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Background In previous influenza challenge studies we observed that the incidence of influenza symptoms was higher in women than in men, and that women experience more symptoms overall. Women also demonstrated lower neuraminidase (NA) inhibition (NAI) antibody titers than men after challenge and regression analysis suggested that NAI titers predict clinical outcomes. We sought to evaluate this using data from a more recent challenge study with more immunologically varied volunteers, while also assessing mucosal immunity. Methods We obtained mucosal and serum samples from healthy adults. Half underwent intramuscular quadrivalent influenza vaccination followed by influenza A (H1N1) intranasal challenge while others just challenge alone. Antibody titers and clinical outcomes between sexes were compared. Results No significant differences in shedding or symptom outcomes were observed between sexes. Similarly, no differences in systemic titers against NA or hemagglutinin (HA) were seen. Serum total IgG and IgA were also similar between sexes. Prior to vaccination, mucosal IgA titers were significantly lower against HA stalk and NA in women, but these differences disappeared after vaccination. In the unvaccinated group, lower nasal IgA titers were also seen in women pre-challenge. At 7 days post-challenge, differences in mucosal titers between sexes disappeared. However, at 56 days post-challenge, mucosal IgA titers against HA, HA stalk, and NA were all significantly lower in women. Conclusion In contrast to our previous findings, no differences in clinical outcomes or systemic NAI titers were observed between men and women, possibly due to differences in underlying immunity between study populations or the lower sample size in this study. However, mucosal differences were noted with women having lower mucosal titers than men against HA stalk and NA at baseline. While influenza vaccination and challenge eliminated differences in the short term, they reappeared 8 weeks after challenge, with all nasal IgA antibody titers (HA, HA stalk, and NA) lower in women. Further studies are necessary to understand the differences in influenza disease and immunity between sexes. Disclosures All Authors: No reported disclosures.

We explore synergies between the Nancy Grace Roman Space Telescope and CMB lensing data to constrain dark energy and modified gravity scenarios. A simulated likelihood analysis of the galaxy clustering and weak lensing data from the Roman Space Telescope High Latitude Survey combined with CMB lensing data from the Simons Observatory is undertaken, marginalizing over important astrophysical effects and calibration uncertainties. Included in the modeling are the effects of baryons on small-scale clustering, scale-dependent growth suppression by neutrinos, as well as uncertainties in the galaxy clustering biases, in the intrinsic alignment contributions to the lensing signal, in the redshift distributions, and in the galaxy shape calibration. The addition of CMB lensing roughly doubles the dark energy figure-of-merit from Roman photometric survey data alone, varying from a factor of 1.7 to 2.4 improvement depending on the particular Roman survey configuration. Alternatively, the inclusion of CMB lensing information can compensate for uncertainties in the Roman galaxy shape calibration if it falls below the design goals. Furthermore, we report the first forecast of Roman constraints on a model-independent structure growth, parameterized by $\sigma_8 (z)$, and on the Hu-Sawicki f(R) gravity as well as an improved forecast of the phenomenological $(\Sigma_0,\mu_0)$ model. We find that CMB lensing plays a crucial role in constraining $\sigma_8(z)$ at z>2, with percent-level constraints forecasted out to z=4. CMB lensing information does not improve constraints on the f(R) models substantially. It does, however, increase the $(\Sigma_0,\mu_0)$ figure-of-merit by a factor of about 1.5., Comment: 19 pages, 12 figures, replaced with accepted version in MNRAS

We study the impact of cosmological scale modifications to general relativity on the dynamics of halos within voids by comparing N-body simulations incorporating Hu-Sawicki $f(R)$ gravity, with $|{f}_{R0}|={10}^{\ensuremath{-}6}$ and ${10}^{\ensuremath{-}5}$, to those of $\mathrm{\ensuremath{\Lambda}}\mathrm{CDM}$. By examining the radial velocity statistics within voids classified based on their size and density-profile, as ``rising'' ($R$-type) or ``shell'' ($S$-type), we find that halo motions in small $R$-type voids, with effective radius $l15\text{ }\text{ }\mathrm{Mpc}/h$, reveal distinctive differences between $f(R)$ and $\mathrm{\ensuremath{\Lambda}}\mathrm{CDM}$ cosmologies. To understand this observed effect, we study the linear and nonlinear fifth forces, and develop an iterative algorithm to accurately solve the nonlinear fifth force equation. We use this to characterize the Chameleon screening mechanism in voids and contrast the behavior with that observed in gravitationally collapsed objects. The force analysis underscores how smaller $R$-type voids exhibit the highest ratios of fifth force to Newtonian force, which source distinguishable differences in the velocity profiles and thereby provide rich environments in which to constrain gravity.

Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates. To address this, we analyzed seropositivity in US adults who have not previously been diagnosed with COVID-19. Individuals with characteristics that reflect the US population (n = 11,382) and who had not previously been diagnosed with COVID-19 were selected by quota sampling from 241,424 volunteers (ClinicalTrials.gov NCT04334954). Enrolled participants provided medical, geographic, demographic, and socioeconomic information and 9,028 blood samples. The majority (88.7%) of samples were collected between May 10(th) and July 31(st), 2020. Samples were analyzed via ELISA for anti-Spike and anti-RBD antibodies. Estimation of seroprevalence was performed by using a weighted analysis to reflect the US population. We detected an undiagnosed seropositivity rate of 4.6% (95% CI: 2.6 – 6.5%). There was distinct regional variability, with heightened seropositivity in locations of early outbreaks. Subgroup analysis demonstrated that the highest estimated undiagnosed seropositivity within groups was detected in younger participants (ages 18-45, 5.9%), females (5.5%), Black/African American (14.2%), Hispanic (6.1%), and Urban residents (5.3%), and lower undiagnosed seropositivity in those with chronic diseases. During the first wave of infection over the spring/summer of 2020 an estimate of 4.6% of adults had a prior undiagnosed SARS-CoV-2 infection. These data indicate that there were 4.8 (95% CI: 2.8-6.8) undiagnosed cases for every diagnosed case of COVID-19 during this same time period in the United States, and an estimated 16.8 million undiagnosed cases by mid-July 2020.

We describe the simulated sky survey underlying the second data challenge (DC2) carried out in preparation for analysis of the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) by the LSST Dark Energy Science Collaboration (LSST DESC). Significant connections across multiple science domains will be a hallmark of LSST; the DC2 program represents a unique modeling effort that stresses this interconnectivity in a way that has not been attempted before. This effort encompasses a full end-to-end approach: starting from a large N-body simulation, through setting up LSST-like observations including realistic cadences, through image simulations, and finally processing with Rubin's LSST Science Pipelines. This last step ensures that we generate data products resembling those to be delivered by the Rubin Observatory as closely as is currently possible. The simulated DC2 sky survey covers six optical bands in a wide-fast-deep (WFD) area of approximately 300 deg^2 as well as a deep drilling field (DDF) of approximately 1 deg^2. We simulate 5 years of the planned 10-year survey. The DC2 sky survey has multiple purposes. First, the LSST DESC working groups can use the dataset to develop a range of DESC analysis pipelines to prepare for the advent of actual data. Second, it serves as a realistic testbed for the image processing software under development for LSST by the Rubin Observatory. In particular, simulated data provide a controlled way to investigate certain image-level systematic effects. Finally, the DC2 sky survey enables the exploration of new scientific ideas in both static and time-domain cosmology., 39 pages, 19 figures, version accepted for publication in ApJS

16.8 million SARS-CoV-2 infections in the US went undiagnosed in the first 6 months of the pandemic compared to 3.5 million diagnosed infections., Elucidating seroprevalence in COVID-19 Symptoms of SARS-CoV-2 infection range from completely asymptomatic, to those of a common cold, to a drop in oxygen saturation and lung function, and death in some patients. To evaluate the proportion of the U.S. population who had an undiagnosed infection during the first wave of the COVID-19 pandemic, we measured antibody prevalence in study participants who had not previously been diagnosed with a SARS-CoV-2 infection. By mid-July of 2020, 16.8 million people had an undiagnosed SARS-CoV-2 infection, almost five times the rate of diagnosed infections., Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates in the United States and elsewhere. To address this, we analyzed seropositivity in 9089 adults in the United States who had not been diagnosed previously with COVID-19. Individuals with characteristics that reflected the U.S. population (n = 27,716) were selected by quota sampling from 462,949 volunteers. Enrolled participants (n = 11,382) provided medical, geographic, demographic, and socioeconomic information and dried blood samples. Survey questions coincident with the Behavioral Risk Factor Surveillance System survey, a large probability-based national survey, were used to adjust for selection bias. Most blood samples (88.7%) were collected between 10 May and 31 July 2020 and were processed using ELISA to measure seropositivity (IgG and IgM antibodies against SARS-CoV-2 spike protein and the spike protein receptor binding domain). The overall weighted undiagnosed seropositivity estimate was 4.6% (95% CI, 2.6 to 6.5%), with race, age, sex, ethnicity, and urban/rural subgroup estimates ranging from 1.1% to 14.2%. The highest seropositivity estimates were in African American participants; younger, female, and Hispanic participants; and residents of urban centers. These data indicate that there were 4.8 undiagnosed SARS-CoV-2 infections for every diagnosed case of COVID-19, and an estimated 16.8 million infections were undiagnosed by mid-July 2020 in the United States.

We present a 5.4$\sigma$ detection of the pairwise kinematic Sunyaev-Zel'dovich (kSZ) effect using Atacama Cosmology Telescope (ACT) and $\it{Planck}$ CMB observations in combination with Luminous Red Galaxy samples from the Sloan Digital Sky Survey (SDSS) DR15 catalog. Results are obtained using three ACT CMB maps: co-added 150 GHz and 98 GHz maps, combining observations from 2008-2018 (ACT DR5), which overlap with SDSS DR15 over 3,700 sq. deg., and a component-separated map using night-time only observations from 2014-2015 (ACT DR4), overlapping with SDSS DR15 over 2,089 sq. deg. Comparisons of the results from these three maps provide consistency checks in relation to potential frequency-dependent foreground contamination. A total of 343,647 galaxies are used as tracers to identify and locate galaxy groups and clusters from which the kSZ signal is extracted using aperture photometry. We consider the impact of various aperture photometry assumptions and covariance estimation methods on the signal extraction. Theoretical predictions of the pairwise velocities are used to obtain best-fit, mass-averaged, optical depth estimates for each of five luminosity-selected tracer samples. A comparison of the kSZ-derived optical depth measurements obtained here to those derived from the thermal SZ effect for the same sample is presented in a companion paper., Comment: 17 pages, 10 figures. Updated to match published version in PRD

We present high signal-to-noise measurements (up to 12$\sigma$) of the average thermal Sunyaev Zel'dovich (tSZ) effect from optically selected galaxy groups and clusters and estimate their baryon content within a 2.1$^\prime$ radius aperture. Sources from the Sloan Digital Sky Survey (SDSS) Baryon Oscillation Spectroscopic Survey (BOSS) DR15 catalog overlap with 3,700 sq. deg. of sky observed by the Atacama Cosmology Telescope (ACT) from 2008 to 2018 at 150 and 98 GHz (ACT DR5), and 2,089 sq. deg. of internal linear combination component-separated maps combining ACT and $\it{Planck}$ data (ACT DR4). The corresponding optical depths, $\bar{\tau}$, which depend on the baryon content of the halos, are estimated using results from cosmological hydrodynamic simulations assuming an AGN feedback radiative cooling model. We estimate the mean mass of the halos in multiple luminosity bins, and compare the tSZ-based $\bar{\tau}$ estimates to theoretical predictions of the baryon content for a Navarro-Frenk-White profile. We do the same for $\bar{\tau}$ estimates extracted from fits to pairwise baryon momentum measurements of the kinematic Sunyaev-Zel'dovich effect (kSZ) for the same data set obtained in a companion paper. We find that the $\bar{\tau}$ estimates from the tSZ measurements in this work and the kSZ measurements in the companion paper agree within $1\sigma$ for two out of the three disjoint luminosity bins studied, while they differ by 2-3$\sigma$ in the highest luminosity bin. The optical depth estimates account for one third to all of the theoretically predicted baryon content in the halos across luminosity bins. Potential systematic uncertainties are discussed. The tSZ and kSZ measurements provide a step towards empirical Compton-$\bar{y}$-$\bar{\tau}$ relationships to provide new tests of cluster formation and evolution models., Comment: 19 pages, 9 figures

We develop a framework to compute the redshift space power spectrum (PS), with kernels beyond Einstein-de Sitter (EdS), that can be applied to a wide variety of generalized cosmologies. We build upon a formalism that was recently employed for standard cosmology in Chen, Vlah & White (2020), and utilize an expansion of the density-weighted velocity moment generating function that explicitly separates the magnitude of the $k$-modes and their angle to the line-of-sight direction dependencies. We compute the PS for matter and biased tracers to 1-loop Perturbation Theory (PT) and show that the expansion has a correct infrared and ultraviolet behavior, free of unwanted divergences. We also add Effective Field Theory (EFT) counterterms, necessary to account for small-scale contributions to PT, and employ an IR-resummation prescription to properly model the smearing of the BAO due to large scale bulk flows within Standard-PT. To demonstrate the applicability of our formalism, we apply it on the $\Lambda$CDM and the Hu-Sawicki $f(R)$ models, and compare our numerical results against the ELEPHANT suite of $N$-body simulations, finding very good agreement up to $k= 0.27\, \text{Mpc}^{-1} h$ at $z=0.5$ for the first three non-vanishing Legendre multipoles of the PS. To our knowledge, the model presented in this work is the most accurate theoretical EFT-PT for modified gravity to date, being the only one that accounts for beyond linear local biasing in redshift-space. Hence, we argue our RSD modeling is a promising tool to construct theoretical templates in order to test deviations from $\Lambda$CDM using real data obtained from the next stage of cosmological surveys such as DESI and LSST., Comment: 56 pages, 11 figures, version 2 with minor changes

Optimal analyses of many signals in the cosmic microwave background (CMB) require map-level extraction of individual components in the microwave sky, rather than measurements at the power spectrum level alone. To date, nearly all map-level component separation in CMB analyses has been performed exclusively using satellite data. In this paper, we implement a component separation method based on the internal linear combination (ILC) approach which we have designed to optimally account for the anisotropic noise (in the 2D Fourier domain) often found in ground-based CMB experiments. Using this method, we combine multi-frequency data from the Planck satellite and the Atacama Cosmology Telescope Polarimeter (ACTPol) to construct the first wide-area, arcminute-resolution component-separated maps (covering approximately 2100 sq. deg.) of the CMB temperature anisotropy and the thermal Sunyaev-Zel'dovich (tSZ) effect sourced by the inverse-Compton scattering of CMB photons off hot, ionized gas. Our ILC pipeline allows for explicit deprojection of various contaminating signals, including a modified blackbody approximation of the cosmic infrared background (CIB) spectral energy distribution. The cleaned CMB maps will be a useful resource for CMB lensing reconstruction, kinematic SZ cross-correlations, and primordial non-Gaussianity studies. The tSZ maps will be used to study the pressure profiles of galaxies, groups, and clusters through cross-correlations with halo catalogs, with dust contamination controlled via CIB deprojection. The data products described in this paper are available on LAMBDA., Comment: 24 pages, 11 figures, matches version accepted by PRD. Data products are available on LAMBDA at https://lambda.gsfc.nasa.gov/product/act/act_dr4_derived_maps_get.cfm

We present the temperature and polarization angular power spectra of the CMB measured by the Atacama Cosmology Telescope (ACT) from 5400 deg$^2$ of the 2013-2016 survey, which covers $>$15000 deg$^2$ at 98 and 150 GHz. For this analysis we adopt a blinding strategy to help avoid confirmation bias and, related to this, show numerous checks for systematic error done before unblinding. Using the likelihood for the cosmological analysis we constrain secondary sources of anisotropy and foreground emission, and derive a "CMB-only" spectrum that extends to $\ell=4000$. At large angular scales, foreground emission at 150 GHz is $\sim$1% of TT and EE within our selected regions and consistent with that found by Planck. Using the same likelihood, we obtain the cosmological parameters for $\Lambda$CDM for the ACT data alone with a prior on the optical depth of $\tau=0.065\pm0.015$. $\Lambda$CDM is a good fit. The best-fit model has a reduced $\chi^2$ of 1.07 (PTE=0.07) with $H_0=67.9\pm1.5$ km/s/Mpc. We show that the lensing BB signal is consistent with $\Lambda$CDM and limit the celestial EB polarization angle to $\psi_P =-0.07^{\circ}\pm0.09^{\circ}$. We directly cross correlate ACT with Planck and observe generally good agreement but with some discrepancies in TE. All data on which this analysis is based will be publicly released., Comment: 44 pages, 27 figures, products available on the NASA LAMBDA website, version accepted for publication in JCAP

The thermal and kinematic Sunyaev-Zel'dovich effects (tSZ, kSZ) probe the thermodynamic properties of the circumgalactic and intracluster medium (CGM and ICM) of galaxies, groups, and clusters, since they are proportional, respectively, to the integrated electron pressure and momentum along the line-of-sight. We present constraints on the gas thermodynamics of CMASS galaxies in the Baryon Oscillation Spectroscopic Survey (BOSS) using new measurements of the kSZ and tSZ signals obtained in a companion paper. Combining kSZ and tSZ measurements, we measure within our model the amplitude of energy injection $\epsilon M_\star c^2$, where $M_\star$ is the stellar mass, to be $\epsilon=(40\pm9)\times10^{-6}$, and the amplitude of the non-thermal pressure profile to be $\alpha_{\rm Nth}, Comment: Corrected error in the algorithm that calculates the kSZ temperature profile for a given GNFW density model. The value of $\log_{\rm10} \rho_0$ changed by 0.75$\sigma$ in Tab.II and Fig.2, and affected the results in the left panels of Fig. 6. Conclusions are unchanged. Erratum published at https://link.aps.org/doi/10.1103/PhysRevD.107.049903

We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey.

We extend the scale-dependent Gaussian Streaming Model (GSM) to produce analytical predictions for the anisotropic redshift-space correlation function for biased tracers in modified gravity models. Employing the Convolution Lagrangian Perturbation Theory (CLPT) re-summation scheme, with a local Lagrangian bias schema provided by the peak-background split formalism, we predict the necessary ingredients that enter the GSM, the real-space halo pairwise velocity and the pairwise velocity dispersion. We further consider effective field theory contributions to the pairwise velocity dispersion in order to model correctly its large scale behavior. We apply our method on two widely-considered modified gravity models, the chameleon-screened f(R) Hu-Sawicki model and the nDGP Vainshtein model and compare our predictions against state-of-the-art N-body simulations for these models. We demonstrate that the GSM approach to predict the monopole and the quadrupole of the redshift-space correlation function for halos, gives very good agreement with the simulation data, for a wide range of screening mechanisms, levels of screening and halo masses at z=0.5 and z=1. Our work shows the applicability of the GSM, for cosmologies beyond GR, demonstrating that it can serve as a powerful predictive tool for the next stage of cosmological surveys like DESI, Euclid, LSST and WFIRST., Comment: 43 pages, 9 figures. Updated to match published version in JCAP

OBJECTIVE Clinical guidelines recommend point-of-care glucose testing and the use of supplemental doses of rapid-acting insulin before meals and at bedtime for correction of hyperglycemia. The efficacy and safety of this recommendation, however, have not been tested in the hospital setting. RESEARCH DESIGN AND METHODS In this open-label, randomized controlled trial, 206 general medicine and surgery patients with type 2 diabetes treated with a basal-bolus regimen were randomized to receive either supplemental insulin (n = 106) at bedtime for blood glucose (BG) >7.8 mmol/L or no supplemental insulin (n = 100) except for BG >19.4 mmol/L. Point-of-care testing was performed before meals, at bedtime, and at 3:00 a.m. The primary outcome was the difference in fasting BG. In addition to the intention-to-treat analysis, an as-treated analysis was performed where the primary outcome was analyzed for only the bedtime BG levels between 7.8 and 19.4 mmol/L. RESULTS There were no differences in mean fasting BG for the intention-to-treat (8.8 ± 2.4 vs. 8.6 ± 2.2 mmol/L, P = 0.76) and as-treated (8.9 ± 2.4 vs. 8.8 ± 2.4 mmol/L, P = 0.92) analyses. Only 66% of patients in the supplement and 8% in the no supplement groups received bedtime supplemental insulin. Hypoglycemia (BG CONCLUSIONS The use of insulin supplements for correction of bedtime hyperglycemia was not associated with an improvement in glycemic control. We conclude that routine use of bedtime insulin supplementation is not indicated for management of inpatients with type 2 diabetes.

We investigate the impact of a variety of analysis assumptions that influence cluster identification and location on the kSZ pairwise momentum signal and covariance estimation. Photometric and spectroscopic galaxy tracers from SDSS, WISE, and DECaLs, spanning redshifts $0.05, Comment: Version accepted for publication in PRD

Models that seek to explain cosmic acceleration through modifications to General Relativity (GR) evade stringent Solar System constraints through a restoring, screening mechanism. Down-weighting the high density, screened regions in favor of the low density, unscreened ones offers the potential to enhance the amount of information carried in such modified gravity models. In this work, we assess the performance of a new "marked" transformation and perform a systematic comparison with the clipping and logarithmic transformations, in the context of $\Lambda$CDM and the symmetron and $f(R)$ modified gravity models. Performance is measured in terms of the fractional boost in the Fisher information and the signal-to-noise ratio (SNR) for these models relative to the statistics derived from the standard density distribution. We find that all three statistics provide improved Fisher boosts over the basic density statistics. The model parameters for the "marked" and clipped transformation that best enhance signals and the Fisher boosts are determined. We also show that the mark is useful both as a Fourier and real space transformation; a marked correlation function also enhances the SNR relative to the standard correlation function, and can on mildly non-linear scales show a significant difference between the $\Lambda$CDM and the modified gravity models. Our results demonstrate how a series of simple analytical transformations could dramatically increase the predicted information extracted on deviations from GR, from large-scale surveys, and give the prospect for a potential detection much more feasible., Comment: 11 pages, 7 figures. Updated to match version published in PRD

Euclid and the Large Synoptic Survey Telescope (LSST) are poised to dramatically change the astronomy landscape early in the next decade. The combination of high cadence, deep, wide-field optical photometry from LSST with high resolution, wide-field optical photometry and near-infrared photometry and spectroscopy from Euclid will be powerful for addressing a wide range of astrophysical questions. We explore Euclid/LSST synergy, ignoring the political issues associated with data access to focus on the scientific, technical, and financial benefits of coordination. We focus primarily on dark energy cosmology, but also discuss galaxy evolution, transient objects, solar system science, and galaxy cluster studies. We concentrate on synergies that require coordination in cadence or survey overlap, or would benefit from pixel-level co-processing that is beyond the scope of what is currently planned, rather than scientific programs that could be accomplished only at the catalog level without coordination in data processing or survey strategies. We provide two quantitative examples of scientific synergies: the decrease in photo-z errors (benefitting many science cases) when high resolution Euclid data are used for LSST photo-z determination, and the resulting increase in weak lensing signal-to-noise ratio from smaller photo-z errors. We briefly discuss other areas of coordination, including high performance computing resources and calibration data. Finally, we address concerns about the loss of independence and potential cross-checks between the two missions and potential consequences of not collaborating., 33 pages, 7 figures, to appear in ApJS, revised with additional references and minor corrections

We consider how upcoming photometric large scale structure surveys can be optimized to measure the properties of dark energy and possible cosmic scale modifications to General Relativity in light of realistic astrophysical and instrumental systematic uncertainities. In particular we include flexible descriptions of intrinsic alignments, galaxy bias and photometric redshift uncertainties in a Fisher Matrix analysis of shear, position and position-shear correlations, including complementary cosmological constraints from the CMB. We study the impact of survey tradeoffs in depth versus breadth, and redshift quality. We parameterise the results in terms of the Dark Energy Task Force figure of merit, and deviations from General Relativity through an analagous Modified Gravity figure of merit. We find that intrinsic alignments weaken the dependence of figure of merit on area and that, for a fixed observing time, a fiducial Stage IV survey plateaus above roughly 10,000deg2 for DE and peaks at about 5,000deg2 as the relative importance of IAs at low redshift penalises wide, shallow surveys. While reducing photometric redshift scatter improves constraining power, the dependence is shallow. The variation in constraining power is stronger once IAs are included and is slightly more pronounced for MG constraints than for DE. The inclusion of intrinsic alignments and galaxy position information reduces the required prior on photometric redshift accuracy by an order of magnitude for both the fiducial Stage III and IV surveys, equivalent to a factor of 100 reduction in the number of spectroscopic galaxies required to calibrate the photometric sample., 13 pages, 6 figures. Fixed an error in equation 19 which changes the right hand panels of figures 1 and 2, and modifies conclusions on the results for fixed observing time

We present constraints on the presence of isocurvature modes from the temperature and polarization CMB spectrum data from the WMAP satellite alone, and in combination with other datasets including SDSS galaxy survey and SNLS supernovae. We find that the inclusion of polarization data allows the WMAP data alone, as well as in combination with complementary observations, to place improved limits on the contribution of CDM and neutrino density isocurvature components individually. With general correlations, the upper limits on these sub-dominant isocurvature components are reduced to ~60% of the first year WMAP results, with specific limits depending on the type of fluctuations. If multiple isocurvature components are allowed, however, we find that the data still allow a majority of the initial power to come from isocurvature modes. As well as providing general constraints we also consider their interpretation in light of specific theoretical models like the curvaton and double inflation., 8 pages, 7 figures. Revised Sec 4 and Figs 3-4 post-publication to correct an error for models with varying isocurvature spectral index

We implement an adaptation of the COLA approach, a hybrid scheme that combines Lagrangian perturbation theory with an N-body approach, to model non-linear collapse in chameleon and symmetron modified gravity models. Gravitational screening is modeled effectively through the attachment of a suppression factor to the linearized Klein-Gordon equations. The adapted COLA approach is benchmarked, with respect to an N-body code both for the $\Lambda$CDM scenario and for the modified gravity theories. It is found to perform well in the estimation of the dark matter power spectra, with consistency of 1 % to $k\sim2.5$ h/Mpc. Redshift space distortions are shown to be effectively modeled through a Lorentzian parameterization with a velocity dispersion fit to the data. We find that COLA performs less well in predicting the halo mass functions, but has consistency, within $1\sigma$ uncertainties of our simulations, in the relative changes to the mass function induced by the modified gravity models relative to $\Lambda$CDM. The results demonstrate that COLA, proposed to enable accurate and efficient, non-linear predictions for $\Lambda$CDM, can be effectively applied to a wider set of cosmological scenarios, with intriguing properties, for which clustering behavior needs to be understood for upcoming surveys such as LSST, DESI, Euclid and WFIRST., Comment: 15 pages, 9 figures. Updated to match version published in PRD

We consider the impact of key astrophysical and measurement systematics on constraints on dark energy and modifications to gravity on cosmic scales. We focus on upcoming photometric "Stage III" and "Stage IV" large scale structure surveys such as DES, SuMIRe, Euclid, LSST and WFIRST. We illustrate the different redshift dependencies of gravity modifications compared to intrinsic alignments, the main astrophysical systematic. The way in which systematic uncertainties, such as galaxy bias and intrinsic alignments, are modelled can change dark energy equation of state and modified gravity figures of merit by a factor of four. The inclusion of cross-correlations of cosmic shear and galaxy position measurements helps reduce the loss of constraining power from the lensing shear surveys. When forecasts for Planck CMB and Stage IV surveys are combined, constraints on the dark energy equation of state and modified gravity model are recovered, relative to those from shear data with no systematic uncertainties, if fewer than 36 free parameters in total are used to describe the galaxy bias and intrinsic alignment models as a function of scale and redshift. To facilitate future investigations, we also provide a fitting function for the matter power spectrum arising from the phenomenological modified gravity model we consider.

Non-Gaussianity in the distribution of inflationary perturbations, measurable in statistics of the cosmic microwave background (CMB) and large scale structure fluctuations, can be used to probe non-trivial initial quantum states for these perturbations. The bispectrum shapes predicted for generic non-Bunch-Davies initial states are non-factorizable ("non-separable") and are highly oscillatory functions of the three constituent wavenumbers. This can make the computation of CMB bispectra, in particular, computationally intractable. To efficiently compare with CMB data one needs to construct a separable template that has a significant similarity with the actual shape in momentum space. In this paper we consider a variety of inflationary scenarios, with different non-standard initial conditions, and how best to construct viable template matches. In addition to implementing commonly used separable polynomial and Fourier bases, we introduce a basis of localized piecewise spline functions. The spline basis is naturally nearly orthogonal, making it easy to implement and to extend to many modes. We show that, in comparison to existing techniques, the spline basis can provide better fits to the true bispectrum, as measured by the cosine between shapes, for sectors of the theory space of general initial states. As such, it offers a useful approach to investigate non-trivial features generated by fundamental properties of the inflationary Universe., 14 pages, 6 figures, comments welcome

The combined 3 year observations from the Wilkinson Microwave Anisotropy Probe (WMAP) have yielded full-sky temperature and polarization maps in five frequency bands (K, Ka, Q, V, W) between 23 and 94 GHz. In this article we discuss the cosmological implications of these observations. The combination of temperature and polarization data leads to a significant improvement in the measurement of the reionization optical depth τ = 0.093 ± 0.029. This, in turn, breaks a number of key degeneracies present in the constraints from temperature measurements alone allowing the WMAP CMB data on its own to offer a powerful insight into the universe’s constituents and the processes that generated the initial conditions for structure formation.

[Abridged] We consider how galaxy clustering data, from Mpc to Gpc scales, from upcoming large scale structure surveys, such as Euclid and DESI, can provide discriminating information about the bispectrum shape arising from a variety of inflationary scenarios. Through exploring in detail the weighting of shape properties in the calculation of the halo bias and halo mass function we show how they probe a broad range of configurations, beyond those in the squeezed limit, that can help distinguish between shapes with similar large scale bias behaviors. We assess the impact, on constraints for a diverse set of non-Gaussian shapes, of galaxy clustering information in the mildly non-linear regime, and surveys that span multiple redshifts and employ different galactic tracers of the dark matter distribution. Fisher forecasts are presented for a Euclid-like spectroscopic survey of H$\alpha$-selected emission line galaxies (ELGs) using recent revisions of the expected H$\alpha$ luminosity function, and a DESI-like survey, of luminous red galaxies (LRGs) and [O-II] doublet-selected ELGs, in combination with Planck-like CMB temperature and polarization data. While ELG samples provide better probes of shapes that are divergent in the squeezed limit, LRG constraints, centered below $z, Comment: 29 pages, 11 figures, 3 tables; prepared for submission to JCAP; Fig 8a corrected

We calculate the constraints on dark energy and cosmic modifications to gravity achievable with upcoming cosmic microwave background (CMB) surveys sensitive to the Sunyaev-Zeldovich (SZ) effects. The analysis focuses on using the mean pairwise velocity of clusters as observed through the kinematic SZ effect (kSZ), an approach based on the same methods used for the first detection of the kSZ effect, and includes a detailed derivation and discussion of this statistic's covariance under a variety of different survey assumptions. The potential of current, Stage II, and upcoming, Stage III and Stage IV, CMB observations are considered, in combination with contemporaneous spectroscopic and photometric galaxy observations. A detailed assessment is made of the sensitivity to the assumed statistical and systematic uncertainties in the optical depth determination, the magnitude and uncertainty in the minimum detectable mass, and the importance of pairwise velocity correlations at small separations, where non-linear effects can start to arise. In combination with Stage III constraints on the expansion history, such as those projected by the Dark Energy Task Force, we forecast 5\% and 2\% for fractional errors on the growth factor, $\gamma$, for Stage III and Stage IV surveys respectively, and 2\% constraints on the growth rate, $f_g$, for a Stage IV survey for $0.2, Comment: 21 pages, 18 figures

Quintessence scenarios provide a simple explanation for the observed acceleration of the Universe. Yet, explaining why acceleration did not start a long time ago remains a challenge. The idea that the transition from radiation to matter domination played a dynamical role in triggering acceleration has been put forward in various guises. We propose a simple dilaton-derived quintessence model in which temporary vacuum domination is naturally triggered by the radiation to matter transition. In this model Einstein's gravity is preserved but quintessence couples non-minimally to the cold dark matter, but not to ``visible'' matter. Such couplings have been attributed to the dilaton in the low-energy limit of string theory beyond tree level. We also show how a cosmological constant in the string frame translates into a quintessence-type of potential in the atomic frame., Comment: 5 pages, 3 figures