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Determinar a frequência e os fatores de risco para a sorologia positiva para toxoplasmose e da presença de lesões oculares atribuíveis ao parasita, e suas características, na cidade de Cássia dos Coqueiros-SP. Casuística e Métodos: Todos os habitantes maiores de 18 anos foram convidados para a coleta de amostra de sangue e realização de sorologia para toxoplasmose. Posteriormente, estes participantes foram convidados a responderem um questionário sobre fatores de risco para a doença e, em outro momento, submeterem-se ao exame oftalmológico. As lesões presumidas de toxoplasmose ocular encontradas foram registradas em vídeo e analisadas por três oftalmologistas mascarados. Foram consideradas como lesões de toxoplasmose ocular aquelas em que houve concordância entre os avaliadores e a sorologia do participante era positiva. Os achados sorológicos e oftalmológicos foram relacionados às respostas obtidas no questionário. Resultados: Foram colhidas amostras de sangue de 1150 participantes, 984 foram avaliadas e 624 (63,4%) apresentaram anticorpos anti-Toxoplasma gondii. Submeteram-se ao exame oftalmológico 721 participantes, 490 (68,0%) com presença de anticorpos anti-Toxoplasma gondii. Após a avaliação das lesões registradas em vídeo (Kappa = 0,37; p

Background Uveitis is an ocular inflammatory disease that may lead to irreversible blindness if not treated early and properly. May be induced by infectious and non-infectious diseases (autoimmune diseases, especially juvenile idiopathic arthritis), or “masquerade” causes. Some uveitis are termed “idiopathic” although autoinflammatory evidence. Treatment effectiveness depends on the accuracy of the ophthalmologic evaluation and the appropriate management, especially when immunosuppressive medications are necessary. (1, 2) Objectives To describe the first year experience of the Integrated Ophthalmology and Pediatric Rheumatology Outpatient Clinic in the management of pediatric patients with autoimmune uveitis. Methods Retrospective chart review study of twenty-four patients followed up from June 2017 to October 2018. The patients clinical evolution at 0, 3, 6, 9 and 12 months was analyzed. Results In this group, 62% were female, and mean age at first appointment and at symptoms onset were 11.7 (2.9 to 17. 5) and 7.3 (1.1 to 12.6) years, respectively. Anterior uveitis was present in 70.8% of the cases, and in 65.6% it was bilateral; cataract or glaucoma was observed in 20.5%. The identified diagnosis during follow-up were: idiopathic autoimmune uveitis in 45.8%, juvenile idiopathic arthritis in 41.6% (20.8% oligoarticular, 16.6% polyarticular, 4.1% associated with enthesitis) and juvenile systemic lupus erythematosus, Kawasaki Disease and Vogt-Koyanagi-Harada syndrome one case of each. Antinuclear antibodies were present in 41% and inflammatory markers in 28.7% patients. At first appointment, 20.5% presented ocular inflammatory activity and 53.3% had sequelae when examined in slit lamp or indirect ophthalmoscopy. Medications used were: topical corticosteroids (61.6%), topical mydriatic (49.2%), oral corticosteroid (41%), methotrexate (41%), etanercept (12.3%), adalimumab (28.7%) and periocular injections of triamcinolone, cyclosporin, tocilizumab, azathioprine (4.1% each). The comparison of the data at inclusion and during follow-up is reported in Table: At the end of 12 months, only 12.3% of the patients still had active uveitis. We have also observed a reducing in 66.6% of topical corticosteroids and 72.2% of oral corticosteroids use during the treatment of uveitis over 12 months Conclusion Considering that before the inclusion, patients were followed independently in each clinic, there was optimization of the treatment and reduction in number of medical appointments after the creation of the integrated outpatient clinic. The interprofessional management teams should be the standard of care for pediatric patients with autoimmune uveitis. References [1] Angeles-Han ST, Rabinovich CE. Uveitis in children. Curr Opin Rheumatol. 2016;28(5):544-9. [2] Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature Working G. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005;140(3):509-16. Disclosure of Interests None declared

Purpose Fungi are a major cause of keratitis, although few medications are licensed for their treatment. The aim of this study is to observe the variation in commercialisation of antifungal eye drops, and to predict the seasonal distribution of fungal keratitis in Brazil. Methods Data from a retrospective study of antifungal eye drops sales from the only pharmaceutical ophthalmologic laboratory, authorized to dispense them in Brazil (Opthalmos) were gathered. These data were correlated with geographic and seasonal distribution of fungal keratitis in Brazil between July 2002 and June 2008. Results A total of 26,087 antifungal eye drop units were sold, with a mean of 2.3 per patient. There was significant variation in antifungal sales during the year (p