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The increase in the share of renewable-based power in the gross power generation in most countries causes significant concerns over the addition of renewable power with the grid, results in stability issues in most developed nations. Energy storage is an emerging technology that is considered the ultimate solution in developing microgrids with distributed renewable power generation. The cool thermal storage plays a vital role in economically promoting renewable power among different storage units. The major objective of the research work is to demonstrate the integration of residential air-conditioning systems with packed bed cool storage units to promote rooftop solar power generation for residential space cooling applications. In order to achieve the said objective, an experimental investigation was made to study the charging/discharging characteristics of a packed bed cool-storage unit combined with a chiller and a cooling coil unit suitable for small capacity air-conditioning applications. The system consists of encapsulated spherical capsules filled with a phase change material blended with distilled water and pseudomonas (nucleating agent) and the heat transfer fluid as a combination of distilled water and Mono-ethylene glycol. A cooling coil unit was connected to the cool-storage tank to transfer cool energy from the storage tank to the space to be cooled when there is a demand. The important parameters, such as instantaneous and cumulative heat transfer during the charging/discharging processes, are presented. The average COP values of the chiller during the charging operation were estimated as 1, 0.93, and 0.89 when the HTF setpoint temperatures were -6°C, -9°C, and -12°C, which shows a decrease in performance as the setpoint temperature decreases. During the discharging process, a cooling load of 2.25 kW is obtained during the first cycle of operation and gradually reduces to 0.3 kW during the sixth cycle of operation. The increase in the HTF temperature during each cycle of operation indicates that the Phase Change Material (PCM) in the balls cannot release the heat as per the demand after a certain period of discharging. Hence, decreasing the internal thermal resistance by suitable measures is essential to achieve uniform heat flux and to operate the system successfully

Recognizing the extreme speeds of reactions with microwaves, anionic forms of surfactants (sodium dodecyl sulfate (SDS) and sodium dodecylbenzenesulfonate (SDBS)) have been intercalated successfully by ion-exchange reactions in binary Li-Al and ternary Li-M-Al (M = Mg, Co, Ni, Cu, and Zn) layered double hydroxide (LDH) systems with the aid of microwaves. The samples have been characterized extensively. The basal spacings of 28.2 and 30.4 Å have been estimated for Li-Al-DS and Li-Al-DBS LDH samples, respectively, suggesting a perpendicular arrangement of DS− and DBS− anions in the interlayer space. The characteristic vibration bands of both LDH and the surfactant (DS− and DBS−) in the FTIR spectra confirmed the binding mode of surfactant molecules within the interlayers. DS−-intercalated Li-Al LDH showed lower thermal stability than the DBS−-intercalated sample. The nitrate-intercalated Li-M-Al (M = Mg, Co, Ni, Cu, and Zn) LDHs were ion-exchanged with SDS and SDBS to yield DS−-and DBS−-intercalated systems. The expanded basal spacings and a change in crystallite morphology confirmed the vertical intercalation of DS− and DBS− in Li-M-Al LDHs. ICP-AES and elemental analyses determined the metal contents and the surfactant content. FTIR spectra of intercalated samples confirmed the surfactant’s presence in the interlayer. The presence of Co, Ni, and Cu in Li-M-Al LDHs has been confirmed from UV-visible spectra. The Li-Al-DBS sample adsorbed iodine efficiently from methanol solutions, and the Langmuir model could explain the adsorption data in a better way. The adsorption followed pseudo-second-order kinetics.

Overlap fermion on the lattice has been shown to properly reproduce topological aspects of gauge fields. In this paper, we review the derivation of Overlap fermion formalism in a torus of three space-time dimensions. Using the formalism, we show how to use the Overlap fermion determinants in the massless and infinite mass limits to construct different continuum topological gauge actions, such as the level-k Chern–Simons action, “half-CS” term and the mixed Chern–Simons (BF) coupling, in a gauge-invariant lattice UV regulated manner. Taking special Abelian and non-Abelian background fields, we demonstrate numerically how the lattice formalism beautifully reproduces the continuum expectations, such as the flow of action under large gauge transformations.

In most developed and developing nations, nearly 40% of the energy generated is utilized in the building sector, in which nearly 50% of the energy is consumed by building cooling/heating systems. However, the energy requirement for building cooling/heating varies continuously with respect to time. Hence, in hot countries, if the cooling system is integrated with a storage system, the cooling system need not be designed for the peak load requirement. Further, this kind of storage system is very useful and economically beneficial in the scenario of dynamic electricity tariff, being introduced in many countries in the emerging renewable energy scenario to solve the grid stability issues. Further, it is very useful to promote microgrid with distributed renewable power generation. Considering the above, the major objective of the present research is to demonstrate the integration of the air-conditioning system with a sensible heat storage unit for residential applications. An experimental setup is constructed, and experiments were conducted to evaluate the heat exchange behavior during the charging and discharging process by varying the inlet temperature and the mass flow rate of the heat exchange fluid through the circuit. It is observed that the set temperature of the cool storage tank is to be maintained above +5°C to achieve better efficiency during the charging process. During the discharging process, the room could be maintained at the required comfort condition for a duration of 285 min with 29 cycles of operations between the set point temperature limits of 25°C to 28°C. When the inlet brine temperature of the cooling unit reached 20°C, in the next cycle, bringing down the room temperature again to 25°C could not be achieved. The results shown in this work are beneficial for efficiently operating the cooling system and useful in promoting renewable energy in the near future in the building sector. Also, the low-temperature sensible heat storage system is capable of maintaining the storage temperature at approximately +4°C, instead of -4°C normally employed in the case of latent heat-based storage system that allows higher performance in the sensible heat storage system.

Polyaniline was synthesized by the chemical oxidative polymerization procedure at room temperature employing hydrogen peroxide (H 2 O 2 ) as oxidant and ferrous chloride (FeCl 2 ·2H 2 O) and vanadyl sulphate (VOSO 4 ·H 2 O) as co-catalysts, respectively. The obtained polymers were characterized by high resolution powder X-ray diffraction, Fourier transform infrared spectroscopy, Raman, UV–Visible, photoluminescence spectroscopy, thermogravimetric Field Emission Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM) techniques. Ordered arrangement indicative of semi-crystalline nature of polyaniline was evidenced from the presence of intense reflection at d = 13.72 Å in the powder X-ray diffraction pattern followed by two lesser intense peaks at 4.61 and 3.47 Å. Fourier transform infrared spectroscopy and Raman spectroscopic results indicated the polyaniline to be emeraldine salt form. Fibrous morphology was observed in scanning electron microscope images. Nearly 93% of Methyl Orange dye was adsorbed in 30 min by the ordered polyaniline at room temperature. No significant difference in the crystallinity and/or ordering was noticed in the powder X-ray diffraction pattern after dye adsorption. The correlation between the ordered structure of polyaniline and its higher adsorption property derived in the current study has the potential to fabricate devices consisting polyaniline to detect dye molecules.

Potential of root system of plants from wide range of families to effectively reduce membrane impermeable ferricyanide to ferrocyanide and blue coloured 2,6-dichlorophenol indophenol (DCPIP) to colourless DCPIPH2 both under non-sterile and sterile conditions, revealed prevalence of immense reducing strength at root surface. As generation of silver nanoparticles (NPs) from Ag+ involves reduction, present investigations were carried to evaluate if reducing strength prevailing at surface of root system can be exploited for reduction of Ag+ and exogenous generation of silver-NPs. Root system of intact plants of 16 species from 11 diverse families of angiosperms turned clear colorless AgNO3 solutions, turbid brown. Absorption spectra of these turbid brown solutions showed silver-NPs specific surface plasmon resonance peak. Transmission electron microscope coupled with energy dispersive X-ray confirmed the presence of distinct NPs in the range of 5-50 nm containing Ag. Selected area electron diffraction and powder X-ray diffraction patterns of the silver NPs showed Bragg reflections, characteristic of crystalline face-centered cubic structure of Ag(0) and cubic structure of Ag2O. Root system of intact plants raised under sterile conditions also generated Ag(0)/Ag2O-NPs under strict sterile conditions in a manner similar to that recorded under non-sterile conditions. This revealed the inbuilt potential of root system to generate Ag(0)/Ag2O-NPs independent of any microorganism. Roots of intact plants reduced triphenyltetrazolium to triphenylformazon and impermeable ferricyanide to ferrocyanide, suggesting involvement of plasma membrane bound dehydrogenases in reduction of Ag+ and formation of Ag(0)/Ag2O-NPs. Root enzyme extract reduced triphenyltetrazolium to triphenylformazon and Ag+ to Ag(0) in presence of NADH, clearly establishing potential of dehydrogenases to reduce Ag+ to Ag(0), which generate Ag(0)/Ag2O-NPs. Findings presented in this manuscript put forth a novel, simple, economically viable and green protocol for synthesis of silver-NPs under ambient conditions in aqueous phase, using root system of intact plants.

Background: Stimulation of a specific site in the dorsolateral subthalamic nucleus (STN) was recently associated with slower motor progression in Parkinson's Disease (PD), based on the deep brain stimulation (DBS) in early-stage PD pilot clinical trial. Here, subject-level visualizations are presented of this early-stage PD dataset to further describe the relationship between active contacts and motor progression. This study also evaluates whether stimulation of the sweet spot and connectivity model associated with slower motor progression is also associated with improvements in long-term motor outcomes in patients with advanced-stage PD., Methods: Active contacts of the early-stage PD cohort (N = 14) were analyzed alongside the degree of two-year motor progression. Sweet spot and connectivity models derived from the early-stage PD cohort were then used to determine how well they can estimate the variance in long-term motor outcomes in an independent STN-DBS cohort of advanced-stage PD patients (N = 29)., Results: In early-stage PD, proximity of stimulation to the dorsolateral STN was associated with slower motor progression. In advanced-stage PD, stimulation proximity to the early PD connectivity model and sweet spot were associated with better long-term motor outcomes (R = 0.60, P < 0.001; R = 0.37, P = 0.046, respectively)., Conclusions: Results suggest stimulation of a specific site in the dorsolateral STN is associated with both slower motor progression and long-term motor improvements in PD., (© 2024. The Author(s).)

Background: Recent imaging studies identified a brain network associated with clinical improvement following deep brain stimulation (DBS) in Parkinson's disease (PD), the PD response network., Objectives: This study aimed to assess the impact of neuromodulation on PD motor symptoms by targeting this network noninvasively using multifocal transcranial direct current stimulation (tDCS)., Methods: In a prospective, randomized, double-blinded, crossover trial, 21 PD patients (mean age 59.7 years, mean Hoehn & Yahr [H&Y] 2.4) received multifocal tDCS targeting the a-priori network. Twenty-minute sessions of tDCS and sham were administered on 2 days in randomized order. Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III) scores were assessed., Results: Before intervention, MDS-UPDRS-III scores were comparable in both conditions (stimulation days: 37.38 (standard deviation [SD] = 12.50, confidence interval [CI] = 32.04, 42.73) vs. sham days: 36.95 (SD = 13.94, CI = 30.99, 42.91), P = 0.63). Active stimulation resulted in a reduction by 3.6 points (9.7%) to 33.76 (SD = 11.19, CI = 28.98, 38.55) points, whereas no relevant change was observed after sham stimulation (36.43 [SD = 14.15, CI = 30.38, 42.48], average improvement: 0.5 [1.4%]). Repeated-measures analysis of variance (ANOVA) confirmed significance (main effect of time: F (1,20) =4.35, P < 0.05). Tukey's post hoc tests indicated MDS-UPDRS-III improvement after active stimulation (t [20] = 2.9, P = 0.03) but not after sham (t [20] = 0.42, P > 0.05). In a subset of patients that underwent DBS surgery later, their DBS response correlated with tDCS effects (R = 0.55, P (1)  = 0.04)., Conclusion: Noninvasive, multifocal tDCS targeting a DBS-derived network significantly improved PD motor symptoms. Despite a small effect size, this study provides proof of principle for the successful noninvasive neuromodulation of an invasively identified network. Future studies should investigate repeated tDCS sessions and their utility for screening before DBS surgery. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society., (© 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)

Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson's disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a large cohort of patients (N = 237 from five centers) to identify tracts associated with improvements in each of the four symptom domains. Tremor improvements were associated with stimulation of tracts connected to primary motor cortex and cerebellum. In contrast, axial symptoms are associated with stimulation of tracts connected to the supplementary motor cortex and brainstem. Bradykinesia and rigidity improvements are associated with the stimulation of tracts connected to the supplementary motor and premotor cortices, respectively. We introduce an algorithm that uses these symptom-response tracts to suggest optimal stimulation parameters for DBS based on individual patient's symptom profiles. Application of the algorithm illustrates that our symptom-tract library may bear potential in personalizing stimulation treatment based on the symptoms that are most burdensome in an individual patient., (© 2024. The Author(s).)

Objective and Design: Although many studies have been conducted to assess the knowledge and practices among healthcare workers, high-risk groups or medical students, very few studies have been conducted among college students from non-medical backgrounds. Our study aimed to assess the knowledge, attitudes and perception about human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) among the college students of the Mumbai region and to determine their association with the socio-demographic variables., Setting and Methods: A cross-sectional online and offline questionnaire survey was conducted among 401 college students from the month of August 2022 to October 2022. Mean score and percentage were used to analyse the data., Results: About 82.04% of participants exhibited good knowledge about HIV transmission and prevention, while 46.38% had a positive attitude towards HIV. Age, gender, religion and education had not influenced either knowledge or attitude significantly. Overall, knowledge score had a weak positive correlation with attitude of the participants., Conclusion: Our study findings indicate that a holistic approach covering knowledge, psychological and societal health aspects is necessary among youth in India for positive changes in people's behaviour and achieving HIV prevention and management goals which will benefit public health at large., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Family Medicine and Primary Care.)

Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)functions remains largely elusive. We studied 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregated the frontal cortex into circuits that had become dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to frontal, ranging from interconnections with sensorimotor cortices in dystonia, the primary motor cortex in Tourette's syndrome, the supplementary motor area in Parkinson's disease, to ventromedial prefrontal and anterior cingulate cortices in obsessive-compulsive disorder. Our findings highlight the integration of deep brain stimulation with brain connectomics as a powerful tool to explore couplings between brain structure and functional impairments in the human brain., (© 2024. The Author(s).)

Background: The Squirrels of South Asia (SOSA) database compiles comprehensive distribution and occurrence information on all squirrel species that occur in this region (34 species). These 34 squirrel species, including tree, flying and ground squirrels, represent 14% of global sciurid diversity. The database collates curated data from various sources such as museums, literature, primary fieldwork, citizen science and social media platforms and covers the entire distributional ranges of the target species, including countries in Central Asia and Southeast Asia when required. The SOSA database enhances our understanding of squirrel distribution, population dynamics and their conservation needs in South Asia by consolidating information. It aims to be a valuable resource for researchers, conservationists and wildlife enthusiasts., New Information: As of March 2023, the database comprises over 40,000 records of 34 species in over 30 countries globally. Spending an average of 334 hours on each species, more than 20 data collectors put in over 10,000 hours to gather, curate and build this database. The database has resulted in novel records of species occurrence in regions and countries that are poorly represented in currently available global data repositories. The current version which has been made public via GBIF comprises of 1187 records of all 34 species across multiple sources. This is a subset of the SOSA database., (Udayraj Swati, Senan D&apos;Souza, Palassery Suresh Aravind, Rakesh Kumar Muni, Nandini Rajamani.)

Objective: This study was undertaken to describe relationships between electrode localization and motor outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early stage Parkinson disease (PD) pilot clinical trial., Methods: To determine anatomical and network correlates associated with motor outcomes for subjects randomized to early DBS (n = 14), voxelwise sweet spot mapping and structural connectivity analyses were carried out using outcomes of motor progression (Unified Parkinson Disease Rating Scale Part III [UPDRS-III] 7-day OFF scores [∆baseline➔24 months, MedOFF/StimOFF]) and symptomatic motor improvement (UPDRS-III ON scores [%∆baseline➔24 months, MedON/StimON])., Results: Sweet spot mapping revealed a location associated with slower motor progression in the dorsolateral STN (anterior/posterior commissure coordinates: 11.07 ± 0.82mm lateral, 1.83 ± 0.61mm posterior, 3.53 ± 0.38mm inferior to the midcommissural point; Montreal Neurological Institute coordinates: +11.25, -13.56, -7.44mm). Modulating fiber tracts from supplementary motor area (SMA) and primary motor cortex (M1) to the STN correlated with slower motor progression across STN DBS subjects, whereas fiber tracts originating from pre-SMA and cerebellum were negatively associated with motor progression. Robustness of the fiber tract model was demonstrated in leave-one-patient-out (R = 0.56, p = 0.02), 5-fold (R = 0.50, p = 0.03), and 10-fold (R = 0.53, p = 0.03) cross-validation paradigms. The sweet spot and fiber tracts associated with motor progression revealed strong similarities to symptomatic motor improvement sweet spot and connectivity in this early stage PD cohort., Interpretation: These results suggest that stimulating the dorsolateral region of the STN receiving input from M1 and SMA (but not pre-SMA) is associated with slower motor progression across subjects receiving STN DBS in early stage PD. This finding is hypothesis-generating and must be prospectively tested in a larger study. ANN NEUROL 2023;94:271-284., (© 2023 American Neurological Association.)

Following its introduction in 2014 and with support of a broad international community, the open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform dedicated to localizing, reconstructing, and visualizing electrodes implanted in the human brain, in the context of deep brain stimulation (DBS) and epilepsy monitoring. Expanding clinical indications for DBS, increasing availability of related research tools, and a growing community of clinician-scientist researchers, however, have led to an ongoing need to maintain, update, and standardize the codebase of Lead-DBS. Major development efforts of the platform in recent years have now yielded an end-to-end solution for DBS-based neuroimaging analysis allowing comprehensive image preprocessing, lead localization, stimulation volume modeling, and statistical analysis within a single tool. The aim of the present manuscript is to introduce fundamental additions to the Lead-DBS pipeline including a deformation warpfield editor and novel algorithms for electrode localization. Furthermore, we introduce a total of three comprehensive tools to map DBS effects to local, tract- and brain network-levels. These updates are demonstrated using a single patient example (for subject-level analysis), as well as a retrospective cohort of 51 Parkinson's disease patients who underwent DBS of the subthalamic nucleus (for group-level analysis). Their applicability is further demonstrated by comparing the various methodological choices and the amount of explained variance in clinical outcomes across analysis streams. Finally, based on an increasing need to standardize folder and file naming specifications across research groups in neuroscience, we introduce the brain imaging data structure (BIDS) derivative standard for Lead-DBS. Thus, this multi-institutional collaborative effort represents an important stage in the evolution of a comprehensive, open-source pipeline for DBS imaging and connectomics., (Copyright © 2023. Published by Elsevier Inc.)

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming., (© 2022. The Author(s).)

The subthalamic nucleus and internal pallidum are main target sites for deep brain stimulation in Parkinson's disease. Multiple trials that investigated subthalamic versus pallidal stimulation were unable to settle on a definitive optimal target between the two. One reason could be that the effect is mediated via a common functional network. To test this hypothesis, we calculated connectivity profiles seeding from deep brain stimulation electrodes in 94 patients that underwent subthalamic and 28 patients with pallidal treatment based on a normative connectome atlas calculated from 1000 healthy subjects. In each cohort, we calculated connectivity profiles that were associated with optimal clinical improvements. The two maps showed striking similarity and were able to cross-predict outcomes in the respective other cohort (R = 0.37 at P < 0.001; R = 0.34 at P = 0.032). Next, we calculated an agreement map, which retained regions common to both target sites. Crucially, this map was able to explain an additional amount of variance in clinical improvements of either cohort when compared to the maps calculated on each cohort alone. Finally, we tested profiles and predictive utility of connectivity maps calculated from different motor symptom subscores with a specific focus on bradykinesia and rigidity. While our study is based on retrospective data and indirect connectivity metrics, it may deliver empirical data to support the hypothesis of a largely overlapping network associated with effective deep brain stimulation in Parkinson's disease irrespective of the specific target., (© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

At the group-level, deep brain stimulation leads to significant therapeutic benefit in a multitude of neurological and neuropsychiatric disorders. At the single-patient level, however, symptoms may sometimes persist despite "optimal" electrode placement at established treatment coordinates. This may be partly explained by limitations of disease-centric strategies that are unable to account for heterogeneous phenotypes and comorbidities observed in clinical practice. Instead, tailoring electrode placement and programming to individual patients' symptom profiles may increase the fraction of top-responding patients. Here, we propose a three-step, circuit-based framework with the aim of developing patient-specific treatment targets that address the unique symptom constellation prevalent in each patient. First, we describe how a symptom network target library could be established by mapping beneficial or undesirable DBS effects to distinct circuits based on (retrospective) group-level data. Second, we suggest ways of matching the resulting symptom networks to circuits defined in the individual patient (template matching). Third, we introduce network blending as a strategy to calculate optimal stimulation targets and parameters by selecting and weighting a set of symptom-specific networks based on the symptom profile and subjective priorities of the individual patient. We integrate the approach with published literature and conclude by discussing limitations and future challenges., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Brain extraction (a.k.a. skull stripping) is a fundamental step in the neuroimaging pipeline as it can affect the accuracy of downstream preprocess such as image registration, tissue classification, etc. Most brain extraction tools have been designed for and applied to human data and are often challenged by non-human primates (NHP) data. Amongst recent attempts to improve performance on NHP data, deep learning models appear to outperform the traditional tools. However, given the minimal sample size of most NHP studies and notable variations in data quality, the deep learning models are very rarely applied to multi-site samples in NHP imaging. To overcome this challenge, we used a transfer-learning framework that leverages a large human imaging dataset to pretrain a convolutional neural network (i.e. U-Net Model), and then transferred this to NHP data using a small NHP training sample. The resulting transfer-learning model converged faster and achieved more accurate performance than a similar U-Net Model trained exclusively on NHP samples. We improved the generalizability of the model by upgrading the transfer-learned model using additional training datasets from multiple research sites in the Primate Data-Exchange (PRIME-DE) consortium. Our final model outperformed brain extraction routines from popular MRI packages (AFNI, FSL, and FreeSurfer) across a heterogeneous sample from multiple sites in the PRIME-DE with less computational cost (20 s~10 min). We also demonstrated the transfer-learning process enables the macaque model to be updated for use with scans from chimpanzees, marmosets, and other mammals (e.g. pig). Our model, code, and the skull-stripped mask repository of 136 macaque monkeys are publicly available for unrestricted use by the neuroimaging community at https://github.com/HumanBrainED/NHP-BrainExtraction., (Copyright © 2021. Published by Elsevier Inc.)