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Objetivo: avaliar os efeitos do tratamento crônico com Celecoxibe e Indometacina sobre a função renal de ratos. Materiais e Métodos: Os ratos foram submetidos a um modelo experimental de doença renal crônica moderada (nefrectomia ¾), randomizados em três grupos, alocados em gaiolas metabólicas individuais e receberam administrações distintas durante quatorze dias por gavagem: 1- Água destilada, 2- Celecoxibe 200mg/Kg e 3- Indometacina 5mg/Kg. Foram avaliados diariamente parâmetros como peso, ingesta hídrica, alimentar, débito urinário e ao final do experimento, foram coletadas amostras de urina e sangue para dosagens de ureia, creatinina sérica e urinária, glicemia e clearance de creatinina. Resultados: Apesar de não haver diferença significativa no clearance de creatinina entre os grupos, a maior mortalidade no grupo indometacina pode evidenciar que seus efeitos adversos na função renal são mais importantes se comparados aos do celecoxibe. Conclusão: O celecoxibe demostrou, sob as condições experimentais utilizadas, ser seguro em ratos submetidos à doença renal crônica moderada. Observou-se aumento significativo na mortalidade do grupo Indometacina. Palavras-chave: celecoxibe, indometacina, doença renal. ABSTRACT Objectives: to evaluate the effect of chronic treatment with Celecoxib and indomethacin on renal function in rats. Methodology: The rats were subjected to an experimental model of moderate chronic kidney disease ( ¾ nephrectomy ) were randomized into three groups allocated in individual metabolic cages and received separate administrations during fourteen days by gavage : 1- Distilled water, 2- Celecoxib 200mg/Kg and 3- Indomethacin 5mg/Kg . Parameters such as body weight, water intake, food , urine , and urine output was evaluated at the end of the experiment , blood and urine samples were collected for serum urea , serum and urinary creatinine, glucose and creatinine clearance were assessed daily . Results: Although there was no significant difference in creatinine clearance between the groups, the higher mortality in the indomethacin group can demonstrate that their adverse effects on renal function are more important if compared to celecoxib. Conclusion: Celecoxib demonstrated, under the experimental conditions used, to be safe in rats with moderate chronic kidney disease. There was a significant increase in mortality Indomethacin Group. Keywords: celecoxib, indomethacin, renal disease.

PURPOSE: To evaluate the effects of acute administration of Sedum dendroideum on the gastric histopathology of rats after the administration of indomethacin. METHODS: Twenty four Wistar rats were randomized into three groups, submitted to feeding privation for 24 hours prior to the oral administration of 50 mg/Kg of indomethacin and during the experimental period of six hours. The control group (C) was giving distilled water, the extract group (E) was treated with the extract of Sedum dendroideum and the group Omeoprazole (O) received 20 mg/Kg of omeoprazole. All the treatments were carried out thirty minutes prior to the administration of indomethacin. After six hour, the stomach of the animals was extirpated for histopathological analysis, which took into account the presence of erosive gastritis, hyperemia and sub mucosa edema. RESULTS: In group C, eight out of eight animals presented that type of lesion, in group E, this number was the same and in group O, three out of the eight rats presented erosive gastritis. CONCLUSION: