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5. Thirty years of experience with solvent/detergent‐treated plasma for transfusion medicine.

Author

Racine‐Brzostek, Sabrina E., Cushing, Melissa M., Gareis, Michelle, Heger, Andrea, Mehta Shah, Trupti, and Scully, Marie

Subjects
*BLOOD transfusion reaction, *HEMORRHAGIC shock, *BLOOD transfusion, *CORONAVIRUS disease treatment, *SURGICAL blood loss, *GRAFT versus host disease, *HEPATITIS C virus
Abstract

This article provides information on the use of solvent/detergent-treated plasma (S/D plasma) in transfusion medicine. S/D plasma is a type of plasma preparation that has been treated to improve safety by inactivating pathogens. It discusses the characteristics, efficacy, and safety of S/D plasma, particularly OctaplasLG, which is a frozen plasma preparation used as an alternative to fresh frozen plasma (FFP). Studies have shown that OctaplasLG is effective and has a good safety profile, with lower incidences of adverse reactions compared to FFP. It is recommended for various indications, including coagulation factor deficiencies, massive transfusion, and therapeutic plasma exchange. OctaplasLG has been found to be cost-effective and has been adopted by several European countries. It also has potential benefits in treating other medical conditions and protecting the endothelium. Overall, OctaplasLG is an effective and well-tolerated alternative to FFP, with expanding clinical utility and potential for improving patient outcomes. [Extracted from the article]

Published
2024
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6. Cytokine signatures of end organ injury in COVID-19

Author

Gómez-Escobar, Luis G., Hoffman, Katherine L., Choi, Justin J., Borczuk, Alain, Salvatore, Steven, Alvarez-Mulett, Sergio L., Galvan, Manuel D., Zhao, Zhen, Racine-Brzostek, Sabrina E., Yang, He S., Stout-Delgado, Heather W., Choi, Mary E., Choi, Augustine M. K., Cho, Soo Jung, and Schenck, Edward J.

Published
2021
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7. Rapid, robust, and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals

Author

Racine-Brzostek, Sabrina E., primary, Yee, Jim K., additional, Sukhu, Ashley, additional, Qiu, Yuqing, additional, Rand, Sophie, additional, Barone, Paul D., additional, Hao, Ying, additional, Yang, He S., additional, Meng, Qing H., additional, Apple, Fred S., additional, Shi, Yuanyuan, additional, Chadburn, Amy, additional, Golden, Encouse, additional, Formenti, Silvia C., additional, Cushing, Melissa M., additional, and Zhao, Zhen, additional

Published
2021
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8. More rapid, robust and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals

Author

Racine-Brzostek, Sabrina E., primary, Yee, Jim, additional, Sukhu, Ashley, additional, Qiu, Yuqing, additional, Rand, Sophie, additional, Barone, Paul, additional, Hao, Ying, additional, Yang, He S., additional, Meng, Qing H, additional, Apple, Fred S, additional, Shi, Yuanyuan, additional, Chadburn, Amy, additional, Golden, Encouse, additional, Formenti, Silvia C., additional, Cushing, Melissa M., additional, and Zhao, Zhen, additional

Published
2021
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11. TOP-Plus Is a Versatile Biosensor Platform for Monitoring SARS-CoV-2 Antibody Durability

Author

Racine-Brzostek, Sabrina E, primary, Karbaschi, Mohsen, additional, Gaebler, Christian, additional, Klasse, P J, additional, Yee, Jim, additional, Caskey, Marina, additional, Yang, He S, additional, Hao, Ying, additional, Sukhu, Ashley, additional, Rand, Sophie, additional, Chadburn, Amy, additional, Shi, Yuanyuan, additional, Zuk, Robert, additional, Nussenzweig, Michel C, additional, Cushing, Melissa M, additional, and Zhao, Zhen, additional

Published
2021
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12. Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients

Author

Yang, He S., primary, Racine-Brzostek, Sabrina E., additional, Karbaschi, Mohsen, additional, Yee, Jim, additional, Dillard, Alicia, additional, Steel, Peter A.D., additional, Lee, William T., additional, McDonough, Kathleen A., additional, Qiu, Yuqing, additional, Ketas, Thomas J., additional, Francomano, Erik, additional, Klasse, P.J., additional, Hatem, Layla, additional, Westblade, Lars, additional, Wu, Heng, additional, Chen, Haode, additional, Zuk, Robert, additional, Tan, Hong, additional, Girardin, Roxanne C., additional, Dupuis, Alan P., additional, Payne, Anne F., additional, Moore, John P., additional, Cushing, Melissa M., additional, Chadburn, Amy, additional, and Zhao, Zhen, additional

Published
2021
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13. Association of Age With SARS-CoV-2 Antibody Response

Author

Yang, He S., primary, Costa, Victoria, additional, Racine-Brzostek, Sabrina E., additional, Acker, Karen P., additional, Yee, Jim, additional, Chen, Zhengming, additional, Karbaschi, Mohsen, additional, Zuk, Robert, additional, Rand, Sophie, additional, Sukhu, Ashley, additional, Klasse, P. J., additional, Cushing, Melissa M., additional, Chadburn, Amy, additional, and Zhao, Zhen, additional

Published
2021
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14. TOP-Plus is a Versatile Biosensor Platform for Monitoring SARS-CoV-2 Antibody Durability

Author

Racine-Brzostek, Sabrina E., primary, Karbaschi, Mohsen, additional, Gaebler, Christian, additional, Klasse, P.J., additional, Yee, Jim, additional, Caskey, Marina, additional, Yang, He S., additional, Hao, Ying, additional, Chadburn, Amy, additional, Shi, Yuanyuan, additional, Zuk, Robert, additional, Nussenzweig, Michel C., additional, Cushing, Melissa M., additional, and Zhao, Zhen, additional

Published
2021
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15. Postconvalescent SARS-CoV-2 IgG and Neutralizing Antibodies are Elevated in Individuals with Poor Metabolic Health

Author

Racine-Brzostek, Sabrina E, primary, Yang, He S, additional, Jack, Gwendolyne A, additional, Chen, Zhengming, additional, Chadburn, Amy, additional, Ketas, Thomas J, additional, Francomano, Erik, additional, Klasse, P J, additional, Moore, John P, additional, McDonough, Kathleen A, additional, Girardin, Roxanne C, additional, Dupuis, Alan P, additional, Payne, Anne F, additional, Ma, Lucy X, additional, Sweeney, Jacob, additional, Zhong, Elaine, additional, Yee, Jim, additional, Cushing, Melissa M, additional, and Zhao, Zhen, additional

Published
2021
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16. Machine Learning Highlights Downtrending of COVID-19 Patients with a Distinct Laboratory Profile

Author

Yang, He S., primary, Hou, Yu, additional, Zhang, Hao, additional, Chadburn, Amy, additional, Westblade, Lars F., additional, Fedeli, Richard, additional, Steel, Peter A. D., additional, Racine-Brzostek, Sabrina E., additional, Velu, Priya, additional, Sepulveda, Jorge L., additional, Satlin, Michael J., additional, Cushing, Melissa M., additional, Kaushal, Rainu, additional, Zhao, Zhen, additional, and Wang, Fei, additional

Published
2021
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17. Machine learning analysis highlights the down-trending of the proportion of COVID-19 patients with a distinct laboratory result profile

Author

Yang, He S., primary, Hou, Yu, additional, Zhang, Hao, additional, Chadburn, Amy, additional, Westblade, Lars F., additional, Fedeli, Richard, additional, Steel, Peter A.D., additional, Racine-Brzostek, Sabrina E., additional, Velu, Priya, additional, Sepulveda, Jorge L., additional, Satlin, Michael J., additional, Cushing, Melissa M., additional, Kaushal, Rainu, additional, Zhao, Zhen, additional, and Wang, Fei, additional

Published
2020
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18. Cytokine Signatures of End Organ Injury in COVID-19

Author

Gómez-Escobar, Luis G., primary, Hoffman, Katherine L., additional, Choi, Justin J., additional, Borczuk, Alain, additional, Salvatore, Steven, additional, Alvarez-Mulett, Sergio L., additional, Galvan, Manuel D., additional, Zhao, Zhen, additional, Racine-Brzostek, Sabrina E., additional, Yang, He S., additional, Stout-Delgado, Heather Winona, additional, Choi, Mary E, additional, Choi, Augustine MK, additional, Cho, Soo Jung, additional, and Schenck, Edward J., additional

Published
2020
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19. Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients

Author

Yang, He S., primary, Racine-Brzostek, Sabrina E., additional, Karbaschi, Mohsen, additional, Yee, Jim, additional, Dillard, Alicia, additional, Steel, Peter A.D., additional, Lee, William T., additional, McDonough, Kathleen A., additional, Qiu, Yuqing, additional, Ketas, Thomas J., additional, Francomano, Erik, additional, Klasse, P. J., additional, Hatem, Layla, additional, Westblade, Lars, additional, Wu, Heng, additional, Chen, Haode, additional, Zuk, Robert, additional, Tan, Hong, additional, Girardin, Roxanne C., additional, Dupuis, Alan P., additional, Payne, Anne F., additional, Moore, John P., additional, Cushing, Melissa M., additional, Chadburn, Amy, additional, and Zhao, Zhen, additional

Published
2020
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22. COVID-19 Viral and Serology Testing in New York City Health Care Workers

Author

Racine-Brzostek, Sabrina E, primary, Yang, He S, additional, Chadburn, Amy, additional, Orlander, Duncan, additional, An, Anjile, additional, Campion, Thomas R, additional, Yee, Jim, additional, Chen, Zhengming, additional, Loda, Massimo, additional, Zhao, Zhen, additional, Kaushal, Rainu, additional, and Cushing, Melissa M, additional

Published
2020
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28. The impact of Daratumumab on transfusion service costs

Author

Cushing, Melissa M., primary, DeSimone, Robert A., additional, Goel, Ruchika, additional, Hsu, Yen-Michael S., additional, Parra, Priscilla, additional, Racine-Brzostek, Sabrina E., additional, Degtyaryova, Diana, additional, Lo, Dian T., additional, Morrison, Meta, additional, Crowley, Kathleen M., additional, Rossi, Adrianna, additional, and Vasovic, Ljiljana V., additional

Published
2019
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30. Premortem Skin Biopsy Assessing Microthrombi, Interferon I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage

Author

Laurence, Jeffrey, Nuovo, Gerard, Racine-Brzostek, Sabrina E., Seshadri, Madhav, Elhadad, Sonia, Crowson, A. Neil, Mulvey, J. Justin, Harp, Joanna, Ahamed, Jasimuddin, and Magro, Cynthia

Abstract

Apart from autopsy, tissue correlates of coronavirus disease 2019 (COVID-19) clinical stage are lacking. Cutaneous punch biopsy specimens of 15 individuals with severe/critical COVID-19 and six with mild/moderate COVID-19 were examined. Evidence for arterial and venous microthrombi, deposition of C5b-9 and MASP2 (representative of alternative and lectin complement pathways, respectively), and differential expression of interferon type I–driven antiviral protein MxA (myxovirus resistance A) versus SIN3A, a promoter of interferon type I–based proinflammatory signaling, were assessed. Control subjects included nine patients with sepsis-related acute respiratory distress syndrome (ARDS) and/or acute kidney injury (AKI) pre–COVID-19. Microthrombi were detected in 13 (87%) of 15 severe/critical COVID-19 patients versus zero of six mild/moderate COVID-19 patients (P < 0.001) and none of the nine pre–COVID-19 ARDS/AKI patients (P < 0.001). Cells lining the microvasculature staining for spike protein of severe acute respiratory syndrome coronavirus 2, the etiologic agent of COVID-19, also expressed tissue factor. C5b-9 deposition occurred in 13 (87%) of 15 severe/critical versus zero of six mild/moderate COVID-19 patients (P < 0.001) and none of the nine pre–COVID-19 ARDS/AKI patients (P < 0.001). MASP2 deposition was also restricted to severe/critical COVID-19 cases. MxA expression occurred in all six mild/moderate versus two (15%) of 13 severe/critical cases (P < 0.001) of COVID-19. In contrast, SIN3A was restricted to severe/critical COVID-19 cases and co-localized with severe acute respiratory syndrome coronavirus 2 spike protein. SIN3A was also elevated in plasma of severe/critical COVID-19 patients versus control subjects (P = 0.0128). In conclusion, we identified premortem tissue correlates of COVID-19 clinical stage using skin. If validated in a longitudinal cohort, this approach could identify individuals at risk for disease progression and enable targeted interventions.

Published
2022
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31. TOP-Plus is a Versatile Biosensor Platform for Monitoring SARS-CoV-2 Antibody Durability.

Author

Racine-Brzostek SE, Karbaschi M, Gaebler C, Klasse PJ, Yee J, Caskey M, Yang HS, Hao Y, Chadburn A, Shi Y, Zuk R, Nussenzweig MC, Cushing MM, and Zhao Z

Abstract

Background: There is a concern that low initial SARS-CoV-2 antibody titers in individuals may drop to undetectable levels within months after infection. Although this may raise concerns over long term immunity, both the antibody levels and avidity of the antibody-antigen interaction should be examined to understand the quality of the antibody response., Methods: A testing-on-a-probe-plus panel (TOP-Plus) was developed, which included a newly developed avidity assay built into the previously described SARS-CoV-2 TOP assays that measured total antibody (TAb), surrogate neutralizing antibody (SNAb), IgM and IgG on a versatile biosensor platform. TAb and SNAb levels were compared with avidity in previously infected individuals at 1.3 and 6.2 months post-infection in paired samples from 80 COVID-19 patients., Results: The newly designed avidity assay in this TOP panel correlated well with a reference Bio-Layer Interferometry avidity assay (R=0.88). The imprecision of the TOP avidity assay was less than 9%. Although TAb and neutralization activity (by SNAb) decreased between 1.3 and 6.2 months post infection, the antibody avidity increased significantly (P < 0.0001).

Published
2021
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32. Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients.

Author

Yang HS, Racine-Brzostek SE, Karbaschi M, Yee J, Dillard A, Steel PAD, Lee WS, McDonough KA, Qiu Y, Ketas TJ, Francomano E, Klasse PJ, Hatem L, Westblade LF, Wu H, Chen H, Zuk R, Tan H, Girardin R, Dupuis AP, Payne AF, Moore JP, Cushing MM, Chadburn A, and Zhao Z

Abstract

The association of mortality with early humoral response to SARS-CoV-2 infection within the first few days after onset of symptoms (DAOS) has not been thoroughly investigated partly due to a lack of sufficiently sensitive antibody testing methods. Here we report two sensitive and automated testing-on-a-probe (TOP) biosensor assays for SARS-CoV-2 viral specific total antibodies (TAb) and surrogate neutralizing antibodies (SNAb), which are suitable for clinical use. The TOP assays employ an RBD-coated quartz probe using a Cy5-Streptavidin-polysacharide conjugate to improved sensitivity and minimize interference. Disposable cartridge containing pre-dispensed reagents requires no liquid manipulation or fluidics during testing. The TOP-TAb assay exhibited higher sensitivity in the 0-7 DAOS window than a widely used FDA-EUA assay. The rapid (18 min) and automated TOP-SNAb correlated well with two well-established SARS-CoV-2 virus neutralization tests. The clinical utility of the TOP assays was demonstrated by evaluating early antibody responses in 120 SARS-CoV-2 RT-PCR positive adult hospitalized patients. Higher baseline TAb and SNAb positivity rates and more robust antibody responses were seen in patients who survived COVID-19 than those who died in the hospital. Survival analysis using the Cox Proportional Hazards Model showed that patients who were TAb and SNAb negative at initial hospital presentation were at a higher risk of in-hospital mortality. Furthermore, TAb and SNAb levels at presentation were inversely associated with SARS-CoV-2 viral load based on concurrent RT-PCR testing. Overall, the sensitive and automated TAb and SNAb assays allow detection of early SARS-CoV-2 antibodies which associate with mortality.

Published
2020
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