Search

The construction industry needs the modern construction methodology and technology. Building Information Modelling (BIM) technology supports to improve the quality of products by reducing design and construction defects, risk of health and safety of workers, and reduce the overall project cost and delivery time. The BIM has capabilities, but it is still unknown and unable to exploit the full scale of its benefits in Architectural Engineering and Construction (AEC) industry. There is a trend to adopting the BIM level 1, which is limited to 2D and only in few cases 3D models uses in the design and construction of the residential and commercial buildings in Nepal. The paper has focused to provide insight into the BIM benefits and identify the potential barriers while adopting BIM Level 3 in Nepal. This was accomplished by developing a 4DBIM model of a multi-story residential building in Nepal and conducting the industry survey via focus group with the AEC professionals’ bases on the developed 4DBIM model. A comprehensive literature review was conducted and presented the findings of benefits and barriers while adopting the BIM. The paper presents and discusses the potential benefits of BIM use, and the challenges faces when implementing in developing country like Nepal. The study found that commercial and governmental projects can immediately be adopted the BIM technology. It is concluded that unavailability of skilled BIM users and lack of proper policies for the BIM adoption are key barriers in Nepal. Hence, new policy is required to achieve and exploit the full scale of the BIM benefits and improve the project delivery in terms of quality, cost and time including Health and Safety of workers and the sustainability of AEC industry.

Objectives To determine significant histologic findings in tonsils and categorize clinical settings in which they occur to identify cases benefiting from histopathologic examination using a computer-based natural language search (NLS) applied to the electronic medical record. Methods The pathology database was queried for tonsillectomy cases accessioned between 2002 and 2018. Tonsils with microscopic examination were reviewed, and indication for examination and diagnoses were tallied. Clinical risk of malignancy was correlated with findings. A NLS was used to interrogate preoperative clinical records of the same group of patients. The search identified cases at risk of significant histologic findings and was implemented as part of standard practice. Results Of the 18,733 bilateral tonsillectomies identified in the pathology database, 494 were palatine tonsils that underwent microscopic examination, 134 had indications concerning for malignancy, and 14 had significant findings on histologic examination. When the NLS was applied to the medical record of the same group, 223 cases were identified as having risk of malignancy, including all flagged by surgeons and pathologists and 89 additional cases. Clinical implementation resulted in identification of all cases benefiting from examination. Conclusions A NLS applied to the electronic medical record to select tonsils for examination was superior to relying on surgeons and pathologists.

Introduction: Variations of branching pattern of the celiac trunk are well documented. Left gastric artery takes origin directly from the aorta in 0.5-15% of cases. bleeding from such artery is rarely reported in literature. this type of rare variation has significant importance in surgical and radiological procedures. Herein, we describe a case of bleeding from a variant left gastric artery. case report: A 56-year-old male was admitted to our hospital with weight loss for endoscopic fine-needle aspiration of splenic abscess. Following fine-needle aspiration the patient had gastric bleed which was diagnosed by contrast-enhanced computed tomography (cEct) scan and abdominal angiography. the cEct scan of abdomen also revealed the variant left gastric artery which was source of bleeding. Upper gastrointestinal endoscopic was done and hemostasis was achieved by applying endoclip. conclusion: Anatomical knowledge of variation is important for management of bleeding from such aberrant artery.

p27(Kip1) is a member of the Cip-Kip family of cyclin-dependent kinase (Cdk) inhibitors that binds to cyclin-Cdk complexes and inhibits their catalytic activity in response to antiproliferative stimuli. p27(Kip1) is regulated by several posttranscriptional mechanisms, including subcellular localization. We have identified a component of the nuclear pore complex (NPC), termed Nup50, through its two-hybrid interactions with p27(Kip1). Nup50 is a nucleoplasmically oriented component of the nuclear pore complex with a role in protein export (T. Guan, R. H. Kehlenbach, E. C. Schirmer, A. Kehlenbach, F. Fan, B. E. Clurman, N. Arnheim, and L. Gerace, Mol. Cell. Biol. 20:5619-5630, 2000). We found that murine Nup50 is a widely expressed nucleoporin and that Nup50 expression is highest in the developing neural tube and adult testes. We have also examined interactions between Nup50 and the NPC and found specific two-hybrid interactions between Nup50 and several well-defined components of the NPC, as well as coimmunoprecipitation of Nup50 with the nucleoporin Nup153 from transfected mammalian cells. In order to study Nup50 function in vivo, we cloned the mouse Nup50 genomic locus and created a targeted Nup50 deletion in the mouse germ line. Nup50 disruption resulted in a complex phenotype characterized by late embryonic lethality, neural tube defects, and intrauterine growth retardation. Although Nup50-null mouse embryo fibroblasts exhibited no defects in either cell cycle control or p27(Kip1) regulation, Nup50 deletion was associated with abnormalities in p27(Kip1) expression and cell proliferation in the developing neuroepithelium. We conclude that Nup50 is a nucleoporin with essential functions during mouse development.

General practitioner Mapperley, Nottingham, 1965-91 (b Lahore, India, 1921; q Lahore 1945; BSc), died from a liver abscess on 14 April 2005.​2005. Figure 1 After house jobs in Lahore he was forced by the partition of India to move south across the new border to remain within India. In 1952 he studied for the diploma in tuberculous diseases and subsequently became medical officer in charge of a sanatorium in Himachal Pradesh and then medical officer co-ordinating the BCG vaccination programme in Delhi. He decided in 1958 to come to the United Kingdom, and after working at several hospitals in northern England set up in general practice in Nottingham. He was the first general practitioner from the Asian subcontinent in Nottingham. He leaves a wife, Ved; three children; and three grandsons.

Objective. —To assess the potential availability and utility of fetal tissues obtained from spontaneous abortions and from ectopic pregnancies for human transplantation therapy. Design. —Tissue collection and analysis by personnel skilled in tissue banking. Setting. —Procurement programs in five tissue banks located in diverse geographical areas that are funded by the National Institutes of Health. Patients. —All women entering obstetric clinics during 1993 who consented to participate in the study. Interventions. —None. Main Outcome Measures. —Evaluation of the products of conception by standard developmental, histological, microbiological, and cytogenetic criteria. Results. —From 22235 obstetric admissions, 1250 spontaneously aborted embryos and 247 products of ectopic pregnancies were obtained. Of these, seven embryos (0.5%) were potentially useful for human transplantation therapy. Conclusion. —Fetal tissues from spontaneous abortions and from ectopic pregnancies are quite limited as feasible sources for human transplantation therapy. ( JAMA . 1995;273:66-68)

The formula of chaksine, the alkaloid from Cassia absus, has been found to be C11H21O3N3 and not C12H21O2N3 as suggested by Siddiqui and Ahmed.