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1. Dealing with disaster : a qualitative exploration of the experiences of healthcare and emergency services staff following a mass casualty incident

Author

Radford, Helen, Cooper, Richard, Preston, Louise, and Goodacre, Steve

Abstract

Background - Globally there has been an increase in mass casualty incidents, which have a detrimental impact on the environment, community, and human life. Research following the 9/11 attacks identified the psychological toll on front line emergency workers and there has been an increased awareness of the prevalence of PTSD within this group. However, research to date has not focused on the UK perspective, nor used qualitative methods to explore the impact on front line emergency workers of being involved in mass casualty incidents (MCIs). Methods - This qualitative study was undertaken using semi-structured interviews with ten UK front line health care professionals (HCPs), who worked at the scene or in the accident and emergency department during an MCI. These participants were selected via purposive and snowball sampling between January 2020 to August 2021. Braun and Clarke's six stage thematic analysis were used to analyse the data. Findings - Eight key themes were identified with three involving external factors, namely training, operational environment and media and these four were associated with both positive and negative perceived outcomes). Three further themes around job satisfaction, scrutiny and support involved both internal and external factors. Job satisfaction was protective for wellbeing, however scrutiny caused decreased motivation to work in the medical profession. In terms of support, most interviewees favoured informal approaches, due to formal support being associated with stigma or judgement. The final theme psychological effects were perceived negatively and involved burnout, insecurity, delayed emotions, avoidance, and difficulties with re-experiencing reminders within the community and during anniversaries of MCIs. These eight themes could be further organised across different aspects of time, place and organisation or agent. Discussion and Conclusion - This exploratory research has revealed unique new insights into experiences of HCPs involved in MCIs in the UK. Policy and practice implications relate to three key areas: tailoring ongoing HCP MCI training/preparedness, enhancing organisational support for staff involved in an MCI and finally reviewing the role of the media. Participant experiences of an MCI varied but revealed significant negative, but some rewarding, aspects which could be linked to different times, locations, and agencies.

Published
2021

3. Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

Author

Munro, Alasdair P S, Feng, Shuo, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Qureshi, Ehsaan, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kanji, Nasir, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Holliday, Kyra, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Bawa, Tanveer, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Maallah, Mina, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Lambe, Teresa, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, Faust, Saul N, Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris, Katechia, Kashyap, Cooper, Alison, Freedman, Andrew, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Harrison, Elizabeth, Snashall, Emma, Mallon, Lewis, Burton, Katharine, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Murira, Jennifer, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Sturdy, Ann, Barcella, Lara, Soussi, Najwa, Mpelembue, Mushiya, Raj, Sreena, Sharma, Rajni, Corrah, Tumena, John, Laurence, Whittington, Ashley, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Abeywickrama, Movin, Spence, Niamh, Packham, Alice, Serafimova, Teona, Aslam, Suahil, McGreevy, Caitlin, Borca, Alessandro, DeLosSantosDominguez, Pamela, Palmer, Emily, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Gokani, Karishma, Trinham, Charlotte, Sabine, Charlette, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Stone, Megan, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Turnbull, Iain, Morshead, Gertraud, Drake-Brockman, Rachael, Smith, Catherine, Li, Grace, Kasanyinga, Mwila, Clutterbuck, Elizabeth A, Bibi, Sagida, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicia, Nabunjo, Martha, Osuji, Carol, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Grierson, Jacques, Males, Samantha, Askoolam, Krishna, Barry, Joshua, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karen, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Hamal, Shama, Ricamara, Marivic, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalvescordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Appleby, Kim, Dineen, Emily, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Denny, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Habash-Bailey, Haniah, Magan, Javier, and Hardy, Anna

Published
2022
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4. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris A, Hughes, Stephen, Longshaw, Laura, Stockport, Jane, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Guha, Arpan, Snashall, Emma, Eadsforth, Tom, Reeder, Sally, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Holliday, Kyra, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Makia, Fiona, Hopkins, NinaSimone, Barcella, Lara, Mpelembue, Mushiya, dabagh, Maja, lang, Matilda, khan, Farida, Adebambo, Olumide, Chita, Sunder, Corrah, Tumena, Whittington, Ashley, John, Laurence, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Serafimova, Teona, Nanino, Elisa, Cooney, Enya, Wilson-Goldsmith, Jaimie, Nguyen, Hanna, Mazzella, Andrea, Jackson, Beth, Aslam, Suahil, Bawa, Tanveer, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Qureshi, Ehsaan, Trinham, Charlotte, Sabine, Charlotte, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Smith, David, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Cifuentes, Liliana, Morshead, Gertraud, Drake-Brockman, Rachael, Kinch, Patrick, Kasanyinga, Mwila, Clutterbuck, Elizabeth A., Bibi, Sagida, Stuart, Arabella SV, Shaw, Robert H, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicja, Nabunjo, Martha, Osuji, Carool, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karren, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Freedman, Andrew, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Ricamara, Marivic, Hamal, Shama, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalves cordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross-Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Habash-Bailey, Haniah, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Dennyl, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Magan, Javier, Hardy, Anna, Appleby, Kim, Munro, Alasdair P S, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Gokani, Karishma, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kwok, Jonathan, Lambe, Teresa, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Murira, Jennifer, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Salkeld, Jo, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Sturdy, Ann, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, and Faust, Saul N

Published
2021
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6. 24-Month Outcomes of Indirect Decompression Using a Minimally Invasive Interspinous Fixation Device versus Standard Open Direct Decompression for Lumbar Spinal Stenosis: A Prospective Comparison

Author

Baranidharan,Ganesan, Bretherton,Beatrice, Feltbower,Richard, Timothy,Jake, Khan,Almas, Subramanian,Ashok, Ahmed,Mushtaq, Crowther,Tracey, Radford,Helen, Gupta,Harun, Chandramohan,Muthusamy, Beall,Douglas, Deer,Timothy, Hedman,Thomas, Baranidharan,Ganesan, Bretherton,Beatrice, Feltbower,Richard, Timothy,Jake, Khan,Almas, Subramanian,Ashok, Ahmed,Mushtaq, Crowther,Tracey, Radford,Helen, Gupta,Harun, Chandramohan,Muthusamy, Beall,Douglas, Deer,Timothy, and Hedman,Thomas

Abstract

Ganesan Baranidharan,1,2 Beatrice Bretherton,1,3 Richard G Feltbower,4 Jake Timothy,5 Almas Latif Khan,6,7 Ashok Subramanian,8 Mushtaq Ahmed,9 Tracey A Crowther,1,10 Helen Radford,10,11 Harun Gupta,12 Muthusamy Chandramohan,13 Douglas P Beall,14 Timothy R Deer,15 Thomas Hedman16 1Pain Management Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK; 2School of Medicine, University of Leeds, Leeds, UK; 3School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK; 4Leeds Institute for Data Analytics, School of Medicine, University of Leeds, Leeds, UK; 5Department of Neuroscience, Leeds Teaching Hospitals NHS Trust, Leeds, UK; 6Department of Spine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK; 7Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK; 8Somerset Spinal Surgery Service, Musgrove Park Hospital, Taunton, UK; 9Department of Trauma and Orthopaedic Surgery, Dudley Group NHS Foundation Trust, Dudley, UK; 10Research & Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK; 11Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK; 12Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK; 13Radiology Department, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK; 14Comprehensive Specialty Care, Edmond, OK, USA; 15The Spine and Nerve Center of the Virginias, Charleston, WV, USA; 16Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USACorrespondence: Ganesan Baranidharan, Pain Management Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Email g.baranidharan@nhs.netPurpose: An early-stage, multi-centre, prospective, randomised control trial with five-year follow-up was approved by Health Research Authority to compare the efficacy of a minimally invasive, laterally implanted interspinous fixation device (IFD) to open direct surgical decompression in treating lumbar spinal stenosis (LSS). Two-year results

Published
2024

7. 24-Month Outcomes of Indirect Decompression Using a Minimally Invasive Interspinous Fixation Device versus Standard Open Direct Decompression for Lumbar Spinal Stenosis: A Prospective Comparison.

Author

Baranidharan, Ganesan, Bretherton, Beatrice, Feltbower, Richard G, Timothy, Jake, Khan, Almas Latif, Subramanian, Ashok, Ahmed, Mushtaq, Crowther, Tracey A, Radford, Helen, Gupta, Harun, Chandramohan, Muthusamy, Beall, Douglas P, Deer, Timothy R, and Hedman, Thomas

Subjects
SPINAL stenosis, PATIENT reported outcome measures, LEG pain, VISUAL analog scale, PHYSICAL mobility, SURGICAL decompression
Abstract

Purpose: An early-stage, multi-centre, prospective, randomised control trial with five-year follow-up was approved by Health Research Authority to compare the efficacy of a minimally invasive, laterally implanted interspinous fixation device (IFD) to open direct surgical decompression in treating lumbar spinal stenosis (LSS). Two-year results are presented. Patients and Methods: Forty-eight participants were randomly assigned to IFD or decompression. Primary study endpoints included changes from baseline at 8-weeks, 6, 12 and 24-months follow-ups for leg pain (visual analogue scale, VAS), back pain (VAS), disability (Oswestry Disability Index, ODI), LSS physical function (Zurich Claudication Questionnaire), distance walked in five minutes and number of repetitions of sitting-to-standing in one minute. Secondary study endpoints included patient and clinician global impression of change, adverse events, reoperations, operating parameters, and fusion rate. Results: Both treatment groups demonstrated statistically significant improvements in mean leg pain, back pain, ODI disability, LSS physical function, walking distance and sitting-to-standing repetitions compared to baseline over 24 months. Mean reduction of ODI from baseline levels was between 35% and 56% for IFD (p< 0.002), and 49% to 55% for decompression (p< 0.001) for all follow-up time points. Mean reduction of IFD group leg pain was between 57% and 78% for all time points (p< 0.001), with 72% to 94% of participants having at least 30% reduction of leg pain from 8-weeks through 24-months. Walking distance for the IFD group increased from 66% to 94% and sitting-to-standing repetitions increased from 44% to 64% for all follow-up time points. Blood loss was 88% less in the IFD group (p=0.024) and operating time parameters strongly favoured IFD compared to decompression (p< 0.001). An 89% fusion rate was assessed in a subset of IFD participants. There were no intraoperative device issues or re-operations in the IFD group, and only one healed and non-symptomatic spinous process fracture observed within 24 months. Conclusion: Despite a low number of participants in the IFD group, the study demonstrated successful two-year safety and clinical outcomes for the IFD with significant operation-related advantages compared to surgical decompression. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Munro, Alasdair P S, primary, Janani, Leila, additional, Cornelius, Victoria, additional, Aley, Parvinder K, additional, Babbage, Gavin, additional, Baxter, David, additional, Bula, Marcin, additional, Cathie, Katrina, additional, Chatterjee, Krishna, additional, Dodd, Kate, additional, Enever, Yvanne, additional, Gokani, Karishma, additional, Goodman, Anna L, additional, Green, Christopher A, additional, Harndahl, Linda, additional, Haughney, John, additional, Hicks, Alexander, additional, van der Klaauw, Agatha A, additional, Kwok, Jonathan, additional, Lambe, Teresa, additional, Libri, Vincenzo, additional, Llewelyn, Martin J, additional, McGregor, Alastair C, additional, Minassian, Angela M, additional, Moore, Patrick, additional, Mughal, Mehmood, additional, Mujadidi, Yama F, additional, Murira, Jennifer, additional, Osanlou, Orod, additional, Osanlou, Rostam, additional, Owens, Daniel R, additional, Pacurar, Mihaela, additional, Palfreeman, Adrian, additional, Pan, Daniel, additional, Rampling, Tommy, additional, Regan, Karen, additional, Saich, Stephen, additional, Salkeld, Jo, additional, Saralaya, Dinesh, additional, Sharma, Sunil, additional, Sheridan, Ray, additional, Sturdy, Ann, additional, Thomson, Emma C, additional, Todd, Shirley, additional, Twelves, Chris, additional, Read, Robert C, additional, Charlton, Sue, additional, Hallis, Bassam, additional, Ramsay, Mary, additional, Andrews, Nick, additional, Nguyen-Van-Tam, Jonathan S, additional, Snape, Matthew D, additional, Liu, Xinxue, additional, Faust, Saul N, additional, Riordan, Andrew, additional, Ustianowski, Andrew, additional, Rogers, Chris A, additional, Hughes, Stephen, additional, Longshaw, Laura, additional, Stockport, Jane, additional, Hughes, Rachel, additional, Grundy, Lynne, additional, Tudor Jones, Lona, additional, Guha, Arpan, additional, Snashall, Emma, additional, Eadsforth, Tom, additional, Reeder, Sally, additional, Storton, Kim, additional, Munusamy, Malathi, additional, Tandy, Bridget, additional, Egbo, Akamino, additional, Cox, Stephen, additional, Ahmed, Nabeela Nazir, additional, Shenoy, Anil, additional, Bousfield, Rachel, additional, Wixted, Donna, additional, Gutteridge, Helen, additional, Mansfield, Becky, additional, Herbert, Christopher, additional, Holliday, Kyra, additional, Calderwood, James, additional, Barker, Dominique, additional, Brandon, Jacqueline, additional, Tulloch, Hayley, additional, Colquhoun, Suzie, additional, Thorp, Helen, additional, Radford, Helen, additional, Evans, Julie, additional, Baker, Helena, additional, Thorpe, Jeanette, additional, Batham, Sally, additional, Hailstone, Jessica, additional, Phillips, Rachael, additional, Kumar, Dileep, additional, Westwell, Fran, additional, Makia, Fiona, additional, Hopkins, NinaSimone, additional, Barcella, Lara, additional, Mpelembue, Mushiya, additional, dabagh, Maja, additional, lang, Matilda, additional, khan, Farida, additional, Adebambo, Olumide, additional, Chita, Sunder, additional, Corrah, Tumena, additional, Whittington, Ashley, additional, John, Laurence, additional, Roche, Siobhan, additional, Wagstaff, Lynda, additional, Farrier, Adam, additional, Bisnauthsing, Karen, additional, Serafimova, Teona, additional, Nanino, Elisa, additional, Cooney, Enya, additional, Wilson-Goldsmith, Jaimie, additional, Nguyen, Hanna, additional, Mazzella, Andrea, additional, Jackson, Beth, additional, Aslam, Suahil, additional, Bawa, Tanveer, additional, Broadhead, Samantha, additional, Farooqi, Sadaf, additional, Piper, Jo, additional, Weighell, Rowena, additional, Pickup, Lorinda, additional, Shamtally, Djamila, additional, Domingo, Jason, additional, Kourampa, Evgenia, additional, Hale, Colin, additional, Gibney, Jennifer, additional, Stackpoole, Michael, additional, Rashid-Gardner, Zalina, additional, Lyon, Rebecca, additional, McDonnell, Chloe, additional, Cole, Christine, additional, Stewart, Anna, additional, McMillan, Gillian, additional, Savage, Mary, additional, Beckett, Helen, additional, Moorbey, Chantelle, additional, Desai, Amisha, additional, Brown, Claire, additional, Naker, Kush, additional, Qureshi, Ehsaan, additional, Trinham, Charlotte, additional, Sabine, Charlotte, additional, Moore, Sophie, additional, Hurdover, Steve, additional, Justice, Edwin, additional, Smith, David, additional, Plested, Emma, additional, Ferreira Da Silva, Carla, additional, White, Rachel, additional, Robinson, Hannah, additional, Cifuentes, Liliana, additional, Morshead, Gertraud, additional, Drake-Brockman, Rachael, additional, Kinch, Patrick, additional, Kasanyinga, Mwila, additional, Clutterbuck, Elizabeth A., additional, Bibi, Sagida, additional, Stuart, Arabella SV, additional, Shaw, Robert H, additional, Singh, Michael, additional, Champaneri, Trishna, additional, Irwin, Margaret, additional, Khan, Mohammed, additional, Kownacka, Alicja, additional, Nabunjo, Martha, additional, Osuji, Carool, additional, Hladkiwskyj, John, additional, Galvin, Dominic, additional, Patel, Gita, additional, Mouland, Johanna, additional, Longhurst, Beverley, additional, Moon, Maria, additional, Giddins, Beth, additional, Pereira Dias Alves, Carlota, additional, Richmond, Leah, additional, Minnis, Christine, additional, Baryschpolec, Sonia, additional, Elliott, Scott, additional, Fox, Lauren, additional, Graham, Victoria, additional, Baker, Natalie, additional, Godwin, Kerry, additional, Buttigieg, Karren, additional, Knight, Chanice, additional, Brown, Phillip, additional, Lall, Paminder, additional, Shaik, Imam, additional, Chiplin, Emily, additional, Brunt, Emily, additional, Leung, Stephanie, additional, Allen, Lauren, additional, Thomas, Steve, additional, Fraser, Sara, additional, Choi, Bea, additional, Gouriet, Jade, additional, Freedman, Andrew, additional, Perkins, Jonathan, additional, Gowland, Andrew, additional, Macdonald, Jonathan, additional, Seenan, John Paul, additional, Starinskij, Igor, additional, Seaton, Andrew, additional, Peters, Erica, additional, Singh, Stephen, additional, Gardside, Ben, additional, Bonnaud, Avril, additional, Davies, Ceri, additional, Gordon, Elizabeth, additional, Keenan, Samantha, additional, Hall, Jane, additional, Wilkins, Suzanne, additional, Tasker, Suzanne, additional, James, Rob, additional, Seath, Ingrid, additional, Littlewood, Kelly, additional, Newman, Joseph, additional, Boubriak, Iryna, additional, Suggitt, Debbie, additional, Haydock, Helen, additional, Bennett, Sara, additional, Woodyatt, Wiesia, additional, Hughes, Kerry, additional, Bell, Judith, additional, Coughlan, Tricia, additional, van Welsenes, Donald, additional, Kamal, Mohammed, additional, Cooper, Chris, additional, Tunstall, Simon, additional, Ronan, Nicholas, additional, Cutts, Rebecca, additional, Dare, Tracey, additional, Yim, Yee Ting Nicole, additional, Whittley, Sarah, additional, Ricamara, Marivic, additional, Hamal, Shama, additional, Adams, Kirsty, additional, Baker, Holly, additional, Driver, Kimberley, additional, Turner, Nicola, additional, Rawlins, Todd, additional, Roy, Subarna, additional, Merida-Morillas, Marta, additional, Sakagami, Yukari, additional, Andrews, Antonette, additional, Goncalves cordeiro, Lillian, additional, Stokes, Matthew, additional, Ambihapathy, Wythehi, additional, Spencer, Joanne, additional, Parungao, Nina, additional, Berry, Lisa, additional, Cullinane, James, additional, Presland, Laura, additional, Ross-Russell, Amy, additional, Warren, Sarah, additional, Baker, Jonathan, additional, Oliver, Abigail, additional, Buadi, Amanda, additional, Lee, Kim, additional, Haskell, Louise, additional, Romani, Rossana, additional, Bentley, Ian, additional, Whitbred, Tim, additional, Fowler, Simon, additional, Gavin, John, additional, Magee, Alan, additional, Watson, Tara, additional, Nightingale, Kari, additional, Marius, Phedra, additional, Summerton, Eloise, additional, Locke, Emily, additional, Honey, Thomas, additional, Lingwood, Aidan, additional, de la Haye, Anastasia, additional, Elliott, Ryan Stephen, additional, Underwood, Karen, additional, King, Mikayala, additional, Davies-Dear, Sharon, additional, Horsfall, Emily, additional, Chalwin, Olivia, additional, Burton, Holly, additional, Edwards, Christopher J, additional, Welham, Benjamin, additional, Garrahy, Sarah, additional, Hall, Fran, additional, Ladikou, Eleni, additional, Mullan, Dee, additional, Hansen, Daniel, additional, Campbell, Marion, additional, Dos Santos, Filipa, additional, Habash-Bailey, Haniah, additional, Lakeman, Nicki, additional, Branney, Debbie, additional, Vamplew, Luke, additional, Hogan, Alison, additional, Frankham, Jorden, additional, Wiselka, Martin, additional, Vail, Dennyl, additional, Wenn, Victoria, additional, Renals, Valerie, additional, Ellis, Kate, additional, Lewis-Taylor, Jessica, additional, Magan, Javier, additional, Hardy, Anna, additional, and Appleby, Kim, additional

Published
2021
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16. One‐Year Results of Prospective Research Study Using 10 kHzSpinal Cord Stimulation in Persistent Nonoperated Low Back Pain of Neuropathic Origin: Maiden Back Study

Author

Baranidharan, Ganesan, Feltbower, Richard, Bretherton, Beatrice, Crowther, Tracey, Cooper, Lynne, Castino, Paulito, and Radford, Helen

Abstract

Spinal cord stimulation (SCS) is a recommended treatment for chronic neuropathic pain. Persistent nonoperative low back pain of neuropathic origin has profound negative impacts on patient's lives. This prospective, open label, research study aimed to explore the use of SCS in patients with associated features of central sensitisation such as allodynia and hyperalgesia. Twenty‐one patients with back pain and hyperalgesia or allodynia who had not had prior spinal surgery underwent a SCS trial followed by full implantation. SCS comprised administering electrical impulses epidurally at a frequency of 10 kHz and pulse width of 30 μsec. Patients attended follow‐up visits after 6 and 12 months of SCS. Repeated measure ANOVAs/Friedman tests explored change after 6 and 12 months of 10 kHz SCS. Independent sample t‐tests/Mann–Whitney U tests examined differences in response after 12 months of 10 kHz SCS. Back and leg pain, quality of life (QoL), pain‐related disability, and morphine equivalence significantly improved compared with baseline following 6 and 12 months of 10 kHz SCS. There were no increases in the consumption of opioids, amitriptyline, gabapentin or pregabalin in any patient. After 12 months of treatment, 52% encountered ≥50% improvement in back pain, 44% achieved remission (0–3 cm back pain VAS), 40% reported ODI scores between 0 and 40 and 60% experienced a reduction of at least 10 ODI points. Patients reporting ≥10‐point improvement in ODI had significantly longer pain history durations and experienced significantly greater improvements in back pain, leg pain and QoL than those reporting <10‐point improvement in ODI. The 10 kHz SCS improved back and leg pain, QoL, pain‐related disability and medication consumption in patients with nonoperative back pain of neuropathic origin. With further research incorporating a sham control arm, the efficacy of 10 kHz SCS in this patient cohort will become more established.

Published
2021
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19. Transcutaneous electrical nerve stimulation (TENS) for cancer bone pain.

Author

Searle, Robert D., Bennett, Michael I., Johnson, Mark I., Callin, Sarah, Radford, Helen, Searle, Robert D., Bennett, Michael I., Johnson, Mark I., Callin, Sarah, and Radford, Helen

Abstract

In the cancer population, painful bony metastases are common, difficult to treat and significantly reduce quality of life. Common treatments include opioid analgesics, bisphosphonates, and radiotherapy; yet these have significant side effects and are not universally effective. Transcutaneous electrical nerve stimulation (TENS) is inexpensive, relatively free from side effects, and widely available. We present a case study of successful TENS therapy in a patient with cancer bone pain and discuss the rationale for using TENS in this setting.

Published
2009

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