gordon, Short, Bryn, Heylen, Rachel A., Williams, Craig, Short, Robert D., and Jenkins, Toby A.

Abstract

We present the concept of a versatile drug-loaded composite hydrogel that can be activated using an argon-based cold atmospheric plasma (CAP) jet to deliver both a drug and CAP-generated molecules, concomitantly, in a tissue target. To demonstrate this concept, we utilized the antibiotic gentamicin that is encapsulated in sodium polyacrylate (PAA) particles, which are dispersed within a poly(vinyl alcohol) (PVA) hydrogel matrix. The final product is a gentamicin-PAA-PVA composite hydrogel suitable for an on-demand triggered release using CAP. We show that by activating using CAP, we can effectively release gentamicin from the hydrogel and also eradicate the bacteria effectively, both in the planktonic state and within a biofilm. Besides gentamicin, we also successfully demonstrate the applicability of the CAP-activated composite hydrogel loaded with other antimicrobial agents such as cetrimide and silver. This concept of a composite hydrogel is potentially adaptable to a range of therapeutics (such as antimicrobials, anticancer agents, and nanoparticles) and activatable using any dielectric barrier discharge CAP device.

Published
2023

36. Our current clinical understanding of Candida biofilms: where are we two decades on?

Author

Ramage, Gordon, Borghi, Elisa, Rodrigues, Célia Fortuna, Kean, Ryan, Williams, Craig, and Lopez‐Ribot, Jose

Subjects
*BIOFILMS, *CANDIDA, *MEDICAL microbiology, *BACTERIAL communities, *ANTIFUNGAL agents
Abstract

Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress pace has continued to mirror the bacterial biofilm community, albeit at a decreased volume. It is apparent that Candida species have a considerable capacity to colonize surfaces and interfaces and form tenacious biofilm structures, either alone or in mixed species communities. From the oral cavity, to the respiratory and genitourinary tracts, wounds, or in and around a plethora of biomedical devices, the scope of these infections is vast. These are highly tolerant to antifungal therapies that has a measurable impact on clinical management. This review aims to provide a comprehensive overight of our current clinical understanding of where these biofilms cause infections, and we discuss existing and emerging antifungal therapies and strategies. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

38. Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials

Author

Gaur, Nishtha, primary, Patenall, Bethany L., additional, Ghimire, Bhagirath, additional, Thet, Naing T., additional, Gardiner, Jordan E., additional, Le Doare, Krystal E., additional, Ramage, Gordon, additional, Short, Bryn, additional, Heylen, Rachel A., additional, Williams, Craig, additional, Short, Robert D., additional, and Jenkins, Toby A., additional

Published
2023
Full Text
View/download PDF

39. Longitudinal changes in subgingival biofilm composition following periodontal treatment

Author

Johnston, William, primary, Rosier, Bob T., additional, Carda‐Diéguez, Miguel, additional, Paterson, Michael, additional, Watson, Paddy, additional, Piela, Krystyna, additional, Goulding, Marilyn, additional, Ramage, Gordon, additional, Baranyia, Divyashri, additional, Chen, Tsute, additional, Al‐Hebshi, Nezar, additional, Mira, Alex, additional, and Culshaw, Shauna, additional

Published
2023
Full Text
View/download PDF

41. Biofilm-forming capability of highly virulent, multidrug-resistant Candida auris

Author

Sherry, Leighann, Ramage, Gordon, Kean, Ryan, Borman, Andrew, Johnson, Elizabeth M., Richardson, Malcolm D., and Rautemaa-Richardson, Riina

Subjects
Antiparasitic agents -- Health aspects, Microbial drug resistance -- Health aspects, Infection -- Health aspects, Amphotericin B -- Health aspects, Health
Abstract

The yeast pathogen Candida auris was first detected in 2009 from an ear canal infection in Japan (1). This species initially attracted attention because of its reduced susceptibility to azoles [...]

Published
2017
Full Text
View/download PDF

42. Yeast Biofilms

Author

Ramage, Gordon, Mowat, Eilidh, Williams, Craig, Ribot, Jose L. Lopez, Ashbee, Ruth, editor, and Bignell, Elaine M., editor

Published
2010
Full Text
View/download PDF

47. Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes

Author

Butcher, Mark C., Short, Bryn, Ramalingam Veena, Chandra Lekha, Bradshaw, Dave, Pratten, Jonathan R., McLean, William, Shaban, Suror Mohamad Ahmad, Ramage, Gordon, and Delaney, Christopher

Abstract

Background: \ud As one of the most prevalent infective diseases worldwide, it is crucial that we not only know the constituents of the oral microbiome in dental caries but also understand its functionality.\ud \ud Methods: \ud Herein we present a reproducible meta-analysis to effectively report the key components and the associated functional signature of the oral microbiome in dental caries. Publicly available sequencing data was downloaded from online repositories and subjected to a standardised analysis pipeline before analysis.\ud \ud Results: \ud Meta-analyses identified significant differences in alpha and beta diversities of carious microbiomes when compared to healthy ones. Additionally, machine learning and receiver operator characteristic analysis showed an ability to discriminate between healthy and disease microbiomes. We identified from importance values, as derived from random forest analyses, a group of genera, notably containing Selenomonas, Aggregatibacter, Actinomyces and Treponema, which can be predictive of dental caries. Finally, we propose the most appropriate study design for investigating the microbiome of dental caries by synthesising the studies, which had the most accurate differentiation based on random forest modelling.\ud \ud Interpretation: \ud In conclusion, we have developed a non-biased, reproducible pipeline, which can be applied to microbiome meta-analyses of multiple diseases, but importantly we have derived from our meta-analysis a key group of organisms that can be used to identify individuals at risk of developing dental caries based on oral microbiome inhabitants.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results