1. Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study
- Author
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Govind R Patel, Indu Thanvi, Mohammad Nadeem, and Rahul Kanwaria
- Subjects
dengue ,coagulation abnormalities ,coagulation parameters ,prothrombin time ,activated partial thromboplastin time ,bleeding manifestations ,Arctic medicine. Tropical medicine ,RC955-962 - Abstract
Objective: To evaluate coagulation abnormalities and their relationship with bleeding manifestations among patients with dengue. Methods: This observational study was conducted on 292 adult dengue patients who were admitted to a tertiary care hospital of Western India from July 2021 to June 2022. Coagulation tests including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer were performed. Patients were monitored for bleeding manifestations. Results: Coagulation abnormalities were reported in 42.8% of the patients. Overall, prolonged aPTT was the most common coagulation abnormality (40.8%), followed by low fibrinogen (38.7%), raised D-dimer (31.2%), raised INR (26.0%) and prolonged PT (19.2%). Bleeding manifestations were present in 19.9% patients. PT, INR, aPTT and D-dimer levels were significantly higher (P
- Published
- 2023
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