1. Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99.
- Author
-
Rak Lee S, Schalk F, Schwitalla JW, Benndorf R, Vollmers J, Kaster AK, de Beer ZW, Park M, Ahn MJ, Jung WH, Beemelmanns C, and Kim KH
- Subjects
- Animals, Anti-Bacterial Agents pharmacology, Bacteria drug effects, Genistein chemistry, Genistein pharmacology, Halogenation, Isoflavones pharmacology, Magnetic Resonance Spectroscopy, Mass Spectrometry, Metabolic Networks and Pathways, Microbial Sensitivity Tests, Molecular Structure, Actinomadura chemistry, Anti-Bacterial Agents chemistry, Isoflavones chemistry, Isoptera microbiology
- Abstract
Based on high-resolution tandem mass spectrometry (HR-MS
2 ) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.- Published
- 2020
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