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Summary: Background: Globally, fall-related injuries are a substantial problem, and 80% of fatal falls occur in low-income and middle-income countries. We aimed to measure time from injury to hip-fracture surgery in people aged 50 years or older living in low-income and middle-income regions, as well as to measure the proportion of patients with surgical stabilisation of their hip fracture within 72 h of admission to hospital and to identify risk factors associated with surgical delay. Methods: For this secondary analysis, we analysed data collected from Africa, Latin America, China, India, and Asia (excluding China and India) for the International Orthopaedic Multicentre Study in Fracture Care (INORMUS) between March 29, 2014, and June 15, 2022. Patients from INORMUS were included in this analysis if they were aged 50 years or older and had an isolated, primary hip fracture sustained from a ground-level fall. Staff at participating hospitals identified patients with musculoskeletal injury and referred them for assessment of eligibility. We report time from injury to surgery as three distinct time periods: time from injury to hospital admission, time from admission to surgery, and a total time from injury to surgery. Date and time of injury were self-reported by patients at the time of study recruitment. If time to hospital admission after injury exceeded 24 h, patients reported the primary reason for delayed admission. Reasons for surgery, no surgery, and surgical delay were reported by the treating team. For patients undergoing surgery, multivariable regression analyses were used to identify risk factors for surgical delay. Findings: 4486 adults aged 50 years or older with an isolated, primary hip fracture were enrolled in INORMUS from 55 hospitals in 24 countries. Countries were grouped into five regions: Africa (418 [9·3%] of 4486), Latin America (558 [12·4%]), China (1680 [37·4%]), India (1059 [23·6%]) and Asia (excluding China and India; 771 [17·2%]). Of 4486 patients, 3805 (84·8%) received surgery. The rate of surgery was similar in all regions except in Africa, where only 193 (46·3%) of 418 patients had surgery. Overall, 2791 (62·2%) of 4486 patients were admitted to hospital within 24 h of injury. However, 1019 (22·7%) of 4486 patients had delayed hospital admission of 72 h or more from injury. The two most common reasons for delayed admission of more than 24 h were transfer from another hospital (522 [36·2%] of 1441) and delayed care-seeking because patients thought the injury would heal on its own (480 [33·3%]). Once admitted to hospital, 1451 (38·1%) of 3805 patients who received surgery did so within 72 h (median 4·0 days [IQR 1·7–6·0]). Regional variation was seen in the proportion of patients receiving surgery within 72 h of hospital admission (92 [17·9%] of 514 in Latin America, 53 [27·5%] of 193 in Africa, 454 [30·9%] of 1471 in China, 318 [44·4%] of 716 in Asia [excluding China and India], and 534 [58·6%] of 911 in India). Of all 3805 patients who received operative treatment, 2353 (61·8%) waited 72 h or more from hospital admission. From time of injury, the proportion of patients who were surgically stabilised within 72 h was 889 (23·4%) of 3805 (50 [9·7%] of 517 in Latin America, 31 [16·1%] of 193 in Africa, 277 [18·8%] of 1471 in China, 189 [26·4%] of 716 in Asia [excluding China and India], and 342 [37·5%] of 911 in India). Interpretation: Access to surgery within 72 h of hospital admission was poor, with factors that affected time to surgery varying by region. Data are necessary to understand existing pathways of hip-fracture care to inform the local development of quality-improvement initiatives. Funding: The National Health and Medical Research Council of Australia, the Canadian Institutes of Health Research, McMaster Surgical Associates, Hamilton Health Sciences, and the US National Institutes of Health.

Summary: Background: The Lancet Commission on Global Surgery established the Three Delays framework, categorising delays in accessing timely surgical care into delays in seeking care (First Delay), reaching care (Second Delay), and receiving care (Third Delay). Globally, knowledge gaps regarding delays for fracture care, and the lack of large prospective studies informed the rationale for our international observational study. We investigated delays in hospital admission as a surrogate for accessing timely fracture care and explored factors associated with delayed hospital admission. Methods: In this prospective observational substudy of the ongoing International Orthopaedic Multicenter Study in Fracture Care (INORMUS), we enrolled patients with fracture across 49 hospitals in 18 low-income and middle-income countries, categorised into the regions of China, Africa, India, south and east Asia, and Latin America. Eligible patients were aged 18 years or older and had been admitted to a hospital within 3 months of sustaining an orthopaedic trauma. We collected demographic injury data and time to hospital admission. Our primary outcome was the number of patients with open and closed fractures who were delayed in their admission to a treating hospital. Delays for patients with open fractures were defined as being more than 2 h from the time of injury (in accordance with the Lancet Commission on Global Surgery) and for those with closed fractures as being a delay of more than 24 h. Secondary outcomes were reasons for delay for all patients with either open or closed fractures who were delayed for more than 24 h. We did logistic regression analyses to identify risk factors of delays of more than 2 h in patients with open fractures and delays of more than 24 h in patients with closed fractures. Logistic regressions were adjusted for region, age, employment, urban living, health insurance, interfacility referral, method of transportation, number of fractures, mechanism of injury, and fracture location. We further calculated adjusted relative risk (RR) from adjusted odds ratios, adjusted for the same variables. This study was registered with ClinicalTrials.gov, NCT02150980, and is ongoing. Findings: Between April 3, 2014, and May 10, 2019, we enrolled 31 255 patients with fractures, with a median age of 45 years (IQR 31–62), of whom 19 937 (63·8%) were men, and 14 524 (46·5%) had lower limb fractures, making them the most common fractures. Of 5256 patients with open fractures, 3778 (71·9%) were not admitted to hospital within 2 h. Of 25 999 patients with closed fractures, 7141 (27·5%) were delayed by more than 24 h. Of all regions, Latin America had the greatest proportions of patients with delays (173 [88·7%] of 195 patients with open fractures; 426 [44·7%] of 952 with closed fractures). Among patients delayed by more than 24 h, the most common reason for delays were interfacility referrals (3755 [47·7%] of 7875) and Third Delays (cumulatively interfacility referral and delay in emergency department: 3974 [50·5%]), while Second Delays (delays in reaching care) were the least common (423 [5·4%]). Compared with other methods of transportation (eg, walking, rickshaw), ambulances led to delay in transporting patients with open fractures to a treating hospital (adjusted RR 0·66, 99% CI 0·46–0·93). Compared with patients with closed lower limb fractures, patients with closed spine (adjusted RR 2·47, 99% CI 2·17–2·81) and pelvic (1·35, 1·10–1·66) fractures were most likely to have delays of more than 24 h before admission to hospital. Interpretation: In low-income and middle-income countries, timely hospital admission remains largely inaccessible, especially among patients with open fractures. Reducing hospital-based delays in receiving care, and, in particular, improving interfacility referral systems are the most substantial tools for reducing delays in admissions to hospital. Funding: National Health and Medical Research Council of Australia, Canadian Institutes of Health Research, McMaster Surgical Associates, and Hamilton Health Sciences.

3-methoxy-4-(1-phenyl-1H-benzimidazol-2-yl)phenol (MPBP) was synthesized by adding N-phenyl-o-phenylenediamine, 4-hydroxy-2-methoxybenzaldehyde and ammonium acetate in the presence of ethanol and nano silica at 80 °C. Newly synthesized benzimidazole was characterized by proton NMR, carbon NMR, LC-Mass spectral studies and elemental analysis. Nickel alloys play a major role in fields like automobiles and ship building owing to their stability in Acid, Base and Saline environments. CNT's are having high stability against corrosion. So it has been planned to prepare 3-methoxy-4-(1-phenyl-1H-benzimidazol-2-yl)phenol-functionalized carbon nanotubes for corrosion-inhibiting barrier layer on nickel alloy surfaces. The evidence of corrosion inhibition efficiency of 3-methoxy-4-(1-phenyl-1H-benzimidazol-2-yl)phenol-functionalized carbon nanotubes coated on nickel alloys was confirmed by FTIR spectral studies (essence of spectra need to include). The nature of inhibition of corrosion was determined using electrochemical methods. 3-methoxy-4-(1-phenyl-1H-benzimidazol-2-yl) phenol functionalized CNTs displayed excellent corrosion inhibition on the nickel alloy surface. [ABSTRACT FROM AUTHOR]

The recycling of semisynthetic metalworking fluids (MWFs) using alumina membranes is significantly impacted by aggregated MWF microemulsions that cause partial and complete blocking of membrane pores. In this paper, computational fluid dynamic methods are employed to model both a portion of a sintered alumina membrane with tortuous pores and the microemulsions passing through it. Several particle size distributions, measured experimentally at various times through the membrane service life and under two different cross-flow velocities, were used to determine the particle sizes simulated in the flow. Simulated MWF particles smaller than the largest pore diameter were found to completely block the pore through the build-up of a network of particles that blocked smaller diameter inlets and outlets. The results demonstrate as well that significant membrane flux reduction can occur by partial blocking of pore inlets and outlets even in the absence of complete blocking. [DOI: 10.1115/1.2976149]

In this paper, the fouling of sintered [alpha]-alumina membranes by an uncontaminated semisynthetic metalworking fluid (MWF) is addressed. Experimental evidence of the form of flux reduction curves, scanning electron microscope images of the membranes, and MWF particle size measurements is used to identify two fouling mechanisms, pore blocking and partial pore blocking, as the major contributors to flux decline. A probability-based mechanistic model is developed based on the time-dependent particle size distribution and membrane pore sizes. The model is fitted to experimental data from two commonly used membrane pore sizes with good agreement. Partial blocking is shown to be a predominant first step in the pore blocking mechanism in microfiltration of semisynthetic MWFs due to the tortuous nature of the pores present in sintered ceramic membranes. [DOI: 10.1115/1.2953234] Keywords: microfiltration, metalworking fluids, cutting fluids, membrane fouling

Membrane microfiltration is a promising technology that has been shown to extend metalworking fluid (MWF) life by eliminating contaminants while allowing the fluid to stay in use. However, the efficacy of this technology is compromised by the clogging of the filter pores in a process known as membrane fouling. In this paper the fouling issue is addressed by the development of a semi-synthetic MWF specifically designed to not foul microfiltration membranes. The composition of the designed MWF is discussed and compared with a commercial MWF. Cross-flow microfiltration fouling tests were carried out in low-pressure, high-velocity conditions on ceramic [alpha]-alumina membranes. Several common MWF components are shown not to be factors of membrane fouling on these membranes. The flux of the designed fluid was found to reach an immediate steady state at about twice the value of the steady-state flux of the tested commercial fluid. Scanning electron microscope imaging was used to further evaluate membrane fouling by each fluid. The machining capabilities of the designed fluid were examined in terms of cutting forces and machining temperature. [DOI: 10.1115/1.2401207] Keywords: microfiltration, membrane fouling, metalworking fluids

This paper discusses the influence of metalworking fluid management policy and operational changes on metalworking fluid functionality in terms of lubricating and cooling ability. Several important pathways for metalworking fluid depletion are reviewed. Using an instrumented drilling-based test-bed, the effects of lubricating component depletion, microfiltration, and dilutant water hardness were assessed. It was observed that microfiltration had no effect on fluid functionality. Increases in dilutant water hardness were found to produce decreases in drilling forces and temperature. Additionally, increasing dilutant hardness decreased microfiltration flux, but this effect can be counteracted with the addition of a chelating agent. [DOI: 10.1115/1.1765145]

Certain components found in metalworking fluid formulations are known to be prone to selective depletion via adsorption onto the surfaces of particulate generated during metal cutting operations. The characteristics of adsorption for a multi-component synthetic metalworking fluid are investigated in order to determine the affect that machining particulate contamination has on component depletion from this fluid. Experimental measurements indicate that the corrosion inhibiting component of the formulation is especially prone to depletion via the adsorption mechanism. A Langmuir isotherm/mass balance based predictive model is developed to determine the effect of chip adsorption on depletion from industrial metalworking fluid systems and is experimentally verified. An industrial case study is applied to further investigate selective component depletion via the adsorption mechanism.

Functional component depletion and physical interaction of contaminants with the machining process are thought to be the primary determinants of metalworking fluid useful life. An oil/water partition coefficient and mass balance based model is derived that is capable of accounting for the effect of tramp oil induced extraction of metalworking fluid components. After developing general expressions for the predictive model the magnitude of extraction for a synthetic metalworking fluid is investigated. The model is then used to predict system concentrations over time in the presence of such metalworking fluid contaminants and is verified via laboratory experimentation and an industrial case study. The partition coefficient/mass balance modeling procedure is further utilized to determine the amounts and frequency required for tankside addition of metalworking fluid components, while accounting for depletion by the tramp oil mechanism. [DOI: 10.1115/1.1537259]

Microfiltration is capable of reducing health hazards and environmental pollution associated with metalworking fluids (MWFs) by enabling recycling and microbial removal. This paper investigates chemical characteristics of MWFs that can lead to flux decline during microfiltration using aluminum oxide membranes by studying the family of polyoxyalkylene diblock copolymers comprised of ethylene oxide and propylene oxide. These copolymers are commonly used as lubricant additives in metalworking fluids and serve as a model for beginning to understand the relationship between metalworking fluid formulation and microfiltration flux. It is found that increasing the hydrophobic content of the copolymers can lead to reduced flux. Anionic modification and increasing molecular weight of the copolymers can also lead to reduced flux. Insufficient cleaning of anionic copolymers from the membrane leads to pH-dependent flux of deionized water during subsequent filtration. The pH-dependence of flux arises due to swelling caused by electrostatic repulsions between the aluminum oxide surface and anionic copolymers that remain adsorbed to the surface of the membrane. This swelling serves to resist permeate flow above the isoelectric point of aluminum oxide. This phenomenon is observed directly using Field Emission Environmental Scanning Electron Microscopy (FE-ESEM). [DOI: 10.1115/1.1392993]

4-Aminobutyltriethoxysilane functionalized TiO2 nanoparticles (TiO2-ABTES) dispersed diglycidyl ethers of bisphenol-A (DGEBA-GY260) were studied for antimicrobial applications. Epoxy nano-hybrid coatings of four different concentrations (1, 3, 5 and 7 wt %) were developed using TiO2-ABTES as the dispersed phase and a commercially available DGEBA as the matrix phase. Triethylenetetramine (TETA) used to cure the nanocomposites films. The structural characteristics of these materials were investigated by Fourier transform infrared spectral studies, Scanning electron microscopy and atomic force microscope analysis. The surface characteristics of the samples were estimated from contact angle measurements and calculated surface free energy and adhesion energy. The bacteriological tests were done using the agar diffusion method with different concentrations of TiO2-ABTES. The antimicrobial activity test noted that the antimicrobial activity of 7 wt% TiO2-ABTES nanoparticles loaded epoxy nanocomposite film has a better inhibition zone against all pathogens under study. [ABSTRACT FROM AUTHOR]