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The current study aimed to assess the phytochemical profile of Macaranga indica (MI) leaves, as well as their antioxidant, thrombolytic, and neuropharmacological activities. Methanol extract from Macaranga indica (MEMI) Wight leaves was used to investigate these activities to validate the therapeutic profile using a wellestablished method. GraphPad Prism, version 9.4.1 was used to analyze the experimental results. In vitro, the antioxidant DPPH free radical scavenging assay yielded an IC50 value of 9.58 µg/ml. Reducing power capacity showed an increase in absorbance with the increase of different concentrations. Quantitative analyses of phytochemical elicit the presence of phenol (777±12.13), flavonoid (99.94±0.62), flavonol (244±2.53), total antioxidant (184.48±1.92) mg/g in the dry extract. In vitro thrombolytic activity showed a highly statistically significant (P < 0.0001) clot lysis (42.66±3.19%). In vivo antidepressant, anxiolytic, and sedative activities evaluated the statistically significant (P < 0.001 at 200 mg/kg and P < 0.0001 at 400 mg/kg) by decreasing immobility time of forced swimming test, (P < 0.0001) by reducing anxiety of elevated plus maze and hole board test and (P = 0.0106) mice movement were gradually decreasing of hole cross test. These findings indicate that the crude extract of MEMI leaves has significant antioxidant, thrombolytic, and neuropharmacological properties. [ABSTRACT FROM AUTHOR]

BACKGROUND: Seizure outcomes after lesionectomy have been proven to be equivalent to excision, which ablates the epileptogenic cortex with the lesion. Different forms of resection surgery, as well as temporal lobectomy, are being investigated as therapeutic options for people with focal epilepsy who have not responded to medication. Although seizure control is the primary goal of epilepsy surgery, lowering or quitting antiepileptic drugs (AEDs) following epilepsy surgery is also an essential goal for patients and epileptologists. CASE PRESENTATION: We described a thirteen-year-old female who had suffered from headaches and multiple bouts of complex partial seizures for three years before undergoing surgery for a well-circumscribed lesion occupying the medial portion of the left temporal lobe next to the pole, with modest compression of the ipsilateral crus of the midbrain. Following surgery, the patient was kept on levetiracetam and phenytoin, which was later converted to a single antiepileptic drug with complete seizure control. CONCLUSION: Patients on multiple antiepileptic drugs for control of temporal lobe lesional seizures can be kept on a single antiepileptic drug after resection of the lesion and slowly the dose can be reduced. [ABSTRACT FROM AUTHOR]

Cellulose nanomaterials are low cost, biocompatible and readily combined with other materials to produce nanocomposites with a range of applications. Cellulose nanomaterials have many advantageous properties, including high mechanical and thermal stability, high specific surface area, and biodegradability. The highly flexible cellulose structure can be exploited to transform bulk cellulose into isolated nanostructured fibers that retain the original thermal, mechanical, and optical properties of the bulk material. In this review, we highlight recent advances in the environmental application of cellulose nanocomposites. We introduce the different chemical, mechanical, and biological pathways used for preparation of cellulose nanomaterials. Recent rapid technological advancements in the preparation of cellulose nanocomposites by combining metal nanoparticles, organic polymers, and metal-organic frameworks (MOFs) with cellulose are then discussed. Finally, we summarize the latest progress in the application of cellulose nanocomposites in environmental science and engineering and provide a perspective on the future outlook of cellulose nanocomposites. [ABSTRACT FROM AUTHOR]