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1. Skin as the target for allergy prevention and treatment

Author

Marques-Mejias, Andreina, Bartha, Irene, Ciaccio, Christina E., Chinthrajah, R. Sharon, Chan, Susan, Hershey, Gurjit K. Khurana, Hui-Beckman, Jessica W., Kost, Laurie, Lack, Gideon, Layhadi, Janice A., Leung, Donald Y.M., Marshall, Hannah F., Nadeau, Kari C., Radulovic, Suzana, Rajcoomar, Reena, Shamji, Mohamed H., Sindher, Sayantani, and Brough, Helen A.

Published
2024
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4. Association of frequent moisturizer use in early infancy with the development of food allergy

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Boyle, Robert J., Chalmers, Joanne R., Williams, Hywel C., Versteeg, Serge A., van Ree, Ronald, Lack, Gideon, and Flohr, Carsten

Published
2021
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7. Biomarkers of peanut allergy in children over time.

Author

Foong, Ru‐Xin, Du Toit, George, van Ree, Ronald, Bahnson, Henry T., Radulovic, Suzana, Craven, Jo, Kwok, Matthew, Jama, Zainab, Versteeg, Serge A., Brough, Helen A., Logan, Kirsty, Perkin, Michael R., Flohr, Carsten, Lack, Gideon, and Santos, Alexandra F.

Subjects
PEANUT allergy, MAST cells, FOOD allergy, CELL anatomy, SKIN tests
Abstract

Background: Various biomarkers are used to define peanut allergy (PA). We aimed to observe changes in PA resolution and persistence over time comparing biomarkers in PA and peanut sensitised but tolerant (PS) children in a population‐based cohort. Methods: Participants were recruited from the EAT and EAT‐On studies, conducted across England and Wales, and were exclusively breastfeed babies recruited at 3 months old and followed up until 7–12 years old. Clinical characteristics, skin prick test (SPT), sIgE to peanut and peanut components and mast cell activation tests (MAT) were assessed at 12 months, 36 months and 7–12 years. PA status was determined at the 7–12 year time point. Results: The prevalence of PA was 2.1% at 7–12 years. Between 3 and 7–12 year, two children developed PA and one outgrew PA. PA children had larger SPT, higher peanut‐sIgE, Ara h 2‐sIgE and MAT (all p <.001) compared to PS children from 12 months onwards. SPT, peanut‐sIgE, Ara h 2‐sIgE and MAT between children with persistent PA, new PA, outgrown PA and PS were statistically significant from 12 months onwards (p <.001). Those with persistent PA had SPT, peanut‐sIgE and Ara h 2‐sIgE that increased over time and MAT which was highest at 36 months. New PA children had increased SPT and peanut‐sIgE from 36 months to 7–12 years, but MAT remained low. PS children had low biomarkers across time. Conclusions: In this cohort, few children outgrow or develop new PA between 36 months and 7–12 years. Children with persistent PA have raised SPT, peanut‐sIgE, Ara h 2‐sIgE and MAT evident from infancy that consistently increase over time. [ABSTRACT FROM AUTHOR]

Published
2024
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11. An Unintentional Randomized Trial of Early Environmental Exposure to Peanut: The Younger Siblings of LEAP Participants

Author

Lack, Gideon, primary, Du Toit, George, additional, Radulovic, Suzana, additional, Feeney, Mary, additional, Fischer, Helen, additional, Byron, Margie, additional, Dunaway, Lars, additional, Calatroni, Agustin, additional, Johnson, Molly, additional, Foong, Ru-Xin, additional, Marques-Mejias, Andreina, additional, Bartha, Irene, additional, Brough, Helen, additional, Basting, Monica, additional, Baloh, Carolyn, additional, Laidlaw, Tanya, additional, Bahnson, Henry, additional, Roberts, Graham, additional, Plaut, Marshall, additional, Wheatley, Lisa, additional, and Huffaker, Michelle, additional

Published
2024
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12. Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

Author

Du Toit, George, Roberts, Graham, Sayre, Peter H, Bahnson, Henry T, Radulovic, Suzana, Santos, Alexandra F, Brough, Helen A, Phippard, Deborah, Basting, Monica, Feeney, Mary, Turcanu, Victor, Sever, Michelle L, Gomez Lorenzo, Margarita, Plaut, Marshall, and Lack, Gideon

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Food Allergies, Prevention, Clinical Research, Nutrition, Pediatric, Clinical Trials and Supportive Activities, Digestive Diseases, Good Health and Well Being, Arachis, Chi-Square Distribution, Diet, Eczema, Egg Hypersensitivity, Female, Humans, Immunoglobulin E, Immunoglobulin G, Infant, Intention to Treat Analysis, Male, Peanut Hypersensitivity, Prevalence, Risk, Skin Tests, LEAP Study Team, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe prevalence of peanut allergy among children in Western countries has doubled in the past 10 years, and peanut allergy is becoming apparent in Africa and Asia. We evaluated strategies of peanut consumption and avoidance to determine which strategy is most effective in preventing the development of peanut allergy in infants at high risk for the allergy.MethodsWe randomly assigned 640 infants with severe eczema, egg allergy, or both to consume or avoid peanuts until 60 months of age. Participants, who were at least 4 months but younger than 11 months of age at randomization, were assigned to separate study cohorts on the basis of preexisting sensitivity to peanut extract, which was determined with the use of a skin-prick test--one consisting of participants with no measurable wheal after testing and the other consisting of those with a wheal measuring 1 to 4 mm in diameter. The primary outcome, which was assessed independently in each cohort, was the proportion of participants with peanut allergy at 60 months of age.ResultsAmong the 530 infants in the intention-to-treat population who initially had negative results on the skin-prick test, the prevalence of peanut allergy at 60 months of age was 13.7% in the avoidance group and 1.9% in the consumption group (P

Published
2015

13. Challenges experienced with early introduction and sustained consumption of allergenic foods in the Enquiring About Tolerance (EAT) study: A qualitative analysis

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Voorheis, Paula, Bell, Sadie, Cornelsen, Laura, Quaife, Matthew, Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Flohr, Carsten, Lack, Gideon, and Perkin, Michael R.

Published
2019
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14. Factors influencing adherence in a trial of early introduction of allergenic food

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Perkin, Michael R., Bahnson, Henry T., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Knibb, Rebecca, Craven, Joanna, Flohr, Carsten, Mills, E.N., Versteeg, Serge A., van Ree, Ronald, and Lack, Gideon

Published
2019
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15. Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Logan, Kirsty, Bahnson, Henry T., Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Flohr, Carsten, Mills, E.N., Versteeg, Serge A., van Ree, Ronald, and Lack, Gideon

Published
2019
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16. Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity

Author

Chan, Susan, Fox, Adam, Fisher, Helen, Abraham, Mable, Adam, Muhsinah, Coverdale, Louise, Duncan, Claire, Nixon, Amy, O'Dwyer-Leeson, Una, Offord, Victoria, Sheridan, Aine, Watson, Fiona, Witham, Natalie, Cockerell, Kathryn, Harland, Gail, Miller, Tiffany, Stedman, Charlotte, Clarke, Catherine, Cleaver, Richard, Deutsch, Gemma, Parr, Alicia, Becares, Natalia, Crossley, Matthew, Francisco, Natalia do Couto, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Wester, Rianne, Wilson, Alastair, Wu, Celine, Heath, Jenna, Hersee, Kathryn, Patkunam, Devi, Asare, Adam, Chani, Eduard, Evind, Judith, Lim, Noha, Plough, Audrey, Whitehouse, Don, Lorenzo, Margarita Gomez, Panza, Joy Laurienzo, Lussier, Stephanie, Hu, Jack, Mason, Travis, Tsilochristou, Olympia, du Toit, George, Sayre, Peter H., Roberts, Graham, Lawson, Kaitie, Sever, Michelle L., Bahnson, Henry T., Radulovic, Suzana, Basting, Monica, Plaut, Marshall, and Lack, Gideon

Published
2019
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17. Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention.

Author

Du Toit, George, Huffaker, Michelle F., Radulovic, Suzana, Feeney, Mary, Fisher, Helen R., Byron, Margie, Dunaway, Lars, Calatroni, Agustin, Johnson, Molly, Foong, Ru-Xin, Marques-Mejias, Andreina, Bartha, Irene, Basting, Monica, Brough, Helen A., Baloh, Carolyn, Laidlaw, Tanya M., Bahnson, Henry T., Roberts, Graham, Plaut, Marshall, and Wheatley, Lisa M.

Subjects
FOOD allergy prevention, PEANUTS, IMMUNOLOGICAL tolerance, RESEARCH funding, STATISTICAL sampling, IMMUNOGLOBULINS, QUESTIONNAIRES, RANDOMIZED controlled trials, DESCRIPTIVE statistics, EARLY intervention (Education), LONGITUDINAL method, ANAPHYLAXIS, ADOLESCENCE
Abstract

Background: A randomized trial demonstrated consumption of peanut from infancy to age 5 years prevented the development of peanut allergy. An extension of that trial demonstrated the effect persisted after 1 year of peanut avoidance. This follow-up trial examined the durability of peanut tolerance at age 144 months after years of ad libitum peanut consumption. Methods: Participants from a randomized peanut consumption trial were assessed for peanut allergy following an extended period of eating or avoiding peanuts as desired. The primary end point was the rate of peanut allergy at age 144 months. Results: We enrolled 508 of the original 640 participants (79.4%); 497 had complete primary end point data. At age 144 months, peanut allergy remained significantly more prevalent in participants in the original peanut avoidance group than in the original peanut consumption group (15.4% [38 of 246 participants] vs. 4.4% [11 of 251 participants]; P<0.001). Participants in both groups reported avoiding peanuts for prolonged periods of time between 72 and 144 months. Participants at 144 months in the peanut consumption group had levels of Ara h2-specific immunoglobulin E (a peanut allergen associated with anaphylaxis) of 0.03 ± 3.42 kU/l and levels of peanut-specific immunoglobulin G4 of 535.5 ± 4.98 µg/l, whereas participants in the peanut avoidance group had levels of Ara h2-specific immunoglobulin E of 0.06 ± 11.21 kU/l and levels of peanut-specific immunoglobulin G4 of 209.3 ± 3.84 µg/l. Adverse events were uncommon, and the majority were related to the food challenge. Conclusions: Peanut consumption, starting in infancy and continuing to age 5 years, provided lasting tolerance to peanut into adolescence irrespective of subsequent peanut consumption, demonstrating that long-term prevention and tolerance can be achieved in food allergy. (Funded by the National Institute of Allergy and Infectious Diseases and others; ITN070AD, ClinicalTrials.gov number, NCT03546413.) [ABSTRACT FROM AUTHOR]

Published
2024
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18. Partial egg consumption modifies the diagnostic performance of allergy tests to predict outcome of double-blind placebo-controlled food challenges to egg

Author

Marques-Mejias, Andreina, primary, Radulovic, Suzana, additional, Foong, Ru-Xin, additional, Bartha, Irene, additional, Krawiec, Marta, additional, Kwok, Matthew, additional, Jama, Zainab, additional, Harrison, Faye, additional, Ricci, Cristian, additional, Lack, Gideon, additional, Du Toit, George, additional, and Santos, Alexandra F., additional

Published
2023
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19. Biomarkers to predict changes in peanut allergy in children over time

Author

Foong, Ru-Xin, primary, Toit, George Du, additional, Ree, Ronald Van, additional, H, Tee Bahnson, additional, Radulovic, Suzana, additional, Craven, Jo, additional, Kwok, Matthew, additional, Jama, Zainab, additional, S.A., Versteeg, additional, Brough, Helen A., additional, Logan, Kirsty, additional, Perkin, Michael, additional, Flohr, Carsten, additional, Lack, Gideon, additional, and Santos, Alexandra, additional

Published
2023
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20. Allergen specificity of early peanut consumption and effect on development of allergic disease in the Learning Early About Peanut Allergy study cohort

Author

Chan, Susan, Fox, Adam, Abraham, Mable, Adam, Muhsinah, Coverdale, Louise, Duncan, Claire, Nixon, Amy, O’Dwyer-Leeson, Una, Offord, Victoria, Sheridan, Aine, Watson, Fiona, Witham, Natalie, Cockerell, Kathryn, Harland, Gail, Miller, Tiffany, Stedman, Charlotte, Clarke, Catherine, Cleaver, Richard, Deutsch, Gemma, Parr, Alicia, Becares, Natalia, Crossley, Matthew, Francisco, Natalia do Couto, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Wester, Rianne, Wilson, Alastair, Wu, Celine, Heath, Jenna, Hersee, Kathryn, Patkunam, Devi, Asare, Adam, Chani, Eduard, Evind, Judith, Lim, Noha, Plough, Audrey, Lorenzo, Margarita Gomez, Panza, Joy Laurienzo, Johnson, Jackie, Hu, Jack, Mason, Travis, du Toit, George, Sayre, Peter H., Roberts, Graham, Lawson, Kaitie, Sever, Michelle L., Bahnson, Henry T., Fisher, Helen R., Feeney, Mary, Radulovic, Suzana, Basting, Monica, Plaut, Marshall, and Lack, Gideon

Published
2018
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21. Basophil activation test as predictor of severity and threshold of allergic reactions to egg

Author

Radulovic, Suzana, primary, Foong, Ru‐Xin, additional, Bartha, Irene, additional, Marques‐Mejias, Andreina, additional, Krawiec, Marta, additional, Kwok, Matthew, additional, Jama, Zainab, additional, Harrison, Faye, additional, Ricci, Cristian, additional, Lack, Gideon, additional, Du Toit, George, additional, and Santos, Alexandra F., additional

Published
2023
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22. Basophil activation test as predictor of severity and threshold of allergic reactions to egg.

Author

Radulovic, Suzana, Foong, Ru‐Xin, Bartha, Irene, Marques‐Mejias, Andreina, Krawiec, Marta, Kwok, Matthew, Jama, Zainab, Harrison, Faye, Ricci, Cristian, Lack, Gideon, Du Toit, George, and Santos, Alexandra F.

Subjects
*ALLERGIES, *ACTIVATION energy, *FOOD allergy, *BASOPHILS, *SKIN tests
Abstract

Background: Identifying patients at risk of severe allergic reactions and/or low threshold of reactivity is very important, particularly for staple foods like egg. Methods: One hundred and fifty children underwent double‐blind placebo‐controlled food challenge (DBPCFC) to baked egg (BE), skin prick testing and blood collection for serology and basophil activation test (BAT). Patients who passed BE DBPCFC underwent loosely cooked egg (LCE) DBPCFC. Severity of allergic reactions was classified following Practall guidelines and threshold dose was determined during DBPCFC. Results: Sixty out of 150 (40%) children reacted to BE and 16 out of 77 (21%) to LCE on DBPCFC. Considering DBPCFC to BE, 23 children (38%) had severe reactions and 33 (55%) reacted to 0.13 g or less of egg protein (low threshold group). Two children (2 out of 16 = 12%) had severe reactions to LCE. Demographic, clinical and most immunological features were not significantly different between severe/non‐severe BE reactors or low/high threshold groups. Severe BE reactors had higher ovomucoid‐sIgE (p =.009) and higher BAT to BE (p =.001). Patients with lower threshold to BE had higher IgE‐specific activity (p =.027) and BAT to egg (p =.007) but lower severity score (p =.008). Optimal cut‐offs for ovomucoid‐sIgE had 100% sensitivity, 35% specificity and 60% accuracy and for BAT 76% sensitivity, 74% specificity and 75% accuracy to identify BE severe reactors. Optimal cut‐offs for specific activity had 70% sensitivity, 68% specificity and 69% accuracy and for BAT 70% sensitivity, 72% specificity and 71% accuracy to identify low threshold patients. Conclusions: BAT was the best biomarker to predict severity and threshold of allergic reactions to BE and can be useful when making decisions about management of egg allergy. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition

Author

Chan, Susan, Fox, Adam, Abraham, Mable, Adam, Muhsinah, Clough, Lyn, Coverdale, Louise, Fisher, Helen, Henley, Fiona, Hussain, Saadia, Johnston, Victoria, Nixon, Amy, O'Dwyer-Leeson, Una, Sheridan, Aine, Amarra, Tammy, Cockerell, Kathryn, Lacey, Sarah, Harland, Gail, Stedman, Charlotte, Towell, Ruth, Basting, Monica, Clarke, Catherine, Cleaver, Richard, Deutsch, Gemma, Harris, Erica, Nirenstein, Lori, Parr, Alicia, Becares, Natalia, Crossley, Matthew, do Couto Francisco, Natalia, Richards, Kerry, Patel, Deeviya, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Wester, Rianne, Wilson, Alastair, Wu, Celine, Heath, Jenna, Hersee, Kathryn, Patkunam, Devi, Adamkiewicz, Michael, Asare, Adam, Chani, Eduard, Evind, Judith, Harris, Kristina, Lim, Noha, Nasser, Nariman, Plough, Audrey, Romaine, Jennifer, Stahly, Michael, Panza, Joy Laurienzo, McCachren, Susan, Mason, Travis, Nelson, Valerie, Feeney, Mary, Du Toit, George, Roberts, Graham, Sayre, Peter H., Lawson, Kaitie, Bahnson, Henry T., Sever, Michelle L., Radulovic, Suzana, Plaut, Marshall, and Lack, Gideon

Published
2016
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25. Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Nesbeth, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Craven, Joanna, Logan, Kirsty, Strachan, David, Marrs, Tom, Radulovic, Suzana, Campbell, Linda E., MacCallum, Stephanie F., McLean, W.H. Irwin, Lack, Gideon, and Flohr, Carsten

Published
2016
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26. Enquiring About Tolerance (EAT) study: Feasibility of an early allergenic food introduction regimen

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Nesbeth, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Flohr, Carsten, and Lack, Gideon

Published
2016
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27. Developing a Prediction Model for Determination of Peanut Allergy Status in the Learning Early About Peanut Allergy (LEAP) Studies

Author

Sever, Michelle L, Calatroni, Agustin, Roberts, Graham, du Toit, George, Bahnson, Henry T, Radulovic, Suzana, Larson, David, Byron, Margie, Santos, Alexandra F, Huffaker, Michelle F, Wheatley, Lisa M, and Lack, Gideon

Abstract

Background: The Learning Early About Peanut Allergy (LEAP) study team developed a protocol-specific algorithm using dietary history, peanut-specific IgE, and skin prick test (SPT) to determine peanut allergy status if the oral food challenge (OFC) could not be administered or did not provide a determinant result.Objective: To investigate how well the algorithm determined allergy status in LEAP; to develop a new prediction model to determine peanut allergy status when OFC results are not available in LEAP Trio, a follow-up study of LEAP participants and their families; and to compare the new prediction model with the algorithm.Methods: The algorithm was developed for the LEAP protocol before the analysis of the primary outcome. Subsequently, a prediction model was developed using logistic regression.Results: Using the protocol-specified algorithm, 73% (453/617) of allergy determinations matched the OFC, 0.6% (4/617) were mismatched, and 26% (160/617) participants were nonevaluable. The prediction model included SPT, peanut-specific IgE, Ara h 1, Ara h 2, and Ara h 3. The model inaccurately predicted 1 of 266 participants as allergic who were not allergic by OFC and 8 of 57 participants as not allergic who were allergic by OFC. The overall error rate was 9 of 323 (2.8%) with an area under the curve of 0.99. The prediction model additionally performed well in an external validation cohort.Conclusion: The prediction model performed with high sensitivity and accuracy, eliminated the problem of nonevaluable outcomes, and can be used to estimate peanut allergy status in the LEAP Trio study when OFC is not available.

Published
2023

28. EAACI Molecular Allergology User's Guide 2.0

Author

Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin

Abstract

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

Published
2023

29. EAACI Molecular Allergology User's Guide 2.0

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin

Published
2023

30. EAACI Molecular Allergology User's Guide 2.0

Author

Dramburg, Stephanie, primary, Hilger, Christiane, additional, Santos, Alexandra F., additional, de las Vecillas, Leticia, additional, Aalberse, Rob C., additional, Acevedo, Nathalie, additional, Aglas, Lorenz, additional, Altmann, Friedrich, additional, Arruda, Karla L., additional, Asero, Riccardo, additional, Ballmer‐Weber, Barbara, additional, Barber, Domingo, additional, Beyer, Kirsten, additional, Biedermann, Tilo, additional, Bilo, Maria Beatrice, additional, Blank, Simon, additional, Bosshard, Philipp P., additional, Breiteneder, Heimo, additional, Brough, Helen A., additional, Bublin, Merima, additional, Campbell, Dianne, additional, Caraballo, Luis, additional, Caubet, Jean Christoph, additional, Celi, Giorgio, additional, Chapman, Martin D., additional, Chruszcz, Maksymilian, additional, Custovic, Adnan, additional, Czolk, Rebecca, additional, Davies, Janet, additional, Douladiris, Nikolaos, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Ehlers, Anna, additional, Eigenmann, Philippe, additional, Gadermaier, Gabriele, additional, Giovannini, Mattia, additional, Gomez, Francisca, additional, Grohman, Rebecca, additional, Guillet, Carole, additional, Hafner, Christine, additional, Hamilton, Robert G., additional, Hauser, Michael, additional, Hawranek, Thomas, additional, Hoffmann, Hans Jürgen, additional, Holzhauser, Thomas, additional, Iizuka, Tomona, additional, Jacquet, Alain, additional, Jakob, Thilo, additional, Janssen‐Weets, Bente, additional, Jappe, Uta, additional, Jutel, Marek, additional, Kalic, Tanja, additional, Kamath, Sandip, additional, Kespohl, Sabine, additional, Kleine‐Tebbe, Jörg, additional, Knol, Edward, additional, Knulst, André, additional, Konradsen, Jon R., additional, Korošec, Peter, additional, Kuehn, Annette, additional, Lack, Gideon, additional, Le, Thuy‐My, additional, Lopata, Andreas, additional, Luengo, Olga, additional, Mäkelä, Mika, additional, Marra, Alessandro Maria, additional, Mills, Clare, additional, Morisset, Martine, additional, Muraro, Antonella, additional, Nowak‐Wegrzyn, Anna, additional, Nugraha, Roni, additional, Ollert, Markus, additional, Palosuo, Kati, additional, Pastorello, Elide Anna, additional, Patil, Sarita Ulhas, additional, Platts‐Mills, Thomas, additional, Pomés, Anna, additional, Poncet, Pascal, additional, Potapova, Ekaterina, additional, Poulsen, Lars K., additional, Radauer, Christian, additional, Radulovic, Suzana, additional, Raulf, Monika, additional, Rougé, Pierre, additional, Sastre, Joaquin, additional, Sato, Sakura, additional, Scala, Enrico, additional, Schmid, Johannes M., additional, Schmid‐Grendelmeier, Peter, additional, Schrama, Denise, additional, Sénéchal, Hélène, additional, Traidl‐Hoffmann, Claudia, additional, Valverde‐Monge, Marcela, additional, van Hage, Marianne, additional, van Ree, Ronald, additional, Verhoeckx, Kitty, additional, Vieths, Stefan, additional, Wickman, Magnus, additional, Zakzuk, Josefina, additional, Matricardi, Paolo M., additional, and Hoffmann‐Sommergruber, Karin, additional

Published
2023
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34. Diagnostic utility of allergy tests to predict baked egg and lightly cooked egg allergies compared to double‐blind placebo‐controlled food challenges.

Author

Krawiec, Marta, Radulovic, Suzana, Foong, Ru‐Xin, Marques‐Mejias, Andreina, Bartha, Irene, Kwok, Matthew, Jama, Zainab, Harrison, Faye, Ricci, Cristian, Lack, Gideon, Du Toit, George, and Santos, Alexandra F.

Subjects
*FOOD allergy, *ALLERGIES, *EGGS, *SKIN tests, *EGG whites
Abstract

Background: Double‐blind placebo‐controlled food challenges (DBPCFC) are the gold‐standard to diagnose food allergy. However, they can cause allergic reactions of unpredictable severity. We assessed accuracy of current and new diagnostic tests compared to DBPCFC to baked egg (BE) and to lightly cooked egg (LCE). Methods: Children aged 6 months to 15 years were assessed for possible egg allergy as part of the BAT2 study (NCT03309488). They underwent clinical assessment, skin prick test (SPT), specific IgE (sIgE) and basophil activation test (BAT). The results of the tests were compared with DBPCFC outcomes to both BE and LCE. Results: A total of 150 children underwent DBPCFC to BE, 60 (40%) reacted to and 85 (57%) tolerated BE and 5 (3%) had inconclusive oral food challenges (OFC). Seventy‐seven children tolerant to BE had DBPCFC to LCE and 16 reacted. The test within each modality with the best diagnostic performance for BE allergy was as follows: SPT to egg white (EW) (AUC = 0.726), sIgE to EW (AUC = 0.776) and BAT to egg (AUC = 0.783). BAT (AUC = 0.867) was the best test in the younger than 2 years age group. Applying 100% sensitivity and 100% specificity cut‐offs, followed by OFC, resulted in 100% diagnostic accuracy. BAT enabled the greatest reduction in OFC (41%). Using sIgE followed by BAT allowed to reduce the number of BATs performed by about 30% without significantly increasing the number of OFC. Conclusions: The best diagnostic test was BAT to egg in terms of diagnostic accuracy and reduction in number of OFC. Using sIgE to EW followed by BAT required fewer BATs with sustained OFC reduction and diagnostic accuracy. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Association of frequent moisturizer use in early infancy with the development of food allergy

Author

Perkin, Michael R., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Boyle, Robert J., Chalmers, Joanne R., Williams, Hywel C., Versteeg, Serge A., Van Ree, Ronald, Lack, Gideon, and Flohr, Carsten

Abstract

BackgroundFood allergy is thought to develop through transcutaneous sensitization, especially in the presence of skin barrier impairment and inflammation. Regular moisturizer application to infant skin could potentially promote transcutaneous sensitization and the development of food allergy.ObjectivesWe tested this hypothesis in the Enquiring About Tolerance (EAT) study population.MethodsThe EAT study was a population-based randomized clinical trial conducted from January 15, 2008, to August 31, 2015, and recruited 1303 exclusively breastfed 3-month-old infants and their families from England and Wales. At enrollment at 3 months, families completed a questionnaire that included questions about frequency and type of moisturizer applied, use of corticosteroid creams, and parental report of dry skin or eczema. Infants were examined for visible eczema at the enrollment visit.ResultsA statistically significant dose-response relationship was observed between parent-reported moisturization frequency at 3 months of age and the subsequent development of food allergy. Each additional moisturization per week was associated with an adjusted odds ratio of 1.20 (95% CI, 1.13-1.27; P [less than].0005) for developing food allergy. For infants with no visible eczema at the enrollment visit, the corresponding adjusted odds ratio was 1.18 (95% CI, 1.07-1.30; P = .001) and for those with eczema at the enrollment visit, 1.20 (95% CI, 1.11-1.31; P [less than] .0005). Moisturizer frequency showed similar dose-response relationships with the development of both food and aeroallergen sensitization at 36 months.ConclusionsThese findings support the notion that regular application of moisturizers to the skin of young infants may promote the development of food allergy through transcutaneous sensitization.

Published
2021

47. Reply

Author

Brough, Helen A., Caubet, Jean-Christoph, Mazon, Angel, Haddad, Diab, Bergmann, Marcel M., Wassenberg, Jacqueline, Panetta, Valentina, Gourgey, Rosalynd, Radulovic, Suzana, Nieto, Maria, Santos, Alexandra F., Nieto, Antonio, Lack, Gideon, and Eigenmann, Philippe A.

Published
2020
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48. Geographic association of Rickettsia felis-infected opossums with human murine typhus, Texas. (Research)

Author

Boostrom, Ardys, Beier, Magda S., Macaluso, Jacqueline A., Macaluso, Kevin R., Sprenger, Daniel, Hayes, Jack, Radulovic, Suzana, and Azad, Abdu F.

Subjects
Rickettsia -- Demographic aspects, Medical tests -- Innovations, Communicable diseases -- Research
Abstract

Application of molecular diagnostic technology in the past 10 years has resulted in the discovery of several new species of pathogenic rickettsiae, including Rickettsia felis. As more sequence information for [...]

Published
2002

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