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4. Haemodynamic, hormonal and renal actions of osteocrin in normal sheep.

Author

Scott, Nicola J. A., Prickett, Timothy C. R., Charles, Christopher J., Espiner, Eric A., Richards, A. Mark, and Rademaker, Miriam T.

Subjects
METABOLIC clearance rate, CENTRAL venous pressure, NATRIURETIC peptides, VENOUS pressure, HOMEOSTASIS
Abstract

Osteocrin (OSTN) is an endogenous protein sharing structural similarities with the natriuretic peptides [NPs; atrial (ANP), B‐type (BNP) and C‐type (CNP) NP], which are hormones known for their crucial role in maintaining pressure/volume homeostasis. Osteocrin competes with the NPs for binding to the receptor involved in their clearance (NPR‐C). In the present study, having identified, for the first time, the major circulating form of OSTN in human and ovine plasma, we examined the integrated haemodynamic, endocrine and renal effects of vehicle‐controlled incremental infusions of ovine proOSTN (83–133) and its metabolism in eight conscious normal sheep. Incremental i.v. doses of OSTN produced stepwise increases in circulating concentrations of the peptide, and its metabolic clearance rate was inversely proportional to the dose. Osteocrin increased plasma levels of ANP, BNP and CNP in a dose‐dependent manner, together with concentrations of their intracellular second messenger, cGMP. Increases in plasma cGMP were associated with progressive reductions in arterial pressure and central venous pressure. Plasma cAMP, renin and aldosterone were unchanged. Despite significant increases in urinary cGMP levels, OSTN administration was not associated with natriuresis or diuresis in normal sheep. These results support OSTN as an endogenous ligand for NPR‐C in regulating plasma concentrations of NPs and associated cGMP‐mediated bioactivity. Collectively, our findings support a role for OSTN in maintaining cardiovascular homeostasis. What is the central question of this study?What role does osteocrin (OSTN) have in integrated cardiovascular, renal and neurohumoral function in normal health?What is the main finding and its importance?Osteocrin is structurally similar to natriuretic peptides (NPs) that play a crucial role in cardiovascular homeostasis and binds to the NP receptor‐C (NPR‐C). Stepped doses of OSTN raised plasma atrial NP, B‐type NP, C‐type NP and cGMP and reduced arterial and venous pressures. Collectively, these findings provide strong evidence that increased NP levels result from competitive displacement from NPR‐C, not from increased NP secretion, suggesting that OSTN might play a role in maintaining cardiovascular homeostasis. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Comparison of SPEED, S-Trap, and In-Solution-Based Sample Preparation Methods for Mass Spectrometry in Kidney Tissue and Plasma

Author

Templeton, Evelyn M., primary, Pilbrow, Anna P., additional, Kleffmann, Torsten, additional, Pickering, John W., additional, Rademaker, Miriam T., additional, Scott, Nicola J. A., additional, Ellmers, Leigh J., additional, Charles, Christopher J., additional, Endre, Zoltan H., additional, Richards, A. Mark, additional, Cameron, Vicky A., additional, and Lassé, Moritz, additional

Published
2023
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13. Identifying Candidate Protein Markers of Acute Kidney Injury in Acute Decompensated Heart Failure

Author

Templeton, Evelyn, primary, Lassé, Moritz, additional, Kleffmann, Torsten, additional, Ellmers, Leigh, additional, Palmer, Suetonia, additional, Davidson, Trent, additional, Scott, Nicola, additional, Pickering, John, additional, Charles, Christopher, additional, Endre, Zoltan, additional, Cameron, Vicky, additional, Richards, A., additional, Rademaker, Miriam, additional, and Pilbrow, Anna, additional

Published
2022
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14. Harnessing the Power of “Omics”: Discovering Novel microRNA and Protein Biomarkers of Acute Kidney Injury in Acute Heart Failure

Author

Templeton, Evie, primary, Lassé, Moritz, additional, Cameron, Vicky, additional, Pickering, John, additional, Kleffmann, Torsten, additional, Hertzberg, Daniel, additional, Frampton, Chris, additional, Ellmers, Leigh, additional, Palmer, Suetonia, additional, Davidson, Trent, additional, Scott, Nicola, additional, Charles, Christopher, additional, Endre, Zoltan, additional, Richards, Mark, additional, Doughty, Robert, additional, Troughton, Richard, additional, Rademaker, Miriam, additional, and Pilbrow, Anna, additional

Published
2022
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17. Acute Decompensated Heart Failure and the Kidney: Physiological, Histological and Transcriptomic Responses to Development and Recovery

Author

Rademaker, Miriam T., primary, Pilbrow, Anna P., additional, Ellmers, Leigh J., additional, Palmer, Suetonia C., additional, Davidson, Trent, additional, Mbikou, Prisca, additional, Scott, Nicola J. A., additional, Permina, Elizabeth, additional, Charles, Christopher J., additional, Endre, Zoltán H., additional, and Richards, A. Mark, additional

Published
2021
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18. Urocortin 1 administration from onset of rapid left ventricular pacing represses progression to overt heart failure

Author

Rademaker, Miriam T., Charles, Chris J., and Richards, A. Mark

Subjects
Heart failure -- Research, Hemodynamics -- Research, Congestive heart failure -- Drug therapy, Congestive heart failure -- Research, Cardiovascular research, Biological sciences
Abstract

Urocortin 1 (Ucn1) may be involved in the pathophysiology of heart failure (HF), but the impact of Ucn1 administration on progression of the disease is unknown. The aim of this study was to investigate the effects of Ucn1 in sheep from the onset of cardiac overload and during the subsequent development of HF. Eight sheep underwent two 4-day periods of HF induction by rapid left ventricular pacing (225 beats/min) in conjunction with continuous infusions of Ucn1 (0.1 [micro]g * [kg.sup.-1] * [h.sup.-1] iv) and a vehicle control (0.9% saline). Compared with control, Ucn1 attenuated the pacing-induced decline in cardiac output (2.43 [+ or -] 0.46 vs. 3.70 [+ or -] 0.89 1/min on day 4, P < 0.01) and increases in left atrial pressure (24.9 [+ or -] 1.0 vs. 11.9 [+ or -] 1.1 mmHg, P < 0.001) and peripheral resistance (38.7 [+ or -] 9.4 vs. 25.2 [+ or -] 6.1 mmHg * [1.sup.-1] * min, P < 0.001). Ucn1 wholly prevented increases in plasma renin activity (4.02 [+ or -] 1.17 vs. 0.87 [+ or -] 0.1 nmol * [1.sup.-1] * [h.sup.-1], P < 0.001), aldosterone (1,313 [+ or -] 324 vs. 413 [+ or -] 174 pmol/l, P < 0.001), endothelin-1 (3.8 [+ or -] 0.5 vs. 2.0 [+ or -] 0.1 pmol/l, P < 0.001), and vasopressin (10.8 [+ or -] 4.1 vs. 1.8 [+ or -] 0.2 pmol/l, P < 0.05) during pacing alone and blunted the progressive increases in plasma epinephrine (2,132 [+ or -] 697 vs. 1,250 [+ or -] 264 pmol/l, P < 0.05), norepinephrine (3.61 [+ or -] 0.73 vs. 2.07 [+ or -] 0.52 nmol/l, P < 0.05), and atrial (P < 0.05) and brain (P < 0.01) natriuretic peptide levels. Ucn1 administration also maintained urine sodium excretion (0.75 [+ or -] 0.34 vs. 1.59 [+ or -] 0.50 mmol/h on day 4, P < 0.05) and suppressed pacing-induced declines in creatinine clearance (P < 0.05). These findings indicate that Ucn1 treatment from the onset of cardiac overload has the ability to repress the ensuing hemodynamic and renal deterioration and concomitant adverse neurohumoral activation, thereby delaying the development of overt HF. These data strongly support a use for Ucn1 as a therapeutic option early in the course of the disease. cardiac output; hormones; renal function

Published
2007

21. Contributors

Author

Aalen, Reidunn B., primary, Abdel-Wahab, Yasser H.A., additional, Adams, Michael E., additional, Adan, Roger A.H., additional, Ahima, Rexford S., additional, Ahmed, Naima, additional, Al-Massadi, Omar, additional, Altstein, Miriam, additional, Anouar, Youssef, additional, Anselmi, Laura, additional, Ansorge, Siegfried, additional, Antcheva, Nikolinka, additional, Antonova-Koch, Yevgeniya, additional, Appel, Jon R., additional, Arik, Anam J., additional, Arter, Alison L., additional, Arvan, Peter, additional, Ashkenazi, Avraham, additional, Baas, P.W., additional, Bado, André, additional, Baird, Andrew, additional, Baiula, Monica, additional, Bakaletz, Lauren O., additional, Bakken, Earl E., additional, Balaskó, Márta, additional, Baldwin, Graham S., additional, Banks, William A., additional, Barra, Donatella, additional, Barson, Jessica R., additional, Basille, Magali, additional, Bauer, Natalie N., additional, Bedini, Andrea, additional, Beeton, Christine, additional, Begley, David J., additional, Beinfeld, Margery C., additional, Bendena, William G., additional, Benoit, Stephen C., additional, Bentov, Itay, additional, Bern, Howard, additional, Bierbaum, Gabriele, additional, Billington, Charles J., additional, Blasiak, Anna, additional, Block, Norman L., additional, Bloom, Stephen. R., additional, Bonney, Iwona, additional, Bowie, John H., additional, Boyd, Sunny K., additional, Brain, Susan D., additional, Brede, Dag A., additional, Broeck, Jozef Vanden, additional, Brown, Kelly L., additional, Brown, Mark R., additional, Bugni, James M., additional, Bundgaard, Jens R., additional, Burel, Delphine, additional, Butenko, Melinka A., additional, Call, Melissa J., additional, Calò, Girolamo, additional, Campbell, Duncan John, additional, Carlsson, Anna, additional, Carr, Daniel B., additional, Carraway, Robert E., additional, Carreira, Marcos C., additional, Casanueva, Felipe F., additional, Cassella, Sarah N., additional, Casson, Stuart A., additional, Castaño, Justo P., additional, Cebrat, Marek, additional, Chappe, Valerie, additional, Chatenet, David, additional, Chen, Keqiang, additional, Chen, Chen, additional, Chen, Longchuan, additional, Chen, Duan, additional, Cheng, Carrie Y.Y., additional, Cho, Sung Ki, additional, Chow, Billy K.C., additional, Christopoulos, Arthur, additional, Chu, Shijian, additional, Clarke, Iain J., additional, Coast, Geoffrey M., additional, Compere, Vincent, additional, Concepcion, Gisela P., additional, Cone, Roger D., additional, Conlon, J. Michael, additional, Cornélissen, Germaine, additional, Courel, Maité, additional, Couture, Réjean, additional, Cramer, W.A., additional, Croft, Nathan P., additional, Crujeiras, Ana B., additional, Cuttitta, Frank, additional, Cynis, Holger, additional, D’Acquisto, F., additional, Davis, Jon F., additional, Davis, Thomas P., additional, de La Serre, Claire Barbier, additional, de Lartigue, Guillaume, additional, de Lecea, Luis, additional, de Oliveira Santos, Marcelo, additional, De Waard, Michel, additional, Bolette Hartmann, Carolyn F. Deacon, additional, Delestre, Charlène, additional, Delgado, Mario, additional, Demuth, Hans-Ulrich, additional, Deng, Xiaoming, additional, Dharmawardhana, Palitha, additional, Di Cosmo, Anna, additional, Dias, Simoni Campos, additional, Dickerson, Jonathan W., additional, Diep, Dzung B., additional, Dircksen, H., additional, Dischinger, Jasmin, additional, do Rego, Jean-Claude, additional, Dobner, Paul R., additional, Dockray, Graham J., additional, Dores, Robert M., additional, Ducroc, Robert, additional, Dudek, Nadine L., additional, Dumont, Yvan, additional, Duraffourd, Celine, additional, Duterte-Boucher, Dominique, additional, Eberlé, Alex N., additional, Egleton, Richard D., additional, Eipper, Betty A., additional, Engel, Jorg B., additional, Englander, Ella W., additional, Epelbaum, Jacques, additional, Erlanson-Albertsson, Charlotte, additional, Evangelista, S., additional, Fagan, Karen A., additional, Farber, Joshua M., additional, Farkasfalvi, Klára, additional, Fekete, Csaba, additional, Flatt, Peter R., additional, Flower, R.J., additional, Forssmann, Wolf-Georg, additional, Fournier, Alain, additional, Foy, Kevin Chu, additional, Franco, Octávio Luiz, additional, Frenkel, Dan, additional, Fricker, Lloyd D., additional, de la Fuente-Núñez, César, additional, Fukuda, Hiroo, additional, Gäde, Gerd, additional, Galas, Ludovic, additional, Gallagher, Patricia E., additional, Gandolfo, Pierrick, additional, Garcia-Espinosa, Maria A., additional, García-Sanmartín, Josune, additional, Geary, Nori, additional, Geng, Hua, additional, Germano, Patrizia M., additional, Goetze, Jens P., additional, Gonzalez, Alexis A., additional, Gonzalez, Ana, additional, Gosnell, Blake A., additional, Goto, Katsutoshi, additional, Gourcerol, Guillaume, additional, Gozes, I., additional, Gracia-Navarro, Francisco, additional, Grayson, Bernadette E., additional, Greeley, George H., additional, Greenwald-Yarnell, Megan, additional, Gressens, Pierre, additional, Grider, John R., additional, Grünewald, Jan, additional, Guerreiro, Juliano R., additional, Guerrini, Remo, additional, Guida, Filomena, additional, Guilhaudis, Laure, additional, Guilmeau, Sandra, additional, Gundlach, Andrew L., additional, Gutkowska, Jolanta, additional, Hackbarth, Clifton, additional, Haim Ohana, Y., additional, Halberg, Franz, additional, Hallberg, Mathias, additional, Hamidi, Sayyed A., additional, Han, Song, additional, Han, Ji-Sheng, additional, Hancock, Robert E.W., additional, Haque, Samer-ul, additional, Hara-Nishimura, Ikuko, additional, Hariton, Aliza, additional, Hartsock, Wendy J., additional, Harvey, Alan L., additional, Hasunuma, Itaru, additional, Henning, Robert J., additional, Heppner, Kristy M., additional, Hertweck, Kate L., additional, Herzog, Herbert, additional, Higashiyama, Tetsuya, additional, Hinuma, Shuji, additional, Hippenstiel, Stefan, additional, Hirakawa, Yuki, additional, Hirose, Shuichi, additional, Hirsch, Jochen R., additional, Hocke, Andreas C., additional, Hodges, Robert S., additional, Hoffmann, Werner, additional, Hökfelt, Tomas, additional, Holst, Jens Juul, additional, Holzer, Peter, additional, Horodyski, Frank M., additional, Hosoda, Hiroshi, additional, Hou, Xiaowen, additional, Huffaker, Alisa, additional, Iijima, Norio, additional, Ikeuchi, Momoko, additional, Imperial, Julita S., additional, Improta, Giovanna, additional, Inui, Akio, additional, Irwin, Nigel, additional, Ishii, Munehiro, additional, Iturrioz, Xavier, additional, Ivanisevic, Ljubica, additional, Iwao, Hiroshi, additional, Iwata, Takeo, additional, Izumi, Yasukatsu, additional, Izumiyama, Hajime, additional, Jankowski, Marek, additional, Janssen, Tom, additional, Jégou, Sylvie, additional, Jensen, Robert T., additional, Jethwa, Preeti H., additional, Johannessen, Helene, additional, Johanson, Conrad, additional, Judkowski, Valeria, additional, Kaczmarek, Przemyslaw, additional, Kageyama, Haruaki, additional, Kakimoto, Tatsuo, additional, Kang, Ki Sung, additional, Kangawa, Kenji, additional, Kastin, Abba J., additional, Kato, Johji, additional, Kaumaya, Pravin T.P., additional, Keep, Richard F., additional, Kem, William R., additional, Khomenko, Tetyana, additional, Kikuyama, Sakae, additional, Kim, Young-Joon, additional, Kimura, Sadao, additional, King, Ross, additional, Kiptoo, Paul, additional, Kishimoto, Ichiro, additional, Kitamura, Kazuo, additional, Kluczyk, Alicja, additional, Kobori, Hiroyuki, additional, Kodama, Yosuke, additional, Kojima, Masayasu, additional, Kondo, Yuki, additional, Körner, Meike, additional, Kosson, Piotr, additional, Kotz, Catherine M., additional, Krishnan, Bhavani, additional, Kulseng, Bård, additional, Kumpf, Robert, additional, Laburthe, Marc, additional, Lacaille, Hélène, additional, Ladenheim, Ellen E., additional, Ladram, Ali, additional, Laksitorini, Marlyn D., additional, Lambert, David G., additional, Lange, Angela B., additional, Langhans, Wolfgang, additional, Larauche, Muriel, additional, Larhammar, Dan, additional, Larráyoz, Ignacio M., additional, Lattanzi, Roberta, additional, Lechan, Ronald M., additional, Lefranc, Benjamin, additional, Leibowitz, Sarah F., additional, Lelièvre, Vincent, additional, Leprince, Jérôme, additional, Levine, Allen S., additional, Li, Qun, additional, Lifshitz, Veronica, additional, Lihrmann, Isabelle, additional, Chi-Jen Lin, James, additional, Lindberg, Iris, additional, Lindsey, Keith, additional, Lipkowski, Andrzej W., additional, Liron, T., additional, Liu, Junli, additional, Liu, Ying, additional, Liu, Min, additional, Llorens-Cortes, Catherine, additional, Loizidou, Marilena, additional, Lopez, C., additional, Lovejoy, David A., additional, Luca, Vincenzo, additional, Lutz, Thomas A., additional, Ma, Sherie, additional, Mains, Richard E., additional, Malagon, Maria M., additional, Malendowicz, Ludwik K., additional, Wan, Jennifer Man-Fan, additional, Mangoni, Maria Luisa, additional, Manigrasso, Michaele B, additional, Marahiel, Mohamed A., additional, Marco, Heather G., additional, Maric-Bilkan, Christine, additional, Marks, Nikki J., additional, Martin, Roland, additional, Martinez, Vicente, additional, Martínez, Alfredo, additional, Martinez-Fuentes, Antonio J., additional, Masler, Edward P., additional, Matsubayashi, Yoshikatsu, additional, Mattu, Harman S., additional, Maule, Aaron G., additional, McLaughlin, Patricia J., additional, McMurtry, Ivan F., additional, Meelkop, Ellen, additional, Mehdi, Saher, additional, Melchiorri, Pietro, additional, Millar, R.P., additional, Miller, Laurence J., additional, Miller, Miles, additional, Million, Mulugeta, additional, Minamino, Naoto, additional, Mittelman, M., additional, Miyauchi, Takashi, additional, Miyazato, Mikiya, additional, Mizoguchi, Hirokazu, additional, Mohme, Malte, additional, Montero-Hadjadje, Maité, additional, Moody, Terry W., additional, Mookherjee, Neeloffer, additional, Moran, Timothy H., additional, Morganstern, Irene, additional, Mori, Masatomo, additional, Morin, Fabrice, additional, Morris, John F., additional, Moura, Daniel S., additional, Mudge, Anna J., additional, Mul, Joram D., additional, Murthy, Karnam S., additional, Myers, Martin G., additional, Nachman, Ronald J., additional, Nahon, Jean-Louis, additional, Naithani, Sushma, additional, Nakada, Tomoaki, additional, Nakamachi, Tomoya, additional, Nakamura, Yuki, additional, Nalivaeva, Natalia N., additional, Nasrallah, June B., additional, Nässel, Dick R., additional, Navar, L. Gabriel, additional, Neelakantan, Pratap, additional, Negri, Lucia, additional, Nes, Ingolf F., additional, Neumann, D., additional, Neveu, Cindy, additional, Ng, Tzi Bun, additional, Ng, Stephanie Y.L., additional, Nicholson, Graham M., additional, Nicolas, Pierre, additional, Nishikimi, Toshio, additional, Nishiyama, Mariko, additional, Nogueiras, Rubén, additional, Norton, Raymond S., additional, Novotny, Laura A., additional, Nowak, Krzysztof W., additional, Nyberg, Fred, additional, Ochoa-Callejero, Laura, additional, Ove Ögren, Sven, additional, Ohgusu, Hideko, additional, Oh-I, Shinsuke, additional, Ojo, Opeolu O., additional, Olivera, Baldomero M., additional, Olucha-Bordonau, Francisco E., additional, Oppenheim, Joost J., additional, Orchard, Ian, additional, Ouellette, André J., additional, Pacheco-López, Gustavo, additional, Page, Nigel M., additional, Palma, Mario Sergio, additional, Pan, Weihong, additional, Park, Yoonseong, additional, Parmentier, Marc, additional, Passemard, Sandrine, additional, Patterson, Michael, additional, Paunovic, Brankica, additional, Pearce, Gregory, additional, Pedersen, Jens, additional, Peeters, Theo L., additional, Eugene Pekary, A., additional, Pelletier, Georges, additional, Perboni, Simona, additional, Pérez-Tilve, Diego, additional, Perjés, Ábel, additional, Perretti, M., additional, Pétervári, Erika, additional, Pinilla, Clemencia, additional, Pinskim, Jacek, additional, Pisegna, Joseph R., additional, Plankensteiner, Kristof, additional, Podvin, Sonia, additional, Poitras, Pierre, additional, Polese, Gianluca, additional, Pollock, David M., additional, Porto, William Farias, additional, Possani, Lourival D., additional, Pothoulakis, Charalabos, additional, Presse, Françoise, additional, Prieto, Minolfa C., additional, Prutchi-Sagiv, S., additional, Purcell, Anthony W., additional, Purtell, Louise, additional, Quirion, Rémi, additional, Rabat, Catalina Abad, additional, Rademaker, Miriam, additional, Rajpal, Gautam, additional, Randeva, Harpal S., additional, Rebuffat, Sylvie, additional, Reeve, Joseph R., additional, Rehfeld, Jens F., additional, Reinhold, Dirk, additional, Reinscheid, Rainer K., additional, Reubi, Jean Claude, additional, Rezvani, Katayoun, additional, Ribeiro, Suzana Meira, additional, Richard, D., additional, Richards, Mark, additional, Riehle, Michael A., additional, Rinaldi, Andrea C., additional, Rode, Bernd M., additional, de la Vega, Ricardo C. Rodríguez, additional, Rotzinger, Susan, additional, Rucinski, Marcin, additional, Ruskoaho, Heikki, additional, Ryan, Philip J., additional, Sabatier, Jean-Marc, additional, Sahl, Hans-Georg, additional, Said, Sami I., additional, Sakurada, Tsukasa, additional, Sakurada, Shinobu, additional, Salomon, David S., additional, Samson, Willis K., additional, Sandor, Zsuzsanna, additional, Saragovi, H. Uri, additional, Sasaki, Kazuki, additional, Sato, Takahiro, additional, Satou, Ryousuke, additional, Sawa, Shinichiro, additional, Sayegh, Ayman I., additional, Schally, Andrew V., additional, Schilling, Stephan, additional, Schoofs, Liliane, additional, Schooley, David A., additional, Schubert, Mitchell L., additional, Segalas-Milazzo, Isabelle, additional, Seidah, Nabil G., additional, Selsted, Michael E., additional, Seroogy, Kim B., additional, Severini, Cinzia, additional, Sexton, Patrick M., additional, Shai, Yechiel, additional, Sharma, O., additional, Shichiri, Masayoshi, additional, Shimada, Tomoo, additional, Shimizu, Hiroyuki, additional, Shioda, Seiji, additional, Shulkes, Arthur, additional, Siahaan, Teruna J., additional, Siemion, Ignacy Z., additional, Silva, Osmar Nascimento, additional, Silva-Filho, Marcio C., additional, Skwarczynski, Mariusz, additional, Small, Caroline. J., additional, Smith, Craig M., additional, Smith, David E., additional, Smith, A. Ian, additional, Solomon, Beka, additional, Solomon, Travis E., additional, Sospedra, Mireia, additional, Souroujon, M.C., additional, Spampinato, Santi, additional, Spindel, Eliot R., additional, Steiger, A., additional, Stengel, Andreas, additional, Sternini, Catia, additional, Steyn, Frederik J., additional, Stopa, Edward, additional, Strowski, Mathias Z., additional, Sugano, Shigeo S., additional, Sundström, Görel, additional, Sutcliffe, J. Gregor, additional, Suttorp, Norbert, additional, Sweedler, Jonathan V., additional, Szabo, Sandor, additional, Székely, Miklós, additional, Szokodi, István, additional, Taché, Yvette, additional, Takahashi, Kazuhiro, additional, Takei, Yoshio, additional, Takenoya, Fumiko, additional, Talbot, Sébastien, additional, Tallant, E. Ann, additional, Tan, Tricia M., additional, Temmerman, Liesbet, additional, Temmesfeld-Wollbrück, Bettina, additional, Tena-Sempere, Manuel, additional, Thorsell, Annika, additional, Tilakaratne, Nanda, additional, Tobe, Stephen S., additional, Tokudome, Takeshi, additional, Tolstanova, Ganna, additional, Tonon, Marie-Christine, additional, Topping, Jennifer F., additional, Tossi, Alessandro, additional, Tostivint, Hervé, additional, Toth, Istvan, additional, Totsune, Kazuhito, additional, Toyoda, Fumiyo, additional, Troke, Rachel, additional, Tschöp, Matthias H., additional, Tso, Patrick, additional, Tsukaya, Hirokazu, additional, Tsutsui, Kazuyoshi, additional, Tu, Hong, additional, Turner, Anthony J., additional, Ubuka, Takayoshi, additional, Valdivia, Elene R., additional, Vandersmissen, Hans Peter, additional, Vaudry, David, additional, Vaudry, Hubert, additional, Vazquez-Martinez, Rafael, additional, Verbalis, Joseph G., additional, Vicari, Daniele, additional, Vidal, Nicolas, additional, Vignoni, Marzia, additional, Viollet, Cécile, additional, Vishwanatha, K.S., additional, Vivoli, Mirella, additional, Voisin, Thierry, additional, Vu, John P., additional, Walker, John C., additional, Wallace, B.A., additional, Wang, Ji Ming, additional, Wang, Lixin, additional, Wardman, Jonathan H., additional, Watanabe, Takuya, additional, Welch, Hazel, additional, Werner, Haim, additional, Whitmore, L., additional, Wiedemann, Imke, additional, Winsky-Sommerer, Raphaelle, additional, Witt, Ken A., additional, Wojciechowicz, Tatiana, additional, Wong, Jack Ho, additional, Woods, Stephen C., additional, Wootten, Denise, additional, Wu, Vincent, additional, Wurtz, Olivier, additional, Xiong, Ximing, additional, David Xu, Zhi-Qing, additional, Yamaguchi, Yube, additional, Yamaguchi, Takahiro, additional, Yamamoto, Kazutoshi, additional, Yamashita, E., additional, Yamazaki, Hiroyuki, additional, Yang, De, additional, Yoshikawa, Masaaki, additional, Yuan, Pu-Qing, additional, Yung, Sunny C., additional, Zagon, Ian S., additional, Zakharov, S.D., additional, Zaman, Mehfuz, additional, Zhalnina, M.V., additional, Zhang, Ning, additional, Zhang-Auberson, Lixin, additional, Zhao, Chun-Mei, additional, Ziolkowska, Agnieszka, additional, and Zitnan, Dusan, additional

Published
2013
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22. Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: response to cytokines and natriuretic peptide receptor expression profiles

Author

Jarvis, Martin D., Rademaker, Miriam T., Ellmers, Leigh J., Currie, Margaret J., McKenzie, Judith L., Palmer, Barry R., Frampton, Christopher M., Richards, A. Mark, and Cameron, Vicky A.

Subjects
Gene expression -- Research, Transforming growth factors -- Research, Fibroblast growth factors -- Research, Heart diseases -- Physiological aspects, Heart diseases -- Genetic aspects, Biological sciences
Abstract

This study investigated whether gene expression profiles of myofibroblasts derived from infarcted myocardium differ from normal cardiac fibroblasts. We compared the expression of cytoskeletal proteins in cultured ovine cardiac fibroblasts derived from infarcted (ID) and noninfarcted ovine myocardium (NID) and the levels of expression of the natriuretic peptide receptors (NPR)-A and NPR-B in response to treatment with transforming growth factor (TGF)-[beta]1 and/or platelet-derived growth factor (PDGF). Transformation of cultured cardiac fibroblasts to myofibroblasts, as indicated by [alpha]-smooth muscle actin and vimentin expression, was independent of the presence of TGF-[beta]1, PDGF, or cell origin. ID fibroblasts had higher basal levels than NID fibroblasts of NPR-A (ID: 58.0 [+ or -] 32.2 arbitrary density units, NID: undetectable), NPR-B (ID: 780 [+ or -] 155, NID: 330 [+ or -] 38 arbitrary density units) and collagen I (ID: 17.2 [+ or -] 0.5, NID: 10.5 [+ or -] 1.7 pg mRNA/[micro]g total RNA, P < 0.05) but lower levels of [alpha]-SMa expression (ID: 50.2 [+ or -] 7.9, NID: 76.9 [+ or -] 3.2 fluorescence units, P < 0.05). NPR-A mRNA in ID fibroblasts showed a rapid fourfold increase in response to TGF-[beta]1 and/or PDGF at 4 and 2 h, respectively, followed by a profound decline; in NID cells, NPR-A mRNA was undetectable. In ID fibroblasts, cytokines reduced NPR-B mRNA below control levels; in NID fibroblasts, TGF-[beta]1 and PDGF elicited prompt increments in expression: a fourfold increase with TGF-[beta]1 at 8 h and a twofold increase with PDGF at 4 h (P < 0.05). In summary, transformation of cardiac fibroblasts to myofibroblasts in culture is independent of cytokine treatment. Moreover, whether the cultured cardiac fibroblasts are from infarct tissue is a major determinant of NPR expression levels and cytokine responses, even after four to five passages. fibroblast; transforming growth factor-[beta]1; platelet-derived growth factor; [alpha]-smooth muscle actin; collagen

Published
2006

23. Contributors

Author

Aiello, Lloyd Paul, primary, Alexander, Erik K., additional, Allan, Carolyn A., additional, Allolio, Bruno, additional, Angelos, Peter, additional, Appu, Sree, additional, Auchus, Richard J., additional, Avruch, Joseph, additional, Axelrod, Lloyd, additional, Bahn, Rebecca S., additional, Baker, H.W.G., additional, Barnes, Randall B., additional, Bastepe, Murat, additional, Baxter, John D., additional, Beck-Peccoz, Paolo, additional, Bell, Graeme I., additional, Bilezikian, John P., additional, Bloom, Stephen R., additional, Blum, Manfred, additional, Bonnema, Steen J., additional, Botero, Diego, additional, Bouillon, Roger, additional, Boulton, Andrew J.M., additional, Braunstein, Glenn D., additional, Bringhurst, F. Richard, additional, Broekmans, Frank J., additional, Bronstein, Marcello D., additional, Brown, Edward M., additional, Bui, Chuong, additional, Burch, Col. Henry B., additional, Burger, Henry G., additional, Burney, Richard O., additional, Buse, John B., additional, Butler, Peter C., additional, Cappabianca, Paolo, additional, Caramori, Maria Luiza Avancini, additional, Carey, Robert M., additional, Carlton, Esther, additional, Carmody, David, additional, Caro, Jose F., additional, Cavagnini, Francesco, additional, Cavallerano, Jerry, additional, Cavallo, Luigi M., additional, Chan, Shu Jin, additional, Chang, R. Jeffrey, additional, Chapurlat, Roland D., additional, Chatterjee, V. Krishna, additional, Chiovato, Luca, additional, Cho, Kyung J., additional, Christophe, Daniel, additional, Chung, Teng-Teng, additional, Cidlowski, John A., additional, Clark, Adrian J.L., additional, Clark, Peter E., additional, Clemmons, David R., additional, Considine, Robert V., additional, Copinschi, Georges, additional, Copps, Kyle D., additional, Courtney, C. Hamish, additional, Cuttler, Leona, additional, Daley, Melita L., additional, Dattani, Mehul, additional, Davis, Stephen N., additional, de Divitiis, Oreste, additional, De Felice, Mario, additional, DeFronzo, Ralph A., additional, J. De Groot, Leslie, additional, de Kretser, David, additional, Delli, Ahmed J., additional, Delmas, Pierre D., additional, Demay, Marie B., additional, Devroey, Paul, additional, Di Lauro, Roberto, additional, Dinneen, Sean F., additional, Dumont, Jacques E., additional, Dungan, Kathleen M., additional, Drucker, Daniel J., additional, Econs, Michael J., additional, Ehrmann, David A., additional, Eisenhofer, Graeme, additional, Erickson, Gregory F., additional, Eriksson, Barbro, additional, Espiner, Eric, additional, Esposito, Felice, additional, Esser, Victoria, additional, Eugster, Erica A., additional, Farooqi, Sadaf, additional, Fassnacht, Martin, additional, Fauser, Bart C.J.M., additional, Fenzi, Gianfranco, additional, Ferrannini, Ele, additional, Findlay, David M., additional, Finlayson, Courtney, additional, Fisher, Delbert A., additional, Forest, Maguelone G., additional, Foster, Daniel W., additional, Freeman, Mason Wright, additional, Frydenberg, Mark, additional, Fuller, Peter, additional, Gagel, Robert F., additional, Gaglia, Jason L., additional, Galizia, Gianluigi, additional, Gao, Chuanyun, additional, Gardella, Thomas J., additional, Gaylinn, Bruce D., additional, Genant, Harry K., additional, German, Michael S., additional, Ghatei, Mohammad A., additional, Giudice, Linda C., additional, Glasier, Anna, additional, Glorieux, Francis H., additional, González-Maeso, Javier, additional, Gooren, Louis J., additional, Gordon, David F., additional, Gregerson, Karen A., additional, Gross, Milton D., additional, Grossman, Ashley, additional, Guimarães, Valéria C., additional, Gurnell, Mark, additional, Haddad, Nadine, additional, Haisenleder, Daniel J., additional, Handelsman, David J., additional, Hanks, John B., additional, Hannon, Mark John, additional, Hayward, Simon W., additional, Hebrok, Matthias, additional, Hegedüs, Laszlo, additional, Hennemann, Georg, additional, Herndon, Maria K., additional, Hindmarsh, Peter, additional, Ho, Ken K.Y., additional, Horseman, Nelson D., additional, Horwitz, Mara J., additional, Hu, Mimi, additional, Hughes, Ieuan A., additional, Hupfeld, Christopher J., additional, Hussain, Hero K., additional, Illingworth, Peter, additional, Jameson, J. Larry, additional, Josso, Nathalie, additional, Jüppner, Harald, additional, Kalish, Jeffrey, additional, Kaplan, Edwin L., additional, Kerr, Jeffrey B., additional, Klein, Ronald, additional, Knobel, Meyer, additional, Kolibianakis, Efstratios, additional, Kopchick, John J., additional, Kopp, Peter, additional, Korbonits, Márta, additional, Korobkin, Melvyn, additional, Krane, Stephen M., additional, Krohn, Knut, additional, Kronenberg, Henry M., additional, Kyriakis, John M., additional, Lau, Sue Lynn, additional, Lazarus, John H., additional, Learoyd, Diana L., additional, Lebovitz, Harold E., additional, Lee, Paul, additional, Lernmark, Åke, additional, Lewis-Tuffin, Laura J., additional, Lu, Zhi-Liang, additional, Macchia, Paolo Emidio, additional, Maclaren, Noel K., additional, Maenhaut, Carine, additional, Maes, Christa, additional, Main, Katharina M., additional, Malchoff, Carl D., additional, Malchoff, Diana Mark, additional, Malik, Rayaz A., additional, Mandel, Susan J., additional, Mantzoros, Christos, additional, Maratos-Flier, Eleftheria, additional, Marchisotta, Stefania, additional, Marinò, Michele, additional, Marshall, John C., additional, Martin, Thomas F.J., additional, Martin, T. John, additional, Martos-Moreno, Gabriel Á., additional, Mathias, Christopher J., additional, Mauer, Michael, additional, McGee, Elizabeth A., additional, McKenna, Neil J., additional, McLachlan, Robert I., additional, Medeiros-Neto, Geraldo, additional, Meier, Juris J., additional, Melmed, Shlomo, additional, Metzger, Boyd E., additional, Millar, Robert, additional, Miller, Walter L., additional, Misra, Madhusmita, additional, Molitch, Mark E., additional, Moore, David D., additional, Morris, Damian G., additional, Munck, Allan U., additional, Nakamoto, Jon, additional, Náray-Fejes-Tóth, Anikó, additional, Nass, Ralf, additional, Nathan, David M., additional, New, Maria I., additional, Nguyen, Carolyn, additional, Nieman, Lynnette K., additional, Nilson, John H., additional, Norton, Jeffrey A., additional, Oakley, Robert H., additional, Öberg, Kjell, additional, Olefsky, Jerrold M., additional, O’Rahilly, Stephen, additional, Ozcan, Umut, additional, Pacak, Karel, additional, Pacini, Furio, additional, Padia, Shetal H., additional, Paschke, Ralf, additional, Pawson, Adam, additional, Peck, Alison C., additional, Giraldi, Francesca Pecori, additional, Persani, Luca, additional, Phelps, Richard L., additional, Philipson, Louis H., additional, Phillips, Kevin, additional, Pinchera, Aldo, additional, Pomposelli, Frank B., additional, Potts, John T., additional, Quigley, Charmian A., additional, Quinkler, Marcus, additional, Quirk, Christine Campion, additional, Rademaker, Miriam T., additional, Meyts, Ewa Rajpert-De, additional, Ravussin, Eric, additional, Ray, David W., additional, Reame, Nancy King, additional, Refetoff, Samuel, additional, Retnakaran, Ravi, additional, Rey, Rodolfo A., additional, Rhodes, Christopher J., additional, Ridgway, E. Chester, additional, Risbridger, Gail P., additional, Rizza, Robert A., additional, Robinson, Bruce, additional, Roger, Pierre P., additional, Rosenfeld, Michael G., additional, Rosenfield, Robert L., additional, Rosing, James H., additional, Rossing, Peter, additional, Rubin, Robert T., additional, Ruderman, Neil, additional, Russo, Irma H., additional, Russo, Jose, additional, Salameh, Wael Antoine, additional, Salusky, Isidoro B., additional, Samuels, Mary H., additional, Santen, Richard J., additional, Santoro, Nanette, additional, Sarapura, Virginia D., additional, Sealfon, Stuart C., additional, Sexton, Patrick M., additional, Shulman, Gerald I., additional, Silva, Paolo S., additional, Silverberg, Shonni J., additional, Singer, Frederick R., additional, Skakkebaek, Niels E., additional, Skowronska-Krawczyk, Dorota, additional, Smith, Carolyn L., additional, Smith, Philip W., additional, Smith, Roger, additional, Smith, Steven R., additional, Snyder, Peter J., additional, Stanhope, Richard, additional, St-Arnaud, René, additional, Steiner, Donald F., additional, Stevens, Adam, additional, Stewart, Andrew F., additional, Stewart, Paul M., additional, St. Germain, Donald L., additional, Stockigt, Jim, additional, Strauss, Jerome F., additional, Swiersz, Lillian Marie, additional, Tacon, Lyndal J., additional, Taheri, Shahrad, additional, Thakker, Rajesh V., additional, Thompson, Chris, additional, Thorner, Michael O., additional, Timmers, Henri J.L.M., additional, Toppari, Jorma, additional, Traggiai, Cristina, additional, Traub, Michael L., additional, Tseng, Yolanda, additional, Turek, Fred W., additional, Van Cauter, Eve, additional, Van den Berghe, Greet, additional, Van Steirteghem, André C., additional, Vassart, Gilbert, additional, Vilain, Eric, additional, Visser, Theo J., additional, Wajnrajch, Michael P., additional, Wand, Gary, additional, Webb, Paul, additional, Weetman, Anthony P., additional, Weigel, Nancy L., additional, Weir, Gordon C., additional, Weiss, Roy E., additional, Wesseling-Perry, Katherine, additional, White, Anne, additional, White, Kenneth E., additional, White, Morris F., additional, Whyte, Michael P., additional, Wiersinga, Wilmar M., additional, Wolfsdorf, Joseph I., additional, and Zinman, Bernard, additional

Published
2010
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25. Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine

Author

Charles, Christopher J., Nicholls, M. Gary, Rademaker, Miriam T., and Richards, A. Mark

Subjects
Noradrenaline -- Physiological aspects, Sodium nitroferricyanide -- Physiological aspects, Homeostasis -- Physiological aspects, Biological sciences
Abstract

Charles, Christopher J., M. Gary Nicholls, Miriam T. Rademaker, and A. Mark Richards. Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine. Am J Physiol Regulatory Integrative Comp Physiol 281: R1887-R1894, 2001.--The role of adrenomedullin (ADM) in volume and pressure homeostasis remains undefined. Accordingly, we compared the biological responses to infusions of ADM and nitroprusside (NP; matched for reduction of arterial pressure) and assessed their effects on responses to ANG II and norepinephrine in eight conscious sheep. During matched falls in arterial pressure (8-10 mmHg, both P < 0.001) ADM and NP induced similar increases in heart rate. ADM increased cardiac output (P < 0.001), and the fall in calculated peripheral resistance was greater with ADM than NP (P = 0.013). ADM infusions raised plasma ADM levels (P < 0.001), plasma renin activity (P = 0.001), and ANG II (P < 0.001) but tended to blunt any concurrent rise in aldosterone compared with NP (P = 0.056). ADM maintained both urine flow (P < 0.001) and sodium excretion (P = 0.01) compared with falls observed with NP. ADM attenuated the vasopressor actions of exogenous ANG II (P = 0.006) but not norepinephrine. In addition, ADM antagonized the ANG II-induced, rise in plasma aldosterone (P < 0.001). In conclusion, ADM induces a different spectrum of hemodynamic, renal, and endocrine actions to NP. These results clarify mechanisms by which ADM might contribute to volume and pressure homeostasis. arterial pressure; cardiac output; peripheral resistance; aldosterone Received 27 April 2001; accepted in final form 30 July 2001

Published
2001

30. Urocortins as biomarkers in cardiovascular disease.

Author

Vasconcelos, Inês, Adão, Rui, Rademaker, Miriam T., Leite-Moreira, Adelino F., Patrícia Fontes-Sousa, Ana, and Brás-Silva, Carmen

Subjects
CORTICOTROPIN releasing hormone, CARDIOVASCULAR diseases, CENTRAL nervous system, BIOMARKERS, PEPTIDES
Abstract

The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family of peptides and have multiple effects within the central nervous and the cardiovascular systems. With growing evidence indicating significant cardioprotective properties and cardiovascular actions of these peptides, the question arises as to whether the plasma profiles of the Ucns are altered in pathologic settings. While reports have shown conflicting results and findings have not been corroborated in multiple independent cohorts, it seems likely that plasma Ucn concentrations are elevated in multiple cardiovascular conditions. The degree of increase and accurate determination of circulating values of the Ucns requires further validation. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Urocortin 2 infusion in human heart failure

Author

Davis, Mark E., Pemberton, Christopher J., Yandle, Timothy G., Fisher, Steve F., Lainchbury, John G., Frampton, Christopher M., Rademaker, Miriam T., and Richards, Mark

Published
2007

36. Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure

Author

Rademaker, Miriam Tessa, Charles, Christopher John, Kosoglou, Teddy, Protter, Andrew A., Espiner, Eric Arnold, Nicholls, Michael Gary, and Richards, Arthur Mark

Subjects
Hemodynamics -- Physiological aspects, Natriuresis -- Physiological aspects, Biological sciences
Abstract

The quantitative contributions of the enzymatic and clearance-receptor pathways in the metabolism of endogenous natriuretic peptides in the setting of congestive heart failure were probed through administration of neutral endopeptidase inhibitor (NEP) and natriuretic peptide receptor C (NPR-C) to sheep with heart failure. Results have shown that both NEP and NPR-C inhibitors contributed to the clearance of endogenous natriuretic peptides. The functional activity of the clearance-receptor pathway was conserved in heart failure.

Published
1997

37. Hemodynamic, hormonal, and renal effects of adrenomedullin in conscious sheep

Author

Charles, Christopher J., Rademaker, Miriam T., Richards, A. Mark, Cooper, Garth J.S., Coy, David H., Jing, Ning-Yi, and Nicholls, M. Gary

Subjects
Vasodilators -- Physiological aspects, Blood pressure -- Regulation, Kidneys -- Blood-vessels, Regional blood flow -- Regulation, Biological sciences
Abstract

The biological actions of adrenomedullin in conscious sheep were analyzed to characterize the regulatory activity of the vasodilator peptide on renal performance, renal hemodynamics and endocrine activity. Infusions of adrenomedullin resulted in clear-cut renal hemodynamic effects such as reduced filling pressure and arterial pressure. The blood-pressure lowering effects of adrenomedullin was also coupled with increased cardiac output and renin stimulation in conscious sheep.

Published
1997

41. Chronic ouabain infusion does not cause hypertension in sheep

Author

Pidgeon, Grant B., Richards, A. Mark, Nicholls, M. Gary, Charles, Chris J., Rademaker, Miriam T., Lynn, Kelvin L., Bailey, Ross R., Lewis, Lynley K., and Yandale, Tim G.

Subjects
Hypertension -- Physiological aspects, Sheep -- Physiological aspects, Glycosides -- Physiological aspects, Biological sciences
Abstract

The effect of chronic dosing of the endogenous hormone ouabain on renal function was investigated by examining the role of ouabain in the development of hypertension in sheep. Ouabain infusion reduced heart rate and arterial pressure, and had no effect on pressor responsiveness to angiotensin II (ANG II). However, it reduced urine volume, urinary sodium excretion, plasma renin and ANG II concentration. These results provide evidence that ouabain does not cause hypertension, but it is both antidiuretic and antinatriuretic.

Published
1996

42. Urocortin-1 Infusion in Normal Humans

Author

Davis, Mark E., Pemberton, Chris J., Yandle, Timothy G., Lainchbury, John G., Rademaker, Miriam T., Nicholls, M Gary, Frampton, Christopher M., and Richards, A Mark

Published
2004

49. Natriuretic peptide analogues with distinct vasodilatory or renal activity: integrated effects in health and experimental heart failure.

Author

Rademaker, Miriam T, Scott, Nicola J A, Koh, Cho Yeow, Kini, R Manjunatha, and Richards, A Mark

Subjects
*BRAIN natriuretic factor, *HEART failure, *CYCLIC guanylic acid, *REGULATION of blood pressure, *LEFT heart atrium, *ENDOCRINE glands
Abstract

Aims Management of acute decompensated heart failure (ADHF) requires disparate treatments depending on the state of systemic/peripheral perfusion and the presence/absence of expanded body–fluid volumes. There is an unmet need for therapeutics that differentially treat each aspect. Atrial natriuretic peptide (ANP) plays an important role in blood pressure and volume regulation. We investigate for the first time the integrated haemodynamic, endocrine and renal effects of human ANP analogues, modified for exclusive vasodilatory (ANP-D R D) or diuretic (ANP-D G D) activities, in normal health and experimental ADHF. Methods and results We compared the effects of incremental infusions of ANP analogues ANP-D R D and ANP-D G D with native ANP, in normal (n  = 8) and ADHF (n  = 8) sheep. ANP-D R D administration increased plasma cyclic guanosine monophosphate (cGMP) in association with dose-dependent reductions in arterial pressure in normal and heart failure (HF) sheep similarly to ANP responses. In contrast to ANP, which in HF produced a diuresis/natriuresis, this analogue was without significant renal effect. Conversely, ANP-D G D induced marked stepwise increases in urinary cGMP, urine volume, and sodium excretion in HF comparable to ANP, but without accompanying vasodilatory effects. All peptides increased packed cell volume relative to control in both states, and in HF, decreased left atrial pressure. In response to ANP-D R D-induced blood pressure reductions, plasma renin activity rose compared to control only during the high dose in normals, and not at all in HF—suggesting relative renin inhibition, with no increase in aldosterone in either state, whereas renin and aldosterone were both significantly reduced by ANP-D G D in HF. Conclusion These ANP analogues exhibit distinct vasodilatory (ANP-D R D) and diuretic/natriuretic (ANP-D G D) activities, and therefore have the potential to provide precision therapy for ADHF patients with differing pathophysiological derangement of pressure–volume homeostasis. [ABSTRACT FROM AUTHOR]

Published
2021
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