Search

Your search keyword '"Radbill, Brian"' showing total 24 results
Start Over Author "Radbill, Brian"
24 results on '"Radbill, Brian"'

5. Rationale and strategies for early detection and management of diabetic kidney disease

Author

Radbill, Brian, Murphy, Barbara, and LeRoith, Derek

Subjects
American Diabetes Association -- Standards, National Kidney Foundation -- Standards, Kidney diseases -- Diagnosis, Kidney diseases -- Care and treatment, Diabetes -- Diagnosis, Diabetes -- Care and treatment
Abstract

Diabetic kidney disease (DKD) occurs in 20% to 40% of patients with diabetes mellitus and is the leading cause of chronic kidney disease and end-stage renal disease in the United [...]

Published
2008

8. Contributors

Author

Akalin, Enver, primary, Appel, Alice Sue, additional, Appel, Gerald B., additional, Aslam, Shakil, additional, Atkins, Robert C., additional, Austin, Howard A., additional, Balow, James E., additional, Barratt, Jonathan, additional, Barrett, Brendan J., additional, Becker, Bryan N., additional, Berl, Tomas, additional, Blake, Catherine, additional, Blake, Peter G., additional, Blumberg, Emily A., additional, Bonventre, Joseph V., additional, Brater, D. Craig, additional, Braun, William E., additional, Bravo, Emmanuel L., additional, Brener, Zachary Z., additional, Briscoe, David M., additional, Bromberg, Jonathan, additional, Burkart, John, additional, Capasso, Giovambattista, additional, Cappuccio, Francesco P., additional, Carson, Culley C., additional, Chadban, Steven J., additional, Chapman, Arlene B., additional, Chen, Joline L.T., additional, Chesney, Russell W., additional, Cheung, Alfred K., additional, Cho, Monique E., additional, Cohen, Lewis M., additional, Conlin, Paul R., additional, Cruz, Dinna, additional, Cullis, Brett, additional, Curhan, Gary C., additional, Curtis, John J., additional, Cutie, Christopher J., additional, D-Amico, Giuseppe, additional, Davies, Simon J., additional, Davis, Connie L., additional, Davison, Sara N., additional, De Caterina, Raffaele, additional, Dember, Laura M., additional, Denton, Mark, additional, Depner, Thomas A., additional, Derksen, J. Eric, additional, Dharnidharka, Vikas R., additional, Dixon, Bradley S., additional, Dobbie, Hamish, additional, Druml, Wilfred, additional, DuBose, Thomas D., additional, Dworkin, Lance D., additional, Ellison, David H., additional, Fadem, Stephen Z., additional, Feehally, John, additional, Feinfeld, Donald A., additional, Fishbane, Steven, additional, Fitzpatrick, John M., additional, Ford, Daniel J., additional, Fornasieri, Alessandro, additional, Garnick, Marc B., additional, Gaston, Robert S., additional, Germain, Michael J., additional, Ginès, Pere, additional, Gonin, Joyce M., additional, Greene, Eddie L., additional, Grundy, Scott M., additional, Habli, Mounira, additional, Hall, Andrew, additional, Halperin, Mitchell L., additional, Harbord, Nikolas B., additional, Hewins, Peter, additional, Himmelfarb, Jonathan, additional, Hollenberg, Norman K., additional, Imai, Enyu, additional, Isaka, Yoshitaka, additional, Jang, Hye Ryoun, additional, Jayne, David, additional, Kaluvapalle, Jay R., additional, Kamel, Kamel S., additional, Kapa, Suraj, additional, Kaplan, Norman M., additional, Kist-van Holthe, Joana E., additional, Klotman, Mary E., additional, Klotman, Paul E., additional, Kopp, Jeffrey B., additional, Krakoff, Lawrence R., additional, Lentz, Aaron C., additional, Lerner, Susan M., additional, Levine, Jerrold S., additional, Levy, Jeremy B., additional, Lewis, Edmund J., additional, Lewis, Julia B., additional, Lin, Shih-Hua, additional, Llach, Francisco, additional, Luft, Friedrich C., additional, Mann, Samuel J., additional, Martin, Kevin J., additional, Masud, Tahsin, additional, Mathew, Roy O., additional, McDougal, W. Scott, additional, McKusick, Michael, additional, Mehta, Ravindra L., additional, Minetti, Luigi, additional, Mirot, Adam M., additional, Mitch, William E., additional, Moss, Alvin H., additional, Murphy, Barbara, additional, Nadim, Mitra K., additional, Neilson, Eric G., additional, Nora, Elizabeth H., additional, Noris, Marina, additional, Nouri, Pouneh, additional, Oh, Man S., additional, O-Meara, Yvonne M., additional, Palmer, Biff F., additional, Papademetriou, Vasilios, additional, Parfrey, Patrick S., additional, Patel, Manish P., additional, Pépin, Marie-Noëlle, additional, Plant, William D., additional, Pusey, Charles D., additional, Qazi, Rizwan A., additional, Rabb, Hamid, additional, Radbill, Brian D., additional, Rahbari-Oskoui, Frederic F., additional, Rees, Andrew J., additional, Remuzzi, Giuseppe, additional, Ricci, Zaccaria, additional, Ritz, Eberhard, additional, Rodig, Nancy M., additional, Ronco, Claudio, additional, Rubin, Robert H., additional, Rubin, Robert J., additional, Ruggenenti, Piero, additional, Salant, David J., additional, Sanders, Paul W., additional, Savage, Caroline O.S., additional, Sayegh, Mohamed H., additional, Schieppati, Arrigo, additional, Schröppel, Bernd, additional, Schulman, Gerald, additional, Shemin, Douglas G., additional, Sibai, Baha M., additional, Silva, Sandra, additional, Sims, Karen D., additional, Smith, James P., additional, Smith, Richard J.H., additional, Somers, Michael J.G., additional, Somers, Virend K., additional, Taal, Maarten W., additional, Takabatake, Yoshitsugu, additional, Taylor, Eric N., additional, Tessier, Edward G., additional, Textor, Stephen C., additional, Thurman, Joshua M., additional, Tolkoff-Rubin, Nina E., additional, Toto, Robert D., additional, Turner, A. Neil, additional, Unwin, Robert, additional, Vassalotti, Joseph A., additional, Vega, Gloria Lena, additional, Vella, John P., additional, Waldman, Meryl, additional, Wali, Ravinder K., additional, Wanner, Christoph, additional, Whittier, William L., additional, Wilcox, Christopher S., additional, Williams, John D., additional, Winchester, James F., additional, Wyatt, Christina M., additional, Yeun, Jane Y., additional, Yu, Alan S.L., additional, and Zoccali, Carmine, additional

Published
2008
Full Text
View/download PDF

13. Effect of Cholecalciferol Supplementation on Inflammation and Cellular Alloimmunity in Hemodialysis Patients: Data from a Randomized Controlled Pilot Trial

Author

Li, Lily, primary, Lin, Marvin, additional, Krassilnikova, Maria, additional, Ostrow, Katya, additional, Bader, Amanda, additional, Radbill, Brian, additional, Uribarri, Jaime, additional, Tokita, Joji, additional, Leisman, Staci, additional, Lapsia, Vijay, additional, Albrecht, Randy A., additional, García-Sastre, Adolfo, additional, Branch, Andrea D., additional, Heeger, Peter S., additional, and Mehrotra, Anita, additional

Published
2014
Full Text
View/download PDF

14. The surgical management of renal hyperparathyroidism

Author

Madorin, Catherine, primary, Owen, Randall P., additional, Fraser, William D., additional, Pellitteri, Phillip K., additional, Radbill, Brian, additional, Rinaldo, Alessandra, additional, Seethala, Raja R., additional, Shaha, Ashok R., additional, Silver, Carl E., additional, Suh, Matthew Y., additional, Weinstein, Barrie, additional, and Ferlito, Alfio, additional

Published
2011
Full Text
View/download PDF

16. Loss of Matrix Metalloproteinase-2 Amplifies Murine Toxin-Induced Liver Fibrosis by Upregulating Collagen I Expression

Author

Radbill, Brian D., primary, Gupta, Ritu, additional, Ramirez, Maria Celeste M., additional, DiFeo, Analisa, additional, Martignetti, John A., additional, Alvarez, Carlos E., additional, Friedman, Scott L., additional, Narla, Goutham, additional, Vrabie, Raluca, additional, Bowles, Robert, additional, Saiman, Yedidya, additional, and Bansal, Meena B., additional

Published
2010
Full Text
View/download PDF

19. Diabetic Kidney Disease in the Elderly: Diagnosis, Treatment Goals, and Management.

Author

KONCICKI, HOLLY and RADBILL, BRIAN

Abstract

The article discusses the screening of patients with diabetes or diabetic kidney disease (DKD) through the use of albuminuria to measure of kidney damage and estimated glomerular filtration rate (eGFR) for kidney damage. It details that one of the main treatment strategies for DKD is to decrease albuminuria through inhibition of the renin-angiotensin-aldosterone system. The article also states the need to control other confounding conditions, including blood pressure, lipids and hyperglycemia.

Published
2011

20. Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureusamong Patients in an Ambulatory Hemodialysis Center

Author

Patel, Gopi, Jenkins, Stephen G., Mediavilla, José R., Kreiswirth, Barry N., Radbill, Brian, Salgado, Cassandra D., and Calfee, David P.

Abstract

Objective.To describe the epidemiology of methicillin-resistant Staphylococcus aureus(MRSA) carriage and transmission in an ambulatory hemodialysis population.Design.Prospective cohort study.Setting.Outpatient hemodialysis facility affiliated with a large academic medical center.Participants.Of the 170 facility patients, 103 (61%) participated in the study.Methods.Swab specimens of the nares, axillae, and vascular access site were collected from participants weekly for 3 weeks and then monthly for 5 months. Demographic and clinical data were collected monthly for 12 months. Molecular analysis of MRSA isolates was performed.Results.The baseline MRSA carriage prevalence was 12%. Factors associated with MRSA carriage included a history of MRSA; failed renal transplantation; hospital admission within 6 months; and receipt of a first-generation cephalosporin, cefepime, or vancomycin. Six subjects acquired MRSA after enrollment (incidence, 1.2 per 100 patient-months at-risk; overall prevalence, 18%). Molecular analysis suggested that transmission occurred within the facility. The incidence of MRSA infection among carriers was 1.76 per 100 patient-months. Community-associated strains (ie, USA300) were isolated from 28% of carriers and at least 25% of infections.Conclusions.The prevalence of MRSA carriage and the incidence of infection among carriers were high among ambulatory hemodialysis patients, and community-associated MRSA was responsible for a large portion of the MRSA burden. A relatively high rate of MRSA acquisition was observed, with indirect evidence of intrafacility transmission. Additional studies are needed to confirm these findings and to identify effective and feasible methods to prevent MRSA transmission and infection among hemodialysis patients.

Published
2011
Full Text
View/download PDF

21. Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development.

Author

Xiaohong Li, Hyink, Deborah P., Radbill, Brian, Sudol, Marius, Haojiang Zhang, Zheleznova, Nadezda N., and Wilson, Patricia D.

Subjects
*KIDNEYS, *PROTEIN kinases, *BONE morphogenetic proteins, *EPITHELIAL cells, *MORPHOGENESIS, *NEPHROLOGY, *MEDICAL research
Abstract

The regulation of epithelial branching morphogenesis by bone morphogenetic protein-7 depends, in part, on functionally defined cyclic adenosine monophosphate (cAMP)-dependent protein kinases. We previously identified protein kinase-X (PRKX), a cAMP-dependent kinase, as a regulator of epithelial morphogenesis during kidney development and found that it binds to and phosphorylates Polycystin-1. Overexpression of PRKX stimulates renal epithelial cell migration, tubulogenesis, ureteric bud branching, and glomerular induction in embryonic mouse kidney explants in organ cultures. Here we determined the physiological functions of endogenous PRKX. Knockdown by siRNA of PRKX gene expression in a human fetal collecting tubule (HFCT) cell line exceeded 70% and resulted in decreased cell migration and increased adhesion of the cells to a collagen I matrix. In embryonic mouse kidney explants, the same degree of knockdown decreased ureteric bud branching and glomerular induction. Because PRKX BAG-3 PIN-1 and MAGI-1 are all expressed in ureteric bud derivatives, we tested for interactions among them and found that PRKX binds to all three proteins through its WW domain as determined by TransSignal domain arrays, and it coimmunoprecipitated with Pin-1 in HFCT cell lysates. These studies suggest that Polycystin-1 and Pin-1 may mediate the function of PRKX in kidney development.Kidney International (2009) 76, 54–62; doi:10.1038/ki.2009.95; published online 15 April 2009 [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

23. Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression

Author

Bansal, Meena B., Kovalovich, Kellen, Gupta, Ritu, Li, Wei, Agarwal, Akansha, Radbill, Brian, Alvarez, Carlos E., Safadi, Rifaat, Fiel, M. Isabel, Friedman, Scott L., and Taub, Rebecca A.

Subjects
*INTERLEUKIN-6, *MESSENGER RNA, *APOPTOSIS, *NECROSIS
Abstract

Background/Aims: Interleukin-6 stimulates liver regeneration and promotes hepatoprotection following experimental liver injury, but underlying mechanisms have not been fully characterized. Because studies suggest matrix metalloproteinase-2 (MMP-2) may promote liver injury, we examined whether IL-6 exerted its protective effects via regulation of MMP-2. Methods: MMP-2 was analyzed in livers of IL-6−/− and IL-6+/+ mice following CCl4 administration. IL-6−/− mice were pretreated with IL-6 and liver histology and MMP-2 expression were examined after liver injury. IL-6−/− mice were treated with an MMP-2 inhibitor and assessment of injury (histology and serum ALT levels), apoptosis by TUNEL assay, and hepatocyte proliferation by BRDU-labeling was performed. These studies were complemented by analysis of cultured stellate cells. Results: MMP-2 mRNA, protein, and activity was increased in IL-6−/− livers. Restoration of IL-6 signaling in IL-6−/− mice rescued injury and restored MMP-2 expression to wild-type levels. Furthermore, pharmacologic inhibition of MMP-2 decreased hepatocellular injury and apoptosis in IL-6−/− mice. In cultured stellate cells, recombinant IL-6 suppressed endogenous MMP-2 mRNA and protein expression. Conclusions: IL-6 may be hepatoprotective in acute injury through down-regulation of MMP-2. These findings suggest a role for MMP-2 in amplifying liver injury in vivo. [Copyright &y& Elsevier]

Published
2005
Full Text
View/download PDF

24. Contributors

Author

Akalin, Enver, Appel, Alice Sue, Appel, Gerald B., Aslam, Shakil, Atkins, Robert C., Austin, Howard A., III, Balow, James E., Barratt, Jonathan, Barrett, Brendan J., Becker, Bryan N., Berl, Tomas, Blake, Catherine, Blake, Peter G., Blumberg, Emily A., Bonventre, Joseph V., Brater, D. Craig, Braun, William E., Bravo, Emmanuel L., Brener, Zachary Z., Briscoe, David M., Bromberg, Jonathan, Burkart, John, Capasso, Giovambattista, Cappuccio, Francesco P., Carson, Culley C., III, Chadban, Steven J., Chapman, Arlene B., Chen, Joline L.T., Chesney, Russell W., Cheung, Alfred K., Cho, Monique E., Cohen, Lewis M., Conlin, Paul R., Cruz, Dinna, Cullis, Brett, Curhan, Gary C., Curtis, John J., Cutie, Christopher J., D-Amico, Giuseppe, Davies, Simon J., Davis, Connie L., Davison, Sara N., De Caterina, Raffaele, Dember, Laura M., Denton, Mark, Depner, Thomas A., Derksen, J. Eric, Dharnidharka, Vikas R., Dixon, Bradley S., Dobbie, Hamish, Druml, Wilfred, DuBose, Thomas D., Jr., Dworkin, Lance D., Ellison, David H., Fadem, Stephen Z., Feehally, John, Feinfeld, Donald A., Fishbane, Steven, Fitzpatrick, John M., Ford, Daniel J., Fornasieri, Alessandro, Garnick, Marc B., Gaston, Robert S., Germain, Michael J., Ginès, Pere, Gonin, Joyce M., Greene, Eddie L., Grundy, Scott M., Habli, Mounira, Hall, Andrew, Halperin, Mitchell L., Harbord, Nikolas B., Hewins, Peter, Himmelfarb, Jonathan, Hollenberg, Norman K., Imai, Enyu, Isaka, Yoshitaka, Jang, Hye Ryoun, Jayne, David, Kaluvapalle, Jay R., Kamel, Kamel S., Kapa, Suraj, Kaplan, Norman M., Kist-van Holthe, Joana E., Klotman, Mary E., Klotman, Paul E., Kopp, Jeffrey B., Krakoff, Lawrence R., Lentz, Aaron C., Lerner, Susan M., Levine, Jerrold S., Levy, Jeremy B., Lewis, Edmund J., Lewis, Julia B., Lin, Shih-Hua, Llach, Francisco, Luft, Friedrich C., Mann, Samuel J., Martin, Kevin J., Masud, Tahsin, Mathew, Roy O., McDougal, W. Scott, McKusick, Michael, Mehta, Ravindra L., Minetti, Luigi, Mirot, Adam M., Mitch, William E., Moss, Alvin H., Murphy, Barbara, Nadim, Mitra K., Neilson, Eric G., Nora, Elizabeth H., Noris, Marina, Nouri, Pouneh, Oh, Man S., O-Meara, Yvonne M., Palmer, Biff F., Papademetriou, Vasilios, Parfrey, Patrick S., Patel, Manish P., Pépin, Marie-Noëlle, Plant, William D., Pusey, Charles D., Qazi, Rizwan A., Rabb, Hamid, Radbill, Brian D., Rahbari-Oskoui, Frederic F., Rees, Andrew J., Remuzzi, Giuseppe, Ricci, Zaccaria, Ritz, Eberhard, Rodig, Nancy M., Ronco, Claudio, Rubin, Robert H., Rubin, Robert J., Ruggenenti, Piero, Salant, David J., Sanders, Paul W., Savage, Caroline O.S., Sayegh, Mohamed H., Schieppati, Arrigo, Schröppel, Bernd, Schulman, Gerald, Shemin, Douglas G., Sibai, Baha M., Silva, Sandra, Sims, Karen D., Smith, James P., Smith, Richard J.H., Somers, Michael J.G., Somers, Virend K., Taal, Maarten W., Takabatake, Yoshitsugu, Taylor, Eric N., Tessier, Edward G., Textor, Stephen C., Thurman, Joshua M., Tolkoff-Rubin, Nina E., Toto, Robert D., Turner, A. Neil, Unwin, Robert, Vassalotti, Joseph A., Vega, Gloria Lena, Vella, John P., Waldman, Meryl, Wali, Ravinder K., Wanner, Christoph, Whittier, William L., Wilcox, Christopher S., Williams, John D., Winchester, James F., Wyatt, Christina M., Yeun, Jane Y., Yu, Alan S.L., and Zoccali, Carmine

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results