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225 results on '"Rajan, Gunesh P."'

5. HEARRING group genetic marker study: genetic background of CI patients.

Author

Usami, Shin-ichi, Nishio, Shin-ya, Gavilán, Javier, Van de Heyning, Paul, Mertens, Griet, Karltorp, Eva, Skarżyński, Henryk, Hagr, Abdulrahman, Manoj, Manikoth, Staecker, Hinrich, Zernotti, Mario E., Rajan, Gunesh P., Müller, Joachim, Simon, Florian, and Anderson, Ilona

Subjects
COCHLEAR implants, RESEARCH funding, GENETIC markers, DEAFNESS, RESEARCH, HEARING disorders, ACOUSTIC stimulation, HEARING impaired, SEQUENCE analysis, GENETIC testing, SALIVA
Abstract

Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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6. Two-phase survey on the frequency of use and safety of MRI for hearing implant recipients

Author

van de Heyning, Paul, Mertens, Griet, Topsakal, Vedat, de Brito, Ruben, Wimmer, Wilhelm, Caversaccio, Marco D., Dazert, Stefan, Volkenstein, Stefan, Zernotti, Mario, Parnes, Lorne S., Staecker, Hinrich, Bruce, Iain A., Rajan, Gunesh, Atlas, Marcus, Friedland, Peter, Skarzynski, Piotr H., Sugarova, Serafima, Kuzovkov, Vladislav, Hagr, Abdulrahman, Mlynski, Robert, Schmutzhard, Joachim, Usami, Shin-Ichi, Lassaletta, Luis, Gavilán, Javier, Godey, Benoit, Raine, Christopher H., Hagen, Rudolf, Sprinzl, Georg M., Brown, Kevin, Baumgartner, Wolf-Dieter, and Karltorp, Eva

Published
2021
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13. Minimally Traumatic Cochlear Implant Surgery: Expert Opinion in 2010 and 2020

Author

Topsakal, Vedat, primary, Agrawal, Sumit, additional, Atlas, Marcus, additional, Baumgartner, Wolf-Dieter, additional, Brown, Kevin, additional, Bruce, Iain A., additional, Dazert, Stefan, additional, Hagen, Rudolf, additional, Lassaletta, Luis, additional, Mlynski, Robert, additional, Raine, Christopher H., additional, Rajan, Gunesh P., additional, Schmutzhard, Joachim, additional, Sprinzl, Georg Mathias, additional, Staecker, Hinrich, additional, Usami, Shin-ichi, additional, Van Rompaey, Vincent, additional, Zernotti, Mario, additional, and Heyning, Paul van de, additional

Published
2022
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15. Systematic Literature Review of Hearing Preservation Rates in Cochlear Implantation Associated With Medium- and Longer-Length Flexible Lateral Wall Electrode Arrays

Author

Van de Heyning, Paul H, primary, Dazert, Stefan, additional, Gavilan, Javier, additional, Lassaletta, Luis, additional, Lorens, Artur, additional, Rajan, Gunesh P, additional, Skarzynski, Henryk, additional, Skarzynski, Piotr H, additional, Tavora-Vieira, Dayse, additional, Topsakal, Vedat, additional, Usami, Shin-ichi, additional, Van Rompaey, Vincent, additional, Weiss, Nora M, additional, and Polak, Marek, additional

Published
2022
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21. Overall Neutrophil-to-Lymphocyte Ratio and SUVmax of Nodal Metastases Predict Outcome in Head and Neck Cancer Before Chemoradiation

Author

Werner, Jonas, Strobel, Klaus, Lehnick, Dirk, Rajan, Gunesh P., Werner, Jonas, Strobel, Klaus, Lehnick, Dirk, and Rajan, Gunesh P.

Abstract

Introduction: This study investigates the pretherapeutic neutrophil-to-lymphocyte ratio (NLR) with markers of tumor metabolism in 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and their potential prognostic value in head and neck cancer patients prior to primary chemoradiation. Materials and Methods: NLR and metabolic markers of primary tumor and nodal metastases including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were retrospectively assessed in a consecutive cohort of head and neck squamous cell cancer patients undergoing primary chemoradiation. The main outcome measure was survival. Results: The study included 90 patients of which 74 had lymph node metastases at diagnosis. Median follow-up time of nodal positive patients (n=74) was 26.5 months (IQR 18–44). The NLR correlated significantly with metabolic markers of the primary tumor (TLG: rs=0.47, P<0.001; MTV: rs=0.40, P<0.001; SUVmax:rs=0.34, P=0.003), but much less with FDG-PET/CT surrogate markers of metabolic activity in nodal metastases (TLG: rs=0.15, P=0.19; MTV: rs=0.25, P=0.034; SUVmax: rs=0.06, P=0.63). For nodal positive cancer patients, multivariate analysis showed that an increased NLR (HR=1.19, 95% CI=1.04-1.37, P=0.012) and SUVmax of lymph node metastasis (HR=1.09; 95% CI=0.991.19; P=0.081) are independently predictive of disease-specific survival. High NLR had a negative prognostic value for overall survival (HR=1.16, 95% CI=1.02-1.33, P=0.021). Conclusion: NLR correlates positively with metabolic markers of the primary tumor, suggestive of an unspecificinflammatory response in the host as a possible reflection of increased metabolism of the primary tumor. SUVmax of lymph node metastases and the NLR, however, show no correlation and are independently predictive of disease-specific survival. Therefore, their addition could be used to improve survival prediction in nodal positive head and neck canc, + ID der Publikation: unilu_55240 + Sprache: Englisch + Letzte Aktualisierung: 2021-11-03 16:14:18

Published
2021

22. A Synchrotron and Micro-CT Study of the Human Endolymphatic Duct System : Is Meniere's Disease Caused by an Acute Endolymph Backflow?

Author

Li, Hao, Rajan, Gunesh P., Shaw, Jeremy, Rohani, Seyed Alireza, Ladak, Hanif M., Agrawal, Sumit, Rask-Andersen, Helge, Li, Hao, Rajan, Gunesh P., Shaw, Jeremy, Rohani, Seyed Alireza, Ladak, Hanif M., Agrawal, Sumit, and Rask-Andersen, Helge

Abstract

Background: The etiology of Meniere's disease (MD) and endolymphatic hydrops believed to underlie its symptoms remain unknown. One reason may be the exceptional complexity of the human inner ear, its vulnerability, and surrounding hard bone. The vestibular organ contains an endolymphatic duct system (EDS) bridging the different fluid reservoirs. It may be essential for monitoring hydraulic equilibrium, and a dysregulation may result in distension of the fluid spaces or endolymphatic hydrops. Material and Methods: We studied the EDS using high-resolution synchrotron phase contrast non-invasive imaging (SR-PCI), and micro-computed tomography (micro-CT). Ten fresh human temporal bones underwent SR-PCI. One bone underwent micro-CT after fixation and staining with Lugol's iodine solution (I2KI) to increase tissue resolution. Data were processed using volume-rendering software to create 3D reconstructions allowing orthogonal sectioning, cropping, and tissue segmentation. Results: Combined imaging techniques with segmentation and tissue modeling demonstrated the 3D anatomy of the human saccule, utricle, endolymphatic duct, and sac together with connecting pathways. The utricular duct (UD) and utriculo-endolymphatic valve (UEV or Bast's valve) were demonstrated three-dimensionally for the first time. The reunion duct was displayed with micro-CT. It may serve as a safety valve to maintain cochlear endolymph homeostasis under certain conditions. Discussion: The thin reunion duct seems to play a minor role in the exchange of endolymph between the cochlea and vestibule under normal conditions. The saccule wall appears highly flexible, which may explain occult hydrops occasionally preceding symptoms in MD on magnetic resonance imaging (MRI). The design of the UEV and connecting ducts suggests that there is a reciprocal exchange of fluid among the utricle, semicircular canals, and the EDS. Based on the anatomic framework and previous experimental data, we speculate that precipito

Published
2021
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32. Overall Neutrophil-to-Lymphocyte Ratio and SUVmax of Nodal Metastases Predict Outcome in Head and Neck Cancer Before Chemoradiation.

Author

Werner, Jonas, Strobel, Klaus, Lehnick, Dirk, and Rajan, Gunesh P.

Subjects
HEAD & neck cancer, NEUTROPHIL lymphocyte ratio, NECK dissection, PROGNOSIS, METASTASIS, COMPUTED tomography, TUMOR markers
Abstract

Introduction: This study investigates the pretherapeutic neutrophil-to-lymphocyte ratio (NLR) with markers of tumor metabolism in 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and their potential prognostic value in head and neck cancer patients prior to primary chemoradiation. Materials and Methods: NLR and metabolic markers of primary tumor and nodal metastases including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were retrospectively assessed in a consecutive cohort of head and neck squamous cell cancer patients undergoing primary chemoradiation. The main outcome measure was survival. Results: The study included 90 patients of which 74 had lymph node metastases at diagnosis. Median follow-up time of nodal positive patients (n=74) was 26.5 months (IQR 18–44). The NLR correlated significantly with metabolic markers of the primary tumor (TLG: rs=0.47, P <0.001; MTV: rs=0.40, P <0.001; SUVmax: rs=0.34, P =0.003), but much less with FDG-PET/CT surrogate markers of metabolic activity in nodal metastases (TLG: rs=0.15, P =0.19; MTV: rs=0.25, P =0.034; SUVmax: rs=0.06, P =0.63). For nodal positive cancer patients, multivariate analysis showed that an increased NLR (HR=1.19, 95% CI=1.04-1.37, P =0.012) and SUVmax of lymph node metastasis (HR=1.09; 95% CI=0.99-1.19; P =0.081) are independently predictive of disease-specific survival. High NLR had a negative prognostic value for overall survival (HR=1.16, 95% CI=1.02-1.33, P =0.021). Conclusion: NLR correlates positively with metabolic markers of the primary tumor, suggestive of an unspecific inflammatory response in the host as a possible reflection of increased metabolism of the primary tumor. SUVmax of lymph node metastases and the NLR, however, show no correlation and are independently predictive of disease-specific survival. Therefore, their addition could be used to improve survival prediction in nodal positive head and neck cancer patients undergoing primary chemoradiation. [ABSTRACT FROM AUTHOR]

Published
2021
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36. The SCIP flap for Head and Neck Reconstruction

Author

Scaglioni, Mario F., Meroni, Matteo, Meschino, Antonio, and Rajan, Gunesh P.

Abstract

Head and neck defects present a unique challenge in reconstructive surgery due to the complex anatomy of this area. Different defects often require a variety of reconstructive techniques. The Superficial Circumflex Iliac artery Perforator (SCIP) flap is particularly notable for its versatility in this context. It provides a thin, pliable skin island that can be integrated with bone, muscle, fascia, and other structures. Additionally, the morbidity associated with the donor site of the SCIP flap is generally low and well-tolerated. This article offers a comprehensive overview of the evolution of this technique, illustrating how the SCIP flap can be an precious tool for head and neck reconstructions.

Published
2024
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40. Towards a Unified Testing Framework for Single-Sided Deafness Studies: A Consensus Paper

Author

Van de Heyning, Paul, primary, Távora-Vieira, Dayse, additional, Mertens, Griet, additional, Van Rompaey, Vincent, additional, Rajan, Gunesh P., additional, Müller, Joachim, additional, Hempel, John Martin, additional, Leander, Daniel, additional, Polterauer, Daniel, additional, Marx, Mathieu, additional, Usami, Shin-ichi, additional, Kitoh, Ryosuke, additional, Miyagawa, Maiko, additional, Moteki, Hideaki, additional, Smilsky, Kari, additional, Baumgartner, Wolf-Dieter, additional, Keintzel, Thomas Georg, additional, Sprinzl, Georg Mathias, additional, Wolf-Magele, Astrid, additional, Arndt, Susan, additional, Wesarg, Thomas, additional, Zirn, Stefan, additional, Baumann, Uwe, additional, Weissgerber, Tobias, additional, Rader, Tobias, additional, Hagen, Rudolf, additional, Kurz, Anja, additional, Rak, Kristen, additional, Stokroos, Robert, additional, George, Erwin, additional, Polo, Ruben, additional, Medina, María del Mar, additional, Henkin, Yael, additional, Hilly, Ohad, additional, Ulanovski, David, additional, Rajeswaran, Ranjith, additional, Kameswaran, Mohan, additional, Di Gregorio, Maria Fernanda, additional, and Zernotti, Mario E., additional

Published
2016
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45. Towards a Unified Testing Framework for Single-Sided Deafness Studies: A Consensus Paper.

Author

Van de Heyning, Paul, Távora-Vieira, Dayse, Mertens, Griet, Van Rompaey, Vincent, Rajan, Gunesh P., Müller, Joachim, Hempel, John Martin, Leander, Daniel, Polterauer, Daniel, Marx, Mathieu, Usami, Shin-ichi, Kitoh, Ryosuke, Miyagawa, Maiko, Moteki, Hideaki, Smilsky, Kari, Baumgartner, Wolf-Dieter, Keintzel, Thomas Georg, Sprinzl, Georg Mathias, Wolf-Magele, astrid, and arndt, Susan

Subjects
DEAFNESS, HEARING aids, COCHLEAR implants, COMPARATIVE studies, CONSENSUS (Social sciences), LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, NOISE, QUALITY of life, RESEARCH, STATISTICAL sampling, SPEECH perception, TINNITUS, EVALUATION research, RANDOMIZED controlled trials, ACOUSTIC localization, TREATMENT effectiveness
Abstract

Background: While hearing aids for a contralateral routing of signals (CROS-HA) and bone conduction devices have been the traditional treatment for single-sided deafness (SSD) and asymmetric hearing loss (AHL), in recent years, cochlear implants (CIs) have increasingly become a viable treatment choice, particularly in countries where regulatory approval and reimbursement schemes are in place. Part of the reason for this shift is that the CI is the only device capable of restoring bilateral input to the auditory system and hence of possibly reinstating binaural hearing. Although several studies have independently shown that the CI is a safe and effective treatment for SSD and AHL, clinical outcome measures in those studies and across CI centers vary greatly. Only with a consistent use of defined and agreed-upon outcome measures across centers can high-level evidence be generated to assess the safety and efficacy of CIs and alternative treatments in recipients with SSD and AHL.Methods: This paper presents a comparative study design and minimum outcome measures for the assessment of current treatment options in patients with SSD/AHL. The protocol was developed, discussed, and eventually agreed upon by expert panels that convened at the 2015 APSCI conference in Beijing, China, and at the CI 2016 conference in Toronto, Canada.Results: A longitudinal study design comparing CROS-HA, BCD, and CI treatments is proposed. The recommended outcome measures include (1) speech in noise testing, using the same set of 3 spatial configurations to compare binaural benefits such as summation, squelch, and head shadow across devices; (2) localization testing, using stimuli that rove in both level and spectral content; (3) questionnaires to collect quality of life measures and the frequency of device use; and (4) questionnaires for assessing the impact of tinnitus before and after treatment, if applicable.Conclusion: A protocol for the assessment of treatment options and outcomes in recipients with SSD and AHL is presented. The proposed set of minimum outcome measures aims at harmonizing assessment methods across centers and thus at generating a growing body of high-level evidence for those treatment options. [ABSTRACT FROM AUTHOR]

Published
2017
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