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Your search keyword '"Rakotondrasoa, Andriniaina"' showing total 11 results
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11 results on '"Rakotondrasoa, Andriniaina"'

4. Neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the community of a low-income country (NeoLIC): protocol for a household cohort study in Moramanga, Madagascar

Author

Harimanana, Aina, primary, Rakotondrasoa, Andriniaina, additional, Rivoarilala, Lalainasoa Odile, additional, Criscuolo, Alexis, additional, Opatowski, Lulla, additional, Rakotomanana, Elliot Fara Nandrasana, additional, Herindrainy, Perlinot, additional, Collard, Jean-Marc, additional, Crucitti, Tania, additional, and Huynh, Bich-Tram, additional

Published
2022
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5. Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors

Author

Huynh, Bich-Tram, primary, Passet, Virginie, additional, Rakotondrasoa, Andriniaina, additional, Diallo, Thierno, additional, Kerleguer, Alexandra, additional, Hennart, Melanie, additional, Lauzanne, Agathe De, additional, Herindrainy, Perlinot, additional, Seck, Abdoulaye, additional, Bercion, Raymond, additional, Borand, Laurence, additional, Pardos de la Gandara, Maria, additional, Delarocque-Astagneau, Elisabeth, additional, Guillemot, Didier, additional, Vray, Muriel, additional, Garin, Benoit, additional, Collard, Jean-Marc, additional, Rodrigues, Carla, additional, and Brisse, Sylvain, additional

Published
2020
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8. Phenotypic and molecular characterisations of carbapenem-resistant Acinetobacter baumannii strains isolated in Madagascar

Author

Simo Tchuinte, Pierrette Landrie, primary, Rabenandrasana, Mamitiana Alain Noah, additional, Kowalewicz, Carole, additional, Andrianoelina, Volasoa Herilalaina, additional, Rakotondrasoa, Andriniaina, additional, Andrianirina, Zafitsara Zo, additional, Enouf, Vincent, additional, Ratsima, Elisoa Hariniaina, additional, Randrianirina, Frédérique, additional, and Collard, Jean-Marc, additional

Published
2019
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11. Klebsiella pneumoniaecarriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors

Author

Huynh, Bich-Tram, Passet, Virginie, Rakotondrasoa, Andriniaina, Diallo, Thierno, Kerleguer, Alexandra, Hennart, Melanie, Lauzanne, Agathe De, Herindrainy, Perlinot, Seck, Abdoulaye, Bercion, Raymond, Borand, Laurence, Pardos de la Gandara, Maria, Delarocque-Astagneau, Elisabeth, Guillemot, Didier, Vray, Muriel, Garin, Benoit, Collard, Jean-Marc, Rodrigues, Carla, and Brisse, Sylvain

Abstract

ABSTRACTBackgroundKlebsiella pneumoniae(hereafter, Kp) is a major public health threat responsible for high levels of multidrug resistant (MDR) human infections. Besides, Kp also causes severe infections in the community, especially in Asia and Africa. Although most Kp infections are caused by endogenous intestinal carriage, little is known about the prevalence and microbiological characteristics of Kp in asymptomatic human carriage, and attached risk factors including environmental sources exposure.MethodsHere, 911 pregnant women from communities in Madagascar, Cambodia, and Senegal were screened for gut colonization by Kp. Characteristics of Kp strains (antimicrobial susceptibility, genomic diversity, virulence, and resistance genes) were defined, and associated risk factors were investigated.ResultsKp carriage rate was 55.9%, and Kp populations were highly heterogeneous (6 phylogroups, 325 sequence types, Simpson index 99.6%). One third of Kp isolates had acquired antimicrobial resistance genes. MDR-Kp (11.7% to 39.7%) and extended spectrum beta-lactamase (ESBL)-producing Kp (0.7% to 14.7%) varied among countries. Isolates with virulence genes were detected (14.5%). Environmental exposure factors including food, animal contacts, or hospitalization of household members were associated with carriage of Kp, antimicrobial resistance and hypervirulence. However, risk factors were country-specific and Kp subpopulation-specific.ConclusionThis large-scale multicenter study uncovers the huge diversity of Kp in human gut carriage, demonstrates that antimicrobial resistance is widespread in communities of three low-income countries, and underlines the challenges posed by Kp colonization to the control of antimicrobial resistance.

Published
2020
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