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173 results on '"Rajasegaran, Vikneswari"'

1. Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability

Author

Guan, Peiyong, Chen, Jianfeng, Mo, Chengqiang, Fukawa, Tomoya, Zhang, Chao, Cai, Xiuyu, Li, Mei, Hong, Jing Han, Chan, Jason Yongsheng, Ng, Cedric Chuan Young, Lee, Jing Yi, Wong, Suet Far, Liu, Wei, Zeng, Xian, Wang, Peili, Xiao, Rong, Rajasegaran, Vikneswari, Myint, Swe Swe, Lim, Abner Ming Sun, Yeong, Joe Poh Sheng, Tan, Puay Hoon, Ong, Choon Kiat, Xu, Tao, Du, Yiqing, Bai, Fan, Yao, Xin, Teh, Bin Tean, and Tan, Jing

Published
2024
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2. NEAR trial: A single-arm phase II trial of neoadjuvant apalutamide monotherapy and radical prostatectomy in intermediate- and high-risk prostate cancer

Author

Lee, Lui Shiong, Sim, Adelene Y. L., Ong, Chee Wee, Yang, Xinyan, Ng, Cedric C. Y., Liu, Wei, Rajasegaran, Vikneswari, Lim, Abner M. S., Aslim, Edwin Jonathan, Ngo, Nye-Thane, Khor, Li-Yan, Kanesvaran, Ravindran, Allen, John Carson Jr, Tay, Kae Jack, Yuen, John Shyi Peng, Chong, Tsung Wen, Ho, Sun Sien Henry, Teh, Bin Tean, and Chua, Melvin L. K.

Published
2022
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3. Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing

Author

Ng, Cedric Chuan Young, Md Nasir, Nur Diyana, Loke, Benjamin Nathanael, Tay, Timothy Kwang Yong, Thike, Aye Aye, Rajasegaran, Vikneswari, Liu, Wei, Lee, Jing Yi, Guan, Peiyong, Lim, Abner Herbert, Chang, Kenneth Tou En, Gudi, Mihir Ananta, Madhukumar, Preetha, Tan, Benita Kiat Tee, Tan, Veronique Kiak Mien, Wong, Chow Yin, Yong, Wei Sean, Ho, Gay Hui, Ong, Kong Wee, International Fibroepithelial Consortium, Rahman, Norraha Abd, Begum, S. M. Khodeza Nahar, Cheah, Phaik Leng, Chen, Chih Jung, Fuente, Emmanuel Dela, Han, Aaron, Harada, Oi, Kanomata, Naoki, Lee, Cheok Soon, Lee, Jonathan Yu Han, Kamal, Mohammed, Nishimura, Rieko, Ohi, Yasuyo, Sawyer, Elinor J., Teoh, Kean Hooi, Tsang, Alex Koon Ho, Tsang, Julia Yuen-Shan, Tse, Gary M.K., and Yamaguchi, Rin

Published
2021
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5. Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

Author

Lim, Jing Quan, Huang, Dachuan, Tang, Tiffany, Tan, Daryl, Laurensia, Yurike, Peng, Rou-Jun, Wong, Esther Kam Yin, Cheah, Daryl Ming Zhe, Chia, Burton Kuan Hui, Iqbal, Jabed, Grigoropoulos, Nicholas Francis, Nairismägi, Maarja-Liisa, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Hong, Huangming, Kim, Seok Jin, Cho, Junhun, Tse, Eric, Mow, Benjamin, Cai, Qi-Chun, Poon, Li-Mei, Cai, Qing-qing, Tan, Jing, Chan, Jason Yongsheng, Lim, Johnathan Xiande, Goh, Yeow Tee, Phipps, Colin, Rötzschke, Olaf, Cheng, Chee Leong, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Loh, Yvonne Su Ming, Au-Yeung, Rex, Chan, Thomas Sau-Yan, Kwong, Yok-Lam, Hwang, William, Kim, Won Seog, Bei, Jin-Xin, Lin, Tongyu, Ong, Choon Kiat, and Lim, Soon Thye

Published
2020
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6. Transcriptomic convergence despite genomic divergence drive field cancerization in synchronous squamous tumors.

Author

Qiu Xuan Tan, Shannon, Nicholas B., Weng Khong Lim, Jing Xian Teo, Yap, Daniel R. Y., Sze Min Lek, Tan, Joey W. S., Tan, Shih Jia J., Hendrikson, Josephine, Ying Liu, Ng, Gillian, Chong, Clara Y. L., Wanyu Guo, Koh, Kelvin K. N., Ng, Cedric C. Y., Rajasegaran, Vikneswari, Wong, Jolene S. M., Chin Jin Seo, Choon Kiat Ong, and H. Lim, Tony K.

Subjects
TRANSCRIPTOMES, HOMOLOGOUS recombination, PROGENITOR cells, LANDSCAPE changes, TUMORS, CANCER cell differentiation
Abstract

Introduction: Field cancerization is suggested to arise from imbalanced differentiation in individual basal progenitor cells leading to clonal expansion of mutant cells that eventually replace the epithelium, although without evidence. Methods: We performed deep sequencing analyses to characterize the genomic and transcriptomic landscapes of field change in two patients with synchronous aerodigestive tract tumors. Results: Our data support the emergence of numerous genetic alterations in cancer-associated genes but refutes the hypothesis that founder mutation(s) underpin this phenomenon. Mutational signature analysis identified defective homologous recombination as a common underlying mutational process unique to synchronous tumors. Discussion: Our analyses suggest a common etiologic factor defined by mutational signatures and/or transcriptomic convergence, which could provide a therapeutic opportunity. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Correction to: NEAR trial: A single-arm phase II trial of neoadjuvant apalutamide monotherapy and radical prostatectomy in intermediate- and high-risk prostate cancer

Author

Lee, Lui Shiong, Sim, Adelene Y. L., Ong, Chee Wee, Yang, Xinyan, Ng, Cedric C. Y., Liu, Wei, Rajasegaran, Vikneswari, Lim, Abner M. S., Aslim, Edwin Jonathan, Ngo, Nye-Thane, Khor, Li-Yan, Kanesvaran, Ravindran, Allen, John Carson Jr, Tay, Kae Jack, Yuen, John Shyi Peng, Chong, Tsung Wen, Ho, Sun Sien Henry, Teh, Bin Tean, and Chua, Melvin L. K.

Published
2022
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9. An Optimised Protocol Harnessing Laser Capture Microdissection for Transcriptomic Analysis on Matched Primary and Metastatic Colorectal Tumours

Author

Ong, Chin-Ann J., Tan, Qiu Xuan, Lim, Hui Jun, Shannon, Nicholas B., Lim, Weng Khong, Hendrikson, Josephine, Ng, Wai Har, Tan, Joey W. S., Koh, Kelvin K. N., Wasudevan, Seettha D., Ng, Cedric C. Y., Rajasegaran, Vikneswari, Lim, Tony Kiat Hon, Ong, Choon Kiat, Kon, Oi Lian, Teh, Bin Tean, Tan, Grace H. C., Chia, Claramae Shulyn, Soo, Khee Chee, and Teo, Melissa C. C.

Published
2020
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10. A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions

Author

Sim, Yirong, Ng, Gwendolene Xin Pei, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Wong, Suet Far, Liu, Wei, Guan, Peiyong, Nagarajan, Sanjanaa, Ng, Wai Yee, Thike, Aye Aye, Lim, Jeffrey Chun Tatt, Nasir, Nur Diyana Binte Md, Tan, Veronique Kiak Mien, Madhukumar, Preetha, Yong, Wei Sean, Wong, Chow Yin, Tan, Benita Kiat Tee, Ong, Kong Wee, Teh, Bin Tean, and Tan, Puay Hoon

Published
2019
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11. Supplementary Figures 1-6 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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12. Data from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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13. Supplementary Table 5 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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14. Supplementary Methods and Supplementary Figure and Table Legends from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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15. Supplementary Table 4 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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16. Supplementary Table 2 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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17. Supplementary Table 1 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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18. Supplementary Table 4 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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19. Supplementary Table 3 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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20. Supplementary Table 3 from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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21. Supplementary Table 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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22. Supplementary Figure 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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23. Data from Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, primary, Yong, Chern Han, primary, Lim, Jing Quan, primary, Huang, Mi Ni, primary, Padmanabhan, Nisha, primary, Nellore, Vishwa, primary, Kongpetch, Sarinya, primary, Ng, Alvin Wei Tian, primary, Ng, Ley Moy, primary, Choo, Su Pin, primary, Myint, Swe Swe, primary, Thanan, Raynoo, primary, Nagarajan, Sanjanaa, primary, Lim, Weng Khong, primary, Ng, Cedric Chuan Young, primary, Boot, Arnoud, primary, Liu, Mo, primary, Ong, Choon Kiat, primary, Rajasegaran, Vikneswari, primary, Lie, Stefanus, primary, Lim, Alvin Soon Tiong, primary, Lim, Tse Hui, primary, Tan, Jing, primary, Loh, Jia Liang, primary, McPherson, John R., primary, Khuntikeo, Narong, primary, Bhudhisawasdi, Vajaraphongsa, primary, Yongvanit, Puangrat, primary, Wongkham, Sopit, primary, Totoki, Yasushi, primary, Nakamura, Hiromi, primary, Arai, Yasuhito, primary, Yamasaki, Satoshi, primary, Chow, Pierce Kah-Hoe, primary, Chung, Alexander Yaw Fui, primary, Ooi, London Lucien Peng Jin, primary, Lim, Kiat Hon, primary, Dima, Simona, primary, Duda, Dan G., primary, Popescu, Irinel, primary, Broet, Philippe, primary, Hsieh, Sen-Yung, primary, Yu, Ming-Chin, primary, Scarpa, Aldo, primary, Lai, Jiaming, primary, Luo, Di-Xian, primary, Carvalho, André Lopes, primary, Vettore, André Luiz, primary, Rhee, Hyungjin, primary, Park, Young Nyun, primary, Alexandrov, Ludmil B., primary, Gordân, Raluca, primary, Rozen, Steven G., primary, Shibata, Tatsuhiro, primary, Pairojkul, Chawalit, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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24. Supplementary Table 2 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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25. Data from Inhibition of Gastric Cancer Invasion and Metastasis by PLA2G2A, a Novel β-Catenin/TCF Target Gene

Author

Ganesan, Kumaresan, primary, Ivanova, Tatiana, primary, Wu, Yonghui, primary, Rajasegaran, Vikneswari, primary, Wu, Jeanie, primary, Lee, Ming Hui, primary, Yu, Kun, primary, Rha, Sun Young, primary, Chung, Hyun Cheol, primary, Ylstra, Bauke, primary, Meijer, Gerrit, primary, Lian, Kon Oi, primary, Grabsch, Heike, primary, and Tan, Patrick, primary

Published
2023
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26. Supplementary Information, Figures 1-10 from Inhibition of Gastric Cancer Invasion and Metastasis by PLA2G2A, a Novel β-Catenin/TCF Target Gene

Author

Ganesan, Kumaresan, primary, Ivanova, Tatiana, primary, Wu, Yonghui, primary, Rajasegaran, Vikneswari, primary, Wu, Jeanie, primary, Lee, Ming Hui, primary, Yu, Kun, primary, Rha, Sun Young, primary, Chung, Hyun Cheol, primary, Ylstra, Bauke, primary, Meijer, Gerrit, primary, Lian, Kon Oi, primary, Grabsch, Heike, primary, and Tan, Patrick, primary

Published
2023
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27. Correction to: Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

Author

Lim, Jing Quan, Huang, Dachuan, Tang, Tiffany, Tan, Daryl, Laurensia, Yurike, Peng, Rou-Jun, Wong, Esther Kam Yin, Cheah, Daryl Ming Zhe, Chia, Burton Kuan Hui, Iqbal, Jabed, Grigoropoulos, Nicholas Francis, Nairismägi, Maarja-Liisa, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Hong, Huangming, Kim, Seok Jin, Cho, Junhun, Tse, Eric, Mow, Benjamin, Cai, Qi-Chun, Poon, Li-Mei, Cai, Qing-qing, Tan, Jing, Chan, Jason Yongsheng, Lim, Johnathan Xiande, Goh, Yeow Tee, Phipps, Colin, Rötzschke, Olaf, Cheng, Chee Leong, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Loh, Yvonne Su Ming, Au-Yeung, Rex, Chan, Thomas Sau-Yan, Kwong, Yok-Lam, Hwang, William, Kim, Won Seog, Bei, Jin-Xin, Lin, Tongyu, Ong, Choon Kiat, and Lim, Soon Thye

Published
2021
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28. A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples

Author

Ng, Cedric Chuan-Young, primary, Lim, Sandy, additional, Lim, Abner Herbert, additional, Md Nasir, Nur Diyana, additional, Zhang, Jingxian, additional, Rajasegaran, Vikneswari, additional, Lee, Jing Yi, additional, Kok, Jessica Sook Ting, additional, Thike, Aye Aye, additional, Lim, Johnathan Xiande, additional, Weng, Ruifen, additional, Yee, Sidney, additional, Choudhury, Yukti, additional, Chan, Jason Yongsheng, additional, Tan, Puay Hoon, additional, Tan, Min-Han, additional, and Teh, Bin Tean, additional

Published
2022
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29. Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR–CCNB3 gene fusion

Author

Wong, Meng K, Ng, Cedric C Y, Kuick, Chik H, Aw, Sze J, Rajasegaran, Vikneswari, Lim, Jing Q, Sudhanshi, Jain, Loh, Eva, Yin, Minzhi, Ma, Jing, Zhang, Zhongde, Iyer, Prasad, Loh, Amos H P, Lian, Derrick W Q, Wang, Shi, Goh, Shaun G H, Lim, Tse H, Lim, Alvin S T, Ng, Tony, Goytain, Angela, Loh, Alwin H L, Tan, Puay H, Teh, Bin T, and Chang, Kenneth T E

Published
2018
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33. Transcriptomic convergence despite genomic divergence drive field cancerization in synchronous squamous tumors

Author

Ong, Chin-Ann Johnny, primary, Shannon, Nicholas B, additional, Lim, Weng Khong, additional, Tan, Qiu Xuan, additional, Yap, Daniel R.Y., additional, Lek, Sze Min, additional, Tan, Joey W.S., additional, Tan, Shih Jia J., additional, Hendrikson, Josephine, additional, Ng, Wai Har, additional, Liu, Ying, additional, Ng, Gillian, additional, Koh, Kelvin K.N., additional, Ng, Cedric C.Y., additional, Rajasegaran, Vikneswari, additional, Ong, Choon Kiat, additional, Lim, Tony K.H, additional, Teh, Bin Tean, additional, Kon, Oi Lian, additional, Chia, Claramae S., additional, Soo, Khee Chee, additional, and Iyer, N. Gopalakrishna, additional

Published
2021
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34. Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers

Author

Abner Herbert Lim, Jason Yongsheng Chan, Ming-Chin Yu, Tsung-Han Wu, Jing Han Hong, Cedric Chuan Young Ng, Zhen Jie Low, Wei Liu, Rajasegaran Vikneswari, Pin-Cheng Sung, Wen-Lang Fan, Bin Tean Teh, and Sen-Yung Hsieh

Subjects
next generation sequencing, Cancer Research, carcinogens, mutagenesis, genomics, aristolochic acid, Oncology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Aristolochic acids (AAs) are potent mutagens commonly found in herbal plant-based remedies widely used throughout Asian countries. Patients and Methods: To understand whether AA is involved in the tumorigenesis of the oro-gastrointestinal tract, we used whole-exome sequencing to profile 54 cases of four distinct types of oro-gastrointestinal tract cancer (OGITC) from Taiwan. Results: A diverse landscape of mutational signatures including those from DNA mismatch repair and reactive oxygen species was observed. APOBEC mutational signatures were observed in 60% of oral squamous cell carcinomas. Only one sample harbored AA mutational signatures, contradictory to prior reports of cancers from Taiwan. The metabolism of AA in the liver and urinary tract, transient exposure time, and high cell turnover rates at OGITC sites may explain our findings. Conclusion: AA signatures in OGITCs are rare and unlikely to be a major contributing factor in oro-gastrointestinal tract tumorigenesis.

Published
2022
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36. Bizarre giant cells in human angiosarcoma exhibit chemoresistance and contribute to poor survival outcomes

Author

Tan, Grace Fangmin, primary, Goh, Shane, additional, Lim, Abner Herbert, additional, Liu, Wei, additional, Lee, Jing Yi, additional, Rajasegaran, Vikneswari, additional, Sam, Xin Xiu, additional, Tay, Timothy Kwang Yong, additional, Selvarajan, Sathiyamoorthy, additional, Ng, Cedric Chuan‐Young, additional, Teh, Bin Tean, additional, and Chan, Jason Yongsheng, additional

Published
2020
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37. Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma

Author

Kongpetch, Sarinya, primary, Jusakul, Apinya, additional, Lim, Jing Quan, additional, Ng, Cedric Chuan Young, additional, Chan, Jason Yongsheng, additional, Rajasegaran, Vikneswari, additional, Lim, Tse Hui, additional, Lim, Kiat Hon, additional, Choo, Su Pin, additional, Dima, Simona, additional, Popescu, Irinel, additional, Duda, Dan G., additional, Kukongviriyapan, Veerapol, additional, Khuntikeo, Narong, additional, Pairojkul, Chawalit, additional, Rozen, Steven G., additional, Tan, Patrick, additional, and Teh, Bin Tean, additional

Published
2020
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38. Whole exome sequencing identifies clinically relevant mutational signatures in resected hepatocellular carcinoma

Author

Chan, Jason Y., primary, Lim, Abner H., additional, Boot, Arnoud, additional, Lee, Elizabeth, additional, Ng, Cedric C.‐Y., additional, Lee, Jing Y., additional, Rajasegaran, Vikneswari, additional, Liu, Wei, additional, Goh, Shane, additional, Hong, Jing H., additional, Xu, Xiaoying, additional, Bharwani, Lavina D., additional, Chan, Chung Y., additional, Chung, Alexander Y. F., additional, Cheow, Peng C., additional, Tan, Chee‐Kiat, additional, Ho, Choon K., additional, Liau, Kui H., additional, Woon, Winston W. L., additional, Low, Jee K., additional, Chopra, Akhil, additional, Lopes, Gilberto, additional, Rozen, Steven G., additional, Teh, Bin T., additional, and Chang, Alex Y.‐C., additional

Published
2020
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39. Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts

Author

Rajasegaran Vikneswari, Yew Kenneth, Yu Wei-Ping, and Venkatesh Byrappa

Subjects
Evolution, QH359-425
Abstract

Abstract Background The synaptic cell adhesion molecules, protocadherins, are a vertebrate innovation that accompanied the emergence of the neural tube and the elaborate central nervous system. In mammals, the protocadherins are encoded by three closely-linked clusters (α, β and γ) of tandem genes and are hypothesized to provide a molecular code for specifying the remarkably-diverse neural connections in the central nervous system. Like mammals, the coelacanth, a lobe-finned fish, contains a single protocadherin locus, also arranged into α, β and γ clusters. Zebrafish, however, possesses two protocadherin loci that contain more than twice the number of genes as the coelacanth, but arranged only into α and γ clusters. To gain further insight into the evolutionary history of protocadherin clusters, we have sequenced and analyzed protocadherin clusters from the compact genome of the pufferfish, Fugu rubripes. Results Fugu contains two unlinked protocadherin loci, Pcdh1 and Pcdh2, that collectively consist of at least 77 genes. The fugu Pcdh1 locus has been subject to extensive degeneration, resulting in the complete loss of Pcdh1γ cluster. The fugu Pcdh genes have undergone lineage-specific regional gene conversion processes that have resulted in a remarkable regional sequence homogenization among paralogs in the same subcluster. Phylogenetic analyses show that most protocadherin genes are orthologous between fugu and zebrafish either individually or as paralog groups. Based on the inferred phylogenetic relationships of fugu and zebrafish genes, we have reconstructed the evolutionary history of protocadherin clusters in the teleost fish lineage. Conclusion Our results demonstrate the exceptional evolutionary dynamism of protocadherin genes in vertebrates in general, and in teleost fishes in particular. Besides the 'fish-specific' whole genome duplication, the evolution of protocadherin genes in teleost fishes is influenced by lineage-specific gene losses, tandem gene duplications and regional sequence homogenization. The dynamic protocadherin clusters might have led to the diversification of neural circuitry among teleosts, and contributed to the behavioral and physiological diversity of teleosts.

Published
2007
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40. Recurrent PD-L1 Structural Rearrangements in Natural Killer/T Cell Lymphoma Patients with Complete Response to PD-1 Blockade Therapy

Author

Lim, Jing-Quan, Tang, Tiffany, Cai, Qing-qing, Tan, Daryl, Nairismägi, Maarja-Liisa, Laurensia, Yurike, Chia, Burton Kuan Hui, Peng, Rou-Jun, Iqbal, Jabed, Huang, Da Chuan, Song, Tammy, Pang, Wan Lu, Cheah, Daryl Ming Zhe, Young Ng, Cedric Chuan, Rajasegaran, Vikneswari, Hong, Huangming, Tse, Eric, Mow, Benjamin, Cai, Qi Chun, Poon, Li-Mei, Tan, Jing, Grigoropoulos, Nicholas Francis, Goh, Yeow Tee, Phipps, Colin, Rötzschke, Olaf, Cheng, Chee Leong, Lee, Yuh Shan, Loh, Yvonne, Tao, Miriam, Farid, Mohamad, Au-Yeung, Rex, Chan, Thomas Sau-Yan, Ng, Siok-Bian, Kwong, Yok-Lam, Hwang, William, Chng, Wee-Joo, Tousseyn, Thomas, Tan, Patrick, Teh, Bin Tean, Khor, Chiea Chuen, Rozen, Steve, Bei, Jin-Xin, Lin, Tongyu, Lim, Soon Thye, Ong, Choon Kiat, and ICGC Blood Cancer T-cell and NK-cell lymphoma group

Subjects
Oncology, medicine.medical_specialty, business.industry, ICGC Blood Cancer T-cell and NK-cell lymphoma group, Pembrolizumab, medicine.disease, Natural killer T cell, Blockade, Lymphoma, Refractory, Internal medicine, Cohort, medicine, Immunohistochemistry, business, Progressive disease
Abstract

This study aims to identify recurrent genetic alterations in relapsed or refractory (RR) natural-killer/T-cell lymphoma (NKTL) patients who have achieved complete response (CR) with programmed cell death 1 (PD-1) blockade therapy. Seven of the eleven patients treated with pembrolizumab achieved CR while the remaining four had progressive disease (PD). Using whole genome sequencing (WGS), we found recurrent clonal structural rearrangements (SR) of the PD-L1 gene in four of the seven (57%) CR patients’ pretreated tumors. These PD-L1 SRs consist of inter-chromosomal translocations, tandem duplication and micro-inversion that disrupted the suppressive function of PD-L1 3’UTR. Interestingly, recurrent JAK3-activating (p.A573V) mutations were also validated in two CR patients’ tumors that did not harbor the PD-L1 SR. Importantly, these mutations were absent in the four PD cases. With immunohistochemistry (IHC), PD-L1 positivity could not discriminate patients who archived CR (range: 6%-100%) from patients who had PD (range: 35%-90%). PD-1 blockade with pembrolizumab is a potent strategy for RR NKTL patients and genomic screening could potentially accompany PD-L1 IHC positivity to better select patients for anti-PD-1 therapy.

Published
2018

41. Bizarre giant cells in human angiosarcoma exhibit chemoresistance and contribute to poor survival outcomes.

Author

Tan, Grace Fangmin, Goh, Shane, Lim, Abner Herbert, Liu, Wei, Lee, Jing Yi, Rajasegaran, Vikneswari, Sam, Xin Xiu, Tay, Timothy Kwang Yong, Selvarajan, Sathiyamoorthy, Ng, Cedric Chuan‐Young, Teh, Bin Tean, and Chan, Jason Yongsheng

Abstract

Giant cells (GC) are a poorly understood subset of tumor cells that have been increasingly recognized as a potential contributor to tumor heterogeneity and treatment resistance. We aimed to characterize the biological and clinical significance of GC in angiosarcoma, an aggressive rare cancer of endothelial origin. Archival angiosarcoma samples were examined for the presence of GC and compared with clinicopathological as well as NanoString gene expression data. GC were examined in angiosarcoma cell lines MOLAS and ISOHAS using conventional and electron microscopy, single cell whole genome profiling, and other assays. In the cell lines, GC represented a rare population of mitotically active, non–senescent CD31+ cells, and shared similar genomic profiles with regular‐sized cells, consistent with a malignant endothelial phenotype. GC remained viable and persisted in culture following exposure to paclitaxel and doxorubicin. In patient samples, GC were present in 24 of 58 (41.4%) cases. GC was correlated with poorer responses to chemotherapy (25.0% vs 73.3%, P = 0.0213) and independently contributed to worse overall survival outcomes (hazard ratio 2.20, 95% confidence interval 1.17‐4.15, P = 0.0142). NanoString profiling revealed overexpression of genes, including COL11A1, STC1, and ERO1A, accompanied by upregulation of immune‐related metabolic stress and metastasis/matrix remodeling pathways in GC‐containing tumors. In conclusion, GC may contribute to chemoresistance and poor prognosis in angiosarcoma. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Genomic profile of breast sarcomas: a comparison with malignant phyllodes tumours

Author

Lim, Sue Zann, primary, Ng, Cedric Chuan Young, additional, Rajasegaran, Vikneswari, additional, Guan, Peiyong, additional, Selvarajan, Sathiyamoorthy, additional, Thike, Aye Aye, additional, Nasir, Nur Diyana Binte Md, additional, Koh, Valerie Cui Yun, additional, Tan, Benita Kiat Tee, additional, Ong, Kong Wee, additional, Teh, Bin Tean, additional, and Tan, Puay Hoon, additional

Published
2018
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43. Molecular insights into paediatric breast fibroepithelial tumours

Author

Tay, Timothy K Y, primary, Guan, Peiyong, additional, Loke, Benjamin N, additional, Nasir, Nur Diana M, additional, Rajasegaran, Vikneswari, additional, Thike, Aye Aye, additional, Lian, Derrick, additional, Chang, Kenneth T E, additional, Teh, Bin Tean, additional, Ng, Cedric C Y, additional, and Tan, Puay-Hoon, additional

Published
2018
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44. Clear cell sarcomas of the kidney are characterised byBCORgene abnormalities, including exon 15 internal tandem duplications andBCOR-CCNB3gene fusion

Author

Wong, Meng K, primary, Ng, Cedric C Y, additional, Kuick, Chik H, additional, Aw, Sze J, additional, Rajasegaran, Vikneswari, additional, Lim, Jing Q, additional, Sudhanshi, Jain, additional, Loh, Eva, additional, Yin, Minzhi, additional, Ma, Jing, additional, Zhang, Zhongde, additional, Iyer, Prasad, additional, Loh, Amos H P, additional, Lian, Derrick W Q, additional, Wang, Shi, additional, Goh, Shaun G H, additional, Lim, Tse H, additional, Lim, Alvin S T, additional, Ng, Tony, additional, Goytain, Angela, additional, Loh, Alwin H L, additional, Tan, Puay H, additional, Teh, Bin T, additional, and Chang, Kenneth T E, additional

Published
2017
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45. The draft genome of tropical fruit durian (Durio zibethinus)

Author

Teh, Bin Tean, primary, Lim, Kevin, additional, Yong, Chern Han, additional, Ng, Cedric Chuan Young, additional, Rao, Sushma Ramesh, additional, Rajasegaran, Vikneswari, additional, Lim, Weng Khong, additional, Ong, Choon Kiat, additional, Chan, Ki, additional, Cheng, Vincent Kin Yuen, additional, Soh, Poh Sheng, additional, Swarup, Sanjay, additional, Rozen, Steven G, additional, Nagarajan, Niranjan, additional, and Tan, Patrick, additional

Published
2017
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46. Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

Author

Jusakul, Apinya, primary, Cutcutache, Ioana, additional, Yong, Chern Han, additional, Lim, Jing Quan, additional, Huang, Mi Ni, additional, Padmanabhan, Nisha, additional, Nellore, Vishwa, additional, Kongpetch, Sarinya, additional, Ng, Alvin Wei Tian, additional, Ng, Ley Moy, additional, Choo, Su Pin, additional, Myint, Swe Swe, additional, Thanan, Raynoo, additional, Nagarajan, Sanjanaa, additional, Lim, Weng Khong, additional, Ng, Cedric Chuan Young, additional, Boot, Arnoud, additional, Liu, Mo, additional, Ong, Choon Kiat, additional, Rajasegaran, Vikneswari, additional, Lie, Stefanus, additional, Lim, Alvin Soon Tiong, additional, Lim, Tse Hui, additional, Tan, Jing, additional, Loh, Jia Liang, additional, McPherson, John R., additional, Khuntikeo, Narong, additional, Bhudhisawasdi, Vajaraphongsa, additional, Yongvanit, Puangrat, additional, Wongkham, Sopit, additional, Totoki, Yasushi, additional, Nakamura, Hiromi, additional, Arai, Yasuhito, additional, Yamasaki, Satoshi, additional, Chow, Pierce Kah-Hoe, additional, Chung, Alexander Yaw Fui, additional, Ooi, London Lucien Peng Jin, additional, Lim, Kiat Hon, additional, Dima, Simona, additional, Duda, Dan G., additional, Popescu, Irinel, additional, Broet, Philippe, additional, Hsieh, Sen-Yung, additional, Yu, Ming-Chin, additional, Scarpa, Aldo, additional, Lai, Jiaming, additional, Luo, Di-Xian, additional, Carvalho, André Lopes, additional, Vettore, André Luiz, additional, Rhee, Hyungjin, additional, Park, Young Nyun, additional, Alexandrov, Ludmil B., additional, Gordân, Raluca, additional, Rozen, Steven G., additional, Shibata, Tatsuhiro, additional, Pairojkul, Chawalit, additional, Teh, Bin Tean, additional, and Tan, Patrick, additional

Published
2017
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47. Genomic characterisation of breast fibroepithelial lesions in an international cohort.

Author

Md Nasir, Nur Diyana, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Wong, Suet Far, Liu, Wei, Ng, Gwendolene Xin Pei, Lee, Jing Yi, Guan, Peiyong, Lim, Jing Quan, Thike, Aye Aye, Koh, Valerie Cui Yun, Loke, Benjamin Nathanael, Chang, Kenneth Tou En, Gudi, Mihir Ananta, Lian, Derrick Wen Quan, Madhukumar, Preetha, Tan, Benita Kiat Tee, Tan, Veronique Kiak Mien, Wong, Chow Yin, and Yong, Wei Sean

Subjects
BREAST, PHYLLODES tumors, CANCER genes, PATHOLOGY, TUMORS, GENETICS
Abstract

Fibroepithelial lesions (FELs) are a heterogeneous group of tumours comprising fibroadenomas (FAs) and phyllodes tumours (PTs). Here we used a 16‐gene panel that was previously discovered to be implicated in pathogenesis and progression, to characterise a large international cohort of FELs via targeted sequencing. The study comprised 303 (38%) FAs and 493 (62%) PTs which were contributed by the International Fibroepithelial Consortium. There were 659 (83%) Asian and 109 (14%) non‐Asian FELs, while the ethnicity of the rest was unknown. Genetic aberrations were significantly associated with increasing grade of PTs, and were detected more in PTs than FAs for MED12, TERT promoter, RARA, FLNA, SETD2, TP53, RB1, EGFR, and IGF1R. Most borderline and malignant PTs possessed ≥ 2 mutations, while there were more cases of FAs with ≤ 1 mutation compared to PTs. FELs with MED12 mutations had significantly higher rates of TERT promoter, RARA, SETD2, EGFR, ERBB4, MAP3K1, and IGF1R aberrations. However, FELs with wild‐type MED12 were more likely to express TP53 and PIK3CA mutations. There were no significant differences observed between the mutational profiles of recurrent FAs, FAs with a history of subsequent ipsilateral recurrence or contralateral occurrence, and FAs without a history of subsequent events. We identified recurrent mutations which were more frequent in PTs than FAs, with borderline and malignant PTs harbouring cancer driver gene and multiple mutations. This study affirms the role of a set of genes in FELs, including its potential utility in classification based on mutational profiles. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2019
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48. MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression

Author

Tan, Wai Jin, primary, Chan, Jason Yongsheng, additional, Thike, Aye Aye, additional, Lim, Jeffrey Chun Tatt, additional, Md Nasir, Nur Diyana, additional, Tan, Jane Sie Yong, additional, Koh, Valerie Cui Yun, additional, Lim, Weng Khong, additional, Tan, Jing, additional, Ng, Cedric Chuan Yong, additional, Rajasegaran, Vikneswari, additional, Nagarajan, Sanjanaa, additional, Bay, Boon Huat, additional, Teh, Bin Tean, additional, and Tan, Puay Hoon, additional

Published
2016
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49. Genomic landscapes of breast fibroepithelial tumors

Author

Tan, Jing, primary, Ong, Choon Kiat, additional, Lim, Weng Khong, additional, Ng, Cedric Chuan Young, additional, Thike, Aye Aye, additional, Ng, Ley Moy, additional, Rajasegaran, Vikneswari, additional, Myint, Swe Swe, additional, Nagarajan, Sanjanaa, additional, Thangaraju, Saranya, additional, Dey, Sucharita, additional, Nasir, Nur Diyana Md, additional, Wijaya, Giovani Claresta, additional, Lim, Jing Quan, additional, Huang, Dachuan, additional, Li, Zhimei, additional, Wong, Bernice Huimin, additional, Chan, Jason Yong Sheng, additional, McPherson, John R, additional, Cutcutache, Ioana, additional, Poore, Gregory, additional, Tay, Su Ting, additional, Tan, Wai Jin, additional, Putti, Thomas Choudary, additional, Ahmad, Buhari Shaik, additional, Iau, Philip, additional, Chan, Ching Wan, additional, Tang, Anthony P H, additional, Yong, Wei Sean, additional, Madhukumar, Preetha, additional, Ho, Gay Hui, additional, Tan, Veronique Kiak Mien, additional, Wong, Chow Yin, additional, Hartman, Mikael, additional, Ong, Kong Wee, additional, Tan, Benita K T, additional, Rozen, Steven G, additional, Tan, Patrick, additional, Tan, Puay Hoon, additional, and Teh, Bin Tean, additional

Published
2015
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50. Whole‐exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1

Author

McPherson, John Richard, primary, Ong, Choon‐Kiat, additional, Ng, Cedric Chuan‐Young, additional, Rajasegaran, Vikneswari, additional, Heng, Hong‐Lee, additional, Yu, Willie Shun‐Shing, additional, Tan, Benita Kiat‐Tee, additional, Madhukumar, Preetha, additional, Teo, Melissa Ching‐Ching, additional, Ngeow, Joanne, additional, Thike, Aye‐Aye, additional, Rozen, Steven George, additional, Tan, Puay‐Hoon, additional, Lee, Ann Siew‐Gek, additional, Teh, Bin‐Tean, additional, and Yap, Yoon‐Sim, additional

Published
2015
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