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213 results on '"Rajadurai, Pathmanathan"'

4. Gene expression signature for predicting homologous recombination deficiency in triple-negative breast cancer.

Author

Pan, Jia-Wern, Tan, Zi-Ching, Ng, Pei-Sze, Zabidi, Muhammad Mamduh Ahmad, Nur Fatin, Putri, Teo, Jie-Ying, Hasan, Siti Norhidayu, Islam, Tania, Teoh, Li-Ying, Jamaris, Suniza, See, Mee-Hoong, Yip, Cheng-Har, Rajadurai, Pathmanathan, Looi, Lai-Meng, Taib, Nur Aishah Mohd, Rueda, Oscar M., Caldas, Carlos, Chin, Suet-Feung, Lim, Joanna, and Teo, Soo-Hwang

Published
2024
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5. Consensus Guidelines on Human Epidermal Growth Factor Receptor 2 (HER2)-Low Testing in Breast Cancer in Malaysia.

Author

Rajadurai, Pathmanathan, Ravindran, Sarala, Lee, Bang Rom, Md Pauzi, Suria Hayati, Chiew, Seow Fan, Teoh, Kean Hooi, S. Raja Gopal, Navarasi, Md Yusof, Mastura, and Yip, Cheng Har

Subjects
*CONSENSUS (Social sciences), *RESEARCH funding, *IN situ hybridization, *TERMS & phrases, *BREAST tumors, *EARLY detection of cancer, *CLINICAL trials, *CANCER patients, *IMMUNOHISTOCHEMISTRY, *QUALITY assurance, *EPIDERMAL growth factor receptors
Abstract

Simple Summary: At least 50% of breast cancers are estimated to belong to the 'human epidermal growth factor receptor 2 (HER2)-low' category. Since HER2-low breast cancer is amenable to targeted treatment with anti-HER2 antibody-drug conjugates, accurate assessment of patients' HER2-low status is crucial for qualifying them for this treatment. Despite the 2018 American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP) guidelines recognizing the clinical relevance of HER2-low testing, discrepancies in HER2 testing across laboratories globally hinder an accurate identification of HER2-low patients. To overcome these limitations, this consensus guideline aims to elucidate best practices for HER2 testing and HER2-low scoring in breast cancer. This guideline, while adapted to the Malaysian landscape, reflects recommendations from the latest international guidelines to guide pathologists in performing HER2 testing and address common issues faced in the Malaysian context, thus improving the quality of HER2 testing and ensuring the best available cancer care. Breast cancer is one of the most common cancers in Malaysia. Recently, a new nomenclature was introduced for breast cancers with human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) 1+, or 2+ with negative in situ hybridization (ISH), i.e., HER2-low breast cancer. In current clinical practice, these breast cancers are reported as HER2-negative. Clinical trials have shown that HER2-low breast cancer benefits from targeted therapy with anti-HER2 antibody-drug conjugates. Unfortunately, various challenges and obstacles are faced by local pathologists in HER2 testing, which may jeopardize the standard of care for patients with HER2-low breast cancer. This consensus guideline aims to elucidate standard practices pertaining to HER2 testing and HER2-low interpretation in Malaysia. Topics discussed among a panel of local experts include tissue sampling and handling, assay and antibody selection, result interpretation and reporting, and quality assurance. Practice recommendations made in this consensus guideline reflect current international guidelines and, where appropriate, adapted to the Malaysian landscape. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Supplementary Table 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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7. Supplementary Figure 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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8. Supplementary Methods from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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9. Supplementary Figure 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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10. Supplementary Figure 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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11. Supplementary Figure 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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12. Supplementary Table 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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13. Supplementary Table 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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14. Supplementary Table 8 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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15. Supplementary Table 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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16. Supplementary Table 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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17. Supplementary Figure 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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18. Supplementary Figure 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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19. Supplementary Table 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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20. TABLE 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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21. Supplementary Table 9 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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22. Supplementary Table 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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23. Establishment and characterization of an Epstein-Barr virus-positive cell line from a non-keratinizing differentiated primary nasopharyngeal carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, additional, Lee, Hui Mei, additional, Abdul Aziz, Norazlin, additional, Yee, Pei San, additional, Marzuki, Marini, additional, Wong, Ka Wo, additional, Chiang, Alan K.S., additional, Chow, Larry Ka-Yue, additional, Dai, Wei, additional, Liu, Teng Fei, additional, Tan, Lu Ping, additional, Khoo, Alan Soo Beng, additional, Lo, Kwok Wai, additional, Lim, Paul VH, additional, Rajadurai, Pathmanathan, additional, Lightfoot, Howard, additional, Barthorpe, Syd, additional, Garnett, Mathew J, additional, and Cheong, Sok Ching, additional

Published
2024
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24. Clustering of HR+/HER2- breast cancer in an Asian cohort is driven by immune phenotypes

Author

Pan, Jia-Wern, primary, Ragu, Mohana Eswari, additional, Chan, Wei-Qin, additional, Hasan, Siti Norhidayu, additional, Islan, Tania, additional, Teoh, Li-Ying, additional, Jamaris, Suniza, additional, See, Mee-Hoong, additional, Yip, Cheng-Har, additional, Rajadurai, Pathmanathan, additional, Looi, Lai-Meng, additional, Mohd Taib, Nur Aishah, additional, Rueda, Oscar M, additional, Caldas, Carlos, additional, Chin, Suet-Feung, additional, Lim, Joanna, additional, and Teo, Soo-Hwang, additional

Published
2023
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31. Atypical presentation of renal cell carcinoma: a case report

Author

Arumugam, Gunalan Palari, primary, Sachithanandan, Anand, additional, Bikin, Mohamad Isa, additional, Mariappan, Bala Sundaram, additional, Khoo, Li Ser, additional, Thamutaram, Haritharan, additional, Choy, Chun Ngok, additional, Abdul Rahman, Mohd Haris Fadzillah bin, additional, Tan, Kia Lean, additional, Rajadurai, Pathmanathan, additional, Letchumanasamy, Yogendren, additional, and Md Yusof, Mastura binti, additional

Published
2022
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33. Gene signature for predicting homologous recombination deficiency in triple-negative breast cancer

Author

Pan, Jia-Wern, primary, Ng, Pei-Sze, additional, Zabidi, Muhammad Mamduh Ahmad, additional, Nur Fatin, Putri, additional, Teo, Jie-Ying, additional, Hasan, Siti Nurhidayu, additional, Yip, Cheng-Har, additional, Rajadurai, Pathmanathan, additional, Looi, Lai-Meng, additional, Taib, Aishah M, additional, Rueda, Oscar M, additional, Caldas, Carlos, additional, Chin, Suet-Feung, additional, Lim, Joanna Mei Ch'Wan, additional, and Teo, Soo-Hwang, additional

Published
2022
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37. sj-docx-1-cpj-10.1177_00099228211070397 ��� Supplemental material for Turning Blue With a Cry: More Than Meets the Eye

Author

Woodhull, Sanjay, Wang, Justin Qi Yuee, Kulasegarah, Jeyanthi, Terumalay, Sangita Dharshini, Rajadurai, Pathmanathan, Tan, Zhong Yang, and Nathan, Anna Marie

Subjects
FOS: Clinical medicine, 111403 Paediatrics
Abstract

Supplemental material, sj-docx-1-cpj-10.1177_00099228211070397 for Turning Blue With a Cry: More Than Meets the Eye by Sanjay Woodhull, Justin Qi Yuee Wang, Jeyanthi Kulasegarah, Sangita Dharshini Terumalay, Pathmanathan Rajadurai, Zhong Yang Tan and Anna Marie Nathan in Clinical Pediatrics

Published
2022
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38. Turning Blue With a Cry: More Than Meets the Eye

Author

Woodhull, Sanjay, primary, Wang, Justin Qi Yuee, additional, Kulasegarah, Jeyanthi, additional, Terumalay, Sangita Dharshini, additional, Rajadurai, Pathmanathan, additional, Tan, Zhong Yang, additional, and Nathan, Anna Marie, additional

Published
2022
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39. Abstract P5-13-25: PIK3CA registry: A noninterventional, descriptive, retrospective cohort study of PIK3CA mutations in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)

Author

Rajadurai, Pathmanathan, primary, Semiglazova, Tatiana, additional, Hegmane, Alinta, additional, Karak, Fadi El, additional, Chiu, Joanne W, additional, Gupta, Sudeep, additional, Azim, Hamdy A, additional, Kitzen, Josef JEM, additional, Arnaud, Antoine, additional, Haftchenary, Sina, additional, Wu, Jiwen, additional, Menon-Singh, Lakshmi, additional, Smith, LaTonya, additional, and Zhukova, Lyudmila, additional

Published
2022
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43. Abstract P3-08-03: Dissecting the heterogeneity of metaplastic breast cancer: A morphological, immunohistochemical and genomic analysis of a large cohort

Author

JC Liu, Lauren Kalinowski, QC Xu, M Bettington, Stephen B. Fox, JM Saunus, Puay Hoon Tan, E Kalaw, Kate J. Johnstone, Sunil R. Lakhani, Sandra A O'Toole, Katia Nones, A.E. McCart Reed, Kaltin Ferguson, Gary Tse, Irma Gresshoff, Colleen Niland, Peter T. Simpson, Rin Yamaguchi, David Papadimos, Stephen H. Kazakoff, LE Reid, Nick Waddell, Jamie R. Kutasovic, Gavin Harris, D Black, James Bennett, Andrew Scott Reid, Morgan R. Davidson, Rajadurai Pathmanathan, John V. Pearson, Malcolm Lim, Nirmala Pathmanathan, and Ashwini Raghavendra

Subjects
Oncology, Cancer Research, medicine.medical_specialty, biology, CD44, Cancer, medicine.disease, Breast cancer, Internal medicine, Cohort, biology.protein, medicine, PTEN, Stage (cooking), Survival rate, Exome sequencing
Abstract

Although rare, Metaplastic Breast Carcinomas (MBC) account for significant global breast cancer mortality. This subgroup is extremely heterogeneous and by definition exhibits metaplastic change to squamous and/or mesenchymal elements, including but not limited to spindle, squamous, chondroid, osseous and rhabdomyoid elements. The WHO working group recognizes that the current classification is inadequate and in the interim, has suggested a purely descriptive classification. The mixed epithelial-mesenchymal morphology has led to speculation that MBC represent 'stem cell tumours'; in support of this, MBC have been shown to have a CD44+/CD24-/low phenotype. Clinically, patients present with tumours that are larger (higher stage), have increased likelihood of distant metastases at presentation and overall, have a reduced 5-year survival rate compared to Invasive Carcinoma-NST. Hence, this is a unique subtype with poor outcome but without a robust classification or understanding of the biology to aid clinical management. We present a detailed morphological, immunohistochemical and genomic analysis of a large series of MBC (n=347), as amassed through the Asia-Pacific MBC consortium. We consider our morphological dissection using the WHO subtyping guidelines and show that an increasing number of phenotypes in a mixed MBC (classified as WHO_1) significantly associates with a poor prognosis. Immunohistochemical analysis showed that a pure spindle (WHO_5) is significantly less likely to express vimentin, CK5/6, CK14, and CK19 than a mixed WHO_1 with spindle features. Similarly, a WHO_1 with chondroid features is less likely to express EGFR than WHO_1 with chondroid features and rhabdoid or osseous differentiation. Across the cohort, positivity for the AE1/3 antibody and a lack of EGFR expression both significantly associate with a better outcome. We report no significant association between patient age at diagnosis and breast cancer specific survival, nor between age and specific WHO MBC subtypes. We report a significant association between WHO_1 types and increasing tumour grade, and also between tumour size and grade, with tumour size being a highly significant prognostic indicator in this cohort. Our exome sequencing confirms a significant enrichment for TP53 and PTEN mutations in MBC, and intriguingly for concurrent mutations of TP53, PTEN and PIK3CA. A novel enrichment for NF1 mutations is also presented. In summary, we provide a thorough assessment of a large cohort of MBC, including morphology, survival, IHC and exome sequencing, and present our analysis contextualized by the WHO guidelines, extending the existing knowledge base of this rare tumour type. Citation Format: McCart Reed AE, Kalaw E, Nones K, Bettington M, Lim M, Bennett J, Johnstone K, Kutasovic JR, Kazakoff S, Xu QC, Saunus JM, Reid LE, Black D, Niland C, Ferguson K, Gresshoff I, Raghavendra A, Liu JC, Kalinowski L, Reid AS, Davidson M, Pearson JV, Yamaguchi R, Harris G, Tse G, Papadimos D, Pathmanathan R, Pathmanathan N, Tan PH, Fox S, O'Toole S, Waddell N, Simpson PT, Lakhani SR. Dissecting the heterogeneity of metaplastic breast cancer: A morphological, immunohistochemical and genomic analysis of a large cohort [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P3-08-03.

Published
2019

44. EGFR Mutation Testing Practices within the Asia Pacific Region: Results of a Multicenter Diagnostic Survey

Author

Yatabe, Yasushi, Kerr, Keith M., Utomo, Ahmad, Rajadurai, Pathmanathan, Tran, Van Khanh, Du, Xiang, Chou, Teh-Ying, Enriquez, Ma. Luisa D., Lee, Geon Kook, Iqbal, Jabed, Shuangshoti, Shanop, Chung, Jin-Haeng, Hagiwara, Koichi, Liang, Zhiyong, Normanno, Nicola, Park, Keunchil, Toyooka, Shinichi, Tsai, Chun-Ming, Waring, Paul, Zhang, Li, McCormack, Rose, Ratcliffe, Marianne, Itoh, Yohji, Sugeno, Masatoshi, and Mok, Tony

Published
2015
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50. GermlineAPOBEC3Bdeletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype,PIK3CAmutations and immune activation

Author

Pan, Jia‐Wern, primary, Zabidi, Muhammad Mamduh Ahmad, additional, Chong, Boon‐Keat, additional, Meng, Mei‐Yee, additional, Ng, Pei‐Sze, additional, Hasan, Siti Norhidayu, additional, Sandey, Bethan, additional, Bahnu, Saira, additional, Rajadurai, Pathmanathan, additional, Yip, Cheng‐Har, additional, Rueda, Oscar M., additional, Caldas, Carlos, additional, Chin, Suet‐Feung, additional, and Teo, Soo‐Hwang, additional

Published
2021
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