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Your search keyword '"Radomski, Marek W"' showing total 387 results
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387 results on '"Radomski, Marek W"'

16. Extracorporeal life support

Author

Gaffney, Alan M, Wildhirt, Stephen M, Griffin, Michael J, Annich, Gail M, and Radomski, Marek W

Published
2010

28. Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis

Author

Medina, Carlos, Videla, Sebastian, Radomski, Anna, Radomski, Marek W., Antolin, Maria, Guarner, Francisco, Vilaseca, Jaime, Salas, Antonio, and Malagelada, Juan-R.

Subjects
Colitis -- Physiological aspects, Epithelium -- Injuries, Biological sciences
Abstract

Matrix metalloproteinases may play a role in tissue remodelling and destruction associated with inflammation. We investigated activity and expression of matrix metalloproteinases in a rat model of colitis and tested the therapeutic potential of a synthetic inhibitor (CGS-27023-A). Colitis was induced by dextran sulphate sodium (at 5% in drinking water for 5 days) in a group of eight rats, whereas a matched control group received plain water. Activity and expression of matrix metalloproteinases were measured in colonic tissue homogenates using zymography and Western blot on days 3 and 5 after induction of colitis. In another set of experiments, two groups of colitic rats (20 per group) were treated with CGS-27023-A (20 mg/kg) or vehicle, respectively. On days 5 and 14, colonic mucosal lesions were blindly scored by microscopic examination. Induction of colitis led to a significant upregulation of matrix metalloproteinase-9 protein and its activity, but no change in matrix metalloproteinase-2 activity was observed. Treatment with CGS-27023-A significantly decreased the extent and severity of epithelial injury but did not influence mucosal repair. We conclude that increased activity of matrix metalloproteinases may contribute to epithelial damage in this model of colitis. gelatinases; inflammatory bowel disease; matrix metalloproteinase inhibitors; dextran sulphate sodium

Published
2003

34. Extracorporeal life support

Author

Gaffney, Alan M., Wildhirt, Stephen M., Griffin, Michael J., Annich, Gail M., and Radomski, Marek W.

Subjects
Cardiopulmonary bypass -- Complications and side effects, Mental illness -- Risk factors, Nervous system -- Degeneration, Nervous system -- Risk factors
Published
2010

37. Release of gelatinase A during platelet activation mediates aggregation

Author

Sawicki, Grzegorz, Salas, Eduardo, Murat, Jesus, Miszta-Lane, Helena, and Radomski, Marek W.

Subjects
Blood platelets -- Aggregation, Enzymes -- Structure-activity relationship, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A blood platelet aggregation pathway that involves the proenzyme gelatinase A as an active agent has been discovered. The pathway, like those mediated by endoperoxides/thromboxane A2 and ADP1-3, promotes platelet aggregation after vascular injury or in various medical conditions such as thrombosis and metastasis. The research indicates that the presence of Gelatinase A stimulates physiological and pathological activity in platelets. They may be used in the future as anti-thrombotic agents.

Published
1997

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