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Praveen Anand,1 Enas Elsafa,1 Rosario Privitera,1 Kalnisha Naidoo,1 Yiangos Yiangou,1 Philippe Donatien,1 Hani Gabra,2 Harpreet Wasan,2 Laura Kenny,2 Amin Rahemtulla,3 Peter Misra11Department of Neurology; 2Medical Oncology; 3Hematology, Imperial College London, Hammersmith Hospital, London W12 0NN, UKPurpose: Chemotherapy-induced peripheral neuropathy (CIPN) with associated chronic pain is a common and disabling condition. Current treatments for neuropathic pain in CIPN are largely ineffective, with unfavorable side-effects. The capsaicin 8% patch (capsaicin 179 mg patch) is approved for the treatment of neuropathic pain: a single topical cutaneous application can produce effective pain relief for up to 12 weeks. We assessed the therapeutic potential of capsaicin 8% patch in patients with painful CIPN, and its mechanism of action.Patients and methods: 16 patients with chronic painful CIPN (mean duration 2.5 years), in remission for cancer and not receiving chemotherapy, were treated with 30 min application of capsaicin 8% patch to the feet. Symptoms were monitored using the 11-point numerical pain rating scale (NPRS), and questionnaires. Investigations were performed at baseline and three months after patch application, including skin biopsies with a range of markers, and quantitative sensory testing (QST).Results: Patients reported significant reduction in spontaneous pain (mean NPRS: −1.27; 95% CI 0.2409 to 2.301; p=0.02), touch-evoked pain (−1.823; p=0.03) and cold-evoked pain (−1.456; p=0.03). Short-Form McGill questionnaire showed a reduction in neuropathic (p=0.0007), continuous (p=0.01) and overall pain (p=0.004); Patient Global Impression of Change showed improvement (p=0.001). Baseline skin biopsies showed loss of intra-epidermal nerve fibers (IENF), and also of sub-epidermal nerve fibers quantified by image analysis. Post-patch application skin biopsies showed a significant increase towards normalization of intra-epidermal and sub-epidermal nerve fibers (for IENF: structural marker PGP9.5, p=0.009; heat receptor TRPV1, p=0.027; regenerating nerve marker GAP43, p=0.04). Epidermal levels of Nerve Growth Factor (NGF), Neurotrophin-3 (NT-3), and Langerhans cells were also normalized. QST remained unchanged and there were no systemic side-effects, as in previous studies.Conclusion: Capsaicin 8% patch provides significant pain relief in CIPN, and may lead to regeneration and restoration of sensory nerve fibers ie, disease modification.Keywords: capsaicin, neuropathic pain, chemotherapy, skin biopsy

Electronic textiles (E-textiles) have experienced an increase in interest in recent years leading to a variety of new concepts emerging in the field. Despite these technical innovations, there is limited literature relating to the testing of E-textiles for some of the fundamental properties linked to wearer comfort. As such, this research investigates four fundamental properties of E-textiles: air permeability, drape, heat transfer, and moisture transfer. Three different types of E-textiles were explored: an embroidered electrode, a knitted electrode, and a knitted structure with an embedded electronic yarn. All of the E-textiles utilized the same base knitted fabric structure to facilitate a comparative study. The study used established textile testing practices to evaluate the E-textiles to ascertain the suitability of these standards for these materials. The study provides a useful point of reference to those working in the field and highlights some limitations of existing textile testing methodologies when applied to E-textiles.

This study utilized the Simple View of Reading (SVR) model cognitive subtypes to determine the impact of text-to-speech (TTS) software on the reading comprehension of 94 grade 8 students with reading difficulties. Method: paired samples t tests for all four SVR groups were conducted to examine reading comprehension scores under TTS and no-TTS conditions. Results: only those participants with a dyslexic profile (listening comprehension greater than decoding skills), demonstrated significant gains in reading comprehension in the TTS compared to the no-TTS condition; a large effect size (1.58 grade level increase) was found. Furthermore, this group's literal comprehension improved much more than their inferential comprehension when utilizing TTS. Implications: a one-size fits all approach for the selection of TTS for struggling readers is not recommended. SVR subtyping incorporated into psychoeducational assessments can inform appropriate assignment of TTS to struggling readers.

This article emerges from a podcast hosted by a Centre for Migration at a Canadian University in 2021. In this discussion, we explore how podcasts offer a unique and often under-researched arts-based medium that can be used as a form of creative expression to tell stories, build dialogue, and create solidarity. We argue that podcasts offer benefits and learning not only to the listeners but also to participants who are part of the creation process. Drawing upon direct quotes from the podcast and qualitative reflections from the podcast interviewees, this collaboratively written article examines how the podcast stimulates activism and access to deeper understandings and collectively made meanings around the lived experiences of migration. It sheds light upon the less-researched emotional and participatory dimensions of arts-based podcast-making, teaching, and research in adult education. We conclude that the podcast created spaces of disruption, public pedagogy, and praxis.

Employment training services are provided for immigrants to integrate them into the Canadian labour market. Evaluated on short-term labour market outcomes, these programs typically focus on enhancing individuals' employability, while risking naturalizing and reproducing the dominant social and cultural order. "Entry to Hospitality Careers for Women" is a government-funded program based on a partnership between a community organization and a community college specialised in vocational training. Uniquely, this program aims to expand immigrant and refugee women's employment skills as well as their social and cultural spaces. A community-based partnership research project was conducted to explore how the program worked towards these goals. It finds that the program contributed to the personal development of the women, expanded their social space and enhanced their social and economic opportunities to varying degrees. It also points to a set of women-centered pedagogical and programming practices that were conductive to women's learning through the program. Firstly, as a partnership, the program leveraged the resources and expertise accrued in both the community organization and the community college. Secondly, while navigating institutional mandate, the program was oriented towards the needs of the women. Finally, the women-centered and care-based pedagogy was found to be of immediate influence on the program participants. Theoretically, this paper adds to feminist pedagogy by grounding it in the actual work of immigrant service workers, which defies any abstract attempt to fix it within the binary frame of social reproduction and transformation.

The problem of empire has been a key theme in Islamic Liberation Theology (ILT). However insightful, ILT’s engagement with the category of empire has generally presumed a particular colonial configuration in which Muslims are located on the receiving “end” of power, being occupied by an external, non-Muslim force. But what about the presence of Islam within settler colonies, in which voluntary Muslim migrants are structurally complicit in the ongoing disenfranchisement of Indigenous peoples? Focusing on the Canadian context, I ask: How can we decolonise Islam in the settler colony? That is, how can Muslims address their own complicity with the settler colonial project, standing in solidarity with native peoples and revisiting their own faith tradition in the light of that praxis? I argue that decolonising Islam entails three hermeneutical moves: (I) gaining a critical understanding of the socio-historical context, namely, the history of empire on the land; (II) deconstructing the boundaries between “migrant” and “settler”, which actually serves to vindicate the former group, releasing them of accountability and responsibility; and (III) engaging in bold theological reflection on the Islamic tradition. This final theological step, I maintain, is a two-fold dynamic: expounding Islam as both a radical subject that decolonises and a problematic object requiring decolonisation.

This Special Issue is devoted to Islamic Liberation Theology (hitherto ILT) [...]

Electronic textiles (E-textiles) have experienced an increase in interest in recent years leading to a variety of new concepts emerging in the field. Despite these technical innovations, there is limited literature relating to the testing of E-textiles for some of the fundamental properties linked to wearer comfort. As such, this research investigates four fundamental properties of E-textiles: air permeability, drape, heat transfer, and moisture transfer. Three different types of E-textiles were explored: an embroidered electrode, a knitted electrode, and a knitted structure with an embedded electronic yarn. All of the E-textiles utilized the same base knitted fabric structure to facilitate a comparative study. The study used established textile testing practices to evaluate the E-textiles to ascertain the suitability of these standards for these materials. The study provides a useful point of reference to those working in the field and highlights some limitations of existing textile testing methodologies when applied to E-textiles. [ABSTRACT FROM AUTHOR]

Overexposure to hand transmitted vibrations (HTVs) from prolonged use of vibrating power tools can result in severe injuries. By monitoring the exposure of a worker to HTVs, overexposure, and injury, can be mitigated. An ideal HTV-monitoring system would measure vibration were it enters the body, which for many power tools will be the palm and fingers, however this is difficult to achieve using conventional transducers as they will affect the comfort of the user and subsequently alter the way that the tool is held. By embedding a transducer within the core of a textile yarn, that can be used to produce a glove, vibration can be monitored close to where it enters the body without compromising the comfort of the user. This work presents a vibration-sensing electronic yarn that was created by embedding a commercially available accelerometer within the structure of a yarn. These yarns were subsequently used to produce a vibration-sensing glove. The purpose of this study is to characterize the response of the embedded accelerometer over a range of relevant frequencies and vibration amplitudes at each stage of the electronic yarn’s manufacture to understand how the yarn structure influences the sensors response. The vibration-sensing electronic yarn was subsequently incorporated into a fabric sample and characterized. Finally, four vibration-sensing electronic yarns were used to produce a vibration-sensing glove that is capable of monitoring vibration at the palm and index finger.