Search

Your search keyword '"Rajendran, L."' showing total 932 results
Start Over Author "Rajendran, L."
932 results on '"Rajendran, L."'

23. Theoretical and Numerical Analysis of MHD Flows Through a Porous Material

Author

Krishnakumar, S., Lakshmi Narayanan, K., Thamizh Suganya, S., Rajendran, L., Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, Gawad, Iman O., Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Sumesh, M., editor, R. S. Tavares, João Manuel, editor, Vettivel, S. C., editor, and Oliveira, Mario Orlando, editor

Published
2024
Full Text
View/download PDF

28. In silico, anti-inflammatory and acute toxicological evaluation of an indigenous medicinal plant Pterospermum rubiginosum using Sprague-Dawley rats

Author

Rajamohanan Jalaja Anish, Aswathy Nair, V. Saraswathy, Velappan Nair S. Kalpana, and Rajendran L. Shyma

Subjects
Anti-inflammatory, iNOS, LCMS, Molecular docking, Pterospermum rubiginosum, Sprague Dawley rats, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

Abstract Background Pterospermum rubiginosum has been traditionally used by the tribal inhabitants of Southern India for treating bone fractures and as a local anti-inflammatory agent; however, experimental evidence to support this traditional usage is lacking. The present study aimed to investigate the phytochemical characterization, in silico and in vitro anti-inflammatory evaluation, followed by in vivo toxicological screening of P. rubiginosum methanolic bark extract (PRME). Results The LCMS evaluation revealed the presence of 80 significant peaks; nearly 50 molecules were identified using the LCMS database. In silico analysis showed notable interactions with inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6). In vitro gene expression study supported the docking results with significant down-regulation of iNOS, IL-6, and IL-10. PRME was administered orally to the SD rats and was found to be non-toxic up to 1000 mg/kg body weight for 14 days. The antioxidant enzymes catalase and sodium dismutase exhibited an increased value in PRME-administered groups, possibly due to the diverse phytochemical combinations in bark extract. Conclusions PRME administration significantly downregulated the gene expression of inflammatory markers, such as iNOS, IL-6, and IL-10. The molecular docking analysis of iNOS and IL-6 supports the in vitro study. In vivo toxicological study of PRME in SD rats was found to be non-toxic up to a concentration of 1000 mg/kg body weight for 14 days. Graphical abstract

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results