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Background: Percutaneous coronary intervention (PCI) may been associated with high-er risk of cardiac events during this procedure. The goal of this study was to compare high dose atorvastatin therapy with low dose atorvastatin therapy 24 hours before PCI to a reduction in Peri- percutaneous coronary intervention myocardial infarction.Methods: One hundred ninety patients with stable angina were enrolled in a randomiz-ed controlled clinical trial study. All patients received low dose atorvastatin. The patients scheduled for elective PCI were randomized to atorvastatin (80 mg/d, n=95) or placebo (n=95) within 24 hours before the procedure. Creatine kinase-MB, troponin I, and high sensitive C- reactive protein levels were measured at baseline and at 6 and 12 hours after the procedure. PCI related myocardial infarction was defined as increasing of Creatine kinase-MB or troponin I three times compared with values before procedure.Results: Myocardial infarction was detected after coronary intervention in 4.2% of patients in the atorvastatin group and in 13.7% of those in the placebo group (P=0.022). Mean of changed levels of Creatine kinase-MB (0.7±0.5 versus 3.3±1.9 ng/mL, P

Since Euler's original gyro-dynamic analysis nearly two and a half centuries ago, the use of multi-body dynamics (MBD) has spread widely in application scope from large displacement rigid body dynamics to infinitesimal amplitude elastodynamics. In some cases, MBD has become a multi-physics multi-scale analysis, comprising contact mechanics, tribo-dynamics, terramechanics, thermodynamics, biomechanics, etc. It is an essential part of all analyses in many engineering disciplines, including vehicle engineering. This paper provides an overview of historical developments with emphasis on vehicle development and investigation of observed phenomena, including noise, vibration and harshness. The approach undertaken is comprehensive and provides a uniquely focused perspective, one which has not hitherto been reported in the literature. [ABSTRACT FROM AUTHOR]

The present paper proposes a step-by-step random shakedown solution, by considering uncertainty in soil parameters explicitly, to meet the safety requirements of road pavement systems design rationally. To this aim, theoretical-based random analysis, called Random Analytical Shakedown Analysis, is established and then validated through comparison of the obtained predictions with the known Random Mesh-free Shakedown Analysis results. It has been shown that the developed theoretical model can effectively capture the effects of soil spatial variability on the pavement shakedown behaviour in a shakedown analysis model. The difference between the deterministic shakedown limit loads obtained by the proposed method and the mesh-free model is within 2%, which shows the comparable accuracy of the suggested theoretical model with the mesh-free method which comprises hundreds of variables and constraints in the optimisation problem. Another advantage of the developed theoretical solution is the prevention of non-convergence situations occurrence in the mesh-free shakedown analysis. Accordingly, the introduced scheme can be efficiently used for rapid evaluation of the shakedown capacity of spatially-varying pavements. [ABSTRACT FROM AUTHOR]