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3. Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis

Author

van Hoogenhuijze, Nienke E, primary, Lahoz Casarramona, Gemma, additional, Lensen, Sarah, additional, Farquhar, Cindy, additional, Kamath, Mohan S, additional, Kunjummen, Aleyamma T, additional, Raine-Fenning, Nick, additional, Berntsen, Sine, additional, Pinborg, Anja, additional, Mackens, Shari, additional, Inal, Zeynep Ozturk, additional, Ng, Ernest H Y, additional, Mak, Jennifer S M, additional, Narvekar, Sachin A, additional, Martins, Wellington P, additional, Steengaard Olesen, Mia, additional, Torrance, Helen L, additional, Mol, Ben W, additional, Eijkemans, Marinus J C, additional, Wang, Rui, additional, and Broekmans, Frank J M, additional

Published
2023
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6. Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis

Author

Fertiliteitartsen, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Child Health, van Hoogenhuijze, Nienke E, Lahoz Casarramona, Gemma, Lensen, Sarah, Farquhar, Cindy, Kamath, Mohan S, Kunjummen, Aleyamma T, Raine-Fenning, Nick, Berntsen, Sine, Pinborg, Anja, Mackens, Shari, Inal, Zeynep Ozturk, Ng, Ernest H Y, Mak, Jennifer S M, Narvekar, Sachin A, Martins, Wellington P, Steengaard Olesen, Mia, Torrance, Helen L, Mol, Ben W, Eijkemans, Marinus J C, Wang, Rui, Broekmans, Frank J M, Fertiliteitartsen, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Child Health, van Hoogenhuijze, Nienke E, Lahoz Casarramona, Gemma, Lensen, Sarah, Farquhar, Cindy, Kamath, Mohan S, Kunjummen, Aleyamma T, Raine-Fenning, Nick, Berntsen, Sine, Pinborg, Anja, Mackens, Shari, Inal, Zeynep Ozturk, Ng, Ernest H Y, Mak, Jennifer S M, Narvekar, Sachin A, Martins, Wellington P, Steengaard Olesen, Mia, Torrance, Helen L, Mol, Ben W, Eijkemans, Marinus J C, Wang, Rui, and Broekmans, Frank J M

Published
2023

8. Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis.

Author

Hoogenhuijze, Nienke E van, Casarramona, Gemma Lahoz, Lensen, Sarah, Farquhar, Cindy, Kamath, Mohan S, Kunjummen, Aleyamma T, Raine-Fenning, Nick, Berntsen, Sine, Pinborg, Anja, Mackens, Shari, Inal, Zeynep Ozturk, Ng, Ernest H Y, Mak, Jennifer S M, Narvekar, Sachin A, Martins, Wellington P, Olesen, Mia Steengaard, Torrance, Helen L, Mol, Ben W, Eijkemans, Marinus J C, and Wang, Rui

Subjects
INTRACYTOPLASMIC sperm injection, HUMAN in vitro fertilization, FERTILIZATION in vitro, EMBRYO transfer, EMBRYO implantation, DATA integrity
Abstract

BACKGROUND In IVF/ICSI treatment, the process of embryo implantation is the success rate-limiting step. Endometrial scratching has been suggested to improve this process, but it is unclear if this procedure increases the chance of implantation and live birth (LB) and, if so, for whom, and how the scratch should be performed. OBJECTIVE AND RATIONALE This individual participant data meta-analysis (IPD-MA) aims to answer the question of whether endometrial scratching in women undergoing IVF/ICSI influences the chance of a LB, and whether this effect is different in specific subgroups of women. After its incidental discovery in 2000, endometrial scratching has been suggested to improve embryo implantation. Numerous randomized controlled trials (RCTs) have been conducted, showing contradicting results. Conventional meta-analyses were limited by high within- and between-study heterogeneity, small study samples, and a high risk of bias for many of the trials. Also, the data integrity of several trials have been questioned. Thus, despite numerous RCTs and a multitude of conventional meta-analyses, no conclusion on the clinical effectiveness of endometrial scratching could be drawn. An IPD-MA approach is able to overcome many of these problems because it allows for increased uniformity of outcome definitions, can filter out studies with data integrity concerns, enables a more precise estimation of the true treatment effect thanks to adjustment for participant characteristics and not having to make the assumptions necessary in conventional meta-analyses, and because it allows for subgroup analysis. SEARCH METHODS A systematic literature search identified RCTs on endometrial scratching in women undergoing IVF/ICSI. Authors of eligible studies were invited to share original data for this IPD-MA. Studies were assessed for risk of bias (RoB) and integrity checks were performed. The primary outcome was LB, with a one-stage intention to treat (ITT) as the primary analysis. Secondary analyses included as treated (AT), and the subset of women that underwent an embryo transfer (AT+ET). Treatment-covariate interaction for specific participant characteristics was analyzed in AT+ET. OUTCOMES Out of 37 published and 15 unpublished RCTs (7690 participants), 15 RCTs (14 published, one unpublished) shared data. After data integrity checks, we included 13 RCTs (12 published, one unpublished) representing 4112 participants. RoB was evaluated as 'low' for 10/13 RCTs. The one-stage ITT analysis for scratch versus no scratch/sham showed an improvement of LB rates (odds ratio (OR) 1.29 [95% CI 1.02–1.64]). AT, AT+ET, and low-RoB-sensitivity analyses yielded similar results (OR 1.22 [95% CI 0.96–1.54]; OR 1.25 [95% CI 0.99–1.57]; OR 1.26 [95% CI 1.03–1.55], respectively). Treatment-covariate interaction analysis showed no evidence of interaction with age, number of previous failed embryo transfers, treatment type, or infertility cause. WIDER IMPLICATIONS This is the first meta-analysis based on IPD of more than 4000 participants, and it demonstrates that endometrial scratching may improve LB rates in women undergoing IVF/ICSI. Subgroup analysis for age, number of previous failed embryo transfers, treatment type, and infertility cause could not identify subgroups in which endometrial scratching performed better or worse. The timing of endometrial scratching may play a role in its effectiveness. The use of endometrial scratching in clinical practice should be considered with caution, meaning that patients should be properly counseled on the level of evidence and the uncertainties. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Dharmasena case illustrates what is wrong with complaints procedures

Author

Bourne, Tom, Bennett, Phillip, Bobdiwala, Shabnam, Coomarasamy, Arri, Ghaem-Maghami, Sadaf, Guha, Sharmistha, Horne, Andrew, Joash, Karen, Kirk, Emma, Lees, Christoph, Al-Memar, Maya, Papageorghiou, Aris, Raine-Fenning, Nick, Sur, Shyamaly, Timmerman, Dirk, and Ugwamadu, Austin

Published
2015

16. Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF:The E-Freeze RCT

Author

Maheshwari, Abha, Bari, Vasha, Bell, Jennifer L., Bhattacharya, Siladitya, Bhide, Priya, Bowler, Ursula, Brison, Daniel, Child, Tim, Chong, Huey Yi, Cheong, Ying, Cole, Christina, Coomarasamy, Arri, Cutting, Rachel, Goodgame, Fiona, Hardy, Pollyanna, Hamoda, Haitham, Juszczak, Edmund, Khalaf, Yacoub, King, Andrew, Kurinczuk, Jennifer J., Lavery, Stuart, Lewis-Jones, Clare, Linsell, Louise, Macklon, Nick, Mathur, Raj, Murray, David, Pundir, Jyotsna, Raine-Fenning, Nick, Rajkohwa, Madhurima, Robinson, Lynne, Scotland, Graham, Stanbury, Kayleigh, Troup, Stephen, Maheshwari, Abha, Bari, Vasha, Bell, Jennifer L., Bhattacharya, Siladitya, Bhide, Priya, Bowler, Ursula, Brison, Daniel, Child, Tim, Chong, Huey Yi, Cheong, Ying, Cole, Christina, Coomarasamy, Arri, Cutting, Rachel, Goodgame, Fiona, Hardy, Pollyanna, Hamoda, Haitham, Juszczak, Edmund, Khalaf, Yacoub, King, Andrew, Kurinczuk, Jennifer J., Lavery, Stuart, Lewis-Jones, Clare, Linsell, Louise, Macklon, Nick, Mathur, Raj, Murray, David, Pundir, Jyotsna, Raine-Fenning, Nick, Rajkohwa, Madhurima, Robinson, Lynne, Scotland, Graham, Stanbury, Kayleigh, and Troup, Stephen

Abstract

Background Freezing all embryos, followed by thawing and transferring them into the uterine cavity at a later stage (freeze-all), instead of fresh-embryo transfer may lead to improved pregnancy rates and fewer complications during in vitro fertilisation and pregnancies resulting from it. Objective We aimed to evaluate if a policy of freeze-all results in a higher healthy baby rate than the current policy of transferring fresh embryos. Design This was a pragmatic, multicentre, two-arm, parallel-group, non-blinded, randomised controlled trial. Setting Eighteen in vitro fertilisation clinics across the UK participated from February 2016 to April 2019. Participants Couples undergoing their first, second or third cycle of in vitro fertilisation treatment in which the female partner was aged < 42 years. Interventions If at least three good-quality embryos were present on day 3 of embryo development, couples were randomly allocated to either freeze-all (intervention) or fresh-embryo transfer (control). OutcomesThe primary outcome was a healthy baby, defined as a live, singleton baby born at term, with an appropriate weight for their gestation. Secondary outcomes included ovarian hyperstimulation, live birth and clinical pregnancy rates, complications of pregnancy and childbirth, health economic outcome, and State–Trait Anxiety Inventory scores. Results A total of 1578 couples were consented and 619 couples were randomised. Most non-randomisations were because of the non-availability of at least three good-quality embryos (n = 476). Of the couples randomised, 117 (19%) did not adhere to the allocated intervention. The rate of non-adherence was higher in the freeze-all arm, with the leading reason being patient choice. The intention-to-treat analysis showed a healthy baby rate of 20.3% in the freeze-all arm and 24.4% in the fresh-embryo transfer arm (risk ratio 0.84, 95% confidence interval 0.62 to 1.15). Similar results were obtained using complier-average causal effe

Published
2022

18. Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT

Author

Maheshwari, Abha, primary, Bari, Vasha, additional, Bell, Jennifer L, additional, Bhattacharya, Siladitya, additional, Bhide, Priya, additional, Bowler, Ursula, additional, Brison, Daniel, additional, Child, Tim, additional, Chong, Huey Yi, additional, Cheong, Ying, additional, Cole, Christina, additional, Coomarasamy, Arri, additional, Cutting, Rachel, additional, Goodgame, Fiona, additional, Hardy, Pollyanna, additional, Hamoda, Haitham, additional, Juszczak, Edmund, additional, Khalaf, Yacoub, additional, King, Andrew, additional, Kurinczuk, Jennifer J, additional, Lavery, Stuart, additional, Lewis-Jones, Clare, additional, Linsell, Louise, additional, Macklon, Nick, additional, Mathur, Raj, additional, Murray, David, additional, Pundir, Jyotsna, additional, Raine-Fenning, Nick, additional, Rajkohwa, Madhurima, additional, Robinson, Lynne, additional, Scotland, Graham, additional, Stanbury, Kayleigh, additional, and Troup, Stephen, additional

Published
2022
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21. Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze)

Author

Maheshwari, Abha, primary, Bell, Jennifer L, additional, Bhide, Priya, additional, Brison, Daniel, additional, Child, Tim, additional, Chong, Huey Yi, additional, Cheong, Ying, additional, Cole, Christina, additional, Coomarasamy, Arri, additional, Cutting, Rachel, additional, Hardy, Pollyanna, additional, Hamoda, Haitham, additional, Juszczak, Edmund, additional, Khalaf, Yacoub, additional, Kurinczuk, Jennifer J, additional, Lavery, Stuart, additional, Linsell, Louise, additional, Macklon, Nick, additional, Mathur, Raj, additional, Pundir, Jyotsna, additional, Raine-Fenning, Nick, additional, Rajkohwa, Madhurima, additional, Scotland, Graham, additional, Stanbury, Kayleigh, additional, Troup, Stephen, additional, and Bhattacharya, Siladitya, additional

Published
2022
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37. A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI

Author

Metwally, Mostafa, primary, Chatters, Robin, additional, Dimairo, Munya, additional, Walters, Stephen, additional, Pye, Clare, additional, White, David, additional, Bhide, Priya, additional, Chater, Tim, additional, Cheong, Ying, additional, Choudhary, Meenakshi, additional, Child, Tim, additional, Drakeley, Andrew, additional, Evbuomwan, Isaac, additional, Gelbaya, Tarek, additional, Grace, Jan, additional, Harris, Philip, additional, Laird, Susan, additional, da Silva, Sarah Martins, additional, Mohiyiddeen, Lamiya, additional, Pemberton, Kirsty, additional, Raine-Fenning, Nick, additional, Rajkhowa, Madhurima, additional, Young, Tracey, additional, and Cohen, Judith, additional

Published
2021
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38. Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure

Author

Suthaporn, Sutham, primary, Jayaprakasan, Kanna, additional, Thornton, Jim, additional, Walker, Kate, additional, Medrano, Juan Hernandez, additional, Castellanos, Marcos, additional, May, Sean, additional, Polanski, Lukasz, additional, Raine-Fenning, Nick, additional, and Maalouf, Walid E., additional

Published
2021
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39. JCEMPrevalence_supplementary tablesS1-S3.pdf

Author

Smith, Rima, Tobias, Aurelio, Smith, Paul Philip, Middleton, Lee, Kirandeep Sunner, Baker, Krystyna, Farrell-Carver, Samantha, Bender-Atik, Ruth, Agrawal, Rina, Kalsang Bhatia, Chu, Justin J., Edi-Osagie, Edmond, Ewies, Ayman A.A., Ghobara, Tarek, Gupta, Pratima, Jurkovic, Davor, Yakoub Khalaf, Khashia Mulbagal, Nunes, Natalie, Overton, Caroline, Quenby, Siobhan, Rai, Rajendra, Raine-Fenning, Nick, Robinson, Lynne, Ross, Jackie, Sizer, Andrew, Small, Rachel, Underwood, Martyn, Kilby, Mark D., Daniels, Jane, Thangaratinam, Shakila, Shiao-Yng Chan, Boelaert, Kristien, and Arri Coomarasamy

Subjects
endocrine system, endocrine system diseases, education, humanities
Abstract

Supplementary tables for manuscript "The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility".

Published
2020
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41. Freezing All Embryos Versus Fresh Embryo Transfer in In-Vitro Fertilisation – a Multicentre Randomised Controlled Trial in the UK (E-Freeze)

Author

Maheshwari, Abha, primary, Bell, Jennifer L, additional, Bhide, Priya, additional, Brison, Daniel, additional, Child, Tim, additional, Yi Chong, Huey, additional, Cheong, Ying, additional, Cole, Christina, additional, Coomarasamy, Arri, additional, Cutting, Rachel, additional, Hardy, Pollyana, additional, Hamoda, Haitham, additional, Juszczak, Edmund, additional, Khalaf, Yacoub, additional, Kurinczuk, Jenny J., additional, Lavery, Stuart, additional, Linsell, Louise, additional, Macklon, Nick, additional, Mathur, Raj, additional, Pundir, Jyotsna, additional, Raine-Fenning, Nick, additional, Rajkhowa, Madhurima, additional, Scotland, Graham, additional, Stanbury, Kayleigh, additional, Troup, Stephen, additional, Bhattacharya, Siladitya, additional, and Group, E-Freeze Trial Collaborative, additional

Published
2021
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50. The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility

Author

Dhillon-Smith, Rima K, primary, Tobias, Aurelio, additional, Smith, Paul P, additional, Middleton, Lee J, additional, Sunner, Kirandeep K, additional, Baker, Krystyna, additional, Farrell-Carver, Samantha, additional, Bender-Atik, Ruth, additional, Agrawal, Rina, additional, Bhatia, Kalsang, additional, Chu, Justin J, additional, Edi-Osagie, Edmond, additional, Ewies, Ayman, additional, Ghobara, Tarek, additional, Gupta, Pratima, additional, Jurkovic, Davor, additional, Khalaf, Yacoub, additional, Mulbagal, Khashia, additional, Nunes, Natalie, additional, Overton, Caroline, additional, Quenby, Siobhan, additional, Rai, Raj, additional, Raine-Fenning, Nick, additional, Robinson, Lynne, additional, Ross, Jackie, additional, Sizer, Andrew, additional, Small, Rachel, additional, Underwood, Martyn, additional, Kilby, Mark D, additional, Daniels, Jane, additional, Thangaratinam, Shakila, additional, Chan, Shiao, additional, Boelaert, Kristien, additional, and Coomarasamy, Arri, additional

Published
2020
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