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The economic vitality of a nation is contingent upon the advancement of its manufacturing sectors, given their pivotal role in fostering economic growth. These industries frequently encounter challenges such as mitigating deterioration rates, enhancing revenue and reducing overall costs to optimize profits. Consequently, should an item deteriorate while in stock within manufacturing facilities, it results in a gradual escalation of holding costs and total expenses. In this paper discusses determining the most effective production policy for items prone to degradation, analyzing depreciating items using three-stage production inventory models with trapezoidal demand to minimize holding costs based on time-dependent factors in the manufacturing sector. This model aims to decrease overall costs and production time periods, contrasting with the higher cost values of the price-based constant method. Mathematical formulas were developed using MATLAB R2023b to validate the models findings and minimize the inventory systems cost.

Agrarian occupational health is a neglected primary health-care service in India. A nurse-led health promotion program is planned based on a Conceptual Model for the Occupational Health Nurse Specialist prepared by Ms. Janice Dees (1984) inspired from Orem's self-care theory. The interventions included are range of motion exercise, progressive muscle relaxation technique, foot and palm massage, and literacy on safety practices. The wellness of field farmers is expected by following this program plan.

Background: Zincovit tablet is combination of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement. Aims: To investigate the influence of single combined formulation of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement tablets (Zincovit) on lipid profile in normal and diet-induced hypercholesterolemic rats. Materials and Methods: Anti-hyperlipidemic activity of combined formulation of grape seed extract and Zincovit tablets doses ranged from 40 to 160 mg/kg, p.o. was evaluated in normal and diet-induced hypercholesterolemic rats. Results: Hypercholesterolemic animals treated with combined formulation of grape seed extract and Zincovit tablets (nutritional food supplement) at 40, 80 and 160 mg/kg exhibited drastic decrease in serum triglycerides, total cholesterol, LDL-C, VLDL-C and rise of HDL-C in comparison to hypercholesterolemic control group animals. The anti-hyperlipidemic effect of single combined formulation of grape seed extract and Zincovit tablet was comparable with the standard drug atorvastatin treated animals and the variations were statistically non-significant. There was no significant impact of combined formulation of grape seed extract and Zincovit tablets on lipid profile among normal animals in comparison with normal control group. Conclusion: The present study demonstrated that the single combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against diet-induced hypercholesterolemia in Wistar rats.

This study further extends a theoretical model of psychological empowerment by investigating the relationships between self-efficacy, self-confidence and self-esteem. A sample of 383 of Malaysian undergraduates participating in Work Integrated Learning (WIL) programmes across five public universities is used to test the model employing partial-least squares based structural equation modelling. The results have demonstrated that self-efficacy and self-esteem have a positive and significant relationship with self-confidence. This study also confirms the moderating effect of self-esteem on the relationship between self-efficacy and self-confidence. Furthermore, the findings of this study provide insight about psychological attributes of undergraduates participated in WIL programmes. These findings have implications for WIL stakeholders, which are highlighted in the paper.

The tribal communities in South India, especially those in the Wayanad region in the proximity of Kerala state, have low literacy rates and occupy a socio-culturally marginalized status among various demographic clusters in India. The pedagogies employed through mainstream schooling do not appeal to the students in the tribal community, resulting in high dropout rates. Therefore, Madras Christian College, Chennai, has identified tribal communities as an underrepresented group in Indian science education proposing to engage them through "Service Learning Science Camps". Herein we document our activities as formative assessment through teaching chemistry to tribal school children and consolidate the experiences gained by both the student volunteers and tribal students for prospective research. The program enabled the student mentors to explore their leadership skills while administering the science camps. In addition to this, the camps created a pleasurable environment for learning chemistry for the tribal children and increased their inclination toward science. This exercise helps students to change their perception toward tribals and bridge the gap between them by providing a welcoming and supportive environment for pleasurable learning. We propose these camps as a model to reach out and popularize chemistry among the overlooked communities, simultaneously nurturing the minds of college students toward creating an inclusive future.

Introduction: Chloroform, a halogenated hydrocarbon, causes central nervous depression, hepatotoxicity, nephrotoxicity, and rhabdomyolysis. Historically, chloroform had been used as a general anaesthetic and today is still used in chemical industries. Lack of proper personal protective equipment and adequate knowledge about its toxic effects can lead to serious harm.Case report: A 33-year-old gentleman presented to the emergency department (ED) with altered mental status. Given his depressed mental status, the decision was made to intubate shortly after arrival for airway protection. Further history raised suspicion of occupational chloroform exposure. Brown-colored urine further strengthened suspicion of chloroform poisoning with resultant rhabdomyolysis. Forced alkaline diuresis and N-acetylcysteine were started in the ED. His mental status and respiratory efforts improved on hospital day two, and he was ultimately extubated. Creatine phosphokinase and myoglobin levels were initially high but gradually came down by hospital day six. On hospital day 10, the patient was deemed stable and safely discharged.Conclusion: A patient with chloroform inhalation who suffered resultant rhabdomyolysis and hepatotoxicity was successfully treated with early initiation of forced alkaline diuresis, N-acetylysteine, and hemodialysis.

The sudden COVID-19 outbreak has obstructed the conventional method of teaching causing a mandated shift to virtual platforms. A developing country like India which predominantly depended on conventional methods of teaching and learning in the pre-COVID era is gradually gaining success in effectively transitioning into virtual classrooms with the aid of digital programs and online platforms to resume theoretical education. However, chemistry education, in particular, which involves the physical approach to experimentation in conventional laboratories, requires a practical and effective alternative in the virtual arena. Though the country's digital progress has provided virtual experiments that can be helpful in laboratory learning, only very few instructors/teachers are aware of such opportunities. The adaptability and accessibility to virtual laboratories in the Indian context also remain unclear due to various factors that influence the transition from conventional laboratories to virtual laboratories. Therefore, we attempted to evaluate the learning prospects of students by taking up the Royal Society of Chemistry (RSC) screen experiments for virtual titration as an example. This article aims to reflect information from the feedback of students on their first virtual laboratory experience and after completing an academic year to record learning outcomes in comparison to their prior experience on conventionally carrying out titration experiments and to highlight the features of the virtual laboratories that were preferred by students. Among the various components of the virtual laboratory, students state that the quiz is a component that is engaging and ensures knowledge progression. Conclusively, the students perceive that virtual laboratory experiments should be an integrated part of the laboratory curriculum for enhanced learning. In summary, our work throws light on the need for virtual laboratories in chemistry education in India and its prospect in the postpandemic period.

Abstract Background The indiscriminate use of synthetic insecticides is not affordable and poses collateral damage to humans, non-target organisms, and environmental health. Bacillus thuringiensis (Bt) is a cosmopolitan, antagonistic soil bacterium employed as an alternative to chemical insecticides in pest management. In this study, genetic diversity and insecticidal activity of 50 indigenous Bt isolates were investigated in order to find the effective Bt isolates with a broad spectrum of insecticidal activity against lepidopteran insects. Results Most of the Bt isolates investigated appeared as creamy white in colour and fried egg or mucoid-type colonies having a flat or raised elevation with entire or undulated margins. Out of 50 isolates investigated, crystal shapes varied from cuboidal (40.00%), spherical (36.00%), bipyramidal (30.00%), rectangular (10.00%), and minute crystal attached to the spores (28.00%). SDS-PAGE analysis revealed that the molecular weight of the crystal proteins of Bt isolates ranged from ~ 30 to ~ 200 kDa in size. Among the Bt isolates screened, ~ 135 kDa size representing Cry1 protein was observed in 12 isolates (24.00%) and 65 kDa representing Cry2 was observed in 14 isolates (28.00%). PCR analysis was performed for cry1, cry2, cry3, cry4, cry9, vip1, vip2, and vip3 genes, which revealed the presence of cry1 gene alone in 5 isolates, and cry2 alone in 7 isolates, whereas 7 isolates were positive for cry1, cry2, and vip3 genes together. None of the Bt isolates showed the presence of cry3, cry4, cry9, vip1, and vip2 genes. Toxicity of Bt isolates was tested against four species of lepidopteran larvae, viz. Plutella xylostella Linnaeus, Helicoverpa armigera Hubner, Spodoptera litura Fabricius, and S. frugiperda Smith. Among them, 6 isolates (T29, T30, T31, T357, T381, and T388) produced 100% larval mortality against all four species of insects. Conclusion The present study showed the diversity of Bt isolates and confirmed the significance of relentless exploration of Bt isolates for novel genes. Further investigations need to be carried out to disclose the hidden potential of these toxic isolates.

Abstract Literature review demonstrated a surprising lack of publications on digital e-learning pathology resources for senior medical undergraduates and interns. An interactive Digital Pathology Repository (iDPR) integrating two- and three-dimensional (2D, 3D) high-resolution anatomical pathology images with correlated digital histopathology was developed. The novel iDPR was rigorously evaluated using mixed methods to assess pathology knowledge gains (pre- and post-tests), quality impact analysis (questionnaire), user feedback (focus group discussions) and user visual behaviour (eye gaze tracking analysis of 2D/ 3D images). Exposure to iDPR appeared to improve user pathology knowledge, as observed by significantly increased test scores on topic-related quizzes (n = 69, p