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3. Characterisation of older patients that require, but do not undergo, emergency laparotomy: a multicentre cohort study

Author

Shearer, Rosalyn, Mekhail, Peter, Ramsay, George, Nessa, Ashrafun, Iqbal, Rizwan, Maskell, Perry, Majeed, Mudassar, Dai, Nick, Bhojwani, Deepika, Anyomih, Theophilus, Lunevicius, Raimundas, Elkalbash, Rema, Shahzad, Khalid, Ahmed, Salma, Gahunia, Sukhpreet, Hopley, Philip, Nair, Dheepa, Reddington, Anne, Wilson, Jeremy, Lovett, Bryony, Iqbal, Muhammad Rafaih, Ramadan, Wafaa, Affify, Emma, Khan, Fatima, Tan, Silvian, Dawson, Joy, Eltarhoni, Khadiga, Young, Jamie, Lockwood, Sonia, Yiasemidou, Marina, Orchard, Melanie, Orchard, Phillipa, Randall, Jonathan, Barrow, Hannah, Dixon, Steve, Eardley, Nicola, Rajput, Kunal, Santoro, Giovanni, Mason, Sabrina, Bagnall, Nigel Mark, Kourdouli, Amar, Rajain, Sakshi, Curley, Daniel, Chandima Halahakoon, Vijitha, Thrikandiyur, Anu, Worsfold, James, Chouari, Tarak, Dent, Paul, Zhao, Sarah, Belgaumkar, Ajay, Maher, Sarah, Oyewole, Bankole, Weller, Sam, Davis, Mark, Fox, Katherine, Burton, Sarah, Iosif, Evangelia, Tobbal, Muhammed, Abdelkarim, Mostafa, Duvnjak, Haris, Morgan, Richard, Murali, Sreedutt, Murji, Bhaven, Venkatesan, Gowtham, Boardley, Rachael, Carson, Daniel, Galbraith, Norman, MacTier, Mhairi, Mailley, Keir, Meney, Laura, Persson, Pia, Stevenson, Richard, Haigh, Andrew, Kelly, Diane, Mellor, Samantha, Niaz, Muhammad Adnan, Peter, Mark, Smith, Douglas, Perin, Giordano, Hanbali, Nabih, Blackwell, James, Daliya, Prita, Herrod, Philip, Jibreel, Mohammed, Malcolm, Francesca, Photiou, Dana, Al-Khaddar, Ziad, Amir, Farhat, Bughio, Mumtaz, Gardiner, Felicity, Joyce, Nikki, Kennedy-Dalby, Andrew, Khan, Usman, McCoy, Sharon, Smart, Christopher J., Ward, Simon, Abdelsaid, Kirolos, AbdulAal, Yasser, Berski, Michael, Jayasankar, Balaji, Sandhu, Banher, Akhteruzzaman, Tahiyyah, Chan, Shirley, Dickson-Lowe, Richard, Kocsis, Anna Maria, Allen, Rhian, Bateman, Kellie, Shovelton, Charmaine, Smyth, Edward, Taylor, Daniel, Tennant, Anna, Chang, Jessica, Dowdeswell, Megan, Karri, Santosh, Neophytou, Chris, Yassin, Nuha, Bibi, Saira, Ulain, Noor, Evans, Luke, Cross, Katie, Fakhrul-aldeen, Mohammed, Jones, Stacey, Sarveswaran, Janahan, Aljarad, Feras, Collins, Amy, Eves, Joshua, Patel, Maleene, Sharieff, Imran, Smith, Emma, Treus, Estefania, McGuigan, Mari-Claire, Nicholoson, Gary, Pickering, Stacey, Husain, Najam, Narayanasamy, Sangara, Pradeep, Thomas, Rajebhosale, Ramprasad, Ravi, Prabhu, Elabbassy, Islam, Hao, Juen, Mak, Richard, Oliphant, Raymond, Powezka, Katarzyna, Asaad, Peter, Downs, Karen, Hylton, Jackie, Jalali, Uzma, Math, Suraj, Kourounis, Georgios, Mcilveen, Erin, Ng, Hwei Jene, Pope, Oscar, Argyropoulos, Susannah, Faulkner, Gemma, Spurring, Eleanor, Anis, Fady, Javanmard-Emamghissi, Hannah, Lee, Rachel, Redfern, Victoria, Saravanan, Nivetha, Tierney, Gill, Cullen, William, Kantola, Venla, Massey, Lisa, Orabi, Amira, Park, Linda, Rajaretnam, Niroshini, Smart, Neil, Ambler, Olivia, Damaskos, Dimitrios, Ewing, Anne, Mehta, Maithili, Skipworth, Richard, Alagaratnam, Swethan, Chowdhury, Shihad, Gupta, Aayush, Jones, Gareth, Mohamed, Guleed, Varcarda, Massimo, Abdel-dayem, Mahmoud, Mazumdar, Eshan, Miller, Bethany, Shah, Parin, Gupta, Sapna, Hawkings, Nancy, Herbert, Geraint, Indika, Kalhar, Mallison, Georgia, Smith, Laurie, Tolley, Thomas, Williams, Gethin, Burton, Keira, Cavallaro, Davide, Henry, Jayde, Parkin, Edward, Redfern, Jennifer, Sekhar, Hema, Murray, Hannah, Redman, Amelia, Thompson, Dolapo, Thornton, Sophie, Blake, Natalie, Mcleod, Ross, Pressler, Marc, Read, Howard, Shehata, Zak, Thomas, Michael, Walker, Cerys, Brown, Steven, Daniels, Sarah, Hawkins, Debby, Steele, Caroline, Berry, David, Dimitrova, Nora, Massella, Virginia, Mathew, Priya, Patel, Rikhilroy, Bakewell, Zoe, Collins, Alma, Fowler, George, Lawday, Samuel, McCarthy, Kathryn, Sheldon, James, Papakonstantinou, Dimitrios, Cox, Kofi, Kenington, Cleo, Mitchell, Robert, Thrumurthy, Sri, Clifford, Rachael, Kalaiselvan, Ramya, Leptidis, Ioannis, Connolly, Thomas, Evans, William, Kumar, Anil, Malik, Isfand, Nulty, Callula, Rai, Sajal, Brown, Ashley, Chew, Misha, Okpala, Amalachukwu, Tan, Yanyu, Magee, Cathy, Rossborough, Catherine, Manda, Vijay, McColl, Gillian, Norton, William, Ray, Christopher, Abdelrahman, Byrne, Clare, Caddick, Virginia, Ghanem, Ahmed, Marchese, Salvatore, Patel, Sabina, Singh, Kaushiki, Smith, Eleanor, Zarog, Mohamed, Caswell, Jack, Lukaszewicz, Alex, Manson, David, McKnight, Gerard, Duncan, Trish, Brown, Leo, Lam Chan, Deona Mei, Robertson, John, Al-Aqaileh, Ahmad, Chandratreya, Nitya, El-qudah, Jazal, Philip, Ken, Ben Hmida, Rami, Chohda, Ezzat, Gilbert, Kayleigh, Alqallaf, Addullah, Kamarizan, Mohamad, Ben Sassi, Abozed, Amin, Mohamed, Lim, Michael, Longbotham, David, Moussa, Ahmed, Sheridan, Kelda, Wilkins, Alex, Carter, Ben, Hewitt, Jonathan, Price, Angeline, McLennan, Elizabeth, Knight, Stephen R., Reeves, Nicola, Chandler, Susan, Boyle, Jemma, Pearce, Lyndsay, and Moug, Susan J.

Published
2024
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12. Proteomic and metabolomic signatures of U87 glioblastoma cells treated with cisplatin and/or paclitaxel

Author

Ahmed, Munazza, primary, Semreen, Ahlam M., additional, Giddey, Alexander D., additional, Ramadan, Wafaa S., additional, El-Awady, Raafat, additional, Soares, Nelson C., additional, El-Huneidi, Waseem, additional, Bustanji, Yasser, additional, Alqudah, Mohammad A. Y., additional, Alzoubi, Karem H., additional, and Semreen, Mohammad H., additional

Published
2023
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13. Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

Author

Ramadan, Wafaa S., primary, Saber-Ayad, Maha M., additional, Saleh, Ekram, additional, Abdu-Allah, Hajjaj H.M., additional, El-Shorbagi, Abdel-nasser A., additional, Menon, Varsha, additional, Tarazi, Hamadeh, additional, Semreen, Mohamed H., additional, da Cruz Soares, Nelson, additional, Hafezi, Shirin, additional, Venkatakhalam, Thenmozhi, additional, Ahmed, Samrein, additional, Kanie, Osamu, additional, Hamoudi, Rifat, additional, and El-Awady, Raafat, additional

Published
2023
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24. Protective and Therapeutic Effects of Lactic Acid Bacteria against Aflatoxin B1 Toxicity to Rat Organs

Author

Ashi, Hayat, primary, Almalki, Meshal H. K., additional, Hamed, Enas A., additional, Ramadan, Wafaa S., additional, Alahmadi, Tahani F. H., additional, Alami, Outour Tariq, additional, Arafa, Sara H., additional, Alshareef, Atheer K., additional, Alsulami, Fatimah S., additional, Alharbi, Areej F., additional, Al-Harbi, Manahil S., additional, Alqurashi, Ebtehal H., additional, Aashi, Shirin, additional, Alzahrani, Youssef A., additional, Elbanna, Khaled, additional, and Abulreesh, Hussein H., additional

Published
2023
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26. Can Eruca Sativa Oil Ameliorate Nicotine Induced Alteration in Rat Parotid Gland? Histological Study.

Author

Alshali, Rasha A., Ramadan, Wafaa S., Altayyari, Mona W., and Ali, Soad S.

Subjects
*PAROTID glands, *NICOTINE, *ORAL drug administration, *TUMOR proteins, *P53 protein, *RATS
Abstract

Objective: To investigate the possible protective effect of oral administration of Eruca sativa oil against nicotine induced alterations on rat parotid gland using histological,immunohistochemical and morphometric methods. Materials and Methods: Thirty adult male rats were included in the study. They were randomly divided into to the following equal groups G1, control group which received standard rat pellets and oral saline. In G 2 nicotine tartrate was given daily at a dose of 50 mg/kg for 3 weeks. G3 which received nicotine tarterate orally at a dose of 50 mg/kg plus Eruca sativa oil at a dose of 0.5 ml/Kg for 3 weeks. At the end of study, animals were euthanized under deep ether anesthesia and the front of neck was dissected to free and extract the parotid glands in one block. They were fixed in 1% neutral buffered formalin and processed. 5 micron thick sections were stained by Hematoxylin and eosin and Masson trichrome. Immunostaining using specific antibodies for α smooth actin and tumor protein P53 was done, this was followed by morphometric and statistical studies. Results: Histological sections revealed that oral nicotine induced histological alterations in parorid gland compared with control sections manifested as focal atrophy, vacuolation and karyomegaly of serous acini cells. Loss of striated ducts basal striation with degenerated nuclei and vascular congestion along large ducts were observed. Masson trichrome sections showed increased collagen fiber deposition with nicotine intake . Immunohistochemical sections demonstrated increased expression of α smooth actin and P53 in myoeithelial cells. Most of these changes were ameliorated by oral administration of Eruca sativa oil. Conclusion: Oral nicotine has exerted degenerative effect on rat parotid gland. Eruca sativa oil was found to have protective role and can improve the nicotine-induced degeneration. Thus, it can be advised with antismoking management therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Epigenetic modulations in cancer: predictive biomarkers and potential targets for overcoming the resistance to topoisomerase I inhibitors.

Author

Madkour, Moustafa M., Ramadan, Wafaa S., Saleh, Ekram, and El-Awady, Raafat

Subjects
DNA topoisomerase I, TUMOR markers, EPIGENETICS, DNA methyltransferases, GENE expression, DNA methylation
Abstract

Altered epigenetic map is frequently observed in cancer and recent investigations have demonstrated a pertinent role of epigenetic modifications in the response to many anticancer drugs including the DNA damaging agents. Topoisomerase I (Top I) is a well-known nuclear enzyme that is critical for DNA function and cell survival and its inhibition causes DNA strand breaks and cell cycle arrest. Inhibitors of human Top I have proven to be a prosperous chemotherapeutic treatment for a vast number of cancer patients. While the treatment is efficacious in many cases, resistance and altered cellular response remain major therapeutic issues. This review highlights the evidence available till date on the influence of different epigenetic modifications on the response to Top I inhibitors as well as the implications of targeting epigenetic alterations for improving the efficacy and safety of Top I inhibitors. The field of epigenetic research is steadily growing. With its assistance, we could gain better understanding on how drug response and resistance work. Epigenetics can evolve as possible biomarkers and predictors of response to many medications including Top I inhibitors, and could have significant clinical implications that necessitate deeper attention. Epigenetic alterations, including DNA methylation and histone modifications, play a pertinent role in the response to several anticancer treatments, including DNA damaging agents like Top I inhibitors. Although camptothecin derivatives are used clinically as Top I inhibitors for management of cancer, certain types of cancer have inherent and or acquired resistance that limit the curative potential of them. Epigenetic modifications like DNA hypomethylation can either increase or decrease sensitivity to Top I inhibitors by different mechanisms. The combination of Top I inhibitors with the inhibitors of histone modifying enzymes can result in enhanced cytotoxic effects and sensitization of resistant cells to Top I inhibitors. MicroRNAs were found to directly influence the expression of Top I and other proteins in cancer cells resulting in positive or negative alteration of the response to Top I inhibitors. lncRNAs and their genetic polymorphisms have been found to be associated with Top I function and the response to its inhibitors. Clinical trials of epigenetic drugs in combination with Top I inhibitors are plentiful and some of them showed potentially promising outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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32. The Battle between Bacteria and Bacteriophages: A Conundrum to Their Immune System

Author

Teklemariam, Addisu D., primary, Al-Hindi, Rashad R., additional, Qadri, Ishtiaq, additional, Alharbi, Mona G., additional, Ramadan, Wafaa S., additional, Ayubu, Jumaa, additional, Al-Hejin, Ahmed M., additional, Hakim, Raghad F., additional, Hakim, Fanar F., additional, Hakim, Rahad F., additional, Alseraihi, Loojen I., additional, Alamri, Turki, additional, and Harakeh, Steve, additional

Published
2023
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38. Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation

Author

Alsawaf, Seba, primary, Alnuaimi, Fatema, additional, Afzal, Saba, additional, Thomas, Rinku Mariam, additional, Chelakkot, Ayshwarya Lakshmi, additional, Ramadan, Wafaa S., additional, Hodeify, Rawad, additional, Matar, Rachel, additional, Merheb, Maxime, additional, Siddiqui, Shoib Sarwar, additional, and Vazhappilly, Cijo George, additional

Published
2022
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39. Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies

Author

Opo, F A Dain Md, primary, Moulay, Mohammed, additional, Zari, Ali, additional, Alqaderi, Afnan, additional, Alkarim, Saleh, additional, Zari, Talal, additional, Bhuiyan, Mohiuddin Ahmed, additional, Mahmoud, Maged Mostafa, additional, Aljoud, Fadwa, additional, Suhail, Mohd, additional, Edris, Sherif, additional, Ramadan, Wafaa S., additional, Kamal, Mohammad Amjad, additional, Nemmiche, Saïd, additional, and Ahammad, Foysal, additional

Published
2022
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40. Metabolomics Analysis Revealed Significant Metabolic Changes in Brain Cancer Cells Treated with Paclitaxel and/or Etoposide

Author

Semreen, Ahlam M., primary, Alsoud, Leen Oyoun, additional, El-Huneidi, Waseem, additional, Ahmed, Munazza, additional, Bustanji, Yasser, additional, Abu-Gharbieh, Eman, additional, El-Awady, Raafat, additional, Ramadan, Wafaa S., additional, Alqudah, Mohammad A.Y., additional, Shara, Mohd, additional, Abuhelwa, Ahmad Y., additional, Soares, Nelson C., additional, Semreen, Mohammad H., additional, and Alzoubi, Karem H., additional

Published
2022
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43. Further delineation of Temtamy syndrome of corpus callosum and ocular abnormalities

Author

Alrakaf, Laila, Al‐Owain, Mohammed A., Busehail, Maryam, Alotaibi, Maha A., Monies, Dorota, Aldhalaan, Hesham M., Alhashem, Amal, Al‐Hassnan, Zuhair N., Rahbeeni, Zuhair A., Murshedi, Fathiya Al, Ani, Nadia Al, Al‐Maawali, Almundher, Ibrahim, Niema A., Abdulwahab, Firdous M., Alsagob, Maysoon, Hashem, Mais O., Ramadan, Wafaa, Abouelhoda, Mohamed, Meyer, Brian F., Kaya, Namik, Maddirevula, Sateesh, and Alkuraya, Fowzan S.

Published
2018
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48. Effect Of Laparoscopic Tubal Disconnection For The Management Of Hydrosalpinx Before ICSI On Ultrasonographic Markers Of Endometrial Receptivity, Ovarian Blood Flow And Volume.

Author

Esmail, Mohamed K., AbouElew, Soumaya M. H., Ramadan, Wafaa, and Shoab, Amira Y.

Subjects
BLOOD flow, FALLOPIAN tubes, BLOOD volume, HYDROSALPINX, INTRACYTOPLASMIC sperm injection, INFERTILITY, ECTOPIC pregnancy
Abstract

Objective The aim of this study was to investigate the effect of laparoscopic tubal disconnection for the management of hydrosalpinx before ICSI on ultrasonographic markers of endometrial receptivity, ovarian blood flow and volume. Methods Infertility treatment candidate women were divided into two groups, the hydrosalpinx group (HxG) and the non-hydrosalpinx group, totaling 120 women (nHxG). 60 women in the HxG experienced hydrosalpinx, whereas 60 women in the nHxG had unexplained infertility. LH levels in urine samples were used to identify an LH peak. On cycle day LH+6, the TVUS examination was solely done in the HxG. Laparoscopic tubal disconnection was then carried out. On day LH+6 of the cycle, which came before the ICSI cycle, the same ultrasonographic measurements were then collected in both groups. Outcome measures Uterine a. RI and PI, spiral a. RI and PI, ovarian a. RI and PI, endometrial thickness, pattern and volume, endometrial VI, FI and VFI and ovarian VI, FI, VFI and volume and zone of vascular penetration. Results We found no measurably massive contrasts between the two gatherings in the uterine a. RI and PI, winding a. RI and PI, ovarian a. RI and PI, endometrial thickness and volume (p=0.642), or the nHxG following tubal separation. endometrial VI (p=0.887), FI (p=0.646) and VFI (p=0.652) and ovarian VI (p=0.648), FI (p=0.646), VFI (p=0.638) and ovarian volume (p=0.646), endometrial example and zone of vascular infiltration. Conclusions Laparoscopic tubal disconnection has no significant effect on endometrial, subendometrial, uterine, ovarian blood flow, endometrial and ovarian volumes, endometrial pattern and zone of vascular penetration. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Discovery of a first-in-class benzopyrane-derived anticancer agent possessing a dual inhibition of thioredoxin and glutathione reductases

Author

Zaher, Dana, primary, Ramadan, Wafaa, additional, El-Awady, Raafat, additional, Omar, Hany, additional, Hersi, Fatema, additional, Srinivasulu, Vunnam, additional, Hachim, Ibrahim, additional, Marzooq, Farah Al, additional, Vazhappilly, Cijo, additional, Merali, Salim, additional, Merali, Carmen, additional, Soars, Nelson, additional, Schilf, Paul, additional, Ibrahim, Saleh, additional, and AlTel, Taleb, additional

Published
2022
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