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1. The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)

Author

María Caldas, Ángeles Pérez-Aisa, Bojan Tepes, Alma Keco-Huerga, Luis Bujanda, Alfredo J. Lucendo, Luis Rodrigo, Dino Vaira, Luis Fernández-Salazar, Jose M. Huguet, Jorge Pérez-Lasala, Natasa Brglez Jurecic, Galina Fadeenko, Jesús Barrio, Miguel Areia, Juan Ortuño, Rinaldo Pellicano, Marcis Leja, Javier Molina-Infante, Pavel Bogomolov, Sergey Alekseenko, Manuel Domínguez-Cajal, Judith Gómez-Camarero, Vassiliki Ntouli, Samuel J. Martínez-Domínguez, Rafael Ruiz-Zorrilla, Oscar Núñez, Aiman Silkanovna Sarsenbaeva, Pedro Almela, Perminder Phull, Marta Espada, Ignasi Puig, Olga P. Nyssen, Francis Mégraud, Colm O’Morain, Javier P. Gisbert, and on behalf of the Hp-EuReg Investigators

Subjects
statins, Helicobacter pylori, treatment, Therapeutics. Pharmacology, RM1-950
Abstract

Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3; 95%CI = 1.1–1.5), but no association was found with first-line treatment effectiveness (N = 7738); as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76; 95%CI = 0.59–0.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9; 95%CI = 1.4–2.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8; 95%CI = 1.3–5.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates.

Published
2021
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2. European Registry on Helicobacter pylori Management: Effectiveness of First and Second-Line Treatment in Spain

Author

María Caldas, Ángeles Pérez-Aisa, Manuel Castro-Fernández, Luis Bujanda, Alfredo J. Lucendo, Luis Rodrigo, Jose M. Huguet, Jorge Pérez-Lasala, Javier Molina-Infante, Jesús Barrio, Luis Fernández-Salazar, Ángel Lanas, Mónica Perona, Manuel Domínguez-Cajal, Juan Ortuño, Blas José Gómez-Rodríguez, Pedro Almela, Josep María Botargués, Óscar Núñez, Inés Modolell, Judith Gómez, Rafael Ruiz-Zorrilla, Cristóbal De la Coba, Alain Huerta, Eduardo Iyo, Liliana Pozzati, Rosario Antón, Mercé Barenys, Teresa Angueira, Miguel Fernández-Bermejo, Ana Campillo, Javier Alcedo, Ramón Pajares-Villaroya, Marianela Mego, Fernando Bermejo, José Luis Dominguez-Jiménez, Llúcia Titó, Nuria Fernández, Manuel Pabón-Carrasco, Ángel Cosme, Pilar Mata-Romero, Noelia Alcaide, Inés Ariño, Tommaso Di Maira, Ana Garre, Ignasi Puig, Olga P. Nyssen, Francis Megraud, Colm O’Morain, and Javier P. Gisbert

Subjects
Helicobacter pylori, treatment, first-line, second-line, Spain, Therapeutics. Pharmacology, RM1-950
Abstract

The management of Helicobacter pylori infection has to rely on previous local effectiveness due to the geographical variability of antibiotic resistance. The aim of this study was to evaluate the effectiveness of first and second-line H. pylori treatment in Spain, where the empirical prescription is recommended. A multicentre prospective non-interventional registry of the clinical practice of European gastroenterologists concerning H. pylori infection (Hp-EuReg) was developed, including patients from 2013 until June 2019. Effectiveness was evaluated descriptively and through a multivariate analysis concerning age, gender, presence of ulcer, proton-pump inhibitor (PPI) dose, therapy duration and compliance. Overall, 53 Spanish hospitals were included, and 10,267 patients received a first-line therapy. The best results were obtained with the 10-day bismuth single-capsule therapy (95% cure rate by intention-to-treat) and with both the 14-day bismuth-clarithromycin quadruple (PPI-bismuth-clarithromycin-amoxicillin, 91%) and the 14-day non-bismuth quadruple concomitant (PPI-clarithromycin-amoxicillin-metronidazole, 92%) therapies. Second-line therapies were prescribed to 2448 patients, with most-effective therapies being the triple quinolone (PPI-amoxicillin-levofloxacin/moxifloxacin) and the bismuth-levofloxacin quadruple schemes (PPI-bismuth-levofloxacin-amoxicillin) prescribed for 14 days (92%, 89% and 90% effectiveness, respectively), and the bismuth single-capsule (10 days, 88.5%). Compliance, longer duration and higher acid inhibition were associated with higher effectiveness. “Optimized” H. pylori therapies achieve over 90% success in Spain.

Published
2020
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3. Ovesco system for treatment of postpolypectomy bleeding after failure of conventional treatment

Author

Noelia Alcaide, Irene Peñas-Herrero, Lorena Sancho-del-Val, Rafael Ruiz-Zorrilla, Jesús Barrio, and Manuel Pérez-Miranda

Subjects
Ovesco, Clip de nitinol, Hemostasia, Hemorragia gastrointestinal, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

The clip Ovesco (Ovesco, Tübingen, Germany) is a novel endoscopic method for mechanical compression of tissue in the gastrointestinal tract. The indications for treatment are closure of perforations and fistulas and control of bleeding in which the conventional endoscopic treatment has failed. We report two cases about the use of an Ovesco (over-the-scope clip, OTSC) system to control persistent bleeding postpolypectomy after failure of usual treatment.

Published
2014
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5. European Registry on

Author

María, Caldas, Ángeles, Pérez-Aisa, Manuel, Castro-Fernández, Luis, Bujanda, Alfredo J, Lucendo, Luis, Rodrigo, Jose M, Huguet, Jorge, Pérez-Lasala, Javier, Molina-Infante, Jesús, Barrio, Luis, Fernández-Salazar, Ángel, Lanas, Mónica, Perona, Manuel, Domínguez-Cajal, Juan, Ortuño, Blas José, Gómez-Rodríguez, Pedro, Almela, Josep María, Botargués, Óscar, Núñez, Inés, Modolell, Judith, Gómez, Rafael, Ruiz-Zorrilla, Cristóbal, De la Coba, Alain, Huerta, Eduardo, Iyo, Liliana, Pozzati, Rosario, Antón, Mercé, Barenys, Teresa, Angueira, Miguel, Fernández-Bermejo, Ana, Campillo, Javier, Alcedo, Ramón, Pajares-Villaroya, Marianela, Mego, Fernando, Bermejo, José Luis, Dominguez-Jiménez, Llúcia, Titó, Nuria, Fernández, Manuel, Pabón-Carrasco, Ángel, Cosme, Pilar, Mata-Romero, Noelia, Alcaide, Inés, Ariño, Tommaso, Di Maira, Ana, Garre, Ignasi, Puig, Olga P, Nyssen, Francis, Megraud, Colm, O'Morain, Javier P, Gisbert, and Leyanira Torrealba, Medina

Subjects
second-line, Helicobacter pylori, treatment, Spain, first-line, bacterial infections and mycoses, Article
Abstract

The management of Helicobacter pylori infection has to rely on previous local effectiveness due to the geographical variability of antibiotic resistance. The aim of this study was to evaluate the effectiveness of first and second-line H. pylori treatment in Spain, where the empirical prescription is recommended. A multicentre prospective non-interventional registry of the clinical practice of European gastroenterologists concerning H. pylori infection (Hp-EuReg) was developed, including patients from 2013 until June 2019. Effectiveness was evaluated descriptively and through a multivariate analysis concerning age, gender, presence of ulcer, proton-pump inhibitor (PPI) dose, therapy duration and compliance. Overall, 53 Spanish hospitals were included, and 10,267 patients received a first-line therapy. The best results were obtained with the 10-day bismuth single-capsule therapy (95% cure rate by intention-to-treat) and with both the 14-day bismuth-clarithromycin quadruple (PPI-bismuth-clarithromycin-amoxicillin, 91%) and the 14-day non-bismuth quadruple concomitant (PPI-clarithromycin-amoxicillin-metronidazole, 92%) therapies. Second-line therapies were prescribed to 2448 patients, with most-effective therapies being the triple quinolone (PPI-amoxicillin-levofloxacin/moxifloxacin) and the bismuth-levofloxacin quadruple schemes (PPI-bismuth-levofloxacin-amoxicillin) prescribed for 14 days (92%, 89% and 90% effectiveness, respectively), and the bismuth single-capsule (10 days, 88.5%). Compliance, longer duration and higher acid inhibition were associated with higher effectiveness. “Optimized” H. pylori therapies achieve over 90% success in Spain.

Published
2020

6. Rescue of a migrated pancreatic stent using a hand-made loop-catheter

Author

Rafael Ruiz-Zorrilla López, Pablo Palomares Rivas, and Eduardo López Fernández

Subjects
Cholangiopancreatography, Endoscopic Retrograde, medicine.medical_specialty, Catheters, business.industry, Gastroenterology, General Medicine, equipment and supplies, Cannula, Pancreatic stent, Surgery, Loop (topology), Catheter, surgical procedures, operative, Foreign-Body Migration, Humans, Medicine, Stents, Plastic stent, business, Pancreas, Device Removal
Abstract

We present a pancreatic plastic stent migration case and the difficulty of an endoscopic approach to remove it, this time resolved with a hand-made loop catheter using a straight cannula and a NovaGold guide.

Published
2020
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7. EUS-guided drainage of postsurgical pelvic abscesses using lumen-apposing metal stents

Author

Rafael Ruiz Zorrilla, Aránzazu Álvarez Álvarez, Cristóbal de la Coba Ortiz, María Curieses Luengo, and Eduardo López Fernández

Subjects
Endoscopic ultrasound, Male, medicine.medical_specialty, Percutaneous, Abdominal Abscess, Lumen (anatomy), Endosonography, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, medicine, Humans, Drainage, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Gastroenterology, General Medicine, Middle Aged, bacterial infections and mycoses, body regions, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, Stents, Radiology, business, Eus guided drainage
Abstract

Endoscopic ultrasound (EUS) guided drainage of pelvic collections is an alternative to percutaneous or surgical drainage. We present our experience using lumen-apposing metal stents (LAMS) for the drainage of postoperative pelvic abscesses.

Published
2019

9. Ovesco system for treatment of postpolypectomy bleeding after failure of conventional treatment

Author

Irene Penas-Herrero, Noelia Alcaide, Lorena Sancho-del-Val, Rafael Ruiz-Zorrilla, Manuel Perez-Miranda, and Jesús Barrio

Subjects
medicine.medical_specialty, Colonic Polyps, Postoperative Hemorrhage, Hemorragia gastrointestinal, Endoscopy, Gastrointestinal, Mechanical compression, Hemostasia, Humans, Medicine, lcsh:RC799-869, Gastrointestinal bleeding, Aged, Hemostasis, medicine.diagnostic_test, business.industry, Gastroenterology, Conventional treatment, General Medicine, Surgical Instruments, Surgery, Endoscopy, Nitinol clip, Female, lcsh:Diseases of the digestive system. Gastroenterology, business, Endoscopic treatment, Clip de nitinol, Ovesco
Abstract

The clip Ovesco (Ovesco, Tübingen, Germany) is a novel endoscopic method for mechanical compression of tissue in the gastrointestinal tract. The indications for treatment are closure of perforations and fistulas and control of bleeding in which the conventional endoscopic treatment has failed. We report two cases about the use of an Ovesco (over-the-scope clip, OTSC) system to control persistent bleeding postpolypectomy after failure of usual treatment.

Published
2014

10. The utility of faecal calprotectin to predict post-operative recurrence in Crohńs disease

Author

Maria Teresa Herranz Bachiller, Lorena Sancho Del Val, Ramón Atienza Sánchez, Luis Fernández Salazar, Jesús Barrio Andrés, and Rafael Ruiz-Zorrilla

Subjects
Adult, Male, medicine.medical_specialty, Colonoscopy, Disease, Gastroenterology, Sensitivity and Specificity, 03 medical and health sciences, Feces, fluids and secretions, 0302 clinical medicine, Crohn Disease, Ileum, Recurrence, Internal medicine, Statistical significance, Area under curve, medicine, Humans, Post operative, Colectomy, Retrospective Studies, medicine.diagnostic_test, business.industry, digestive, oral, and skin physiology, Middle Aged, Faecal calprotectin, Surgery, Ileocolic resection, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Diagnostic validity, 030211 gastroenterology & hepatology, Female, business, Leukocyte L1 Antigen Complex, Biomarkers
Abstract

Endoscopic recurrence in Crohńs disease occurs in up to 80% of patients during the first year after surgery. Due to this, these patients need close monitoring. Faecal calprotectin has been proposed to be used as a non-invasive marker to monitor inflammatory activity. Up to now the use of faecal markers in endoscopic recurrence has been scarcely studied and with contradictory results.This was a cross-sectional observational study of diagnostic validity. It included all patients with Crohńs disease (CD) and ileocolic resection retrospectively who had had an ileocolonoscopy and a determination of faecal calprotectin before this colonoscopy, from 2007 to 2015.Ninety-seven patients were included. We observed that the mean value of faecal calprotectin increased as the Rutgeerts score increased. The variable of that most statistical significance obtained in bivariate analysis was faecal calprotectin (p 0.0001). Area under curve (AUC) of faecal calprotectin in endoscopic recurrence was 0.74 (95% CI: 0.644-0.842), and an optimal cut-off of 60 mcrgr/gr, obtained a score of 0.45 using Youden test. This indicated that calprotectin would have 88% Sensitivity and 58% Specificity in detecting any recurrence, the NPV was approximately 83,9%. None of the other variables studied had a significant correlation.Faecal calprotectin predicts endoscopic recurrence in CD patients who have gone through surgery, however the cut-off point is still a problem so we cannot recommend calprotectin as a substitute of colonoscopy for CD monitoring and treatment adjustment.

Published
2016

11. EFICACIA DE UN ALGORITMO TERAPÉUTICO COMBINADO CON CPRE Y ECOENDOSCOPIA EN EL TRATAMIENTO DE LAS TRANSECCIONES DUCTALES COMPLETAS DE LA VÍA BILIAR: RESULTADOS A MEDIO PLAZO

Author

I Peñas Herrero, C. Almohalla, F. Garcia Pajares, P Gil Simón, R Sánchez Ocaña, G. Sánchez Antolín, M Pérez-Miranda, Rafael Ruiz-Zorrilla, N Alemán Pérez, and C De La Serna Higuera

Subjects
business.industry, Gastroenterology, Medicine, business, Humanities
Abstract

Introduccion: Las transecciones ductales completas (TDC) de la via biliar no se consideran susceptibles de tratamiento endoscopico. Objetivo: Describir y evaluar la viabilidad de diversos abordajes endoscopicos para tratamiento de TDC. Material y Metodo: Desde septiembre-2010 se registran prospectivamente 248 CPRE por complicaciones postquirurgicas (estenosis/fugas) en 150 pacientes (69 trasplante hepatico TH, 81 Otras). Se identifican TDC en 17 pacientes (Mujeres = 9; edad = 59.6 [43 – 79] anos) con TDC (7 TH; 7 colecistectomia CCx; 3 Otras). Resultados: Se logro recanalizacion en 12/17 TDC (70%), por CPRE aislada en 5 (4 TH, 1 CCx), y por CPRE combinada con abordaje anterogrado por USE en 7 (2 TH, 4 CCx, 1 Otra), en 4 casos la ausencia de dilatacion biliar impidio abordaje USE y en otro no se logro recanalizacion a pesar de hepaticogastrostomia USE-guiada. Hubo 5 fracasos, remitidos a hepatico-yeyunostomia quirurgica. 10/12 casos recanalizados precisaron maniobras forzadas por via anterograda o retrograda: manipulacion con el cabo rigido de la guia, needle-knife, aguja de Artifon, retroperitoneoscopia transhepatica o anastomosis magnetica. Se requirieron 1.5 (1 – 5) CPREs hasta lograr la recanalizacion. Se drenaron endoscopicamente 2 bilomas asociados a TDC. Once pacientes han finalizado 12 ciclos de tratamiento con retirada definitiva de protesis (plasticas, n = 2; metalicas cubiertas ± plasticas, n = 10) tras 323(180 – 503) dias de tutorizacion. Tras un seguimiento medio de 353 (30 – 900) dias, hubo 3 recidivas (hepaticoyeyunostomia quirurgica, tratamiento endoscopico en curso, resuelta tras nuevo ciclo endoscopico, una cada uno). Como complicaciones se registraron 2 colangitis y 1 sangrado. Conclusiones: El 70% de las TDC postquirurgicas pueden recanalizarse endoscopicamente con metodos mecanicos forzados (guia rigida o agujas), diatermicos o magneticos. La USE permite rescatar para reconexion el 60% de los fracasos de la CPRE y el drenaje de bilomas. Los resultados definitivos del tratamiento endoscopico con protesis de las TDC parecen equiparables a los de las estenosis parciales.

Published
2013
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13. Clipping for endoscopic perforations: initial success but late complication requiring surgery

Author

Baltasar Perez-Saborido, Enrique Asensio, José L. Marcos, Rafael Ruiz-Zorrilla, Ruth Martinez, Jose C. Sarmentero, Rosalía Velasco, José Ignacio Blanco, Mario Rodriguez Lopez, Fernando Labarga, Marta Gonzalo, and Sara Mambrilla

Subjects
Male, medicine.medical_specialty, Conservative management, business.industry, Colon, Fistula, medicine.medical_treatment, Late complication, Clipping (medicine), Colonoscopy, medicine.disease, Surgery, Nonoperative treatment, Intestinal Perforation, Medicine, Endoscopic clipping, Humans, Female, CLIPS, business, computer, Abdominal surgery, computer.programming_language
Abstract

This response discusses the article by Kim and colleagues entitled "endoscopic clip closure versus surgery for the treatment of iatrogenic colon perforations developed during diagnostic colonoscopy: a review of 115,285 patients". Iatrogenic colonoscopic perforation, although uncommon, implies serious management problems for endoscopists and surgeons. Nonoperative treatment currently is recommended under certain conditions, and endoscopic clips can primarily close iatrogenic perforations, helping to avoid surgery. Of the 27 colonoscopic perforation cases presented in the article by Kim and colleagues, 16 were managed by endoscopic clipping closure and 11 by primary surgery. Conservative treatment failed for three patients. Only perforation size obtained statistical significance among the nine variables contrasted between the 11 cases with primary surgery and the 13 cases with successful endoscopic clipping. The results for the three patients whose endoscopic closure failed are not reported. The authors of this letter think it would have been interesting if these three patients had been included in the analysis due to the high importance of discovering factors that can predict failure of endoscopic clipping for perforations. To call attention to possible late complications requiring surgery even when initial conservative management of endoscopic perforation succeeds, the authors of this letter present a case of a colocutaneous (actually, sigmoid-scrotal) fistula in a patient 2 weeks after an apparently successful closure of colonoscopic perforation with an “over-the-scope” clip.

Published
2013

14. Tu1335 European Registry on H. pylori Management (HP-EuReg) in Spain: Interim Analysis in First and Second Line Therapies

Author

J. Gomez, Juan Ortuño, Joaquín Hinojosa, Manuel Castro-Fernandez, Angel Lanas, Maria Caldas, Colm O'Morain, Luis Bujanda, Jorge Perez-Lasala, Josep M. Botargues, Monica Perona, Pedro Almela, Alfredo J. Lucendo, Manuel Rodríguez-Téllez, R. Pajares, Luis Fernández Salazar, F Bermejo, Manuel Domínguez-Cajal, Javier Alcedo, Luis Ferrer Barceló, José María Huguet, Cristobal De la Coba, Javier Molina-Infante, Javier P. Gisbert, Rafael Ruiz-Zorrilla, Enrique Medina, Ines Modolell, Jesus Barrio, Angeles Perez Aisa, Mercedes Ramas, Blas-Jose Gomez-Rodriguez, Liliana Pozzati, Adrian G. McNicholl, Luis Rodrigo, and Mercè Barenys

Subjects
Pediatrics, medicine.medical_specialty, Second line, Hepatology, business.industry, Family medicine, Gastroenterology, medicine, Interim analysis, business
Published
2016
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17. HEPATICOGASTROSTOMÍA ENDOSCOPICA (HGE) TEMPORAL CON PRÓTESIS METÁLICAS CUBIERTAS (PMC) PARA DRENAJE Y ACCESO TERAPÉUTICO EN PATOLOGÍA BILIAR BENIGNA NO SUSCEPTIBLE DE CPRE

Author

Pilar Diez-Redondo, S Del Val, I Peñas Herrero, N Alcaide Suárez, M Pérez-Miranda, Angeles M. Vargas, Rafael Ruiz-Zorrilla, G Flores, J Barrio Andrés, and C De La Serna Higuera

Subjects
Gynecology, medicine.medical_specialty, business.industry, Gastroenterology, medicine, business
Published
2012
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21. EUS-guided transenteric gallbladder drainage with a new fistula-forming, lumen-apposing metal stent

Author

Paula Gil-Simon, Rafael Ruiz-Zorrilla, Lorena Sancho Del Val, Pilar Diez-Redondo, Henar Nuñez-Rodriguez, Carlos de la Serna-Higuera, Noelia Alcaide, and Manuel Perez-Miranda

Subjects
Male, medicine.medical_specialty, Duodenum, medicine.medical_treatment, Fistula, Cholecystitis, Acute, Lumen (anatomy), Pilot Projects, Endosonography, medicine, Humans, Radiology, Nuclear Medicine and imaging, Endoscopy, Digestive System, Drainage, Ultrasonography, Interventional, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, business.industry, Gallbladder, Gastroenterology, Follow up studies, Stent, Middle Aged, medicine.disease, Endoscopy, medicine.anatomical_structure, Treatment Outcome, Cholecystitis, Female, Stents, Radiology, business, Follow-Up Studies
Published
2012

22. Cutaneous mucormycosis infection by Absidia in two consecutive liver transplant patients

Author

B. Madrigal Rubiales, Henar Nuñez-Rodriguez, A Vargas García, Félix García-Pajares, C. Almohalla Alvárez, Rafael Ruiz-Zorrilla, Gloria Sánchez-Antolín, I Peñas Herrero, A. Gómez-Nieto, A. Barrera, L Sancho del Val, and Agustín Caro-Patón

Subjects
Male, medicine.medical_specialty, Antifungal Agents, Orthotopic liver transplantation, medicine.medical_treatment, Liver transplantation, Absidia, Amphotericin B, medicine, Dermatomycoses, Humans, Mucormycosis, In patient, Transplantation, Cutaneous mucormycosis, biology, business.industry, Middle Aged, medicine.disease, biology.organism_classification, Combined Modality Therapy, Surgery, Liver Transplantation, surgical procedures, operative, Treatment Outcome, Debridement, Transplant patient, Female, business
Abstract

Mucormycosis, although an infrequent fungal infection, has a high mortality in patients undergoing orthotopic liver transplantation. We present two cases of cutaneous Absidia mucormycosis in two successive patients undergoing liver transplantation in our hospital. In our literature search, we encountered only one published case of Absidia infection in liver transplantation.

Published
2012

23. FÍSTULAS DE ACCESO TERAPÉUTICO (FAT) EN PATOLOGÍA BILIAR COMPLEJA CON PRÓTESIS METÁLICAS CUBIERTAS (PMC) TRANSMURALES TEMPORALES: CONCEPTO, INDICACIONES Y RESULTADOS

Author

MT Herranz Bachiller, N Alcaide Suárez, L Sancho del Val, Rafael Ruiz-Zorrilla, M Pérez-Miranda, MP Diez Redondo, C De la Serna-Higuera, Paula Gil-Simon, Agustín Caro-Patón, and Sara Lorenzo-Pelayo

Subjects
Gynecology, medicine.medical_specialty, business.industry, Gastroenterology, Medicine, business
Published
2011
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24. RECIDIVA TARDÍA DE LAS ESTENOSIS ANASTOMÓTICAS EN PACIENTES TRASPLANTADOS HEPÁTICOS (EA-TOH) TRAS RESPUESTA INICIAL A PRÓTESIS METÁLICA CUBIERTA (PMC)

Author

Gloria Sánchez-Antolín, S Gómez de la Cuesta, Sara Lorenzo-Pelayo, L Sancho del Val, Rafael Ruiz-Zorrilla, C. Almohalla, Félix García-Pajares, Agustín Caro-Patón, C De la Serna-Higuera, and M Pérez-Miranda

Subjects
Gynecology, medicine.medical_specialty, business.industry, Gastroenterology, medicine, business
Published
2011
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25. EUS-guided drainage of liver abscess by using a lumen-apposing metal stent (with video)

Author

Alba Luz Vargas-Garcia, Carlos de la Serna-Higuera, Noelia Alcaide, Lorena Sancho Del Val, Manuel Perez-Miranda, and Rafael Ruiz-Zorrilla

Subjects
Aged, 80 and over, Cholangiopancreatography, Endoscopic Retrograde, Male, medicine.medical_specialty, Cholangitis, business.industry, medicine.medical_treatment, Liver Abscess, Gastroenterology, Lumen (anatomy), Stent, Staphylococcal Infections, medicine.disease, Endosonography, Surgery, Drainage, Humans, Medicine, Stents, Radiology, Nuclear Medicine and imaging, Radiology, business, Ultrasonography, Interventional, Eus guided drainage, Liver abscess
Published
2013
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26. Su1568 EUS-Guided Gallbladder Drainage With Lumen-Apposing Metal Stents vs Percutaneous Transhepatic Approach for Acute Cholecystitis: a Mid-Term Comparative Analysis of Efficacy and Safety

Author

Pilar Diez-Redondo, Rafael Ruiz-Zorrilla, Manuel Perez-Miranda, Paula Gil-Simon, Irene PeñAs, Noelia Alcaide, Lorena Sancho Del Val, Carlos De la Serna, and Alba L. Vargas

Subjects
medicine.medical_specialty, Transhepatic approach, Percutaneous, business.industry, Gallbladder, Gastroenterology, Lumen (anatomy), medicine.anatomical_structure, Acute cholecystitis, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, Drainage, business
Published
2013
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27. Su1353 Endoscopic Porcine Model of Biliary Obstruction Using Over-the-Scope Clips: Feasibility and Applicability to Training in EUS-Guided Drainage Procedures

Author

Manuel Perez-Miranda, Lorena Sancho Del Val, Victor Aguilar Urbano, Carlos De la Serna, Alba L. Vargas, Sara Lorenzo-Pelayo, Irene PeñAs, Rafael Ruiz-Zorrilla, and Noelia Alcaide

Subjects
medicine.medical_specialty, Scope (project management), business.industry, General surgery, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, CLIPS, business, computer, Eus guided drainage, computer.programming_language, Surgery
Published
2013
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28. Colonic polyp secondary to Anisakis simplex

Author

Carlos de-la-Serna-Higuera, Manuel Perez-Miranda, Ramón Atienza-Sánchez, Jesús Barrio-Andrés, María Teresa Herranz-Bachiller, Rafael Ruiz-Zorrilla, Lorena Sancho-del-Val, and Noelia Alcaide-Suárez

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Granuloma, Anisakis simplex, Gastroenterology, Medicine, General Medicine, Colonic Polyp, business, medicine.disease, Surgery
Published
2012
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29. 688 Feasibility and Safety of Covered Self-Expandable Metal Stent (CSEMS) Placement Above the Hepatic Duct Confluence At ERCP in Benign Bile-Duct Disease

Author

Ramon Sanchez-Ocana, Manuel Perez-Miranda, Carlos De la Serna, Fernando Santos Santamarta, Paula Gil-Simon, Irene PeñAs, Alba L. Vargas, Rafael Ruiz-Zorrilla, and Nestor Aleman

Subjects
medicine.medical_specialty, Self expandable, Bile duct, business.industry, medicine.medical_treatment, Gastroenterology, Stent, Surgery, medicine.anatomical_structure, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Duct (anatomy)
Published
2014
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30. Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome

Author

Sara Lorenzo Pelayo, Maria Teresa Herranz Bachiller, Jesús Barrio Andrés, Rafael Ruiz-Zorrilla, Lorena Sancho Del Val, Ramón Atienza Sánchez, Noelia Alcaide Suárez, Manuel Perez Miranda, Fernando Pons, and Carlos De La Serna Higuera

Subjects
Pathology, medicine.medical_specialty, Endometrial Tumor, medicine.diagnostic_test, business.industry, Gastroenterology, Colonoscopy, Case Report, Acanthosis, Cowden syndrome, medicine.disease, Oncology, Hamartomatous polyposis, medicine, Hamartoma, Neurofibromatosis, business, Ganglioneuromatosis
Abstract

Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN II, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome.

Published
2013
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31. Su1353 Perforations During GI Endoscopy: Feasibility, Approaches and Outcomes of Endoscopy Management in Real Practice

Author

Paula Gil-Simon, Manuel Perez-Miranda, Pilar Diez-Redondo, Jesus Barrio, Sara Lorenzo-Pelayo, Carlos De la Serna, Rafael Ruiz-Zorrilla, and Mteresa Herranz

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, Gi endoscopy, business, Endoscopy
Published
2012
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33. 384 Transmural Access and Therapy of Bile-Duct Disease in Patients With Complex Anatomy Using Temporary Covered Self-Expandable Metal Stents (CSEMS)

Author

Manuel Perez-Miranda, Sara Lorenzo-Pelayo, Lorena Sancho Del Val, Rafael Ruiz-Zorrilla, Noelia Alcaide, Agustín Caro-Patón, Carlos De la Serna, and Mteresa Herranz

Subjects
medicine.medical_specialty, medicine.anatomical_structure, business.industry, Bile duct, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, In patient, Radiology, business, Self Expandable Metal Stents, Surgery
Published
2011
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35. European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients

Author

Nyssen OP, Bordin D, Tepes B, Pérez-Aisa Á, Vaira D, Caldas M, Bujanda L, Castro-Fernandez M, Lerang F, Leja M, Rodrigo L, Rokkas T, Kupcinskas L, Pérez- Lasala J, Jonaitis L, Shvets O, Gasbarrini A, Simsek H, Axon ATR, Buzás G, Machado JC, Niv Y, Boyanova L, Goldis A, Lamy V, Tonkic A, Przytulski K, Beglinger C, Venerito M, Bytzer P, Capelle L, Milosavljević T, Milivojevic V, Veijola L, Molina-Infante J, Vologzhanina L, Fadeenko G, Ariño I, Fiorini G, Garre A, Garrido J, F Pérez C, Puig I, Heluwaert F, Megraud F, O'Morain C, Gisbert JP, Romano M, Universidad Autónoma de Madrid (UAM), AS Loginov Moscow Clinical Scientific Center [Moscow, Russian Federation], A.I. Yevdokimov Moscow State University of Medicine and Dentistry [Moscow, Russian Federation], AM DC Rogaska [Rogaska Slatina, Slovenia], Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), University of Bologna/Università di Bologna, Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Liver Unit, Clínica Universitaria, CIBER-EHD, Østfold Hospital, University of Latvia (LU), Universidad de Oviedo [Oviedo], Henry Dunant Hospital [Athens, Greece], Lithuanian University of Health Sciences [Kaunas, Lithuania], Hospital Universitario HM Sanchinarro [Madrid, Spain], Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Leeds General Infirmary (LGI), Leeds Teaching Hospitals NHS Trust, Ferencváros Health Centre [Budapest, Hungary], Faculdade de Medicina da Universidade do Porto (FMUP), Universidade do Porto = University of Porto, Tel Aviv University (TAU), Medical University of Sofia [Bulgarie], Timisoara Hospital [Timisoara, Romania], Centre Hospitalier Universitaire de Charleroi, University of Split, Medical Centre for Postgraduate Education [Warsaw, Poland], University Hospital Basel [Basel], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Copenhagen University Hospital, Meander Medical Center [Amersfoort, Netherlands], University of Belgrade [Belgrade], Herttoniemi Hospital [Helsinki, Finland], San Pedro de Alcantara Hospital [Cáceres, Espagne], Gastrocentr [Perm, Russian Federation], Digestive Ukrainian Academy of Medical Sciences [Kyiv, Ukraine], Hospital Clínico Universitario 'Lozano Blesa' [Zaragoza, Spain], Althaia Xarxa Assistencial Universitària de Manresa [Manresa, Spain], Universitat de Vic-Universitat Central de Catalunya [Manresa, Spain] (UVicUCC), Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne] (CHUS), Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Trinity College Dublin, Hp-EuReg Investigators: Jen Hinojosa, Inmaculada Santaella, Nuria Fernandez Moreno, Ilaria Maria Saracino, Horacio Alonso Galán, Almudena Durán, Jennifer Fernandez Pacheco, Miroslav Vujasinovic, Rinaldo Pellicano Molinette, Zdenko Kikec, Pedro-Luis Gonzalez Cordero, Maia Donday, Polona Lampic, Vid Leban, Aleksander Gruncic Krajnc, Natasa Brglez Jurecic, Galyna Dmytrivna Fadieienko, Lorena Lee, Irene V Barbado, Alfredo José Lucendo, Alfredo José Lucendo, Jesus Barrio RIo Hortega, Tatiana Alekseevna Ilchishina, Irina Voynovan, Luis Ignacio Fernández-Salazar, Jose María Huguet, Pilar Canelles, Aiman Silkanovna Sarsenbaeva, Ines Modolell Consorci, Pedro Almela, Marina Roldán Lafuente, Josep Maria Botargues, Miguel Areia, Luís Elvas, Susana Isabel Alves, Daniel Brito, Ana Teresa Cadime, Sandra Lúcia Madeira Saraiva, Charalampos Tzathas, Vassiliki Ntouli, Alicia C Marin, Cem Simsek, Alba Rocco, Juan Antonio Ortuño, Tommaso Di Maira, Sotirios D Georgopoulos, Stephan Brackmann, Vendel Kristensen Lovisenberg, Blas Jose Gomez-Rodriguez, Perminder Singh Phull, Sergey Alekseyevich, Monica Perona, Rustam Abdulkhakov, Deirdre McNamara, Sinead M Smith, Denise Elizabeth Brennan, Marina Fedorovna Osipenko, Cristobal de la Coba, Pilar Varela, Maria Anatolyevna Livzan, Oleg V Zaytsev, Vladislav Vladimirovich Tsukanov, Alexander Viktorovich Vasyutin, Olga Sergeevna Amelchugova, Spiros Michopoulus, Sergey Gennadievich Burkov, Dan Dumitrascu, Bogdan Ianosi, Ingrid Prytz Berset, Rafael Ruiz-Zorrilla Lopez, Charo Antón, Anne Courillon-Mallet, Natasa Brglez Jurecic, Judith Gomez-Camarero, Manuel Jimenez-Moreno, Ahmet Uygun, Ian Leonard Phillip Beales, Alain Huerta-Madrigal, Javier Alcedo, Mercè Barenys, Francesco Franceschi, Jean-Charles Delchier, Liliana Silvia Pozzati, Monika Augustyn, Maja Seruga, Miriam Hiestand, Patric Mosler, Zaza Beniashvili, Doron Boltin, Hubert Louis, Ramon Pajares, Natalia Valerievna Zakharova, Natalia Nikolaevna Dekhnich, Victor Asparuhov Kamburov, Maria Pina Dore, Lorena Sancho, Oscar Núñez, Katrine Dvergsnes Sørlandet, Peter Malfertheiner, Ana Campillo, Miguel Fernandez-Bermejo, Manuel Domínguez-Cajal, José Luis Domínguez Jiménez, Alicia Algaba, Fernando Bermejo, Borislav Vladimirov, László Czakó, Teresa Angueira, Eduardo Iyo, Ekaterina Yuryevna, Larissa Tarasova, Ludmila Grigorieva, Judith Millastre, Aldis Pukitis, Valeriy Kryvy, Roald Torp, Albert Tomàs, Edurne Amorena, Fermin Estremera, Rossen Nikolov, Asghar Quasim, Yury Aleksandrovich Kucheryavyy, Natalia Baryshnikova, Xavier Calvet, Ariadna Figuerola, Marco Romano, Antonietta Gerarda Gravina, Oscar Núñez, Fazia Mana, Pilar Sánchez-Pobre, Zoya Spassova, Jesús M González-Santiago, Ricardo Marcos-Pinto, F Wolfhagen, Svetlana Cui, Ivonne Leeuwenburgh, Driffa Moussata, Adi Lahat-Zok, Sergii Hryhorovych, Rasmus Goll, Tatyana Vasilyevna, Juris Pokrotnieks, Philippe Émile, Nadiya Byelyayeva, Marta Lozano, Mette Wildner-Christensen, Bengt Odman, Yana Valerieva, Alenka Forte, Antonio Cuadrado, Patrice Pienkowski, Ilze Kikuste, Dag Arne Lihaug Hoff, Jane Moeller Hansen, Konrads Funka, Alla Kononova, Sergey Kolbasnikov, Michael Selgrad, Jolanta Sumskiene, Jonathan Hirsch, Francisco Javier Zozaya Larequi, Alain C Burette, Nora Dancs Petz-Aladar, Janne Rajala Herttoniemi, Christina Reimer, Diogo Libanio, Pedro Pimentel-Nunes, Ivailo Evstatiev, Juozas Kupcinskas, Mikhail Butov, Peter Mensink, T Tang, Andrey Yurevich Baranovsky, Natalya Marchenko, Boris Bastens, Lyudmila Mateva, Dominique Lamarque, Leonardo Henry, Mario Ribeiro, M Ter Borg, Alexander C Ford, Enrique Medina, Manuel Rodriguez-Tellez, Francisco José Rancel, Elisa Martin, Carolina Torres Gonzalez, Lissa Maria Franco, Angel Lanas, Pilar Canelles, Noelia Alcaide, Bruno Richard-Molard, Megraud, Francis, Nyssen O.P., Bordin D., Tepes B., Perez-Aisa A., Vaira D., Caldas M., Bujanda L., Castro-Fernandez M., Lerang F., Leja M., Rodrigo L., Rokkas T., Kupcinskas L., Perez-Lasala J., Jonaitis L., Shvets O., Gasbarrini A., Simsek H., Axon A.T.R., Buzas G., Machado J.C., Niv Y., Boyanova L., Goldis A., Lamy V., Tonkic A., Przytulski K., Beglinger C., Venerito M., Bytzer P., Capelle L., Milosavljevic T., Milivojevic V., Veijola L., Molina-Infante J., Vologzhanina L., Fadeenko G., Arino I., Fiorini G., Garre A., Garrido J., F Perez C., Puig I., Heluwaert F., Megraud F., O'Morain C., Gisbert J.P., Universidad Autonoma de Madrid (UAM), University of Bologna, Università cattolica del Sacro Cuore [Roma] (Unicatt), Universidade do Porto, Tel Aviv University [Tel Aviv], Otto-von-Guericke University [Magdeburg] (OVGU), Nyssen, Op, Bordin, D, Tepes, B, Pérez-Aisa, Á, Vaira, D, Caldas, M, Bujanda, L, Castro-Fernandez, M, Lerang, F, Leja, M, Rodrigo, L, Rokkas, T, Kupcinskas, L, Pérez- Lasala, J, Jonaitis, L, Shvets, O, Gasbarrini, A, Simsek, H, Axon, Atr, Buzás, G, Machado, Jc, Niv, Y, Boyanova, L, Goldis, A, Lamy, V, Tonkic, A, Przytulski, K, Beglinger, C, Venerito, M, Bytzer, P, Capelle, L, Milosavljević, T, Milivojevic, V, Veijola, L, Molina-Infante, J, Vologzhanina, L, Fadeenko, G, Ariño, I, Fiorini, G, Garre, A, Garrido, J, F Pérez, C, Puig, I, Heluwaert, F, Megraud, F, O'Morain, C, Gisbert, Jp, and Romano, M

Subjects
Male, Registrie, Proton Pump Inhibitor, Practice Patterns, 0302 clinical medicine, Clarithromycin, Prospective Studies, Registries, Practice Patterns, Physicians', [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, biology, Gastroenterology, Middle Aged, Anti-Bacterial Agents, 3. Good health, Europe, 030220 oncology & carcinogenesis, Combination, 030211 gastroenterology & hepatology, Drug Therapy, Combination, Female, medicine.drug, Human, Adult, medicine.medical_specialty, TRIPLE THERAPY, QUADRUPLE THERAPY, CONSENSUS, INFECTION, METAANALYSIS, CLARITHROMYCIN, GUIDELINES, RESISTANCE, ARTICLE, Settore MED/12 - GASTROENTEROLOGIA, First line, Helicobacter Infections, 03 medical and health sciences, Drug Therapy, Internal medicine, Anti-Bacterial Agent, medicine, Humans, Medical prescription, Adverse effect, Aged, Physicians', Helicobacter pylori, business.industry, helicobacter pylori - treatment, Proton Pump Inhibitors, Amoxicillin, biology.organism_classification, Metronidazole, Prospective Studie, Concomitant, helicobacter pylori, business, Helicobacter Infection, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

ObjectiveThe best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice is aligned with best standards of care.DesignInternational multicentre prospective non-interventional registry starting in 2013 aimed to evaluate the decisions and outcomes in H. pylori management by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events and outcomes. Data monitoring was performed to ensure data quality. Time-trend and geographical analyses were performed.Results30 394 patients from 27 European countries were evaluated and 21 533 (78%) first-line empirical H. pylori treatments were included for analysis. Pretreatment resistance rates were 23% to clarithromycin, 32% to metronidazole and 13% to both. Triple therapy with amoxicillin and clarithromycin was most commonly prescribed (39%), achieving 81.5% modified intention-to-treat eradication rate. Over 90% eradication was obtained only with 10-day bismuth quadruple or 14-day concomitant treatments. Longer treatment duration, higher acid inhibition and compliance were associated with higher eradication rates. Time-trend analysis showed a region-dependent shift in prescriptions including abandoning triple therapies, using higher acid-inhibition and longer treatments, which was associated with an overall effectiveness increase (84%–90%).ConclusionManagement of H. pylori infection by European gastroenterologists is heterogeneous, suboptimal and discrepant with current recommendations. Only quadruple therapies lasting at least 10 days are able to achieve over 90% eradication rates. European recommendations are being slowly and heterogeneously incorporated into routine clinical practice, which was associated with a corresponding increase in effectiveness.

Published
2020
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