12 results on '"Rachael R. Kirkbride"'
Search Results
2. Intra- and interobserver variability of novel magnetic resonance imaging parameters for hip screening and treatment outcomes at age 5 years
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A Graham, Wilkinson, Sally, Wilkinson, Robert A, Elton, Rachael R, Kirkbride, Thomas, Foster, Freya, Johnson, Sarah, Zycinski, Lianne, Boyce, Neil G, McIntyre, Simon F, McGurk, and Kaseem A, Ajilogba
- Abstract
The outcome measure of neonatal hip screening is usually the radiographic acetabular index.To assess the feasibility of magnetic resonance imaging (MRI) without sedation and compare the utility of outcome parameters measured from MRI images.The invitation for MRI scanning at 5 years of age was incorporated into follow-up for babies who had more than one ultrasound examination during treatment or surveillance.Diagnostic images were obtained in 132 of 134 children. The mean osseous acetabular index (standard deviation [SD]) was 16.6 (3.3) degrees for the right hip and 17.8 (3.2) for the left; the values for the cartilaginous acetabular index were 3.1 (3) and 3.4 (3.2). The mean downslope of a tangent to the lateral bony acetabular roof was 10.4 (4.5) and 9.0 (4.3) with respect to Hilgenreiner's line and that of a line drawn through the apex to the margin of the acetabulum was 3.7 (4.6) and 3.9 (4.7). Intra- and interobserver variation was greater for measures specific to the lateral acetabular roof than for ossific and cartilaginous indices. There was significant negative correlation between the downslope of the tangent to the lateral roof index and the age at onset of treatment on both sides, but no significant correlation for ossific or cartilaginous acetabular indices or apex-marginal index.MRI without sedation at 5 years of age is feasible as an outcome measure for hip screening programmes. Parameters specific to the lateral acetabulum may better reflect acetabular sufficiency, despite having greater observer variation than cartilaginous and ossific acetabular indices.
- Published
- 2022
3. Risk assessment of acute pulmonary embolism utilizing coronary artery calcifications in patients that have undergone CT pulmonary angiography and transthoracic echocardiography
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Benedikt H. Heidinger, Dominique DaBreo, Rachael R. Kirkbride, Mario Santos, Brett J. Carroll, Stephanie A. Feldman, Donya Mohebali, Ian McCormick, Jason D. Matos, Warren J. Manning, and Diana E. Litmanovich
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Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2020
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4. Pulmonary embolism severity before and during the COVID-19 pandemic
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Guo Liang Yong, Michelle C. Williams, Rachael R. Kirkbride, James Tiernan, Vicky Tilliridou, Rebecca Dickinson, John T. Murchison, and Edwin J R van Beek
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Male ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Computed Tomography Angiography ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Severity of Illness Index ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Severity of illness ,Pandemic ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Pandemics ,Coronavirus ,Aged ,Retrospective Studies ,Full Paper ,business.industry ,SARS-CoV-2 ,COVID-19 ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Pulmonary embolism ,Emergency medicine ,Female ,business ,Pulmonary Embolism - Abstract
Objectives: Early in the coronavirus 2019 (COVID-19) pandemic, a high frequency of pulmonary embolism was identified. This audit aims to assess the frequency and severity of pulmonary embolism in 2020 compared to 2019. Methods: In this retrospective audit, we compared computed tomography pulmonary angiography (CTPA) frequency and pulmonary embolism severity in April and May 2020, compared to 2019. Pulmonary embolism severity was assessed with the Modified Miller score and the presence of right heart strain was assessed. Demographic information and 30-day mortality was identified from electronic health records. Results: In April 2020, there was a 17% reduction in the number of CTPA performed and an increase in the proportion identifying pulmonary embolism (26%, n = 68/265 vs 15%, n = 47/320, p < 0.001), compared to April 2019. Patients with pulmonary embolism in 2020 had more comorbidities (p = 0.026), but similar age and sex compared to 2019. There was no difference in pulmonary embolism severity in 2020 compared to 2019, but there was an increased frequency of right heart strain in May 2020 (29 vs 12%, p = 0.029). Amongst 18 patients with COVID-19 and pulmonary embolism, there was a larger proportion of males and an increased 30 day mortality (28% vs 6%, p = 0.008). Conclusion: During the COVID-19 pandemic, there was a reduction in the number of CTPA scans performed and an increase in the frequency of CTPA scans positive for pulmonary embolism. Patients with both COVID-19 and pulmonary embolism had an increased risk of 30-day mortality compared to those without COVID-19. Advances in knowledge: During the COVID-19 pandemic, the number of CTPA performed decreased and the proportion of positive CTPA increased. Patients with both pulmonary embolism and COVID-19 had worse outcomes compared to those with pulmonary embolism alone.
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- 2021
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5. Quality and diagnostic performance of coronary computed tomography angiogram (CCTA): A comparison between pre-liver and pre-kidney transplant patients
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Brian G. Jiang, Michael C. Gavin, Jason Matos, Mark K. Tuttle, Emily Larkin, Rokas Liubauskas, Michael D. Nicholson, Rachael R. Kirkbride, and Diana Litmanovich
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medicine.medical_specialty ,Computed Tomography Angiography ,Stress testing ,Coronary Artery Disease ,Coronary Angiography ,Kidney transplant ,Coronary artery disease ,Predictive Value of Tests ,Internal medicine ,Heart rate ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Retrospective Studies ,business.industry ,Coronary Stenosis ,General Medicine ,medicine.disease ,Coronary computed tomography ,Kidney Transplantation ,Fractional Flow Reserve, Myocardial ,Liver ,Cardiology ,Transplant patient ,Known Coronary Artery Disease ,business ,Tomography, X-Ray Computed - Abstract
Assess and compare the quality and diagnostic performance of CCTA between pre-liver and pre-kidney transplant patients, and gauge impact of CCTA on ICA requirements.Patients without known coronary artery disease (CAD) were selected for CCTA if considered high-risk or after abnormal stress testing. All pre-liver and pre-kidney CCTAs between March 2018 and August 2020 were retrospectively included. CCTA quality was qualitatively graded as excellent/good/fair/poor, and CAD graded asor ≥50% stenosis. Heart rate, coronary artery calcium (CAC) scores, and fractional flow reserve CT (FFR162 pre-transplant patients (91 pre-liver, 71 pre-kidney). Pre-kidney patients had poorer CCTA quality (p = 0.04) and higher heart rate (median: 65 bpm vs 60 bpm, p 0.001). Out of 147 diagnostic CCTAs (pre-liver: 84, pre-kidney: 63), 73 (49.7%) had a ≥50% stenosis (pre-liver: 38 (45.2%), pre-kidney:35 (55.6%)). 12/38 (31.6%) had a significantly reduced FFRDiagnostic-quality CCTAs in high-risk pre-transplant patients are achievable and can greatly reduce ICA requirements by excluding significant CAD. CCTA quality is poorer in pre-kidney transplant patients compared to pre-liver, possibly due to higher heart rate.
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- 2021
6. Radiology Structured Reporting Handbook
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Rodrigo Salgado, Victoria Chernyak, Seth Kligerman, Cornelia Schaefer-Prokop, Susan Tsai, Judy Yee, Elizabeth V. Craig, Priyanka Jha, Charlotte Y. Chung, Doenja M.J. Lambregts, Katherine Kaproth-Joslin, Benjamin D. Spilseth, Anuradha S. Shenoy-Bhangle, Brent D. Weinberg, Robert Fisher, Brett W. Carter, Hernan R. Bello, Jessica B. Robbins, Milena Petranovic, Jean-Nicolas Dacher, Xin (Cynthia) Wu, Koenraad J. Mortele, Temel Tirkes, Tarik K. Alkasab, Nicole E. Curci, Kathryn McGillen, Edward J. Tanner, Muneeb Ahmed, Carol Wu, Atul B. Shinagare, Marta E. Heilbrun, Hakan Sahin, Maya Galperin-Aizenberg, Nicole Hindman, Anne Catherine Kim, Regina G.H. Beets Tan, Jeanne M. Horowitz, Benjamin Wildman-Tobriner, Liina Poder, Bernardo C. Bizzo, Daniela M. Tridente, Thijs Vande Vyvere, Michael J. Hoch, Mark D. Mamlouk, Krupa K. Patel-Lippmann, S. Paran Yap, Francesca Coppola, Jenny K. Hoang, Alejandro Garces-Descovich, Mary Frances Croake, Marta Wojewodzka, Shlomit Goldberg-Stein, Parag P. Tolat, Olga R. Brook, Marco Francone, Thomas W. Loehfelm, Ashley Hawk Aiken, David A. Lynch, Stephanie Nougaret, Julien Dinkel, Jonathan H. Chung, Rachael R. Kirkbride, Khoschy Schawkat, Eric M. Hu, Wieland H. Sommer, Jeff Ames, Ricardo P. J. Budde, Ghaneh Fananapazir, Diana Litmanovich, Lukas Abraszek, Elizabeth A. Sadowski, Thomas J.T. Anderson, Julian Dobranowski, Renata Rocha de Almeida Bizzo, Paul M. Parizel, Jeffrey L. Weinstein, Donald Kim, and Matthew S. Davenport
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medicine.medical_specialty ,business.industry ,Structured reporting ,medicine ,Medical physics ,business - Published
- 2021
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7. Imaging of Cardiac Infections: A Comprehensive Review and Investigation Flowchart for Diagnostic Workup
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Maya Galperin-Aizenberg, Carole A. Ridge, Diana Litmanovich, Rachael R. Kirkbride, Bhavin Rawal, Saeed Mirsadraee, and Kshama Wechalekar
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Myocarditis ,Cardiovascular infection ,Cardiovascular Infections ,Pericarditis ,Fluorodeoxyglucose F18 ,Software Design ,Positron Emission Tomography Computed Tomography ,medicine ,Endocarditis ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical diagnosis ,medicine.diagnostic_test ,business.industry ,COVID-19 ,Magnetic resonance imaging ,Bacterial Infections ,medicine.disease ,Functional imaging ,Virus Diseases ,Radiology ,Radiopharmaceuticals ,business ,Emission computed tomography - Abstract
Infections of the cardiovascular system may present with nonspecific symptoms, and it is common for patients to undergo multiple investigations to arrive at the diagnosis. Echocardiography is central to the diagnosis of endocarditis and pericarditis. However, cardiac computed tomography (CT) and magnetic resonance imaging also play an additive role in these diagnoses; in fact, magnetic resonance imaging is central to the diagnosis of myocarditis. Functional imaging (fluorine-18 fluorodeoxyglucose-positron emission tomography/CT and radiolabeled white blood cell single-photon emission computed tomography/CT) is useful in the diagnosis in prosthesis-related and disseminated infection. This pictorial review will detail the most commonly encountered cardiovascular bacterial and viral infections, including coronavirus disease-2019, in clinical practice and provide an evidence basis for the selection of each imaging modality in the investigation of native tissues and common prostheses.
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- 2020
8. Review of Chest Radiograph Findings of COVID-19 Pneumonia and Suggested Reporting Language
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Diana Litmanovich, Jeffrey P. Kanne, Michael Chung, Rachael R. Kirkbride, and Gregory Kicska
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Radiography ,MEDLINE ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Severity assessment ,0302 clinical medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Intensive care medicine ,Lung ,medicine.diagnostic_test ,SARS-CoV-2 ,business.industry ,COVID-19 ,medicine.disease ,Pneumonia ,Radiology Nuclear Medicine and imaging ,Radiological weapon ,Research studies ,Radiography, Thoracic ,Tomography, X-Ray Computed ,business ,Chest radiograph - Abstract
The diagnosis of coronavirus disease 2019 (COVID-19) is confirmed by reverse transcription polymerase chain reaction. The utility of chest radiography (CXR) remains an evolving topic of discussion. Current reports of CXR findings related to COVID-19 contain varied terminology as well as various assessments of its sensitivity and specificity. This can lead to a misunderstanding of CXR reports and makes comparison between examinations and research studies challenging. With this need for consistency, we propose language for standardized CXR reporting and severity assessment of persons under investigation for having COVID-19, patients with a confirmed diagnosis of COVID-19, and patients who may have radiographic findings typical or suggestive of COVID-19 when the diagnosis is not suspected clinically. We recommend contacting the referring providers to discuss the likelihood of viral infection when typical or indeterminate features of COVID-19 pneumonia on CXR are present as an incidental finding. In addition, we summarize the currently available literature related to the use of CXR for COVID-19 and discuss the evolving techniques of obtaining CXR in COVID-19-positive patients. The recently published expert consensus statement on reporting chest computed tomography findings related to COVID-19, endorsed by the Radiological Society of North American (RSNA), the Society of Thoracic Radiology (STR), and American College of Radiology (ACR), serves as the framework for our proposal.
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- 2020
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9. Correction to: Risk assessment of acute pulmonary embolism utilizing coronary artery calcifications in patients that have undergone CT pulmonary angiography and transthoracic echocardiography
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Dominique DaBreo, Ian McCormick, Stephanie Feldman, Rachael R. Kirkbride, Benedikt H. Heidinger, Diana Litmanovich, Brett J Carroll, Donya Mohebali, Mario Santos, Warren J. Manning, and Jason Matos
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,General Medicine ,medicine.disease ,030218 nuclear medicine & medical imaging ,Pulmonary embolism ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Radiology ,Risk assessment ,business ,Neuroradiology ,Computed tomography angiography ,Artery - Abstract
The original version of this article, published on 13 October 2020, unfortunately contained a mistake.
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- 2020
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10. Impact of noncardiac findings in patients undergoing CT coronary angiography:a substudy of the Scottish computed tomography of the heart (SCOT-HEART) trial
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Michelle C. Williams, Jonathan R. Weir McCall, Giles Roditi, Amanda Hunter, John Dreisbach, Saeed Mirsadraee, David E. Newby, Mark T. Macmillan, Andrew Baird, Fiona Hawke, Rachael R. Kirkbride, Anoop S V Shah, and Edwin J R van Beek
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Male ,NELSON ,030204 cardiovascular system & hematology ,Chest pain ,Coronary Angiography ,GUIDELINES ,Coronary artery disease ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,Lung neoplasms ,030212 general & internal medicine ,SCREENING TRIAL ,PULMONARY NODULES ,Neuroradiology ,Computed tomography angiography ,medicine.diagnostic_test ,STATEMENT ,Radiology, Nuclear Medicine & Medical Imaging ,Interventional radiology ,Heart ,General Medicine ,Middle Aged ,Incidental findings ,3. Good health ,Nuclear Medicine & Medical Imaging ,medicine.anatomical_structure ,cardiovascular system ,Female ,Radiology ,medicine.symptom ,Cardiac ,Life Sciences & Biomedicine ,medicine.medical_specialty ,Chest Pain ,SOCIETY ,Malignancy ,03 medical and health sciences ,LUNG-CANCER ,medicine ,MANAGEMENT ,Journal Article ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Radionuclide Imaging ,Aged ,Lung ,Science & Technology ,business.industry ,MORTALITY ,1103 Clinical Sciences ,medicine.disease ,business ,Tomography, X-Ray Computed - Abstract
Noncardiac findings are common on coronary computed tomography angiography (CCTA). We assessed the clinical impact of noncardiac findings, and potential changes to surveillance scans with the application of new lung nodule guidelines. This substudy of the SCOT-HEART randomized controlled trial assessed noncardiac findings identified on CCTA. Clinically significant noncardiac findings were those causing symptoms or requiring further investigation, follow-up or treatment. Lung nodule follow-up was undertaken following the 2005 Fleischner guidelines. The potential impact of the 2015 British Thoracic Society (BTS) and the 2017 Fleischner guidelines was assessed. CCTA was performed in 1,778 patients and noncardiac findings were identified in 677 (38%). In 173 patients (10%) the abnormal findings were clinically significant and in 55 patients (3%) the findings were the cause of symptoms. Follow-up imaging was recommended in 136 patients (7.6%) and additional clinic consultations were organized in 46 patients (2.6%). Malignancy was diagnosed in 7 patients (0.4%). Application of the new lung nodule guidelines would have reduced the number of patients undergoing a follow-up CT scan: 68 fewer with the 2015 BTS guidelines and 78 fewer with the 2017 Fleischner guidelines; none of these patients subsequently developed malignancy. Clinically significant noncardiac findings are identified in 10% of patients undergoing CCTA. Application of new lung nodule guidelines will reduce the cost of surveillance, without the risk of missing malignancy. • Clinically significant noncardiac findings occur in 10% of patients undergoing CCTA. • Noncardiac findings may be an important treatable cause of chest pain • Further imaging investigations for noncardiac findings were recommended in 8% of patients after CCTA. • New lung nodule follow-up guidelines will result in cost savings.
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- 2018
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11. Serum hepcidin potentially identifies iron deficiency in survivors of critical illness at the time of hospital discharge.
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Shah A, Wray K, James T, Shine B, Morovat R, Stanworth S, McKechnie S, Kirkbride R, Griffith DM, Walsh TS, Drakesmith H, and Roy N
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- Aged, Anemia, Iron-Deficiency mortality, Anemia, Iron-Deficiency therapy, Critical Illness, Female, Humans, Male, Middle Aged, Anemia, Iron-Deficiency blood, Hepcidins blood, Patient Discharge, Survivors
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- 2019
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12. Hydrogen ion concentration and coronary artery bypass graft surgery with and without cardiopulmonary bypass.
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Chuah C, Kirkbride R, Alston R, and Irons J
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- Aged, Blood Gas Analysis, Carbon Dioxide blood, Coronary Artery Bypass, Off-Pump, Female, Hemodilution, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Retrospective Studies, Acidosis physiopathology, Cardiopulmonary Bypass, Coronary Artery Bypass
- Abstract
Background: Acidosis during cardiopulmonary bypass (CPB) has been related to the strong ion difference (SID) and the composition of intravascular fluids that are administered. Less intravascular fluids tend to be administered during off- than on-pump CABG and should influence the degree of acidosis that develops. This study aimed to explore the role of CPB in the development of acidosis by comparing changes in hydrogen ion concentration ([H+]) and electrolytes in patients undergoing on- and off-pump coronary artery bypass graft (CABG) surgery., Methods: Eighty two patients had arterial blood gas measurements pre-operatively, following CABG and at approximately 0600 h the morning after surgery. Carbon dioxide tension (PaCO2) and concentrations of sodium, potassium, chloride, [H+], bicarbonate and haemoglobin were measured and strong ion difference calculated. Data was analysed using mixed repeated-measures analysis of variance., Results: Intra-operatively, mean SID decreased more in the on- compared to the off-pump group (4.0 mmol/L, 95% confidence interval 2.8-5.3 mmol/L, p < 0.001). Neither [H+] or PaCO2 changed significantly and there were no significant difference between the groups. By the morning following surgery, [H+] and PaCO2 had both increased (p < 0.001) and difference in SID had disappeared (p = 0.17)., Conclusion: Despite significant differences in changes in SID, there were no differences in [H+] between patients during or after CABG surgery whether performed on- or off-pump. This may be have been the result of greater haemodilution in the on- compared to the off-pump group, compensating for change in SID by reducing the concentration of weak acids. Although it was associated with significantly greater decrease in SID, CPB was not associated with any significant increased risk of acidosis.
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- 2013
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