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Aim: To assess the dental caries status and oral health–related quality of life (OHRQOL) among children with orofacial cleft reporting to a hospital in India. Materials and Methods: Subjects were divided into two groups. Group 1 cleft children (n = 80) and group 2 noncleft children (n = 80). Decayed, missing, and filled teeth (DMFT) Index, deft Index, and Children Oral Health Impact Profile questionnaire were recorded. Results: The mean DMFT was high in noncleft (3.51±2.45) children than in cleft children (2.75±2.68). The mean deft was high in noncleft (1.11±0.96) children than in cleft children (0.86±3.07). Conclusion: Cleft children have negative impact on OHRQOL than noncleft children.

To demonstrate the applicability of thermogravimetric analyzer as a tool for the quantification of pantaprazole sodium monohydrate in sesquihydrate, studies have been conducted. Thermal analysis (DSC, TGA) crystallographic (PXRD) and spectroscopic techniques (FT-IR) were used for the characterization of the polymorphs. Thermogravimetric analysis (TGA) analysis was explored by high-resolution dynamic (Hi-Res-dynamic) and high-resolution modulated (Hi-Res-modulated) test procedures to quantify the hydrate polymorphic mixtures. The two polymorphic forms exhibited significant differences and good resolution in the second derivative thermogram generated by Hi-Res-modulated test procedure. Thus, the TGA with Hi-Res-modulated test procedure was considered for the quantification of monohydrate in sesquihydrate. The calibration plot was constructed from the known mixtures of two polymorphs by plotting the peak area of the second derivative thermogram against the weight percent of monohydrate. Using this novel approach, 1 wt% limit of detection (LOD) was achieved. The polymorphic purity results, obtained by TGA in Hi-Res-modulated test procedure were found to be in good agreement with the results predicted by FT-IR and was comparable with the actual values of the known polymorphic mixtures. The Hi-Res-modulated TGA technique is very simple and easy to perform the analysis.