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5 results on '"Rajalakshmi Rajagopalan"'

1. Clinicopathological Profile of Lung Cancer Patients in a Teaching Hospital in South India

Author

Srinath Dhandapani, Aravind Srinivasan, Rajalakshmi Rajagopalan, Santhosh Chellamuthu, Aishwarya Rajkumar, and Paramesh Palaniswamy

Subjects
Adenocarcinoma, Image Guided Biopsy, Lung Cancer, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779
Abstract

Introduction: Lung cancer is one of the leading causes of cancer related deaths in the world. The incidence of lung cancer is increasing in India and there is a need to understand the natural history of this disease. Aim of the study: To study the clinico- pathological- radiological profile of patients diagnosed with lung cancer from January 2013 to May 2015 at a tertiary care teaching hospital. Materials and Methods: Inpatient records of all patients admitted during the study period were examined and all patients with a histologically proven diagnosis of bronchogenic carcinoma were recruited. Demographic characteristics, clinical, radiological and pathological details of each patient were recorded. Results: Fifty four patients with lung cancer were identified. Forty three (79.6%) were male and 11 (20.4%) were female. Thirty two (59.7%) were smokers and 22 (40.7%) were non smokers. Cough and expectoration (61.1%) was the most common presenting symptom followed by breathlessness (59.3%). Mass lesion (81.5%) was the most common radiological presentation and adenocarcinoma (42.6%) was the most common histological subtype. When compared to fiber optic bronchoscopy, image guided percutaneous biopsy had a better yield for diagnosing lung cancer (51.9% vs 48.1%). But this difference was not statistically significant (p=0.892) Conclusion: Adenocarcinoma is replacing squamous cell carcinoma as the most common type of lung cancer in India.

Published
2016

3. Persistent Tracheo-cutaneous Fistula: A Case Report

Author

Rabeeh Parambil, Rajalakshmi Rajagopalan, Krithika Sappavoo, Nagesh Nalini Jayanthi, Siva Ashish, Bharat Shenbagaraj, and Subramaniam Suriyan

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tracheo-cutaneous, business.industry, Fistula, medicine, medicine.disease, business, Surgery
Published
2018
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4. Differentiating Pleural Effusions- Criteria Using Pleural Fluid Cholesterol

Author

Rajalakshmi Rajagopalan, Sivakumar Reddy, and Srinath Dhandapani

Subjects
lcsh:Internal medicine, Pathology, medicine.medical_specialty, business.industry, Cholesterol, pleural fluid LDH, Exudates, respiratory system, respiratory tract diseases, chemistry.chemical_compound, chemistry, medicine, Pleural fluid, pleural fluid cholesterol, lcsh:RC31-1245, business, light’s criteria
Abstract

Objective: To assess the efficacy of pleural fluid cholesterol in differentiating transudates and exudates as compared with Light’s criteria. Methods: Patients with pleural effusion during a 6-month period were enrolled in the study and underwent thoracentesis. Pleural fluid was analyzed for the levels of protein, lactate dehydrogenase (LDH), and cholesterol. Etiological diagnosis, which was established after considering clinical and biochemical factors, was the gold standard for comparison. Cut-off values for pleural fluid cholesterol were taken as 60 mg/dL and 45 mg/dL. Results: A total of 53 patients were included for final analysis. Of them, 19 were with transudates and 34 with exudates in their pleural fluids. The sensitivity, specificity, positive predictive value, and negative predictive value of the pleural fluid cholesterol (cut-off >45 mg/dL) were 97.06%, 94.74%, 97.06%, and 94.74%, respectively, for identifying exudates. These values were differentiating better than those obtained by Light’s criteria for pleural fluid cholesterol (cut-off >60 mg/dL) (p45 mg/dL) gave a higher specificity (100%) and positive predictive value (100%) but a lower sensitivity (82.93%) and negative predictive value (63.16%). Conclusion: Pleural fluid cholesterol is better than Light’s criteria for the differentiation of transudates and exudates and is less cumbersome as it does not require a simultaneous blood sampling. Cut-off value of pleural fluid cholesterol for differentiating transudates and exudates should be 45 mg/dL. Further studies are warranted to assess the efficacy of the combination of pleural fluid protein and cholesterol as criteria for classifying effusions.

Published
2016
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5. MULTI-ITEM DETERMINISTIC FUZZY INVENTORY MODEL

Author

Rajalakshmi Rajagopalan, M. Jeeva, and Venkata S. Sarma Yadavalli

Subjects
Range (mathematics), Mathematical optimization, Multi-item, EOQ, crisp, fuzzy set theory, membership functions, manpower planning, Fuzzy set, Fuzzy set operations, Fuzzy number, Ocean Engineering, Sensitivity (control systems), Economic order quantity, Management Science and Operations Research, Fuzzy logic, Membership function, Mathematics
Abstract

In this note, a fuzzy inventory model with multiple items is considered. Economic order quantities (EOQs) are developed for these items. The costs involved in inventory are always assumed to be exact, otherwise called as crisp or hard, but in practice these costs are not exact or precise but vary over a range. In such cases an application of fuzzy set theory plays a vital role in obtaining the EOQ. An application of this model to manpower planning is studied with an example; sensitivity analysis is also made.

Published
2005
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