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308 results on '"Radanovic, Marcia"'

26. Prevalence of potentially reversible dementias in a dementia outpatient clinic of a tertiary university-affiliated hospital in Brazil

Author

Takada Leonel Tadao, Caramelli Paulo, Radanovic Marcia, Anghinah Renato, Hartmann Ana Paula B. J., Guariglia Carla Cristina, Bahia Valéria Santoro, and Nitrini Ricardo

Subjects
dementia, prevalence, Alzheimer's disease, neurosyphilis, hydrocephalus, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The importance of investigating the etiology for dementia lies in the possibility of treating potentially reversible dementias. The aims of this retrospective study are to determine the prevalence of potentially reversible dementias among 454 outpatients seen at the Cognitive and Behavioral Neurology Unit, Hospital das Clínicas, São Paulo University School of Medicine - Brazil, between the years of 1991 and 2001, and observe their evolution in follow-up. Among the initial 454 patients, 275 fulfilled the DSM-IV criteria for dementia. Alzheimer's disease was the most frequent diagnosis (164 cases; 59.6%). Twenty-two cases (8.0%) of potentially reversible dementia were observed, the most frequent diagnoses being neurosyphilis (nine cases) and hydrocephalus (six cases). Full recovery was observed in two patients and partial recovery in 10 patients. Two cases were not treated and eight cases were lost on follow-up. The prevalence found in the present study falls within the range reported in previous studies (0-30%).

Published
2003

27. Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program

Author

Oliveira, Alexandra Martini, primary, Radanovic, Marcia, additional, Mello, Patricia Cotting Homem de, additional, Buchain, Patricia Cardoso, additional, Vizzotto, Adriana Dias Barbosa, additional, Harder, Janaína, additional, Stella, Florindo, additional, Gitlin, Laura N., additional, Piersol, Catherine Verrier, additional, Valiengo, Leandro L.C., additional, and Forlenza, Orestes Vicente, additional

Published
2021
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33. Alzheimer’s Disease

Author

De-Paula, Vanessa J., primary, Radanovic, Marcia, additional, Diniz, Breno S., additional, and Forlenza, Orestes V., additional

Published
2012
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41. Neuropsychiatric symptoms and cerebrovascular risk in non‐demented elders: cross‐sectional study using the mild behavioural impairment checklist (MBI‐C).

Author

Stella, Florindo, Pais, Marcos V., Loureiro, Júlia C., Radanovic, Marcia, and Forlenza, Orestes V.

Subjects
CEREBROVASCULAR disease risk factors, COGNITION disorders, CROSS-sectional method, BEHAVIOR disorders, RISK assessment, NEUROPSYCHOLOGICAL tests, APOLIPOPROTEINS, GENOTYPES, NEURORADIOLOGY, COMORBIDITY, OLD age
Abstract

Background: Neuropsychiatric symptoms (NPS) may represent early clinical manifestations of evolving brain diseases. Studies underpin the occurrence of NPS in the context of mild cognitive impairment (MCI) and prodromal Alzheimer's disease, where symptoms referred to as 'mild behavioural impairment' (MBI) have been shown to predict conversion to dementia and to hasten cognitive/functional decline. However, the association between NPS and cerebrovascular risk factors has been poorly investigated, despite the high prevalence of the latter among individuals with MCI. The aim of the present study was to investigate the association between MBI and cerebrovascular risk in a clinical sample of non‐demented elders. Methods: Sixty‐five MCI and 15 cognitively unimpaired older adults were cross‐sectionally assessed with the Mild Behavioural Impairment Checklist (MBI‐C), using the cut‐off score > 6.5 to define positive screening. Participants were submitted to the Hachinski Ischaemic Score (HIS) to account for cerebrovascular symptoms, vascular risk, and related comorbidities. Neuroimaging scans (magnetic resonance imaging and/or 18F‐fluorodeoxyglucose‐positron emission tomography) and apolipoprotein E genotype were obtained. Results: Positive associations were found between total MBI‐C scores and increasing number of comorbidities present (0–2 comorbidities), but not with three comorbidities. Two domains of the MBI‐C—impulse dyscontrol and social inappropriateness—followed the same trend of the MBI‐C total score, with higher scores with the increasing numbers of comorbidities. No significant associations were found between MBI symptoms and HIS or cerebrovascular burden in neuroimaging assessment. Conclusion: We found weak associations between MBI‐C total score and the presence of comorbidities with cerebrovascular risk, but not with structural or functional neuroimaging abnormalities or HIS. This finding may represent that the presence of comorbidities adds limited risk to the occurrence of MBI in this sample of non‐demented elders. [ABSTRACT FROM AUTHOR]

Published
2022
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42. AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State.

Author

Ibarra, Romel, Radanovic, Marcia, Pais, Marcos V., Talib, Leda L., and Forlenza, Orestes V.

Subjects
*MILD cognitive impairment, *COGNITIVE ability, *COGNITION disorders, *TAU proteins, *CEREBROSPINAL fluid, *ALZHEIMER'S disease
Abstract

Aim: Associations between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) with the severity of cognitive impairment are unclear. We examined the correlations between CSF biomarkers and cognitive performance in the AD continuum. Methods: We studied 143 elderly patients: cognitively unimpaired (n = 51), mild cognitive impairment (MCI) amnestic (n = 55) and nonamnestic (n = 20), and mild AD (n = 17) assessed with the Cambridge Cognitive Test (CAMCOG). We correlated total CAMCOG and its subdomains with CSF Aβ42, T-tau, p-tau levels, and Aβ42/p-tau. Results: In the total sample, T-tau and Aβ42/p-tau correlated with the total CAMCOG (P <.01); all biomarkers correlated with memory (P <.001); T-tau correlated with language (P <.01). Conclusion: Memory and T-tau levels may be the most suitable parameters to reflect cognitive/CSF biomarker correlations. At present, such correlations are of little use in routine clinical practice. [ABSTRACT FROM AUTHOR]

Published
2021
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44. P2‐022: RANDOMIZED AND CONTROLLED CLINICAL TRIAL TO EVALUATE A BRAZILIAN OUTPATIENT VERSION OF THE TAP METHOD (TAILORED ACTIVITY PROGRAM) FOR THE TREATMENT OF NEUROPSYCHIATRIC SYMPTOMS IN INDIVIDUALS WITH DEMENTIA

Author

Oliveira, Alexandra Martini, primary, Radanovic, Marcia, additional, Homem de Mello, Patricia Cotting, additional, Buchain, Patricia Cardoso, additional, Vizzotto, Adriana dias, additional, Harder, Janaina, additional, Stella, Florindo, additional, Piersol, Catherine V., additional, Gitlin, Laura N., additional, Valiengo, Leandro L.C., additional, and Forlenza, Orestes Vicente, additional

Published
2019
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48. An intervention to reduce neuropsychiatric symptoms and caregiver burden in dementia: Preliminary results from a randomized trial of the tailored activity program-outpatient version

Author

de Oliveira, Alexandra Martini, primary, Radanovic, Marcia, additional, Homem de Mello, Patricia Cotting, additional, Buchain, Patricia Cardoso, additional, Dias Vizzotto, Adriana, additional, Harder, Janaína, additional, Stella, Florindo, additional, Piersol, Catherine Verrier, additional, Gitlin, Laura N., additional, and Forlenza, Orestes Vicente, additional

Published
2018
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