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21 results on '"Rajarathinam, Thenmozhi"'

9. Disposable microRNA biosensors based on dual-role polymer-dispersed silver nanowires for diagnosis of viral hemorrhagic septicemia virus infection in olive flounder

Author

Thirumalai, Dinakaran, primary, Kim, Woo Ryung, additional, Joo, Hyeyoung, additional, Rajarathinam, Thenmozhi, additional, Park, Eun Gyung, additional, Lee, Yun Ju, additional, Paik, Hyun-jong, additional, Lee, Jaewon, additional, Kim, Heui-Soo, additional, and Chang, Seung-Cheol, additional

Published
2023
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15. Gene Therapy Options as New Treatment for Inherited Peripheral Neuropathy

Author

Byung-Ok Choi, Rajarathinam Thenmozhi, Na Young Park, Young Bin Hong, and Ji-Su Lee

Subjects
0301 basic medicine, Genetic enhancement, Mutant, Inheritance (genetic algorithm), Inherited Peripheral Neuropathy, Review Article, Gene editing, Biology, Bioinformatics, 03 medical and health sciences, Cellular and Molecular Neuroscience, Gene therapy, 030104 developmental biology, 0302 clinical medicine, Genome editing, microRNA, Antisense oligonucleotide, Neurology (clinical), Inherited peripheral neuropathy, Gene, 030217 neurology & neurosurgery, Function (biology), miRNA
Abstract

Inherited peripheral neuropathy (IPN) is caused by heterogeneous genetic mutations in more than 100 genes. So far, several treatment options for IPN have been developed and clinically evaluated using small molecules. However, gene therapy-based therapeutic strategies have not been aggressively investigated, likely due to the complexities of inheritance in IPN. Indeed, because the majority of the causative mutations of IPN lead to gainof- function rather than loss-of-function, developing a therapeutic strategy is more difficult, especially considering gene therapy for genetic diseases began with the simple idea of replacing a defective gene with a functional copy. Recent advances in gene manipulation technology have brought novel approaches to gene therapy and its clinical application for IPN treatment. For example, in addition to the classically used gene replacement for mutant genes in recessively inherited IPN, other techniques including gene addition to modify the disease phenotype, modulations of target gene expression, and techniques to edit mutant genes have been developed and evaluated as potent therapeutic strategies for dominantly inherited IPN. In this review, the current status of gene therapy for IPN and future perspectives will be discussed.

Published
2020

19. Synthesis of Silica-Coated Magnetic Hydroxyapatite Composites for Drug Delivery Applications

Author

Jayaraman Sivaguru, Rajarathinam Thenmozhi, Junghwan Oh, Subramanian Bharathiraja, Yunok Oh, Panchanathan Manivasagan, and Madhappan Santha Moorthy

Subjects
Materials science, Carboxylic acid, Composite number, Biomedical Engineering, chemistry.chemical_element, Bioengineering, 02 engineering and technology, Calcium, Magnetics, Drug Delivery Systems, medicine, General Materials Science, Neutral ph, Composite material, chemistry.chemical_classification, Magnetic Phenomena, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Ibuprofen, Silicon Dioxide, Durapatite, chemistry, Pharmaceutical Preparations, Drug delivery, Amine gas treating, Leaching (metallurgy), 0210 nano-technology, medicine.drug
Abstract

We have prepared a core-shell magnetic silica-coated hydroxyapatite, Fe₃O₄@SiO₂@HAp composite materials for pH-responsive drug delivery applications. Captopril (Cap) and ibuprofen (Ibu) were chosen as model hydrophilic and hydrophobic drugs, respectively. The drugs were encapsulated into the Fe₃O₄@SiO₂@HAp composite via electrostatic interactions with existing amine and carboxylic acid groups during calcium phosphate shell formation. The formation of calcium phosphate shell not only protects the encapsulated drugs from leaching but also controls the release rate of drugs from the composite system depending on various pH conditions. We have tested the release behavior of Cap and Ibu drugs under different pH conditions such as neutral pH (pH 7.4) and acidic pH (pH 5.0), respectively. The study result reveals that the synthesized Fe₃O₄@SiO₂@HAp composite is suitable for release of both water soluble and water insoluble drugs based on a pH-responsive controlled manner.

Published
2018

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