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213 results on '"Radakovic, Sonja"'

21. Coxsackie B3 Virus-induced Acute Hemorrhagic Edema of Infancy

Author

Soler-Cardona, Ana, Tanew, Adrian, and Radakovic, Sonja

Subjects
purpura, vasculitis, targetoid hemorrhagic edema, infancy, coxsackie B3 virus INTRODUCTION
Abstract

Acute hemorrhagic edema of infancy (AHEI) is a cutaneous leukocytoclastic small vessel vasculitis of unknown incidence. It affects mostly infants aged 4 to 24 months. The distinctive features of AHEI include a generally healthy-appearing child with low-grade or absent fever and rarely painful targetoid purpuric edematous lesions. The disease usually resolves spontaneously within 3 weeks without late sequelae. The main differential diagnosis of AHEI is Henoch-Schönlein purpura (HSP). Initially, purpura fulminans should also be ruled out. We report the case of a 5-year-old girl with low fever and rapidly progressive skin lesions who had been admitted to the pediatric clinic. The child presented with palpable annular targetoid and purpuric plaques of different size predominantly affecting the face and extremities. In addition, there was a painful, hemorrhagic edema on the dorsum of her hands and feet. Based on the course of the disease and the typical clinical presentation, i.e., extensive characteristic skin lesions in a young child in a good general health condition, a diagnosis of AHEI was established. A virus serology test showed increased titers of enterovirus and coxsackievirus. Isolation of virus from feces confirmed an infection with coxsackie B3 virus. To our knowledge, this is the first report linking coxsackie B3 virus infection to AHEI

Published
2021

34. Effectiveness of narrowband UVB phototherapy and psoralen plus UVA photochemotherapy in the treatment of generalized lichen planus: Results from a large retrospective analysis and an update of the literature.

Author

Weber, Benedikt, Marquart, Elias, Radakovic, Sonja, and Tanew, Adrian

Subjects
LICHEN planus, PHOTOCHEMOTHERAPY, PHOTOTHERAPY, RETROSPECTIVE studies, PSORALENS
Abstract

Background: The aim of this retrospective study was to compare the efficacy and safety of different phototherapeutic modalities in the treatment of cutaneous lichen planus (LP). Methods: We retrospectively analyzed the chart data of 53 patients with generalized LP who had been subjected to narrowband UVB (NB‐UVB) or photochemotherapy (PUVA) between January 1997 and April 2020. Of these, 30 patients had received NB‐UVB, 18 patients oral PUVA and 5 patients bath PUVA. Results: Fifty patients completed a full treatment course. The percentage of patients with a complete (>90% clearing) or good (51%‐90% clearing) response was similar for NB‐UVB versus PUVA (86.2% vs. 90.5%; P = 1.00). The number of exposures required for obtaining a complete or good response was also comparable for both treatment groups (NB‐UVB: 28.9 ± 12.3 vs. PUVA: 25.4 ± 10.1; P =.209). Adverse events, in particular gastrointestinal upsets, were recorded in 26.1% of patients treated with oral PUVA while none were observed with NB‐UVB. Conclusion: The therapeutic outcome and the number of treatments required for achieving a complete or good response were comparable for NB‐UVB and PUVA; however, PUVA therapy was associated with a substantially higher rate of moderate adverse events. [ABSTRACT FROM AUTHOR]

Published
2022
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38. The impact of occlusive vs non‐occlusive application of 5‐aminolevulinic acid (BF‐200 ALA) on the efficacy and tolerability of photodynamic therapy for actinic keratosis on the scalp and face: A prospective within‐patient comparison trial

Author

Meierhofer, C., Silic, K., Urban, M. V., Tanew, Adrian, and Radakovic, Sonja

Subjects
PHOTODYNAMIC therapy, ACTINIC keratosis, SCALP, KERATOSIS, ACIDS, PHOTOSENSITIZERS
Abstract

Background: Photodynamic therapy (PDT) is an effective treatment for actinic keratoses (AK). PDT is usually performed with occlusion of the photosensitizer prior to subsequent illumination. Objectives: This study aimed to compare the efficacy and tolerability of occlusive versus non‐occlusive application of a 5‐aminolevulinic gel (BT‐200 ALA) for PDT of multiple AK on the scalp or face. Methods: Prospective, investigator‐blinded, within‐patient comparison study on 45 patients. PDT with occlusion of ALA was performed in a target area on one randomized side of the scalp or face. One week later a contralateral target area received the same treatment except that no occlusion of the ALA gel was performed. 3 and 6 months after PDT, the clearance rate of a predetermined target lesion and the total clearance rate of all AK within the treated areas were determined. PDT‐induced pain and skin phototoxicity and cosmetic outcome were also recorded. Results: Clearance rate of the target AK and total AK clearance rate at 3 months after PDT was 88.4% and 90.6% for occlusive PDT and 58.1% (P =.001) and 70.4% (P =.04) for non‐occlusive PDT. The corresponding values at 6 months after PDT were 69.7% and 72.1% for occlusive PDT and 30.2% (P <.001) and 35.6% (P =.001) for non‐occlusive PDT. Pain score and skin phototoxicity were significantly higher after occlusive ALA application. No difference was observed with respect to cosmetic outcome. Conclusions: Occlusive application of ALA significantly improves the efficacy of PDT but is associated with more pain and increased phototoxicity. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Daylight PDT with MAL - current data and practical recommendations of an expert panel

Author

Ulrich, Claas, Gerber, Peter Arne, Szeimies, Rolf-Markus, Philipp-Dormston, Wolfgang G, Dirschka, Thomas, Radakovic, Sonja, Lonsdorf, Anke S, Hunger, Robert, Berking, Carola, Karrer, Sigrid, and Petering, Holger

Subjects
polycyclic compounds, 610 Medicine & health, therapeutics, eye diseases
Abstract

Die photodynamische Therapie (PDT) gehört zu den Standardverfahren in der Therapie aktinischer Keratosen (AK). Bei der Tageslicht-PDT (Daylight PDT, DL-PDT) mit MAL-Creme handelt es sich um eine neuere Entwicklung, bei der anstelle eines Belichtungssystems das Tageslicht zur Aktivierung des Photosensibilisators genutzt wird. Der vorliegende Review fasst die aktuelle Studienlage basierend auf einer selektiven Literaturrecherche zusammen, fokussiert auf praktische Aspekte in der Durchführung und reflektiert insbesondere auch die Expertenerfahrung der Autoren mit der DL-PDT. Studiendaten zeigen, dass die DL-PDT der konventionellen PDT in ihrer Wirksamkeit nicht unterlegen ist. Sie ist jedoch signifikant besser verträglich, da sie zu deutlich weniger Schmerzen während der Therapie führt. Sie kann in Mitteleuropa von März bis Oktober sowohl an bewölkten als auch an sonnigen Tagen durchgeführt werden. Hierbei ist auf UV-Schutz auch der nicht behandelten Körperareale zu achten. Die Außentemperatur sollte 10°C nicht unterschreiten. An heißen Tagen sollte ein Aufenthalt im Schatten, soweit erforderlich, eingeplant werden. Die DL-PDT mit MAL ist u. a. für Patienten mit Feldkanzerisierung und/oder negativer Schmerzerfahrung bei der cPDT geeignet und stellt eine sinnvolle Ergänzung der aktuellen Therapiemöglichkeiten dar.

Published
2015
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45. Immune Response in Severe Infection: Could Life-Saving Drugs Be Potentially Harmful?

Author

Surbatovic, Maja, Jevdjic, Jasna, Veljovic, Milic, Popovic, Nada, Djordjevic, Dragan, and Radakovic, Sonja

Subjects
Article Subject
Abstract

Critically ill patients suffer a high rate of nosocomial infection with secondary sepsis being a common cause of death. Usage of antibiotics and catecholamines is often necessary, but it can compromise complex immune response to infection. This review explores influence of these life-saving drugs on host immune response to severe infection.

Published
2013
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46. Immunoinflammatory Response in Critically Ill Patients: Severe Sepsis and/or Trauma

Author

Surbatovic, Maja, Veljovic, Milic, Jevdjic, Jasna, Popovic, Nada, Djordjevic, Dragan, and Radakovic, Sonja

Subjects
nervous system, Article Subject, musculoskeletal, neural, and ocular physiology, macromolecular substances
Abstract

Immunoinflammatory response in critically ill patients is very complex. This review explores some of the new elements of immunoinflammatory response in severe sepsis, tumor necrosis factor-alpha in severe acute pancreatitis as a clinical example of immune response in sepsis, immune response in severe trauma with or without secondary sepsis, and genetic aspects of host immuno-inflammatory response to various insults in critically ill patients.

Published
2013
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47. Prognostic Value And Daily Trend Of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein And Lipopolysaccharide-Binding Protein In Critically Ill Patients: Reliable Predictors Of Outcome Or Not?

Author

Djordjevic, Dragan, primary, Pejovic, Janko, additional, Surbatovic, Maja, additional, Jevdjic, Jasna, additional, Radakovic, Sonja, additional, Veljovic, Milic, additional, Peric, Aneta, additional, Andjelic, Tamara, additional, and Popovic, Nada, additional

Published
2015
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