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3. Risk perception and affective state on work exhaustion in obstetrics during the COVID-19 pandemic

Author

Perlini Cinzia, Garzon Simone, Franchi Massimo, Donisi Valeria, Rimondini Michela, Bosco Mariachiara, Uccella Stefano, Cromi Antonella, Ghezzi Fabio, Ginami Maddalena, Sartori Enrico, Ciccarone Francesca, Scambia Giovanni, Del Piccolo Lidia, and Raffaelli Ricciarda

Subjects
health personnel, covid-19, obstetrics, affect, burnout, professional, Medicine
Abstract

A multicenter cross-sectional survey study involving four Italian University Hospitals was performed to test the hypothesis that negative affect and positive affect (affective dimensions) mediate the association between risk perception (perceived risk of infection and death; cognitive dimensions) and the feeling of work exhaustion (WE) among obstetrics healthcare providers (HCPs) during the Coronavirus Disease 2019 (COVID-19) pandemic. Totally, 570 obstetrics HCPs were invited to complete the 104-item IPSICO survey in May 2020. A theoretical model built on the tested hypothesis was investigated by structural equation modelling. The model explained 32.2% of the WE variance. Only negative affect mediated the association between cognitive dimensions and WE and also the association between WE and psychological well-being before the pandemic, experiences of stressful events, female gender, and dysfunctional coping. Non-mediated associations with WE were observed for work perceived as a duty, experience of stressful events, support received by colleagues, and the shift strategy. Only previous psychological well-being, support by colleagues, and shift strategies were inversely associated with WE. Based on study results, monitoring negative than positive affect appears superior in predicting WE, with practical implications for planning psychological interventions in HCPs at the individual, interpersonal, and organizational levels.

Published
2022
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5. Agenesis of the ductus venosus and fetal growth restriction: Is there a relation? A tertiary care center experience and systematic review of the literature.

Author

Piemonti, Linda, Simonetto, Chiara, Bovino, Alessandra, Pinto, Alessia, Garzon, Simone, Grisolia, Gianpaolo, and Raffaelli, Ricciarda

Abstract

An update on the antenatal diagnosis of agenesis of ductus venosus (ADV) by differentiating the various possible types of shunts, focusing on the associated fetal anomalies, and predicting neonatal outcomes. This study reviewed the experience of two tertiary referral centers and literature. An unfavorable outcome was detected in preterm fetuses (p = 0.017), fetuses with a genetic anomaly (p = 0.046) or other associated malformations (p < 0.001). 71% of ADVs with other anomalies had an extrahepatic ADV (p = 0.002). 76% of fetuses with Fetal Growth Restriction (FGR) had an extrahepatic ADV (p = 0.025). ADV may negatively influence fetal growth in cases with extrahepatic vein drainage. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Learning climate and quality of Italian training courses in gynecology and obstetrics

Author

Candiani, Massimo, Casarin, Jvan, Ciavattini, Andrea, Paola, Rossana Di, Greco, Pantaleo, Guaschino, Secondo, Marchesoni, Diego, Milani, Rodolfo, Rizzo, Nicola, Venturini, Pier Luigi, Valente, Elena, Vizza, Enrico, Zanconato, Giovanni, Zullo, Fulvio, Sartori, Enrico, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Garzon, Simone, Raffaelli, Ricciarda, Scambia, Giovanni, and Franchi, Massimo

Published
2019
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15. The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

Author

Ferrari, Filippo Alberto, Magni, Francesca, Bosco, Mariachiara, Biancotto, Giulia, Zorzato, Pier Carlo, Laganà, Antonio Simone, Chiantera, Vito, Raffaelli, Ricciarda, Franchi, Massimo, Uccella, Stefano, Garzon, Simone, Ferrari, Filippo Alberto, Magni, Francesca, Bosco, Mariachiara, Biancotto, Giulia, Zorzato, Pier Carlo, Laganà, Antonio Simone, Chiantera, Vito, Raffaelli, Ricciarda, Franchi, Massimo, Uccella, Stefano, and Garzon, Simone

Subjects
Human papillomaviru, Micronutrients, Cervical cancer, Settore MED/40 - Ginecologia E Ostetricia, Cervical dysplasia, Cancer prevention
Abstract

There is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. We included studies having as their primary objective the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of HPV infection, development of cervical dysplasia, and invasive disease. Healthcare providers should be aware of and incorporate the literature evidence in counseling, although the low quality of evidence provided by available studies recommends further well-designed investigations to give clear indications for clinical practice.

Published
2023

18. The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

Author

Ferrari, Filippo Alberto, primary, Magni, Francesca, additional, Bosco, Mariachiara, additional, Biancotto, Giulia, additional, Zorzato, Pier Carlo, additional, Laganà, Antonio Simone, additional, Chiantera, Vito, additional, Raffaelli, Ricciarda, additional, Franchi, Massimo, additional, Uccella, Stefano, additional, and Garzon, Simone, additional

Published
2023
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23. The Psychological Impact of COVID-19 on Healthcare Providers in Obstetrics: A Cross-Sectional Survey Study

Author

Del Piccolo, Lidia, primary, Donisi, Valeria, additional, Raffaelli, Ricciarda, additional, Garzon, Simone, additional, Perlini, Cinzia, additional, Rimondini, Michela, additional, Uccella, Stefano, additional, Cromi, Antonella, additional, Ghezzi, Fabio, additional, Ginami, Maddalena, additional, Sartori, Enrico, additional, Ciccarone, Francesca, additional, Scambia, Giovanni, additional, and Franchi, Massimo, additional

Published
2021
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38. Evaluation of circ_100219 and miR-135b in serum and exosomes of healthy pregnant women.

Author

Montagnana, Martina, Benati, Marco, Tagetti, Angela, Raffaelli, Ricciarda, Danese, Elisa, Zatti, Nicoletta, Marcon, Denise, Branz, Lorella, Micheli, Chiara, Franchi, Massimo, Fava, Cristiano, and Lippi, Giuseppe

Subjects
EXOSOMES, RNA, PREGNANT women, POLYMERASE chain reaction
Abstract

Aim: Circular RNAs (circRNAs) are recently discovered and highly stable noncoding RNAs acting as gene regulators. These circRNAs can function as miRNA sponges, thereby upregulating or downregulating miRNA target gene expression. MiR-135b is expressed in placenta tissue and can be found in maternal circulation, thus playing a functional role in pregnancy. This miR is a target of circ_100219. This preliminary study was aimed to evaluate circ_100219 and miR-135b expression in pregnant and nonpregnant women, and explore the relationship between circ_100219 and miR-135b in serum and exosomes.Methods: Total RNA was isolated from serum and exosomes of 30 healthy pregnant women (32.9 ± 5.1 years) between 23-27 gestational weeks and 30 healthy nonpregnant women (31.3 ± 5.4 years). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to quantify circ_100219 and miR-135b expression. GAPDH and U6 snRNA were chosen as reference for normalizing expression levels. The differences between pregnant and nonpregnant women were assessed with Mann-Whitney test and correlation with Spearman's test.Results: The circ_100219 expression levels were significantly lower both in serum and exosomes of second trimester pregnant women compared to the control group (p < .0001), whilst Mir-135b expression levels were significantly higher in pregnant than in the control group (p < .0001). A significant negative correlation was observed between circ_100219 and miR-135b expression levels in both serum and exosomes (r = -0.34 and p = .009; r = -0.31 and p = .01, respectively). The circ_100219:miR-135b ratio was significantly increased in nonpregnant women compared to the pregnant group, in both serum and exosomes (49.0 versus 1.1, p < .0001 and 2042.4 versus 28.5, p < .0001, respectively).Conclusions: Our results confirm a role for circ_100219 and miR-135b in physiological pregnancy. Further studies are needed to investigate the circ_100219:miR-135b ratio in pregnancy complications. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Learning climate and quality of Italian training courses in gynecology and obstetrics

Author

Sartori, Enrico, primary, Ghezzi, Fabio, additional, Cromi, Antonella, additional, Laganà, Antonio Simone, additional, Garzon, Simone, additional, Raffaelli, Ricciarda, additional, Scambia, Giovanni, additional, Franchi, Massimo, additional, Candiani, Massimo, additional, Casarin, Jvan, additional, Ciavattini, Andrea, additional, Paola, Rossana Di, additional, Greco, Pantaleo, additional, Guaschino, Secondo, additional, Marchesoni, Diego, additional, Milani, Rodolfo, additional, Rizzo, Nicola, additional, Venturini, Pier Luigi, additional, Valente, Elena, additional, Vizza, Enrico, additional, Zanconato, Giovanni, additional, and Zullo, Fulvio, additional

Published
2019
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45. Complement activation in the plasma and placentas of women with different subsets of antiphospholipid syndrome

Author

Scambi, Cinzia, primary, Ugolini, Sara, additional, Tonello, Marta, additional, Bortolami, Oscar, additional, De Franceschi, Lucia, additional, Castagna, Annalisa, additional, Lotti, Virginia, additional, Corbella, Michela, additional, Raffaelli, Ricciarda, additional, Caramaschi, Paola, additional, Mattia, Elena, additional, Biasi, Domenico, additional, and Ruffatti, Amelia, additional

Published
2019
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