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287 results on '"Radstake, Timothy R.D.J."'

1. Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

Author

Carvalheiro, Tiago, Marut, Wioleta, Pascoal Ramos, M. Inês, García, Samuel, Fleury, Devan, Affandi, Alsya J., Meijers, Aniek S., Giovannone, Barbara, Tieland, Ralph G., Elshof, Eline, Ottria, Andrea, Cossu, Marta, Meizlish, Matthew L., Veenendaal, Tineke, Ramanujam, Meera, Moreno-García, Miguel E., Klumperman, Judith, Liv, Nalan, Radstake, Timothy R.D.J., and Meyaard, Linde

Published
2024
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5. TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance

Author

Çakan, Elif, primary, Ah Kioon, Marie Dominique, additional, Garcia-Carmona, Yolanda, additional, Glauzy, Salomé, additional, Oliver, David, additional, Yamakawa, Natsuko, additional, Vega Loza, Andrea, additional, Du, Yong, additional, Schickel, Jean-Nicolas, additional, Boeckers, Joshua M., additional, Yang, Chao, additional, Baldo, Alessia, additional, Ivashkiv, Lionel B., additional, Young, Ryan M., additional, Staudt, Louis M., additional, Moody, Krishna L., additional, Nündel, Kerstin, additional, Marshak-Rothstein, Ann, additional, van der Made, Caspar I., additional, Hoischen, Alexander, additional, Hayward, Anthony, additional, Rossato, Marzia, additional, Radstake, Timothy R.D.J., additional, Cunningham-Rundles, Charlotte, additional, Ryu, Changwan, additional, Herzog, Erica L., additional, Barrat, Franck J., additional, and Meffre, Eric, additional

Published
2023
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8. Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia

Author

Audia, Sylvain, Rossato, Marzia, Santegoets, Kim, Spijkers, Sanne, Wichers, Catharina, Bekker, Cornelis, Bloem, Andries, Boon, Louis, Flinsenberg, Thijs, Compeer, Ewoud, van den Broek, Theo, Facy, Olivier, Ortega-Deballon, Pablo, Berthier, Sabine, Leguy-Seguin, Vanessa, Martin, Laurent, Ciudad, Marion, Samson, Maxime, Trad, Malika, Lorcerie, Bernard, Janikashvili, Nona, Saas, Philippe, Bonnotte, Bernard, and Radstake, Timothy R.D.J.

Published
2014
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10. Central Role of Semaphorin 3B in a Serum-Induced Arthritis Model and Reduced Levels in Patients With Rheumatoid Arthritis

Author

Igea, Ana, Carvalheiro, Tiago, Malvar-Fernández, Beatriz, Martinez-Ramos, Sara, Rafael-Vidal, Carlos, Niemantsverdriet, Ellis, Varadé, Jezabel, Fernández-Carrera, Andrea, Jimenez, Norman, McGarry, Trudy, Rodriguez-Trillo, Angela, Veale, Douglas, Fearon, Ursula, Conde, Carmen, Pego-Reigosa, Jose M., González-Fernández, África, Reedquist, Kris A., Radstake, Timothy R.D.J., van der Helm-Van Mil, Annette, García, Samuel, Igea, Ana, Carvalheiro, Tiago, Malvar-Fernández, Beatriz, Martinez-Ramos, Sara, Rafael-Vidal, Carlos, Niemantsverdriet, Ellis, Varadé, Jezabel, Fernández-Carrera, Andrea, Jimenez, Norman, McGarry, Trudy, Rodriguez-Trillo, Angela, Veale, Douglas, Fearon, Ursula, Conde, Carmen, Pego-Reigosa, Jose M., González-Fernández, África, Reedquist, Kris A., Radstake, Timothy R.D.J., van der Helm-Van Mil, Annette, and García, Samuel

Abstract

Objective: Semaphorin 3B (Sema3B) decreases the migratory and invasive capacities of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) and suppresses expression of matrix metalloproteinases. We undertook this study to examine the role of Sema3B in a mouse model of arthritis and its expression in RA patients. Methods: Clinical responses, histologic features, and FLS function were examined in wild-type (WT) and Sema3B−/− mice in a K/BxN serum transfer model of arthritis. Protein and messenger RNA expression of Sema3B in mouse joints and murine FLS, as well as in serum and synovial tissue from patients with arthralgia and patients with RA, was determined using enzyme-linked immunosorbent assay, immunoblotting, quantitative polymerase chain reaction, and RNA sequencing. FLS migration was determined using a wound closure assay. Results: The clinical severity of serum-induced arthritis was significantly higher in Sema3B−/− mice compared to WT mice. This was associated with increased expression of inflammatory mediators and increased migratory capacity of murine FLS. Administration of recombinant mouse Sema3B reduced the clinical severity of serum-induced arthritis and the expression of inflammatory mediators. Sema3B expression was significantly lower in the synovial tissue and serum of patients with established RA compared to patients with arthralgia. Serum Sema3B levels were elevated in patients with arthralgia that later progressed to RA, but not in those who did not develop RA; however, these levels drastically decreased 1 and 2 years after RA development. Conclusion: Sema3B expression plays a protective role in a mouse model of arthritis. In RA patients, expression levels of Sema3B in the serum depend on the disease stage, suggesting different regulatory roles in disease onset and progression.

Published
2022

11. CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Author

Affandi, Alsya J., Carvalheiro, Tiago, Ottria, Andrea, de Haan, Judith J., Brans, Maike A.D., Brandt, Maarten M., Tieland, Ralph G., Lopes, Ana P., Fernández, Beatriz Malvar, Bekker, Cornelis P.J., van der Linden, Maarten, Zimmermann, Maili, Giovannone, Barbara, Wichers, Catharina G.K., Garcia, Samuel, de Kok, Michael, Stifano, Giuseppina, Xu, Yan Juan, Kowalska, M. Anna, Waasdorp, Maaike, Cheng, Caroline, Gibbs, Susan, de Jager, Saskia C.A., van Roon, Joel A.G., Radstake, Timothy R.D.J., Marut, Wioleta, Affandi, Alsya J., Carvalheiro, Tiago, Ottria, Andrea, de Haan, Judith J., Brans, Maike A.D., Brandt, Maarten M., Tieland, Ralph G., Lopes, Ana P., Fernández, Beatriz Malvar, Bekker, Cornelis P.J., van der Linden, Maarten, Zimmermann, Maili, Giovannone, Barbara, Wichers, Catharina G.K., Garcia, Samuel, de Kok, Michael, Stifano, Giuseppina, Xu, Yan Juan, Kowalska, M. Anna, Waasdorp, Maaike, Cheng, Caroline, Gibbs, Susan, de Jager, Saskia C.A., van Roon, Joel A.G., Radstake, Timothy R.D.J., and Marut, Wioleta

Abstract

Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic disease in which CXCL4 is increased and strongly correlates with skin and lung fibrosis. Here we aim to elucidate the role of CXCL4 in fibrosis development. CXCL4 levels are increased in multiple inflammatory and fibrotic mouse models, and, using CXCL4-deficient mice, we demonstrate the essential role of CXCL4 in promoting fibrotic events in the skin, lungs, and heart. Overexpressing human CXCL4 in mice aggravates, whereas blocking CXCL4 reduces, bleomycin-induced fibrosis. Single-cell ligand-receptor analysis predicts CXCL4 to affect endothelial cells and fibroblasts. In vitro, we confirm that CXCL4 directly induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Our findings identify a pivotal role of CXCL4 in fibrosis, further substantiating the potential role of neutralizing CXCL4 as a therapeutic strategy.

Published
2022

12. Differential isoform expression of Allergin-1 during acute and chronic inflammation

Author

CTI Meyaard, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, CTI, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Cancer, Geerdink, Ruben J., Pascoal Ramos, Maria Inês, van den Hoogen, Luuk L., Radstake, Timothy R.D.J., Shibayama, Shiro, Shibuya, Akira, Bont, Louis, Meyaard, Linde, CTI Meyaard, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, CTI, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Cancer, Geerdink, Ruben J., Pascoal Ramos, Maria Inês, van den Hoogen, Luuk L., Radstake, Timothy R.D.J., Shibayama, Shiro, Shibuya, Akira, Bont, Louis, and Meyaard, Linde

Published
2022

13. Suppression of IL‐12/IL‐23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon‐γ signaling in dendritic cells: implications for the treatment of psoriasis and interferon‐driven diseases

Author

Vincken, Nanette L.A., primary, Welsing, Paco M.J., additional, Silva‐Cardoso, Sandra C., additional, Bekker, Cornelis P.J., additional, Lopes, Ana P., additional, Nordkamp, Michel Olde, additional, Leijten, Emmerik F.A., additional, Radstake, Timothy R.D.J., additional, and Angiolilli, Chiara, additional

Published
2022
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14. CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Author

Affandi, Alsya J., primary, Carvalheiro, Tiago, additional, Ottria, Andrea, additional, de Haan, Judith J., additional, Brans, Maike A.D., additional, Brandt, Maarten M., additional, Tieland, Ralph G., additional, Lopes, Ana P., additional, Fernández, Beatriz Malvar, additional, Bekker, Cornelis P.J., additional, van der Linden, Maarten, additional, Zimmermann, Maili, additional, Giovannone, Barbara, additional, Wichers, Catharina G.K., additional, Garcia, Samuel, additional, de Kok, Michael, additional, Stifano, Giuseppina, additional, Xu, Yan Juan, additional, Kowalska, M. Anna, additional, Waasdorp, Maaike, additional, Cheng, Caroline, additional, Gibbs, Susan, additional, de Jager, Saskia C.A., additional, van Roon, Joel A.G., additional, Radstake, Timothy R.D.J., additional, and Marut, Wioleta, additional

Published
2022
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15. Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

Author

Carvalheiro, Tiago, primary, Marut, Wioleta, additional, Pascoal Ramos, M. Inês, additional, García, Samuel, additional, Fleury, Devan, additional, Affandi, Alsya J., additional, Meijers, Aniek S., additional, Giovannone, Barbara, additional, Tieland, Ralph G., additional, Elshof, Eline, additional, Ottria, Andrea, additional, Cossu, Marta, additional, Meizlish, Matthew L., additional, Veenendaal, Tineke, additional, Ramanujam, Meera, additional, Moreno-García, Miguel E., additional, Klumperman, Judith, additional, Liv, Nalan, additional, Radstake, Timothy R.D.J., additional, and Meyaard, Linde, additional

Published
2021
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16. A serum protein network predicts the need for systemic immunomodulatory therapy in autoimmune uveitis

Author

Kuiper, Jonas J.W., primary, Verhagen, Fleurieke H., additional, Hiddingh, Sanne, additional, Wennink, Roos A.W., additional, Hansen, Anna M., additional, Casey, Kerry A., additional, Haitjema, Saskia, additional, Hoefer, Imo E., additional, Yakin, Mehmet, additional, Sen, Nida, additional, Radstake, Timothy R.D.J., additional, and de Boer, Joke H., additional

Published
2021
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18. Reply: 1Mellors T, Withers JB, Ameli A, Jones A, Wang M, Zhang L, et al. Clinical validation of a blood-based predictive test for stratification of response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis patients. Netw Syst Med 2020;3:91–104.

Author

Lab Reumatologie/Klinische Immunologie, CTI Pandit, Infection & Immunity, Tao, Weiyang, Radstake, Timothy R.D.J., Pandit, Aridaman, Lab Reumatologie/Klinische Immunologie, CTI Pandit, Infection & Immunity, Tao, Weiyang, Radstake, Timothy R.D.J., and Pandit, Aridaman

Published
2021

19. Characterization of long non-coding rnas in systemic sclerosis monocytes: A potential role for psmb8-as1 in altered cytokine secretion

Author

CTI Borghans, CTI Pandit, Other research (not in main researchprogram), DBG Metabole en Endocriene Ziekten, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Servaas, Nila H., Mariotti, Barbara, van der Kroef, Maarten, Wichers, Catharina G.K., Pandit, Aridaman, Bazzoni, Flavia, Radstake, Timothy R.D.J., Rossato, Marzia, CTI Borghans, CTI Pandit, Other research (not in main researchprogram), DBG Metabole en Endocriene Ziekten, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Servaas, Nila H., Mariotti, Barbara, van der Kroef, Maarten, Wichers, Catharina G.K., Pandit, Aridaman, Bazzoni, Flavia, Radstake, Timothy R.D.J., and Rossato, Marzia

Published
2021

21. Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

Author

van Bon, Lenny, Affandi, Alsya J., Broen, Jasper, Christmann, Romy B., Marijnissen, Renoud J., Stawski, Lukasz, Farina, Giuseppina A., Stifano, Giuseppina, Mathes, Allison L., Cossu, Marta, York, Michael, Collins, Cindy, Wenink, Mark, Huijbens, Richard, Hesselstrand, Roger, Saxne, Tore, DiMarzio, Mike, Wuttge, Dirk, Agarwal, Sandeep K., Reveille, John D., Assassi, Shervin, Mayes, Maureen, Deng, Yanhui, Drenth, Joost P.H., de Graaf, Jacqueline, den Heijer, Martin, Kallenberg, Cees G.M., Bijl, Marc, Loof, Arnoud, van den Berg, Wim B., Joosten, Leo A.B., Smith, Vanessa, de Keyser, Filip, Scorza, Rafaella, Lunardi, Claudio, van Riel, Piet L.C.M., Vonk, Madelon, van Heerde, Waander, Meller, Stephan, Homey, Bernhard, Beretta, Lorenzo, Roest, Mark, Trojanowska, Maria, Lafyatis, Robert, and Radstake, Timothy R.D.J.

Published
2014
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22. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

Author

Abdollahi-Roodsaz, Shahla, Joosten, Leo A.B., Koenders, Marije I., Devesa, Isabel, Roelofs, Mieke F., Radstake, Timothy R.D.J., Heuvelmans-Jacobs, Marleen, Akira, Shizuo, Nicklin, Martin J.H., Ribeiro-Dias, Fatima, and van den Berg, Wim B.

Subjects
Polymerase chain reaction -- Health aspects, Receptor antibodies -- Health aspects, Receptor antibodies -- Research, Rheumatoid arthritis -- Diagnosis, Rheumatoid arthritis -- Prognosis, Rheumatoid arthritis -- Research
Abstract

TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or hostderived ligands found in arthritic joints. Here, we show that TLR2 and TLR4, but not TLR9, are involved in the pathogenesis of autoimmune arthritis and play distinct roles in the regulation of T cells and cytokines. We investigated the involvement of TLR2, TLR4, and TLR9 in the progression of arthritis using IL-1 receptor antagonist-knockout (IL1rn-/-) mice, which spontaneously develop an autoimmune T cell-mediated arthritis. Spontaneous onset of arthritis was dependent on TLR activation by microbial flora, as germ-free mice did not develop arthritis. Clinical and histopathological evaluation of IL1rn-/-Tlr2-/- mice revealed more severe arthritis, characterized by reduced suppressive function of Tregs and substantially increased IFN-[gamma] production by T cells. IL1rn-/-Tlr4-/- mice were, in contrast, protected against severe arthritis and had markedly lower numbers of Th17 cells and a reduced capacity to produce IL-17. A lack of Tlr9 did not affect the progression of arthritis. While any therapeutic intervention targeting TLR2 still seems complicated, the strict position of TLR4 upstream of a number of pathogenic cytokines including IL-17 provides an interesting potential therapeutic target for rheumatoid arthritis., Introduction RA is an autoimmune disease manifested by chronic inflammation and cartilage and bone destruction in multiple joints. Etiopathology of RA has been subjected to intensive research, resulting in the [...]

Published
2008

23. Galectin-9 reflects the interferon signature and correlates with disease activity in systemic autoimmune diseases. Response to: 'Biomarkers: to be or not to be' by Yavuz and Ronnblom : Biomarkers: To be or not to be' by Yavuz and Rönnblom

Author

Van Den Hoogen, Lucas L., Van Der Heijden, Eefje H.M., Hillen, Maarten R., Mertens, Jorre S., Fritsch-Stork, Ruth D.E., Radstake, Timothy R.D.J., and Van Roon, Joel A.G.

Subjects
dermatomyositis, systemic lupus erythematosus, Rheumatology, Biochemistry, Genetics and Molecular Biology(all), Immunology, Journal Article, Immunology and Allergy, autoimmune diseases, sjøgren's syndrome, antiphospholipid syndrome
Published
2020

24. A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease

Author

González-Serna, David, Ochoa, Eguzkine, López-Isac, Elena, Julià, Antonio, Degenhardt, Frauke, Ortego-Centeno, Norberto, Radstake, Timothy R.D.J., Franke, Andre, Marsal, Sara, Mayes, Maureen D., Martín, Javier, Márquez, Ana, Assassi, Shervin, Zhou, Xiaodong, Tan, Filemon K., Arnett, Frank C., Reveille, John D., Gorlova, Olga, Chen, Wei V., Ying, Jun, Gregersen, Peter K., Lee, Annette T., Voskuyl, Alexandre E., de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Broen, Jasper, Koeleman, Bobby P.C., Simeón, Carmen P., Fonollosa, Vicente, Guillén, Alfredo, Carreira, Patricia, Castellví, Iván, González-Gay, Miguel A., Ríos, Raquel, Callejas-Rubio, Jose Luis, Vargas-Hitos, José A., García-Portales, Rosa, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., García-Hernández, Francisco José, Castillo, Ma Jesús, Aguirre, Ma Ángeles, Gómez-Gracia, Inmaculada, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, de la Peña, Paloma García, Vicente, Esther, Andreu, José Luis, Fernández de Castro, Mónica, López-Longo, Francisco Javier, Martínez, Lina, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Rodríguez-Carballeira, Mónica, Narváez, Francisco Javier, Rubio-Rivas, Manel, Ortiz-Santamaría, Vera, Madroñero, Ana Belén, Díaz, Bernardino, Trapiella, Luis, Sousa, Adrián, Egurbide, María Victoria, Fanlo-Mateo, Patricia, Sáez-Comet, Luis, Díaz-González, Federico, Hernández, Vanesa, Beltrán, Emma, Román-Ivorra, José Andrés, Grau, Elena, Alegre-Sancho, Juan José, Blanco-García, Francisco J., Oreiro, Natividad, Freire, Mayka, Balsa, Alejandro, Ortiz, Ana M., Hunzelmann, Nicolas, Riemekasten, Gabriela, Distler, Jörg H.W., Witte, Torsten, Airó, Paolo, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Universidad de Salamanca, Junta de Andalucía, Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad (España), Ministerio de Economía y Competitividad (España), Rheumatology, AII - Inflammatory diseases, Julià, Antonio [0000-0001-6064-3620], Franke, Andre [0000-0003-1530-5811], Mayes, Maureen D [0000-0001-5070-2535], Apollo - University of Cambridge Repository, Mayes, Maureen D. [0000-0001-5070-2535], and Universidad de Cantabria

Subjects
0301 basic medicine, Male, Settore MED/09 - Medicina Interna, 692/699/249/2510, 45/43, Gene Expression, lcsh:Medicine, Genome-wide association study, Single-nucleotide polymorphism, Locus (genetics), Disease, Inflammatory diseases, SLC22A5, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, medicine, Humans, Genetic Predisposition to Disease, Allele, lcsh:Science, Genetic association, 030203 arthritis & rheumatology, Genetics, Crohn's disease, Multidisciplinary, Scleroderma, Systemic, 45, biology, lcsh:R, article, medicine.disease, digestive system diseases, 3. Good health, Settore MED/16 - Reumatologia, 030104 developmental biology, Risk factors, Genetic Loci, Case-Control Studies, biology.protein, Female, lcsh:Q, 692/499, Genome-Wide Association Study
Abstract

We thank Sofia Vargas and Gema Robledo for her excellent technical assistance and all the patients and control donors for their essential collaboration. We thank WTCCC (Welcome Trust Case Control Consortium) for the access to GWAS data of Crohn’s disease patients and healthy controls, Banco Nacional de ADN (University of Salamanca, Spain) who supplied part of the control DNA samples, and dbGap for granting access to the IBD Genetics Consortium (IBDGC) Crohn’s Disease GWAS data (phs000130.v1.p1). The IBDGC Crohn’s Disease Genome-Wide Association Study was conducted by the IBDGC Investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This manuscript was not prepared in collaboration with Investigators of the IBDGC Crohn’s Disease Genome-Wide Association Study and does not necessarily reflect the opinions or views of the IBDGC Crohn’s Disease Genome-Wide Association Study, the NIDDK Central Repositories, or the NIDDK., Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases and all of them showed a significant effect on gene expression. In addition, an enrichment in the IL-12 family and type I interferon signaling pathways was observed among the set of SSc-CD common genetic risk loci. In conclusion, through the first cross-disease meta-analysis of SSc and CD, we identified genetic variants with pleiotropic effects on two clinically distinct immune-mediated disorders. The fact that all these pleiotropic SNPs have opposite allelic effects in SSc and CD reveals the complexity of the molecular mechanisms by which polymorphisms affect diseases., This work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2015-66761-P; IPT-010000-2010-36, cofunded by the European Regional Development Fund), Consejería de Innovación, Ciencia y Tecnología, Junta de Andalucía (Spain) (P12-BIO-1395) and the Cooperative Research Thematic Network (RETICS) programme (RD16/0012/0013) (RIER) from Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Economy, Industry and Competitiveness). AM is recipient of a Miguel Servet fellowship (CP17/00008) from ISCIII (Spanish Ministry of Economy, Industry and Competitiveness). DGS was supported by the Spanish Ministry of Economy and Competitiveness through the FPI programme (SAF2015-66761-P). This work is part of the Doctoral Thesis “Bases Genéticas de la Esclerosis Sistémica: Integrando Genómica y Transcriptómica”.

Published
2020

25. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

Author

Zhernakova, Alexandra, Alizadeh, Behrooz Z., Bevova, Marianna, Van leeuwen, Miek A., Coenen, Marieke, J.H., Franke, Barbara, Franke, Lude, Posthumus, Marcel D., van Heel, David A., van der Steege, Gerrit, Radstake, Timothy, R.d.J., Barrera, Pilar, Roep, Bart O., Koeleman, Bobby P.C., and Wijmenga, Cisca

Subjects
Rheumatoid arthritis -- Genetic aspects, Type 1 diabetes -- Genetic aspects, Autoimmune diseases -- Genetic aspects, Autoimmune diseases -- Risk factors, Biological sciences
Abstract

The article presents the association of type 1 diabetes (TID) with rheumatoid arthritis (RA) with the chromosome 4q27 region. The association shows locus as a general autoimmune risk factor.

Published
2007

26. EULAR points to consider for the use of big data in rheumatic and musculoskeletal diseases

Author

Gossec, Laure, Kedra, Joanna, Servy, Hervé, Pandit, Aridaman, Stones, Simon, Berenbaum, Francis, Finckh, Axel, Baraliakos, Xenofon, Stamm, Tanja A., Gomez-Cabrero, David, Pristipino, Christian, Choquet, Remy, Burmester, Gerd R., Radstake, Timothy R.D.J., Gossec, Laure, Kedra, Joanna, Servy, Hervé, Pandit, Aridaman, Stones, Simon, Berenbaum, Francis, Finckh, Axel, Baraliakos, Xenofon, Stamm, Tanja A., Gomez-Cabrero, David, Pristipino, Christian, Choquet, Remy, Burmester, Gerd R., and Radstake, Timothy R.D.J.

Published
2020

27. CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cells in vitro

Author

Sub Theoretical Biology, Theoretical Biology and Bioinformatics, Silva-Cardoso, Sandra C., Tao, Weiyang, Angiolilli, Chiara, Lopes, Ana P., Bekker, Cornelis P.J., Devaprasad, Abhinandan, Giovannone, Barbara, van Laar, Jaap, Cossu, Marta, Marut, Wioleta, Hack, Erik, de Boer, Rob J., Boes, Marianne, Radstake, Timothy R.D.J., Pandit, Aridaman, Sub Theoretical Biology, Theoretical Biology and Bioinformatics, Silva-Cardoso, Sandra C., Tao, Weiyang, Angiolilli, Chiara, Lopes, Ana P., Bekker, Cornelis P.J., Devaprasad, Abhinandan, Giovannone, Barbara, van Laar, Jaap, Cossu, Marta, Marut, Wioleta, Hack, Erik, de Boer, Rob J., Boes, Marianne, Radstake, Timothy R.D.J., and Pandit, Aridaman

Published
2020

28. Galectin-9 reflects the interferon signature and correlates with disease activity in systemic autoimmune diseases. Response to: 'Biomarkers: to be or not to be' by Yavuz and Ronnblom: Biomarkers: To be or not to be' by Yavuz and Rönnblom

Author

UMC Utrecht, Translationele immunologie, Infection & Immunity, Other research (not in main researchprogram), Van Den Hoogen, Lucas L., Van Der Heijden, Eefje H.M., Hillen, Maarten R., Mertens, Jorre S., Fritsch-Stork, Ruth D.E., Radstake, Timothy R.D.J., Van Roon, Joel A.G., UMC Utrecht, Translationele immunologie, Infection & Immunity, Other research (not in main researchprogram), Van Den Hoogen, Lucas L., Van Der Heijden, Eefje H.M., Hillen, Maarten R., Mertens, Jorre S., Fritsch-Stork, Ruth D.E., Radstake, Timothy R.D.J., and Van Roon, Joel A.G.

Published
2020

29. EULAR points to consider for the use of big data in rheumatic and musculoskeletal diseases

Author

Translationele immunologie, Infection & Immunity, Gossec, Laure, Kedra, Joanna, Servy, Hervé, Pandit, Aridaman, Stones, Simon, Berenbaum, Francis, Finckh, Axel, Baraliakos, Xenofon, Stamm, Tanja A., Gomez-Cabrero, David, Pristipino, Christian, Choquet, Remy, Burmester, Gerd R., Radstake, Timothy R.D.J., Translationele immunologie, Infection & Immunity, Gossec, Laure, Kedra, Joanna, Servy, Hervé, Pandit, Aridaman, Stones, Simon, Berenbaum, Francis, Finckh, Axel, Baraliakos, Xenofon, Stamm, Tanja A., Gomez-Cabrero, David, Pristipino, Christian, Choquet, Remy, Burmester, Gerd R., and Radstake, Timothy R.D.J.

Published
2020

30. Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

Author

Oogheelkunde Onderzoek, Translationele immunologie, Infection & Immunity, MS Oogheelkunde, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Regenerative Medicine and Stem Cells, CTI Van Loosdregt, Immuno/reuma onderzoek 5 (Vastert2), Wennink, Roos A.W., Pandit, Aridaman, Haasnoot, Anne Mieke J.W., Hiddingh, Sanne, Kalinina Ayuso, Viera, Wulffraat, Nico M., Vastert, Bas J., Radstake, Timothy R.D.J., de Boer, Joke H., Kuiper, Jonas J.W., Oogheelkunde Onderzoek, Translationele immunologie, Infection & Immunity, MS Oogheelkunde, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Child Health, Regenerative Medicine and Stem Cells, CTI Van Loosdregt, Immuno/reuma onderzoek 5 (Vastert2), Wennink, Roos A.W., Pandit, Aridaman, Haasnoot, Anne Mieke J.W., Hiddingh, Sanne, Kalinina Ayuso, Viera, Wulffraat, Nico M., Vastert, Bas J., Radstake, Timothy R.D.J., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2020

31. Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

Author

CTI Meyaard, Infection & Immunity, Translationele immunologie, CTI Radstake, CTI, Cancer, Carvalheiro, Tiago, Garcia, Samuel, Pascoal Ramos, M. Inês, Giovannone, Barbara, Radstake, Timothy R.D.J., Marut, Wioleta, Meyaard, Linde, CTI Meyaard, Infection & Immunity, Translationele immunologie, CTI Radstake, CTI, Cancer, Carvalheiro, Tiago, Garcia, Samuel, Pascoal Ramos, M. Inês, Giovannone, Barbara, Radstake, Timothy R.D.J., Marut, Wioleta, and Meyaard, Linde

Published
2020

32. CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis

Author

Other research (not in main researchprogram), Translationele immunologie, CTI Meyaard, Infection & Immunity, DBG Metabole en Endocriene Ziekten, van der Kroef, Maarten, Carvalheiro, Tiago, Rossato, Marzia, de Wit, Floor, Cossu, Marta, Chouri, Eleni, Wichers, Catharina G.K., Bekker, Cornelis P.J., Beretta, Lorenzo, Vazirpanah, Nadia, Trombetta, Elena, Radstake, Timothy R.D.J., Angiolilli, Chiara, Other research (not in main researchprogram), Translationele immunologie, CTI Meyaard, Infection & Immunity, DBG Metabole en Endocriene Ziekten, van der Kroef, Maarten, Carvalheiro, Tiago, Rossato, Marzia, de Wit, Floor, Cossu, Marta, Chouri, Eleni, Wichers, Catharina G.K., Bekker, Cornelis P.J., Beretta, Lorenzo, Vazirpanah, Nadia, Trombetta, Elena, Radstake, Timothy R.D.J., and Angiolilli, Chiara

Published
2020

33. Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome

Author

Other research (not in main researchprogram), Translationele immunologie, CTI Meyaard, Infection & Immunity, DBG Metabole en Endocriene Ziekten, Lab Reumatologie/Klinische Immunologie, van der Kroef, Maarten, van den Hoogen, Lucas L., Mertens, Jorre S., Blokland, Sofie L.M., Haskett, Scott, Devaprasad, Abhinandan, Carvalheiro, Tiago, Chouri, Eleni, Vazirpanah, Nadia, Cossu, Marta, Wichers, Catherina G.K., Silva-Cardoso, Sandra C., Affandi, Alsya J., Bekker, Cornelis P.J., Lopes, Ana P., Hillen, Maarten R., Bonte-Mineur, Femke, Kok, Marc R., Beretta, Lorenzo, Rossato, Marzia, Mingueneau, Michaël, van Roon, Joel A.G., Radstake, Timothy R.D.J., Other research (not in main researchprogram), Translationele immunologie, CTI Meyaard, Infection & Immunity, DBG Metabole en Endocriene Ziekten, Lab Reumatologie/Klinische Immunologie, van der Kroef, Maarten, van den Hoogen, Lucas L., Mertens, Jorre S., Blokland, Sofie L.M., Haskett, Scott, Devaprasad, Abhinandan, Carvalheiro, Tiago, Chouri, Eleni, Vazirpanah, Nadia, Cossu, Marta, Wichers, Catherina G.K., Silva-Cardoso, Sandra C., Affandi, Alsya J., Bekker, Cornelis P.J., Lopes, Ana P., Hillen, Maarten R., Bonte-Mineur, Femke, Kok, Marc R., Beretta, Lorenzo, Rossato, Marzia, Mingueneau, Michaël, van Roon, Joel A.G., and Radstake, Timothy R.D.J.

Published
2020

34. cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation

Author

Oogheelkunde Onderzoek, Infection & Immunity, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Laban, Kamil G., Rijken, Rianne, Hiddingh, Sanne, Mertens, Jorre S., van der Veen, Rob L.P., Eenhorst, Christine A.E., Pandit, Aridaman, Radstake, Timothy R.D.J., de Boer, Joke H., Kalmann, Rachel, Kuiper, Jonas J.W., Oogheelkunde Onderzoek, Infection & Immunity, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Laban, Kamil G., Rijken, Rianne, Hiddingh, Sanne, Mertens, Jorre S., van der Veen, Rob L.P., Eenhorst, Christine A.E., Pandit, Aridaman, Radstake, Timothy R.D.J., de Boer, Joke H., Kalmann, Rachel, and Kuiper, Jonas J.W.

Published
2020

35. A pan-inflammatory microRNA-cluster is associated with orbital non-Hodgkin lymphoma and idiopathic orbital inflammation

Author

Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Other research (not in main researchprogram), Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, CDL Arcadia, Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P.J., Hiddingh, Sanne, van der Veen, Rob L.P., Eenhorst, Christine A.E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F.A., Haitjema, Saskia, de Groot, Mark C.H., Radstake, Timothy R.D.J., de Boer, Joke H., Kuiper, Jonas J.W., Oogheelkunde Onderzoek, Infection & Immunity, MS Oogheelkunde, Other research (not in main researchprogram), Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, CDL Arcadia, Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P.J., Hiddingh, Sanne, van der Veen, Rob L.P., Eenhorst, Christine A.E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F.A., Haitjema, Saskia, de Groot, Mark C.H., Radstake, Timothy R.D.J., de Boer, Joke H., and Kuiper, Jonas J.W.

Published
2020

36. Neutrophil extracellular traps and low-density granulocytes are associated with the interferon signature in systemic lupus erythematosus, but not in antiphospholipid syndrome

Author

Translationele immunologie, Infection & Immunity, UMC Utrecht, CTI Meyaard, CTI, Cancer, MS Reumatologie/Immunologie/Infectie, Van Den Hoogen, Lucas L., Van Der Linden, Maarten, Meyaard, Linde, Fritsch-Stork, Ruth D.E., Van Roon, Joel A., Radstake, Timothy R.D.J., Translationele immunologie, Infection & Immunity, UMC Utrecht, CTI Meyaard, CTI, Cancer, MS Reumatologie/Immunologie/Infectie, Van Den Hoogen, Lucas L., Van Der Linden, Maarten, Meyaard, Linde, Fritsch-Stork, Ruth D.E., Van Roon, Joel A., and Radstake, Timothy R.D.J.

Published
2020

38. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci

Author

Martin, Jose-Ezequiel, Assassi, Shervin, Diaz-Gallo, Lina-Marcela, Broen, Jasper C., Simeon, Carmen P., Castellvi, Ivan, Vicente-Rabaneda, Esther, Fonollosa, Vicente, Ortego-Centeno, Norberto, González-Gay, Miguel A., Espinosa, Gerard, Carreira, Patricia, Camps, Mayte, Sabio, Jose M., Dʼalfonso, Sandra, Vonk, Madelon C., Voskuyl, Alexandre E., Schuerwegh, Annemie J., Kreuter, Alexander, Witte, Torsten, Riemekasten, Gabriella, Hunzelmann, Nicolas, Airo, Paolo, Beretta, Lorenzo, Scorza, Raffaella, Lunardi, Claudio, Van Laar, Jacob, Chee, Meng May, Worthington, Jane, Herrick, Arianne, Denton, Christopher, Fonseca, Carmen, Tan, Filemon K., Arnett, Frank, Zhou, Xiaodong, Reveille, John D., Gorlova, Olga, Koeleman, Bobby P.C., Radstake, Timothy R.D.J., Vyse, Timothy, Mayes, Maureen D., Alarcón-Riquelme, Marta E., and Martin, Javier

Published
2013
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41. Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up

Author

Martin, Jose-Ezequiel, Broen, Jasper C., Carmona, F. David, Teruel, Maria, Simeon, Carmen P., Vonk, Madelon C., van ‘t Slot, Ruben, Rodriguez-Rodriguez, Luis, Vicente, Esther, Fonollosa, Vicente, Ortego-Centeno, Norberto, González-Gay, Miguel A., García-Hernández, Francisco J., de la Peña, Paloma García, Carreira, Patricia, Voskuyl, Alexandre E., Schuerwegh, Annemie J., van Riel, Piet L.C.M., Kreuter, Alexander, Witte, Torsten, Riemekasten, Gabriella, Airo, Paolo, Scorza, Raffaella, Lunardi, Claudio, Hunzelmann, Nicolas, Distler, Jörg H.W., Beretta, Lorenzo, van Laar, Jacob, Chee, Meng May, Worthington, Jane, Herrick, Ariane, Denton, Christopher, Tan, Filemon K., Arnett, Frank C., Assassi, Shervin, Fonseca, Carmen, Mayes, Maureen D., Radstake, Timothy R.D.J., Koeleman, Bobby P.C., and Martin, Javier

Published
2012
Full Text
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42. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations

Author

Bossini-Castillo, Lara, Martin, Jose-Ezequiel, Broen, Jasper, Gorlova, Olga, Simeo[Combining Acute Accent]n, Carmen P., Beretta, Lorenzo, Vonk, Madelon C., Luis Callejas, Jose, Castellví, Ivan, Carreira, Patricia, José García-Hernández, Francisco, Ferna[Combining Acute Accent]ndez Castro, Mo[Combining Acute Accent]nica, Coenen, Marieke J.H., Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg H.W., Koeleman, Bobby P., Voskuyl, Alexandre E., Schuerwegh, Annemie J., Palm, Øyvind, Hesselstrand, Roger, Nordin, Annika, Airó, Paolo, Lunardi, Claudio, Scorza, Raffaella, Shiels, Paul, van Laar, Jacob M., Herrick, Ariane, Worthington, Jane, Denton, Christopher, Tan, Filemon K., Arnett, Frank C., Agarwal, Sandeep K., Assassi, Shervin, Fonseca, Carmen, Mayes, Maureen D., Radstake, Timothy R.D.J., and Martin, Javier

Published
2012
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45. CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis

Author

van der Kroef, Maarten, primary, Carvalheiro, Tiago, additional, Rossato, Marzia, additional, de Wit, Floor, additional, Cossu, Marta, additional, Chouri, Eleni, additional, Wichers, Catharina G.K., additional, Bekker, Cornelis P.J., additional, Beretta, Lorenzo, additional, Vazirpanah, Nadia, additional, Trombetta, Elena, additional, Radstake, Timothy R.D.J., additional, and Angiolilli, Chiara, additional

Published
2020
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46. Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti‐CD74 autoantibodies in human ankylosing spondylitis

Author

Kempen, Tessa S., primary, Leijten, Emmerik F.A., additional, Lindenbergh, Marthe F.S., additional, Nordkamp, Michel Olde, additional, Driessen, Christoph, additional, Lebbink, Robert‐Jan, additional, Baerlecken, Niklas, additional, Witte, Torsten, additional, Radstake, Timothy R.D.J., additional, and Boes, Marianne, additional

Published
2020
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47. cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non‐Hodgkin orbital lymphoma and idiopathic orbital inflammation

Author

Laban, Kamil G., primary, Rijken, Rianne, additional, Hiddingh, Sanne, additional, Mertens, Jorre S., additional, der Veen, Rob L. P., additional, Eenhorst, Christine A.E., additional, Pandit, Aridaman, additional, Radstake, Timothy R.D.J., additional, Boer, Joke H., additional, Kalmann, Rachel, additional, and Kuiper, Jonas J. W., additional

Published
2020
Full Text
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48. Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine

Author

Kurnat-Thoma, Emma, primary, Baranova, Ancha, additional, Baird, Pat, additional, Brodsky, Elia, additional, Butte, Atul J., additional, Cheema, Amrita K., additional, Cheng, Feixiong, additional, Dutta, Shuchismita, additional, Grant, Christina, additional, Giordano, James, additional, Maitland-van der Zee, Anke H., additional, Fridsma, Douglas B., additional, Jarrin, Robert, additional, Kann, Maricel G., additional, Keeney, Jonathon, additional, Loscalzo, Joseph, additional, Madhavan, Guru, additional, Maron, Bradley A., additional, McBride, Dennis K., additional, McKean, Maeve, additional, Mun, Seong K., additional, Palmer, James C., additional, Patel, Bakul, additional, Parakh, Kapil, additional, Pariser, Anne R., additional, Pristipino, Christian, additional, Radstake, Timothy R.D.J., additional, Rajasimha, Harsha K., additional, Rouse, William B., additional, Rozman, Damjana, additional, Saleh, Alif, additional, Schmidt, Harald H.H.W., additional, Schultz, Nikolaus, additional, Sethi, Tavpritesh, additional, Silverman, Edwin K., additional, Skopac, Jessica, additional, Svab, Igor, additional, Trujillo, Sylvia, additional, Valentine, James E., additional, Verma, Dinesh, additional, West, Bruce J., additional, and Vasudevan, Sona, additional

Published
2020
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49. Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis

Author

Broen, Jasper C.A., Wolvers-Tettero, Ingrid L.M., Geurts-van Bon, Lenny, Vonk, Madelon C., Coenen, Marieke J.H., Lafyatis, Robert, Radstake, Timothy R.D.J., and Langerak, Anton W.

Subjects
Scleroderma (Disease) -- Genetic aspects, Scleroderma (Disease) -- Research, Scleroderma (Disease) -- Risk factors, Systemic scleroderma -- Genetic aspects, Systemic scleroderma -- Research, Systemic scleroderma -- Risk factors, T cells -- Physiological aspects, T cells -- Research, T cells -- Genetic aspects, X chromosome -- Physiological aspects, X chromosome -- Research, Genetic susceptibility -- Research, Health
Published
2010

50. Common and different genetic background for rheumatoid arthritis and coeliac disease

Author

Coenen, Marieke J.H., Trynka, Gosia, Heskamp, Sandra, Franke, Barbara, van Diemen, Cleo C., Smolonska, Joanna, van Leeuwen, Miek, Brouwer, Elisabeth, Boezen, Marike H., Postma, Dirkje S., Platteel, Mathieu, Zanen, Pieter, Lammers, Jan-Willem W.J., Groen, Harry J.M., Mali, Willem P.T.M., Mulder, Chris J., Tack, Greetje J., Verbeek, Wieke H.M., Wolters, Victorien M., Houwen, Roderick H.J., Mearin, M Luisa, van Heel, David A., Radstake, Timothy R.D.J., van Riel, Piet L.C.M., Wijmenga, Cisca, Barrera, Pilar, and Zhernakova, Alexandra

Published
2009

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