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221 results on '"Rahman, Masudur"'

1. Primary caregiver burden and undiagnosed mental health illness in out-patients with inflammatory bowel disease—A multicentric prospective survey from the IBD Emerging Nations’ Consortium

Author

Banerjee, Rupa, Pal, Partha, Hilmi, Ida, Raghunathan, Nalini, Rahman, Masudur, Limsrivillai, Julajak, Kamani, Lubna, Ghoshal, Uday C., Aye, Than Than, Joshi, Neeraj, Alavinejad, Pezhman, Peddi, Kiran, Patel, Rajendra, Godbole, Shubhankar, and Reddy, Duvurru Nageswhar

Published
2024
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4. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Ashraful, Nahar Begum, SM Khodeza, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, Yilmaz, Omer H, Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, and Syed, Sana

Published
2024
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5. Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J, Marie, Chelsea, Mazumder, Ramendra Nath, Mudenda, Victor, Mulenga, Chola, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, VanBuskirk, Kelley, Mweetwa, Monica, Kolterman, Tad, Raghavan, Shyam, Ahmed, Tahmeed, Ali, S Asad, Nahar Begum, SM Khodeza, Besa, Ellen, Denno, Donna M, Jamil, Zehra, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Mouksassi, Samer, Petri, William A, Jr., Tarr, Phillip I, Sullivan, Peter B, and Moskaluk, Christopher A

Published
2024
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6. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, and Denno, Donna M

Published
2024
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7. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Zyambo, Kanekwa, Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, and Denno, Donna M

Published
2024
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8. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Zyambo, Kanekwa, Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Jr, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Ömer H Yilmaz, Raghavan, Shyam S, Moskaluk, Christopher A, and Liu, Ta-Chiang

Published
2024
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9. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Jr., Tarr, Phillip I, and Denson, Lee A

Published
2024
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10. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Jr., and Ali, S Asad

Published
2024
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11. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Jr, Sullivan, Peter B, and Tarr, Phillip I

Published
2024
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17. Transient High Salt Intake Promotes T-Cell–Mediated Hypertensive Vascular Injury.

Author

Yakoub, Mina, Rahman, Masudur, Kleimann, Patricia, Hoffe, Jasmina, Feige, Milena, Bouvain, Pascal, Alter, Christina, Kluczny, Jennifer Isabel, Reidel, Sophia, Nederlof, Rianne, Hering, Lydia, Argov, Doron, Arifaj, Denada, Kantauskaite, Marta, Meister, Jaroslawna, Kleinewietfeld, Markus, Rump, Lars Christian, Jantsch, Jonathan, Flögel, Ulrich, and Müller, Dominik N.

Abstract

BACKGROUND: Dietary high salt (HS) intake has a strong impact on cardiovascular diseases. Here, we investigated the link between HS-aggravated immune responses and the development of hypertensive vascular disease. METHODS: ApolipoproteinE-deficient mice were transiently treated with HS (1% NaCl) via drinking water for 2 weeks, followed by a washout period, and subsequent Ang II (angiotensin II) infusion (1000 ng/kg per min for 10 days) to induce abdominal aortic aneurysms/dissections and inflammation. RESULTS: While transient HS intake alone triggered nonpathologic infiltration of activated T cells into the aorta, subsequent Ang II infusion increased mortality and the incidence of abdominal aortic aneurysms/dissections and atherosclerosis compared with hypertensive control mice. There were no differences in blood pressure between both groups. In transient HS-treated hypertensive mice, the aortic injury was associated with increased inflammation, accumulation of neutrophils, monocytes, CD69+CD4+ T cells, as well as CD4+ and CD8+ memory T cells. Mechanistically, transient HS intake increased expression levels of aortic RORγt as well as splenic CD4+TH17 and CD8+TC1 T cells in Ang II–treated mice. Isolated aortas of untreated mice were incubated with supernatants of TH17, TH1, or TC1 cells polarized in vitro under HS or normal conditions which revealed that secreted factors of HS-differentiated TH17 and TC1 cells, but not TH1 cells accelerated endothelial dysfunction. CONCLUSIONS: Our data suggest that transient HS intake induces a subclinical T-cell–mediated aortic immune response, which is enhanced by Ang II. We propose a 2-hit model, in which HS acts as a predisposing factor to enhance hypertension-induced TH17 and TC1 polarization and aortic disease. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles.

Author

Darguzyte, Milita, Antczak, Philipp, Bachurski, Daniel, Hoelker, Patrick, Abedpour, Nima, Gholamipoorfard, Rahil, Schlößer, Hans A., Wennhold, Kerstin, Thelen, Martin, Garcia-Marquez, Maria A., Koenig, Johannes, Schneider, Andreas, Braun, Tobias, Klawonn, Frank, Damrat, Michael, Rahman, Masudur, Kleid, Jan-Malte, Theobald, Sebastian J., Bauer, Eugen, and von Kaisenberg, Constantin

Subjects
HLA histocompatibility antigens, LYMPHOCYTE subsets, MAJOR histocompatibility complex, LYMPHOID tissue, KILLER cells, T cells
Abstract

Background: Humanized mice transplanted with CD34+ hematopoietic cells (HPCs) are broadly used to study human immune responses and infections in vivo and for testing therapies pre-clinically. However, until now, it was not clear whether interactions between the mouse major histocompatibility complexes (MHCs) and/or the human leukocyte antigens (HLAs) were necessary for human T-cell development and immune reactivity. Methods: We evaluated the long-term (20-week) human hematopoiesis and human T-cell development in NOD Scid Gamma (NSG) mice lacking the expression of MHC class I and II (NSG-DKO). Triplicate experiments were performed with HPCs obtained from three donors, and humanization was confirmed in the reference strain NOD Rag Gamma (NRG). Further, we tested whether humanized NSG-DKO mice would respond to a lentiviral vector (LV) systemic delivery of HLA-A*02:01, HLA-DRB1*04:01, human GM-CSF/IFN-α, and the human cytomegalovirus gB antigen. Results: Human immune reconstitution was detectable in peripheral blood from 8 to 20 weeks after the transplantation of NSG-DKO. Human single positive CD4+ and CD8+ T-cells were detectable in lymphatic tissues (thymus, bone marrow, and spleen). LV delivery harnessed the detection of lymphocyte subsets in bone marrow (αβ and γδ T-cells and NK cells) and the expression of HLA-DR. Furthermore, RNA sequencing showed that LV delivery increased the expression of different human reactome pathways, such as defense responses to other organisms and viruses. Conclusions: Human T-cell development and reactivity are independent of the expression of murine MHCs in humanized mice. Therefore, humanized NSG-DKO is a promising new model for studying human immune responses, as it abrogates the xenograft mouse MHC interference. [ABSTRACT FROM AUTHOR]

Published
2024
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20. T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

Author

Darguzyte, Milita, primary, Amtczak, Philipp, additional, Bachurski, Daniel, additional, Hoelker, Patrick, additional, Abedpour, Nima, additional, Gholaminpoorfard, Rahil, additional, Schlösser, Hans, additional, Wennhold, Kerstin, additional, Thelen, Martin, additional, Garcia-Marquez, Maria, additional, Koenig, Johannes, additional, Schneider, Andreas, additional, Braun, Tobias, additional, Klawonn, Frank, additional, Damrat, Michael, additional, Rahman, Masudur, additional, Kleid, Jan-Malte, additional, Theobald, Sebastian, additional, Bauer, Eugen, additional, von Kaisenberg, Constantin, additional, Talbot, Steven R, additional, Schultz, Lenny, additional, Soper, Brian, additional, and Stripecke, Renata, additional

Published
2024
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21. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multi-country analysis

Author

Ehsan, Lubaina, primary, Coomes, David, additional, Kelly, Paul, additional, Greene, Adam R., additional, Ali, S. Asad, additional, Mulenga, Chola, additional, Denno, Donna M., additional, VanBuskirk, Kelley, additional, Raghib, Muhammad Faraz, additional, Mahfuz, Mustafa, additional, Moore, Sean R., additional, Hossain, M. Shabab, additional, Ahmed, Tahmeed, additional, Sullivan, Peter B., additional, Moskaluk, Christopher A., additional, Syed, Sana, additional, Ahmed, Kumail, additional, Ahmed, Sheraz, additional, Alam, Md. Ashraful, additional, Begum, S.M. Khodeza Nahar, additional, Das, Subhasish, additional, Denson, Lee A., additional, Fahim, Shah Mohammad, additional, Gazi, Md. Amran, additional, Hasan, Md. Mehedi, additional, Hotwani, Aneeta, additional, Iqbal, Junaid, additional, Jamil, Zehra, additional, Kabir, Furqan, additional, Liu, Ta-Chiang, additional, Mazumder, Ramendra Nath, additional, Ragahavan, Shyam S., additional, Rahman, Masudur, additional, Rahman, Najeeb, additional, Sadiq, Kamran, additional, Sarker, Shafiqul Alam, additional, Tarr, Phillip I., additional, Tearney, Guillermo J., additional, Umrani, Fayaz, additional, Umutesi, Grace, additional, and Yilmaz, Omer H., additional

Published
2024
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24. Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction

Author

VanBuskirk, Kelley, Mweetwa, Monica, Kolterman, Tad, Raghavan, Shyam, Ahmed, Tahmeed, Ali, S Asad, Nahar Begum, SM Khodeza, Besa, Ellen, Denno, Donna M, Jamil, Zehra, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Mouksassi, Samer, Petri, William A, Tarr, Phillip I, Sullivan, Peter B, Moskaluk, Christopher A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J, Marie, Chelsea, Mazumder, Ramendra Nath, Mudenda, Victor, Mulenga, Chola, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Tearney, Guillermo J, Umrani, Fayaz, and Yilmaz, Omer H

Abstract

Environmental enteric dysfunction (EED) is characterized by reduced absorptive capacity and barrier function of the small intestine, leading to poor ponderal and linear childhood growth.

Published
2024
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25. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental Enteric Dysfunction (EED) is an acquired disorder of asymptomatic altered gut function, the etiology of which is unknown. EED is postulated to be a major contributor to growth faltering in early childhood in regions where early-life enteropathogenic carriage is prevalent. Few studies have examined the critical organ (the upper small bowel) with enteropathogens in the evolution of small bowel disease.

Published
2024
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26. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., and Zyambo, Kanekwa

Abstract

Validated biomarkers could catalyze environmental enteric dysfunction (EED) research.

Published
2024
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27. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Yilmaz, Ömer H, Raghavan, Shyam S, Moskaluk, Christopher A, Liu, Ta-Chiang, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic intestinal disorder associated with growth impairment, delayed neurocognitive development, and impaired oral vaccine responses.

Published
2024
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28. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Tarr, Phillip I, Denson, Lee A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an inflammatory condition of the small intestine that is prevalent in children residing in low- and middle-income countries. EED is accompanied by profound histopathologic changes in the small bowel, loss of absorptive capacity, increased intestinal permeability, increased microbial translocation, and nutrient loss.

Published
2024
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29. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Sullivan, Peter B, Tarr, Phillip I, Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, and Umrani, Fayaz

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic acquired disorder characterized by upper small bowel inflammation, villus blunting, and gut permeability. It is a major contributor to poor growth in childhood as well as other highly consequential outcomes such as delayed neuorcognitive development. After decades of intermittent interest in this entity, we are now seeing a resurgence in the field of EED. However, recent studies have been hampered by a lack of investigation of the target tissue—the upper small bowel. In 2016, the EEDBI (Environmental Enteric Dysfunction Biopsy Initiative) Consortium was established as a common scientific platform across 3 independent EED biopsy cohort studies in Bangladesh, Pakistan, and Zambia. Two centers in the United States recruited comparison groups of children undergoing endoscopy for clinical indications. The EEDBI Consortium goal was to augment the contributions of the individual centers and answer high-level questions amenable to analysis and interpretation across the studies. Here, we describe the Consortium and its cohorts and recruitment procedures across studies. We also offer details applicable to all papers in this supplement, which describe EED mucosal histology, morphometry, immunohistochemistry, and transcriptomics as well as histology relationship to pathogens and biomarkers.

Published
2024
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30. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Ali, S Asad, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, and Yilmaz, Omer H.

Abstract

Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade chronic systemic inflammation.

Published
2024
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31. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, Syed, Sana, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Begum, SM Khodeza Nahar, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Md Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, and Yilmaz, Omer H

Abstract

Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes.

Published
2024
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35. Critical Role of Neprilysin in Kidney Angiotensin Metabolism

Author

Kaltenecker, Christopher C., Domenig, Oliver, Kopecky, Chantal, Antlanger, Marlies, Poglitsch, Marko, Berlakovich, Gabriela, Kain, Renate, Stegbauer, Johannes, Rahman, Masudur, Hellinger, Roland, Gruber, Christian, Grobe, Nadja, Fajkovic, Harun, Eskandary, Farsad, Böhmig, Georg A., Säemann, Marcus D., and Kovarik, Johannes J.

Published
2020
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41. Abstract P312: High Potassium Intake Aggravates Cardiovascular Damage Accompanied By Premature Senescence In Hypertensive Apolipoproteine-ko Mice Under High Salt Diet

Author

Arifaj, Denada, primary, Lang, Alexander, additional, Yakoub, Mina, additional, Argov, Doron, additional, Rahman, Masudur, additional, Hering, Lydia, additional, Temme, Sebastian, additional, Rump, Lars Christian, additional, Gerdes, Norbert, additional, and Stegbauer, Johannes, additional

Published
2022
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42. Fitness Trainers’ Educational Qualification and Experience and Its Association with Their Trainees’ Musculoskeletal Pain: A Cross-Sectional Study

Author

Ahmed, Sohel, primary, Rashid, Mamunur, additional, Sarkar, Abu-sufian, additional, Islam, Mohammad Jahirul, additional, Akter, Rahemun, additional, Rahman, Masudur, additional, Islam, Shahana, additional, Sheel, Devjanee, additional, Polash, Sarwar Alam, additional, Akter, Mahfuza, additional, Afride, Shayed, additional, and Kader, Manzur, additional

Published
2022
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44. Fitness trainers’ educational qualification and experience and its association with their trainees’ musculoskeletal pain: A cross-sectional study

Author

Sohel, Ahmed, Rashid, Mamunur, Sarkar, Abu-sufian, Jahirul Islam, Mohammad, Akter, Rahemun, Rahman, Masudur, Islam, Shahana, Sheel, Devjanee, Alam Polash, Sarwar, Akter, Mahfuza, Afride, Shayed, Kader, Manzur, Sohel, Ahmed, Rashid, Mamunur, Sarkar, Abu-sufian, Jahirul Islam, Mohammad, Akter, Rahemun, Rahman, Masudur, Islam, Shahana, Sheel, Devjanee, Alam Polash, Sarwar, Akter, Mahfuza, Afride, Shayed, and Kader, Manzur

Abstract

This is a cross-sectional study that examined the association between fitness trainers’ educational qualifications and experience, and the risk of their trainees’ musculoskeletal pain. The study included 1177 trainees (aged 15–60 years) from 74 fitness centers in Bangladesh. Data were collected by using the Nordic musculoskeletal questionnaire, including potential confounders such as demographic factors (e.g., age, occupation), and training-related factors (e.g., workout knowledge, overweight lifting). Multiple logistic regression was performed for a binary outcome (pain—yes or no), and a generalized linear model was fitted for the ordinal outcome (pain—sites of the body). The trainers’ lower experience (no or ≤1 year) was associated with higher odds of their trainees’ musculoskeletal pain (OR: 2.53, 95% CI: 1.18–5.44) compared to trainers with >5 years of experience; however, no association was found between the trainers’ education and the risk of their trainees’ musculoskeletal pain, after controlling for potential confounders. Similarly, the trainees trained by trainers with lower experience had more than two-time the risk of having pain in different sites (IRR: 2.04, 95% CI: 1.50–2.79). The trainers’ experience may play a pivotal role in the trainees’ musculoskeletal pain. Further study is warranted in this regard.

Published
2022
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46. Exploring the socio-economic impacts of tourism: A study of Cox’s Bazar, Bangladesh

Author

Rahman, Masudur

Subjects
Impacts of tourism
Abstract

This study evaluates the socio-economic impact of tourism development on the local community in Cox’s Bazar, Bangladesh.The country wants to utilize tourism as an economic development tool to reduce poverty and stimulate socio-economic wellbeing. Tourism has profound impact on the local community of the destination as it brings economic and socio-cultural changes.The significant positive economic impacts are increased employment and earning opportunities, enhanced standard of living, more investments, infrastructural development, and new business linkages and opportunities. However some negative economic impacts been identified, like increased income disparity, increased land price and rent, price hike of essential goods and services, seasonality effects and leakage of earnings. A frustrating finding is that majority of the tourism assets and well-paid jobs are enjoyed by non-locals whereas the local community does not enjoy its rightful share due to uneven benefit distribution. The positive socio-cultural impacts include women empowerment, more participation in education, limited outward migration, and enhanced social safety and security. Some negative socio-cultural impacts are displacement of poor from their land, increased social gap, frustration, social disorder and loss of cultural originality. Unfortunately the local community is not fully aware of the value of their cultural heritage and so they try to imitate tourist’s socio-cultural traits. A major difference from other tourism impact studies is tourism does not contribute in raising crime, gambling, and prostitution in Cox’s Bazar. The local community is involved in tourism activities but has minimal involvement in the decision making process. This study revealsthat the local community is totally excluded from the policy formulation process and policy makers do not consider the socio-economic impacts of tourism development on the local community.Local community is benefiting from tourism development but significant scope exists to increase their active participation and equitable benefit sharing. Some recommendations are made forthe Development of Tourism in Cox’s Bazar to maximize positive impacts and minimize negative impacts along with some insights for further research in this field.

Published
2022
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47. An integrated model to decipher online food delivery app adoption behavior in the COVID-19 pandemic.

Author

Gani, Mohammad Osman, Faroque, Anisur R, Muzareba, Abureza M, Amin, Sanjida, and Rahman, Masudur

Subjects
LOCAL delivery services, COVID-19 pandemic, STRUCTURAL equation modeling, TRUST, MOBILE apps
Abstract

The demand for online food delivery has increased considerably throughout the world during the COVID-19 pandemic. Consumers' habits in searching for information on and making decisions about ready-to-eat food have changed remarkably during this time. The purpose of this research is to explore consumers' use of online food delivery services (OFDS) during the pandemic via applications (apps) and the moderating role played by the consumers' perceived trust in the information. Data were collected from 246 users through e-mail and structural equation modeling using PLS-3 was used to analyze the data. We have shown 12 recent insights into OFDAs behavioral intention. We found that information and food service attributes influence the perceived usefulness of OFDS and ultimately shape the respondents' intention to use it. Behavioral intention toward OFDS and perceived trust have a considerable influence on the use of OFDA. This research offers insights into the effects of the pandemic on the food delivery market and shows the dynamics of the interrelationships among various information- and restaurant-related attributes that lead to actual use. [ABSTRACT FROM AUTHOR]

Published
2023
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48. CADMIUM TOXICITY IN NATURE GENERATES THE CANCEROUS PROBLEMS

Author

QASIM ALI, MUHAMMAD, primary, DEB, APU, additional, HASAN, MD. SHANZID, additional, RAHMAN, MASUDUR, additional, RAHMAN, HABIBUR, additional, AFRIN, SADIA, additional, RAHMAN BHUIYAN, MD. KHALEDUR, additional, ROY, UTHPALLKUMAR, additional, UDDIN, MOHAMMAD BURHAN, additional, MUDHAFAR, MUSTAFA, additional, SYRMOS, NIKOLAOS, additional, and AHMED MAHEDI, MD. REZWAN, additional

Published
2022
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