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A series of 2-aryl/alkyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines (S1–S11) were synthesized with an eco-friendly and recoverable nanocatalyst (GO-Fe3O4–Ti(IV)) as an efficient magnetic composite. The new nanocatalyst was characterized by FT-IR, XRD and, EDS analysis. A conformable procedure, easy to work up and having a short reaction time with high yields are some advantages of this method. The new catalyst is also thermal-stable, reusable and, environment-friendly. The chemical structures of the synthesized 1,3-oxazine compounds were confirmed by comparing their melting points with those reported in literature. Then, the anticonvulsant activity of these compounds was assessed by the intraperitoneal pentylenetetrazole test (ipPTZ). Compounds S10 and S11 displayed considerable activity against chemically-induced seizure tests. The molecular simulation was also done to achieve their binding affinities as γ‐aminobutyric acid A (GABA‐A) receptor agonists as an assumptive mechanism of their anticonvulsant action. The result of molecular studies represented strongly matched with biological activity. Molecular docking simulation of the potent compound (S10) and diazepam as the positive control was performed and some critical residues like Thr262, Asn265, Met286, Phe289, and Val290 were identified. Based on the anticonvulsant results and also in silico ADME predictions, S11 can be to become a potential drug candidate as an anticonvulsant agent. [ABSTRACT FROM AUTHOR]

Introduction: Tobacco use is widely spread throughout the world. Smoking has several adverse effects on human health ranging from minor health conditions to death. Aim: This study aimed to investigate effect of smoking on level of saliva cyanide, interleukin-2 (IL-2) and interferon-gamma (IFN-γ) among smokers compared to nonsmokers in the city of Ilam, Iran. Material and methods : This study was carried out among two equal groups of smokers as cases and nonsmokers as controls (N = 76) which were matched in terms of their age range. Dental roll and direct saliva method were used to collect samples. The saliva sample was stored at –18°C. The level of salivary cyanide was measured using the spectrophotometric method. IL-2 and IFN-γ were measured by ELISA. Results and discussion: We found level of cyanide in the saliva of smokers was higher than that in nonsmokers. In addition, level of cyanide in the smokers’ saliva increased (164.21 ± 18.54 μg/mL) significantly compared to nonsmokers (42.63 ± 24.01 μg/mL). A significant increase was found in the level of IFN-γ and IL-2 among smokers compared to nonsmokers. However, there was a significant decrease in the level of IFN-γ and IL-2 with increased intensity of smoking. Conclusions : Heavy smoking was associated with an increased level of salivary cyanide and a decreased level of sera IFN-γ. Recognizing immunosuppression mechanisms produced by cigarette-smoking is a platform for identifying the best therapeutic and management approaches in smoke-induced diseases. [ABSTRACT FROM AUTHOR]