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5. List of Contributors

Author

Allen, Paul D., primary, Amadi, Ovid C., additional, Anderson, Mark, additional, Andersson, Daniel C., additional, Archer, Stephen L., additional, Arnett, Andrea L.H., additional, Arnoldi, Richard, additional, Arrowsmith, Sarah, additional, Barton, Elisabeth R., additional, Bassel-Duby, Rhonda, additional, Belmonte, Stephen L., additional, Yaou, Rabah Ben, additional, Benjamin, Ivor J., additional, Berk, Bradford C., additional, Bers, Donald M., additional, Bertrand, Anne T., additional, Betzenhauser, Matthew J., additional, Birnbaum, Morris J., additional, Black, Brian L., additional, Blaxall, Burns C., additional, Bolli, Roberto, additional, Bonanno, Elena, additional, Bonne, Gisèle, additional, Bönnemann, Carsten G., additional, Bowens, Nina, additional, Brønnum, Hasse, additional, Bruneau, Benoit G., additional, Buckingham, Margaret, additional, Burdyga, Theodor, additional, Butler-Browne, Gillian, additional, Buttrick, Peter, additional, Cahill, P.A., additional, Calvert, John W., additional, Campbell, Kevin P., additional, Cannon, Stephen C., additional, Cattaneo, Paola, additional, Chakravarti, Aravinda, additional, Chamberlain, Jeffrey S., additional, Chaponnier, Christine, additional, Chin, Stephanie E., additional, David Cohen, Ethan, additional, Cohn, Ronald D., additional, Condorelli, Gianluigi, additional, Cummins, James H., additional, Davies, Kelvin P., additional, Deasy, Bridget, additional, DeMazumder, Deeptankar, additional, Demer, Linda, additional, de Wit, Cor, additional, Dietz, Harry C., additional, Di Lisa, Fabio, additional, DiMauro, Salvatore, additional, Dobner, Stephan, additional, Dorn, Gerald W., additional, Doroudgar, Shirin, additional, Edgerton, V. Reggie, additional, Emerson, Charles P., additional, Engel, Andrew G., additional, Esser, Karyn A., additional, Fang, Yong-Hu, additional, Feng, QiPing, additional, Fishman, Glenn I., additional, Force, Thomas, additional, Frangogiannis, Nikolaos G., additional, Franzini-Armstrong, Clara, additional, Frey, Norbert, additional, Frid, Maria G., additional, Gabbiani, Giulio, additional, Gelb, Bruce D., additional, George, Eric M., additional, Gerdes, A. Martin, additional, Gharaibeh, Burhan, additional, Gillespie, Hamilton S., additional, Glembotski, Christopher C., additional, Gori, Tommaso, additional, Granger, Joey P., additional, Griendling, Kathy K., additional, Gunst, Susan J., additional, Guttridge, Denis C., additional, Hajjar, Roger J., additional, Haller, Ronald G., additional, Hernández-Ochoa, Erick O., additional, Herring, Neil, additional, Hilenski, Lula L., additional, Hill, Joseph A., additional, Hill, Michael A., additional, Himeda, Charis L., additional, Hinz, Boris, additional, Houser, Steven R., additional, Huard, Johnny, additional, Jackson, William F., additional, Lynn Jefferies, John, additional, Kalluri, Raghu, additional, Kamal, Fadia A., additional, Kapoor, Ashish, additional, Kass, David A., additional, Katz, Arnold M., additional, Kelly, Daniel P., additional, Khakoo, Aarif Y., additional, Kharade, Sujay V., additional, Kim, Eugene, additional, Kim, Jung A., additional, Kitsis, Richard N., additional, Kobayashi, Yvonne M., additional, Komuro, Issei, additional, Kramerova, Irina, additional, Kwartler, Callie S., additional, Lakatta, Edward G., additional, Lally, Triona, additional, Larsson, Lars, additional, Latronico, Michael V.G., additional, Lavandero, Sergio, additional, Lavasani, Mitra, additional, Lee, Richard T., additional, Lee, Se-Jin, additional, il Lee, Young, additional, Lefer, David J., additional, Leinwand, Leslie A., additional, Levine, Benjamin, additional, Li, Yong, additional, Liggett, Stephen B., additional, Lin, Zhiqiang, additional, Liu, Ning, additional, Lopez, Jose R., additional, Losordo, Douglas W., additional, MacRae, Calum A., additional, Maejima, Yasuhiro, additional, Majesky, Mark W., additional, Marks, Andrew R., additional, Martin, Melissa L., additional, Mauriello, Alessandro, additional, Mayeuf, Alicia, additional, McCarthy, John J., additional, McNally, Elizabeth, additional, Meininger, Gerald A., additional, Mercola, Mark, additional, Miano, Joseph M., additional, Carrie Miceli, M., additional, Milewicz, Dianna M., additional, Morgan, Kathleen G., additional, Morrisey, Edward E., additional, Mouly, Vincent, additional, Münzel, Thomas, additional, Murphy, Anne, additional, Muslin, Anthony J., additional, Kannan Mutharasan, R., additional, Nagaraju, Kanneboyina, additional, Naito, Atsuhiko T., additional, Napolitano, Carlo, additional, Nathan, Sandeep, additional, Nozik-Grayck, Eva, additional, Ochala, Julien, additional, Offermanns, Stefan, additional, Olson, Eric N., additional, Orlandi, Augusto, additional, Papait, Roberto, additional, Parmacek, Michael S., additional, Patel, Amit R., additional, Paterson, David J., additional, Pathan, Asif R., additional, Patterson, Cam, additional, Paul, Richard J., additional, Piao, Lin, additional, Priori, Silvia G., additional, Pu, William T., additional, Ram, Rashmi, additional, Rame, J. Eduardo, additional, Ramos, Julian N., additional, Redmond, E.M., additional, Reggiani, Carlo, additional, Rich, Stuart, additional, Rinaldi, Chiara, additional, Rothermel, Beverly A., additional, Roy, Roland R., additional, Rusch, Nancy J., additional, Ryan, John J., additional, Sadoshima, Junichi, additional, San Martín, Alejandra, additional, Scarpulla, Richard C., additional, Schiaffino, Stefano, additional, Schiffrin, Ernesto L., additional, Schneider, Jay W., additional, Schneider, Martin F., additional, Schober, Andreas, additional, Scimeca, Manuel, additional, Scorrano, Luca, additional, Shih, Tiffany L., additional, Shiojima, Ichiro, additional, Siegman, Marion J., additional, Smolock, Elaine, additional, Solaro, R. John, additional, Somlyo, Avril V., additional, Sowers, James R., additional, Spagnoli, Luigi Giusto, additional, Spencer, Melissa J., additional, Spragg, David, additional, Stastna, Miroslava, additional, Steenbergen, Charles, additional, Stenmark, Kurt R., additional, Strait, James B., additional, Sweeney, H. Lee, additional, Taegtmeyer, Heinrich, additional, Takimoto, Eiki, additional, Thakali, Keshari M., additional, Thompson, Wesley J., additional, Thornton, Charles, additional, Tidball, James G., additional, Tintut, Yin, additional, Tomaselli, Gordon F., additional, Touyz, Rhian M., additional, Towbin, Jeffrey A., additional, Tsai, Kevin, additional, Vallese, Denis, additional, Van Eyk, Jennifer E., additional, Van Rooij, Eva, additional, Vetterkind, Susanne, additional, Voermans, Nicol C., additional, Volpe, Antonio, additional, Wang, Xuejun, additional, Wang, Yanggan, additional, Wang, Yibin, additional, Ware, Stephanie, additional, Weber, Christian, additional, Whaley-Connell, Adam, additional, Wilke, Russell A., additional, Wirth, Angela, additional, Wray, Susan, additional, Yada, Erica, additional, Yeager, Michael E., additional, Yutzey, Katherine E., additional, Zablocki, Daniela, additional, Zhang, Cuihua, additional, Zhang, Hanrui, additional, Zhang, Pingbo, additional, Zhe, Zhou, additional, and Zhou, Bin, additional

Published
2012
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13. Mammalian enabled (Mena) is a critical regulator of cardiac function

Author

Aguilar, Frédérick, primary, Belmonte, Stephen L., additional, Ram, Rashmi, additional, Noujaim, Sami F., additional, Dunaevsky, Olga, additional, Protack, Tricia L., additional, Jalife, Jose, additional, Todd Massey, H., additional, Gertler, Frank B., additional, and Blaxall, Burns C., additional

Published
2011
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14. Dietary ω3 fatty acids modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model

Author

Mayyas, Fadia, primary, Sakurai, Seiichiro, additional, Ram, Rashmi, additional, Rennison, Julie H., additional, Hwang, Eui-Seock, additional, Castel, Laurie, additional, Lovano, Beth, additional, Brennan, Marie-Luise, additional, Bibus, Douglas, additional, Lands, Bill, additional, Barnard, John, additional, Chung, Mina K., additional, and Van Wagoner, David R., additional

Published
2010
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18. Blockade of atrial-specific K+-currents increases atrial but not ventricular contractility by enhancing reverse mode Na+/Ca2+-exchange

Author

Schotten, Ulrich, de Haan, Sunniva, Verheule, Sander, Harks, Erik G.A., Frechen, Dirk, Bodewig, Eva, Greiser, Maura, Ram, Rashmi, Maessen, Jos, Kelm, Malte, Allessie, Maurits, and Van Wagoner, David R.

Subjects
MUSCLE cells, TACHYCARDIA, ATRIAL fibrillation, CELLS
Abstract

Abstract: Background: AVE0118 (2′-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide) blocks atrial ultrarapid delayed rectifier currents (I Kur) and prolongs the atrial action potential (AP) plateau without affecting ventricular repolarisation. In patients with atrial contractile dysfunction due to atrial tachyarrhythmias, this response might increase atrial contractility without risk of ventricular proarrhythmia. This study was designed to evaluate the inotropic mechanisms of AVE0118. Methods and results: In isometrically contracting atrial trabeculae, AVE0118 increased contractile force by 55.4% in sinus rhythm patients (n =9) and by 107.4% in patients with atrial fibrillation (n =8). In freshly isolated canine atrial myocytes studied under perforated patch current clamp (37 °C), AVE0118 increased myocyte fractional shortening from 3.8±0.6 to 9.6±0.8% and prolonged action potential duration at 30% repolarisation from 9±2 to 102±11 ms. Clamping cells to an AP waveform recorded during exposure to AVE0118 produced the same inotropic response as the drug itself. In action potential clamp, peak Ca2+ inward current (I CaL) current declined from 5.5±1.3 pA/pF during control to 4.1±0.7 pA/pF when an AP recorded in the presence of AVE0118 was used as command waveform. However, I CaL was more sustained with AVE0118 and the time integral did not change (135±37 vs. 173±30 pA/pF⁎ms, p =ns). Importantly, blockade of reverse mode Na+/Ca2+-exchanger activity with 5 μM KBR7943 or using a Na+-free pipette solution abolished the positive inotropic effect of the AP recorded in the presence of AVE0118. In ventricular myocytes AVE0118 did not elicit a positive inotropic response. Conclusions: Block of I Kur by AVE0118 enhances atrial contractility both in patients with sinus rhythm and atrial fibrillation. The positive inotropic effect is atrial-specific and due to the changes of the action potential configuration which enhances Ca2+ entry via reverse mode Na+/Ca2+ exchange. [Copyright &y& Elsevier]

Published
2007
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23. Expression and Phosphorylation of Left Atrial Connexin 43 in Human and Experimental Atrial Fibrillation

Author

Ram, Rashmi

Subjects
Biomedical Research, Connexin 43, Inflammation, Atrial Fibrillation
Abstract

Background: Atrial fibrillation (AF) is a prevalent and increasingly common arrhythmia that increases risk of stroke and death. Electrical and structural remodeling processes contribute to the development of persistent AF. Remodeling promotes heterogeneous ion channel activity and conduction that form a substrate for re-entrant activity. Connexins are proteins that underlie conduction between myocytes; conduction is regulated by connexin expression and phosphorylation. Connexin 43 (Cx43) is the most abundant cardiac connexin. We tested the hypothesis that left atrial (LA) expression and/or phosphorylation of Cx43 is dynamically modulated in human AF, and in two animal models of AF. Methods: Histologic, confocal and western analyses were performed to examine the expression, phosphorylation and distribution of Cx43 in LA tissues from cardiac surgery patients (i) with or without a history of AF, (ii) in sinus rhythm or AF at surgery. Left and right atrial Cx43 expression, distribution and phosphorylation was also evaluated in a goat model of short- and long-term AF, and in a canine model of post-surgical AF. Results: Our studies demonstrate that: (i) atrial rhythm acutely modulates Cx43 expression and phosphorylation, (ii) Cx43 expression tends to increase within three weeks of AF, and redistributes to the lateral surface of myocytes with prolonged AF, (iii) Cx43 is present not only in the intercalated disk, but also in the mitochondria of both human and canine atria, (iv) C-reactive protein is detectable in the LA of patients with human AF, and its presence reflects current rhythm, (v) inflammation in the setting of post-operative AF modulates Cx43 expression and phosphorylation differently in left and right atria, and (vi) dietary supplementation with ω3-PUFAs attenuates basal Cx43 expression and phosphorylation, likely enhancing the safety factor of conduction, thus limiting arrhythmia inducibility. Conclusions: Cx43 expression and phosphorylation are dynamically modulated by stresses imposed by abnormal hemodynamics, autonomic tone, heart rate and inflammation. Redistribution of Cx43 likely affects the anisotropic properties of atrial conduction, and contributes to the development of persistent atrial fibrillation. Expression of Cx43 in cardiac mitochondria suggests that it may have additional important functions within the myocyte, beyond its widely appreciated role as mediator of cell-to-cell coupling.

Published
2008

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