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209 results on '"Racca, Patrizia"'

1. Multi-institutional analysis of outcomes for thermosphere microwave ablation treatment of colorectal liver metastases: the SMAC study

Author

De Cobelli, Francesco, Calandri, Marco, Della Corte, Angelo, Sirovich, Roberta, Gazzera, Carlo, Della Vigna, Paolo, Bonomo, Guido, Varano, Gianluca Maria, Maiettini, Daniele, Mauri, Giovanni, Camisassi, Nicola, Steidler, Stephanie, Ratti, Francesca, Gusmini, Simone, Ronzoni, Monica, Aldrighetti, Luca, Odisio, Bruno C., Racca, Patrizia, Fonio, Paolo, Veltri, Andrea, and Orsi, Franco

Published
2022
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2. Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify outcomes in patients with RAS wild-type metastatic colorectal cancer: a translational objective of the Valentino study

Author

Manca, Paolo, Corallo, Salvatore, Lonardi, Sara, Fucà, Giovanni, Busico, Adele, Leone, Alberto Giovanni, Corti, Francesca, Antoniotti, Carlotta, Procaccio, Letizia, Smiroldo, Valeria, Ratti, Margherita, Murialdo, Roberto, Racca, Patrizia, Pagani, Filippo, Randon, Giovanni, Martinetti, Antonia, Sottotetti, Elisa, Prisciandaro, Michele, Ambrosini, Margherita, Raimondi, Alessandra, Morano, Federica, and Pietrantonio, Filippo

Published
2022
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3. Impact of early tumor shrinkage and depth of response on the outcomes of panitumumab-based maintenance in patients with RAS wild-type metastatic colorectal cancer

Author

Manca, Paolo, Corallo, Salvatore, Randon, Giovanni, Lonardi, Sara, Cremolini, Chiara, Rimassa, Lorenza, Bergamo, Francesca, Antoniotti, Carlotta, Smiroldo, Valeria, Zaniboni, Alberto, Murialdo, Roberto, Tampellini, Marco, Tomasello, Gianluca, Clavarezza, Matteo, Racca, Patrizia, Antista, Maria, Raimondi, Alessandra, Prisciandaro, Michele, Pagani, Filippo, Palermo, Federica, Greco, Francesca Gabriella, Vaiani, Marta, Di Bartolomeo, Maria, de Braud, Filippo, Calareso, Giuseppina, Morano, Federica, and Pietrantonio, Filippo

Published
2021
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4. Systemic doxycycline for pre-emptive treatment of anti-EGFR-related skin toxicity in patients with metastatic colorectal cancer receiving first-line panitumumab-based therapy: a post hoc analysis of the Valentino study

Author

Raimondi, Alessandra, Corallo, Salvatore, Lonardi, Sara, Antoniotti, Carlotta, Rimassa, Lorenza, Amatu, Alessio, Tampellini, Marco, Racca, Patrizia, Murialdo, Roberto, Clavarezza, Matteo, Zaniboni, Alberto, Toscano, Giuseppe, Tomasello, Gianluca, Petrelli, Fausto, Antonuzzo, Lorenzo, Giordano, Monica, Cinieri, Saverio, Longarini, Raffaella, Niger, Monica, Antista, Maria, Ambrosini, Margherita, Pagani, Filippo, Prisciandaro, Michele, Randon, Giovanni, de Braud, Filippo, Di Bartolomeo, Maria, Pietrantonio, Filippo, and Morano, Federica

Published
2021
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5. Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial

Author

Falcone, Alfredo, Lonardi, Sara, De Braud, Filippo Guglielmo Maria, Bordonaro, Roberto, Maiello, Evaristo, Tamburini, Emiliano, Santini, Daniele, Frassineti, Giovanni Luca, Gamucci, Teresa, Aprile, Giuseppe, Zaniboni, Alberto, Granetto, Cristina, Buonadonna, Angela, Di Costanzo, Francesco, Tomasello, Gianluca, Gianni, Luca, Di Donato, Samantha, Carlomagno, Chiara, Clavarezza, Matteo, Racca, Patrizia, Mambrini, Andrea, Roselli, Mario, Allegrini, Giacomo, Sobrero, Alberto, Aglietta, Massimo, Corgna, Enrichetta, Cortesi, Enrico, Corsi, Domenico Cristiano, Ballestrero, Alberto, Bonetti, Andrea, Di Clemente, Francesco, Ruggeri, Enzo, Ciardiello, Fortunato, Benasso, Marco, Vitello, Stefano, Cinieri, Saverio, Mosconi, Stefania, Silvestris, Nicola, Frassoldati, Antonio, Cupini, Samantha, Bertolini, Alessandro, Tortora, Giampaolo, Bengala, Carmelo, Ferrari, Daris, Ardizzoia, Antonia, Milandri, Carlo, Chiara, Silvana, Romano, Gianpiero, Miraglia, Stefania, Scaltriti, Laura, Pucci, Francesca, Blasi, Livio, Brugnatelli, Silvia, Fioretto, Luisa, Ribecco, Angela Stefania, Longarini, Raffaella, Frisinghelli, Michela, Banzi, Maria, Cremolini, Chiara, Antoniotti, Carlotta, Rossini, Daniele, Loupakis, Fotios, Pietrantonio, Filippo, Latiano, Tiziana Pia, Passardi, Alessandro, Marmorino, Federica, Grande, Roberta, Murgioni, Sabina, Moretto, Roberto, Corallo, Salvatore, Cordio, Stefano, Antonuzzo, Lorenzo, Masi, Gianluca, Ronzoni, Monica, Ritorto, Giuliana, Cupini, Samanta, Mammoliti, Serafina, Fenocchio, Elisabetta, Zagonel, Vittorina, Fontanini, Gabriella, Ugolini, Clara, and Boni, Luca

Published
2020
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7. Quality of life, compliance, safety and effectiveness in fit older metastatic colorectal patients with cancer treated in first-line with chemotherapy plus cetuximab: A restrospective analysis from the ObservEr study

Author

Rosati, Gerardo, Pinto, Carmine, Di Fabio, Francesca, Chiara, Silvana, Lolli, Ivan R., Ruggeri, Enzo M., Ciuffreda, Libero, Ferrara, Raimondo, Antonuzzo, Lorenzo, Adua, Daniela, Racca, Patrizia, Bilancia, Domenico, Benincasa, Elena, Stroppolo, Maria Elena, and Di Costanzo, Francesco

Published
2018
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8. AtezoTRIBE: a randomised phase II study of FOLFOXIRI plus bevacizumab alone or in combination with atezolizumab as initial therapy for patients with unresectable metastatic colorectal cancer

Author

Antoniotti, Carlotta, Borelli, Beatrice, Rossini, Daniele, Pietrantonio, Filippo, Morano, Federica, Salvatore, Lisa, Lonardi, Sara, Marmorino, Federica, Tamberi, Stefano, Corallo, Salvatore, Tortora, Giampaolo, Bergamo, Francesca, Brunella, Di Stefano, Boccaccino, Alessandra, Grassi, Elisa, Racca, Patrizia, Tamburini, Emiliano, Aprile, Giuseppe, Moretto, Roberto, Boni, Luca, Falcone, Alfredo, and Cremolini, Chiara

Published
2020
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10. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial

Author

Sartore-Bianchi, Andrea, Trusolino, Livio, Martino, Cosimo, Bencardino, Katia, Lonardi, Sara, Bergamo, Francesca, Zagonel, Vittorina, Leone, Francesco, Depetris, Ilaria, Martinelli, Erika, Troiani, Teresa, Ciardiello, Fortunato, Racca, Patrizia, Bertotti, Andrea, Siravegna, Giulia, Torri, Valter, Amatu, Alessio, Ghezzi, Silvia, Marrapese, Giovanna, Palmeri, Laura, Valtorta, Emanuele, Cassingena, Andrea, Lauricella, Calogero, Vanzulli, Angelo, Regge, Daniele, Veronese, Silvio, Comoglio, Paolo M, Bardelli, Alberto, Marsoni, Silvia, and Siena, Salvatore

Published
2016
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11. Supplementary Data from The Added Value of Baseline Circulating Tumor DNA Profiling in Patients with Molecularly Hyperselected, Left-sided Metastatic Colorectal Cancer

Author

Manca, Paolo, primary, Corallo, Salvatore, primary, Busico, Adele, primary, Lonardi, Sara, primary, Corti, Francesca, primary, Antoniotti, Carlotta, primary, Procaccio, Letizia, primary, Clavarezza, Matteo, primary, Smiroldo, Valeria, primary, Tomasello, Gianluca, primary, Murialdo, Roberto, primary, Sartore-Bianchi, Andrea, primary, Racca, Patrizia, primary, Pagani, Filippo, primary, Randon, Giovanni, primary, Martinetti, Antonia, primary, Sottotetti, Elisa, primary, Palermo, Federica, primary, Perrone, Federica, primary, Tamborini, Elena, primary, Prisciandaro, Michele, primary, Raimondi, Alessandra, primary, Di Bartolomeo, Maria, primary, Morano, Federica, primary, and Pietrantonio, Filippo, primary

Published
2023
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12. Assessment of a HER2 scoring system for colorectal cancer: results from a validation study

Author

Valtorta, Emanuele, Martino, Cosimo, Sartore-Bianchi, Andrea, Penaullt-Llorca, Frédérique, Viale, Giuseppe, Risio, Mauro, Rugge, Massimo, Grigioni, Walter, Bencardino, Katia, Lonardi, Sara, Zagonel, Vittorina, Leone, Francesco, Noe, Johannes, Ciardiello, Fortunato, Pinto, Carmine, Labianca, Roberto, Mosconi, Stefania, Graiff, Claudio, Aprile, Giuseppe, Frau, Barbara, Garufi, Carlo, Loupakis, Fotios, Racca, Patrizia, Tonini, Giuseppe, Lauricella, Calogero, Veronese, Silvio, Truini, Mauro, Siena, Salvatore, Marsoni, Silvia, and Gambacorta, Marcello

Published
2015
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16. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Author

Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B., Nicolantonio, Federica Di, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, and Bardelli, Alberto

Subjects
Colorectal cancer -- Development and progression -- Genetic aspects -- Care and treatment -- Research, Biological sciences, Health
Abstract

Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and clonal evolution. The molecular profile of CRC is routinely assessed in surgical or bioptic samples (1). Genotyping of CRC tissue has inherent limitations; a tissue sample represents a single snapshot in time, and it is subjected to spatial selection bias owing to tumor heterogeneity. Repeated tissue samples are difficult to obtain and cannot be used for dynamic monitoring of disease progression and response to therapy. We exploited circulating tumor DNA (ctDNA) to genotype colorectal tumors and track clonal evolution during treatment with the epidermal growth factor receptor (EGFR)-specific antibodies cetuximab or panitumumab. We identified alterations in ctDNA of patients with primary or acquired resistance to EGFR blockade in the following genes: KRAS, NRAS, MET, ERBB2, FLT3, EGFR and MAP2K1. Mutated KRAS clones, which emerge in blood during EGFR blockade, decline upon withdrawal of EGFR-specific antibodies, indicating that clonal evolution continues beyond clinical progression. Pharmacogenomic analysis of CRC cells that had acquired resistance to cetuximab reveals that upon antibody withdrawal KRAS clones decay, whereas the population regains drug sensitivity. ctDNA profiles of individuals who benefit from multiple challenges with anti-EGFR antibodies exhibit pulsatile levels of mutant KRAS. These results indicate that the CRC genome adapts dynamically to intermittent drug schedules and provide a molecular explanation for the efficacy of rechallenge therapies based on EGFR blockade., An improved understanding of the underlying molecular pathology of CRC has enabled tailored treatment regimens and helped optimize outcomes. CRC tissue is currently used to define the molecular status of [...]

Published
2015

17. Temozolomide Followed by Combination With Low-Dose Ipilimumab and Nivolumab in Patients With Microsatellite-Stable, O6-Methylguanine–DNA Methyltransferase–Silenced Metastatic Colorectal Cancer: The MAYA Trial

Author

Morano, Federica, primary, Raimondi, Alessandra, additional, Pagani, Filippo, additional, Lonardi, Sara, additional, Salvatore, Lisa, additional, Cremolini, Chiara, additional, Murgioni, Sabina, additional, Randon, Giovanni, additional, Palermo, Federica, additional, Antonuzzo, Lorenzo, additional, Pella, Nicoletta, additional, Racca, Patrizia, additional, Prisciandaro, Michele, additional, Niger, Monica, additional, Corti, Francesca, additional, Bergamo, Francesca, additional, Zaniboni, Alberto, additional, Ratti, Margherita, additional, Palazzo, Michele, additional, Cagnazzo, Celeste, additional, Calegari, Maria Alessandra, additional, Marmorino, Federica, additional, Capone, Iolanda, additional, Conca, Elena, additional, Busico, Adele, additional, Brich, Silvia, additional, Tamborini, Elena, additional, Perrone, Federica, additional, Di Maio, Massimo, additional, Milione, Massimo, additional, Di Bartolomeo, Maria, additional, de Braud, Filippo, additional, and Pietrantonio, Filippo, additional

Published
2022
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18. Temozolomide Followed by Combination With Low-Dose Ipilimumab and Nivolumab in Patients With Microsatellite-Stable, O6-Methylguanine-DNA Methyltransferase-Silenced Metastatic Colorectal Cancer: The MAYA Trial

Author

Morano, Federica, Raimondi, Alessandra, Pagani, Filippo, Lonardi, Sara, Salvatore, Lisa, Cremolini, Chiara, Murgioni, Sabina, Randon, Giovanni, Palermo, Federica, Antonuzzo, Lorenzo, Pella, Nicoletta, Racca, Patrizia, Prisciandaro, Michele, Niger, Monica, Corti, Francesca, Bergamo, Francesca, Zaniboni, Alberto, Ratti, Margherita, Palazzo, Michele, Cagnazzo, Celeste, Calegari, Maria Alessandra, Marmorino, Federica, Capone, Iolanda, Conca, Elena, Busico, Adele, Brich, Silvia, Tamborini, Elena, Perrone, Federica, Di Maio, Massimo, Milione, Massimo, Di Bartolomeo, Maria, de Braud, Filippo, Pietrantonio, Filippo, Morano, Federica, Raimondi, Alessandra, Pagani, Filippo, Lonardi, Sara, Salvatore, Lisa, Cremolini, Chiara, Murgioni, Sabina, Randon, Giovanni, Palermo, Federica, Antonuzzo, Lorenzo, Pella, Nicoletta, Racca, Patrizia, Prisciandaro, Michele, Niger, Monica, Corti, Francesca, Bergamo, Francesca, Zaniboni, Alberto, Ratti, Margherita, Palazzo, Michele, Cagnazzo, Celeste, Calegari, Maria Alessandra, Marmorino, Federica, Capone, Iolanda, Conca, Elena, Busico, Adele, Brich, Silvia, Tamborini, Elena, Perrone, Federica, Di Maio, Massimo, Milione, Massimo, Di Bartolomeo, Maria, de Braud, Filippo, and Pietrantonio, Filippo

Abstract

N/A

Published
2022

19. Reinduction of an Anti-EGFR-based First-line Regimen in Patients with RAS Wild-type Metastatic Colorectal Cancer Enrolled in the Valentino Study

Author

Fucà, Giovanni, primary, Raimondi, Alessandra, additional, Prisciandaro, Michele, additional, Lonardi, Sara, additional, Cremolini, Chiara, additional, Ratti, Margherita, additional, Clavarezza, Matteo, additional, Murialdo, Roberto, additional, Sartore-Bianchi, Andrea, additional, Smiroldo, Valeria, additional, Berenato, Rosa, additional, Racca, Patrizia, additional, Bergamo, Francesca, additional, Corallo, Salvatore, additional, Di Bartolomeo, Maria, additional, de Braud, Filippo, additional, Morano, Federica, additional, and Pietrantonio, Filippo, additional

Published
2022
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20. Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify outcomes in patients with RAS wild-type metastatic colorectal cancer: a translational objective of the Valentino study

Author

Manca, Paolo, primary, Corallo, Salvatore, additional, Lonardi, Sara, additional, Fucà, Giovanni, additional, Busico, Adele, additional, Leone, Alberto Giovanni, additional, Corti, Francesca, additional, Antoniotti, Carlotta, additional, Procaccio, Letizia, additional, Smiroldo, Valeria, additional, Ratti, Margherita, additional, Murialdo, Roberto, additional, Racca, Patrizia, additional, Pagani, Filippo, additional, Randon, Giovanni, additional, Martinetti, Antonia, additional, Sottotetti, Elisa, additional, Prisciandaro, Michele, additional, Ambrosini, Margherita, additional, Raimondi, Alessandra, additional, Morano, Federica, additional, and Pietrantonio, Filippo, additional

Published
2021
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23. Italian results of the PRECONNECT study: safety and efficacy of trifluridine/tipiracil in metastatic colorectal cancer

Author

Zaniboni, Alberto, primary, Barone, Carlo Antonio, additional, Banzi, Maria Chiara, additional, Bergamo, Francesca, additional, Blasi, Livio, additional, Bordonaro, Roberto, additional, Bartolomeo, Maria Di, additional, Costanzo, Francesco Di, additional, Frassineti, Giovanni Luca, additional, Garufi, Carlo, additional, Giuliani, Francesco, additional, Latiano, Tiziana Pia, additional, Martinelli, Erika, additional, Personeni, Nicola, additional, Racca, Patrizia, additional, Tamburini, Emiliano, additional, Tonini, Giuseppe, additional, Besse, Marie Georges, additional, Spione, Mario, additional, and Falcone, Alfredo, additional

Published
2021
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24. The Added Value of Baseline Circulating Tumor DNA Profiling in Patients with Molecularly Hyperselected, Left-sided Metastatic Colorectal Cancer

Author

Manca, Paolo, primary, Corallo, Salvatore, additional, Busico, Adele, additional, Lonardi, Sara, additional, Corti, Francesca, additional, Antoniotti, Carlotta, additional, Procaccio, Letizia, additional, Clavarezza, Matteo, additional, Smiroldo, Valeria, additional, Tomasello, Gianluca, additional, Murialdo, Roberto, additional, Sartore-Bianchi, Andrea, additional, Racca, Patrizia, additional, Pagani, Filippo, additional, Randon, Giovanni, additional, Martinetti, Antonia, additional, Sottotetti, Elisa, additional, Palermo, Federica, additional, Perrone, Federica, additional, Tamborini, Elena, additional, Prisciandaro, Michele, additional, Raimondi, Alessandra, additional, Di Bartolomeo, Maria, additional, Morano, Federica, additional, and Pietrantonio, Filippo, additional

Published
2021
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25. Prospective, randomised, multicentre, open-label trial, designed to evaluate the best timing of closure of the temporary ileostomy (early versus late) in patients who underwent rectal cancer resection and with indication for adjuvant chemotherapy: the STOMAD (STOMa closure before or after ADjuvant therapy) randomised controlled trial

Author

Massucco, Paolo, primary, Fontana, Andrea, additional, Mineccia, Michela, additional, Perotti, Serena, additional, Ciccone, Giovannino, additional, Galassi, Claudia, additional, Giuffrida, Maria Carmela, additional, Marino, Donatella, additional, Monsellato, Igor, additional, Paris, Myriam Katja, additional, Perinotti, Roberto, additional, Racca, Patrizia, additional, Monagheddu, Chiara, additional, Saccona, Fabio, additional, Ponte, Elisa, additional, Mistrangelo, Massimiliano, additional, Santarelli, Mauro, additional, Tomaselli, Francesco, additional, Reddavid, Rossella, additional, Birolo, Simone, additional, Calabrò, Marcello, additional, Pipitone, Nicoletta, additional, Panier Suffat, Luca, additional, Carrera, Monica, additional, Potente, Francesco, additional, Brunetti, Marco, additional, Rimonda, Roberto, additional, Adamo, Vincenzo, additional, Piscioneri, Domenico, additional, Cravero, Francesca, additional, Serventi, Alberto, additional, Giaminardi, Eliana, additional, Mazza, Luca, additional, Bellora, Paolo, additional, Colli, Fabio, additional, De Rosa, Clemente, additional, Battafarano, Francesco, additional, Trapani, Renza, additional, Mellano, Alfredo, additional, Gibin, Enrico, additional, and Bellomo, Paola, additional

Published
2021
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27. Temozolomide Followed by Combination With Low-Dose Ipilimumab and Nivolumab in Patients With Microsatellite-Stable, O6-Methylguanine-DNA Methyltransferase-Silenced Metastatic Colorectal Cancer: The MAYA Trial.

Author

Morano, Federica, Raimondi, Alessandra, Pagani, Filippo, Lonardi, Sara, Salvatore, Lisa, Cremolini, Chiara, Murgioni, Sabina, Randon, Giovanni, Palermo, Federica, Antonuzzo, Lorenzo, Pella, Nicoletta, Racca, Patrizia, Prisciandaro, Michele, Niger, Monica, Corti, Francesca, Bergamo, Francesca, Zaniboni, Alberto, Ratti, Margherita, Palazzo, Michele, and Cagnazzo, Celeste

Published
2022
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29. Bone Marrow-Sparing IMRT in Anal Cancer Patients Undergoing Concurrent Chemo-Radiation: Results of the First Phase of a Prospective Phase II Trial

Author

Arcadipane, Francesca, primary, Silvetti, Patrick, additional, Olivero, Francesco, additional, Gastino, Alessio, additional, De Luca, Viola, additional, Mistrangelo, Massimiliano, additional, Cassoni, Paola, additional, Racca, Patrizia, additional, Gallio, Elena, additional, Lesca, Adriana, additional, Fiandra, Christian, additional, Ricardi, Umberto, additional, and Franco, Pierfrancesco, additional

Published
2020
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30. Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial

Author

Cremolini, Chiara, primary, Antoniotti, Carlotta, additional, Rossini, Daniele, additional, Lonardi, Sara, additional, Loupakis, Fotios, additional, Pietrantonio, Filippo, additional, Bordonaro, Roberto, additional, Latiano, Tiziana Pia, additional, Tamburini, Emiliano, additional, Santini, Daniele, additional, Passardi, Alessandro, additional, Marmorino, Federica, additional, Grande, Roberta, additional, Aprile, Giuseppe, additional, Zaniboni, Alberto, additional, Murgioni, Sabina, additional, Granetto, Cristina, additional, Buonadonna, Angela, additional, Moretto, Roberto, additional, Corallo, Salvatore, additional, Cordio, Stefano, additional, Antonuzzo, Lorenzo, additional, Tomasello, Gianluca, additional, Masi, Gianluca, additional, Ronzoni, Monica, additional, Di Donato, Samantha, additional, Carlomagno, Chiara, additional, Clavarezza, Matteo, additional, Ritorto, Giuliana, additional, Mambrini, Andrea, additional, Roselli, Mario, additional, Cupini, Samanta, additional, Mammoliti, Serafina, additional, Fenocchio, Elisabetta, additional, Corgna, Enrichetta, additional, Zagonel, Vittorina, additional, Fontanini, Gabriella, additional, Ugolini, Clara, additional, Boni, Luca, additional, Falcone, Alfredo, additional, De Braud, Filippo Guglielmo Maria, additional, Maiello, Evaristo, additional, Frassineti, Giovanni Luca, additional, Gamucci, Teresa, additional, Di Costanzo, Francesco, additional, Gianni, Luca, additional, Racca, Patrizia, additional, Allegrini, Giacomo, additional, Sobrero, Alberto, additional, Aglietta, Massimo, additional, Cortesi, Enrico, additional, Corsi, Domenico Cristiano, additional, Ballestrero, Alberto, additional, Bonetti, Andrea, additional, Di Clemente, Francesco, additional, Ruggeri, Enzo, additional, Ciardiello, Fortunato, additional, Benasso, Marco, additional, Vitello, Stefano, additional, Cinieri, Saverio, additional, Mosconi, Stefania, additional, Silvestris, Nicola, additional, Frassoldati, Antonio, additional, Cupini, Samantha, additional, Bertolini, Alessandro, additional, Tortora, Giampaolo, additional, Bengala, Carmelo, additional, Ferrari, Daris, additional, Ardizzoia, Antonia, additional, Milandri, Carlo, additional, Chiara, Silvana, additional, Romano, Gianpiero, additional, Miraglia, Stefania, additional, Scaltriti, Laura, additional, Pucci, Francesca, additional, Blasi, Livio, additional, Brugnatelli, Silvia, additional, Fioretto, Luisa, additional, Ribecco, Angela Stefania, additional, Longarini, Raffaella, additional, Frisinghelli, Michela, additional, and Banzi, Maria, additional

Published
2020
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31. Additional file 1 of AtezoTRIBE: a randomised phase II study of FOLFOXIRI plus bevacizumab alone or in combination with atezolizumab as initial therapy for patients with unresectable metastatic colorectal cancer

Author

Antoniotti, Carlotta, Borelli, Beatrice, Rossini, Daniele, Pietrantonio, Filippo, Morano, Federica, Salvatore, Lisa, Lonardi, Sara, Marmorino, Federica, Tamberi, Stefano, Corallo, Salvatore, Tortora, Giampaolo, Bergamo, Francesca, Brunella, Di Stefano, Boccaccino, Alessandra, Grassi, Elisa, Racca, Patrizia, Tamburini, Emiliano, Aprile, Giuseppe, Moretto, Roberto, Boni, Luca, Falcone, Alfredo, and Cremolini, Chiara

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, ComputingMilieux_LEGALASPECTSOFCOMPUTING, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Additional file 1. List of Ethics Committees that approved the study protocol.

Published
2020
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33. Negative Hyperselection of Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer Who Received Panitumumab-Based Maintenance Therapy

Author

Morano, Federica, primary, Corallo, Salvatore, additional, Lonardi, Sara, additional, Raimondi, Alessandra, additional, Cremolini, Chiara, additional, Rimassa, Lorenza, additional, Murialdo, Roberto, additional, Zaniboni, Alberto, additional, Sartore-Bianchi, Andrea, additional, Tomasello, Gianluca, additional, Racca, Patrizia, additional, Clavarezza, Matteo, additional, Adamo, Vincenzo, additional, Perrone, Federica, additional, Gloghini, Annunziata, additional, Tamborini, Elena, additional, Busico, Adele, additional, Martinetti, Antonia, additional, Palermo, Federica, additional, Loupakis, Fotios, additional, Milione, Massimo, additional, Fucà, Giovanni, additional, Di Bartolomeo, Maria, additional, de Braud, Filippo, additional, and Pietrantonio, Filippo, additional

Published
2019
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35. Maintenance Therapy With Panitumumab Alone vs Panitumumab Plus Fluorouracil-Leucovorin in Patients With RAS Wild-Type Metastatic Colorectal Cancer

Author

Pietrantonio, Filippo, primary, Morano, Federica, additional, Corallo, Salvatore, additional, Miceli, Rosalba, additional, Lonardi, Sara, additional, Raimondi, Alessandra, additional, Cremolini, Chiara, additional, Rimassa, Lorenza, additional, Bergamo, Francesca, additional, Sartore-Bianchi, Andrea, additional, Tampellini, Marco, additional, Racca, Patrizia, additional, Clavarezza, Matteo, additional, Berenato, Rosa, additional, Caporale, Marta, additional, Antista, Maria, additional, Niger, Monica, additional, Smiroldo, Valeria, additional, Murialdo, Roberto, additional, Zaniboni, Alberto, additional, Adamo, Vincenzo, additional, Tomasello, Gianluca, additional, Giordano, Monica, additional, Petrelli, Fausto, additional, Longarini, Raffaella, additional, Cinieri, Saverio, additional, Falcone, Alfredo, additional, Zagonel, Vittorina, additional, Di Bartolomeo, Maria, additional, and de Braud, Filippo, additional

Published
2019
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36. Performance indicators for monitoring the integrated care pathway of patients with colorectal cancer: the E.Pic.A. project

Author

Ricotti, Andrea, primary, Messori Ioli, Giovanni, additional, Altini, Mattia, additional, Bachini, Letizia, additional, Balzi, William, additional, Frassineti, Giovanni Luca, additional, Gemmi, Fabrizio, additional, Massa, Ilaria, additional, Pierini, Andrea, additional, Bertetto, Oscar, additional, and Racca, Patrizia, additional

Published
2019
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37. HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

Author

Sartore-Bianchi, Andrea, primary, Amatu, Alessio, additional, Porcu, Luca, additional, Ghezzi, Silvia, additional, Lonardi, Sara, additional, Leone, Francesco, additional, Bergamo, Francesca, additional, Fenocchio, Elisabetta, additional, Martinelli, Erika, additional, Borelli, Beatrice, additional, Tosi, Federica, additional, Racca, Patrizia, additional, Valtorta, Emanuele, additional, Bonoldi, Emanuela, additional, Martino, Cosimo, additional, Vaghi, Caterina, additional, Marrapese, Giovanna, additional, Ciardiello, Fortunato, additional, Zagonel, Vittorina, additional, Bardelli, Alberto, additional, Trusolino, Livio, additional, Torri, Valter, additional, Marsoni, Silvia, additional, and Siena, Salvatore, additional

Published
2019
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38. Performance indicators for monitoring the integrated care pathway of patients with colorectal cancer: the E.Pic.A. project: Performance indicators for colorectal cancer

Author

Ricotti, Andrea, Messori Ioli, Giovanni, Altini, Mattia, Bachini, Letizia, Balzi, William, Frassineti, Giovanni Luca, Gemmi, Fabrizio, Massa, Ilaria, Pierini, Andrea, Bertetto, Oscar, Racca, Patrizia, Ricotti, Andrea, Messori Ioli, Giovanni, Altini, Mattia, Bachini, Letizia, Balzi, William, Frassineti, Giovanni Luca, Gemmi, Fabrizio, Massa, Ilaria, Pierini, Andrea, Bertetto, Oscar, and Racca, Patrizia

Abstract

Background: Given limitations in economic resources, achieving sustainability in healthcare is an increasingly important issue driving policy decisions. Colorectal cancer (CRC) is a frequent oncological diagnosis with an incidence that is expected to increase, making the efficient utilisation of resources a major priority for its diagnosis and treatment. To assess potentially inappropriate utilisation of services in the integrated care pathway of patients with malignant CRC, a series of key performance indicators (KPIs) have been developed by a multidisciplinary panel of the E.Pic.A. project (Economic Appropriateness of an Integrated Care Pathway).Methods: The KPIs identified had to comply with criteria of reliability, representativeness, accessibility and operativity. A definition is provided for each of the KPIs, along with the methodology used to calculate it and a reference target.Results: Eight KPIs were identified that can measure inadequacies of services provided in the diagnostic and treatment pathways for CRC: four for instrumental diagnostics, three for surgery and one for oncologic therapy.Conclusions: Use of the methodology described can help payors to obtain detailed information on inappropriate and wasteful use of healthcare resources, which would then permit their reallocation for interventions with higher value for patients with CRC and other pathologies. (HTA & Market Access, Oncology)

Published
2019

39. Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation

Author

Franco, Pierfrancesco, primary, Arcadipane, Francesca, additional, Ragona, Riccardo, additional, Lesca, Adriana, additional, Gallio, Elena, additional, Mistrangelo, Massimiliano, additional, Trino, Elisabetta, additional, Cassoni, Paola, additional, Arena, Vincenzo, additional, Baccega, Massimo, additional, Racca, Patrizia, additional, Faletti, Riccardo, additional, Rondi, Nadia, additional, Morino, Mario, additional, and Ricardi, Umberto, additional

Published
2018
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40. First-Line Panitumumab Plus FOLFOX-4 Followed by Maintenance Therapy with Single-Agent Panitumumab or Panitumumab Plus 5-FU/LV in Patients with RAS Wild-Type Metastatic Colorectal Cancer: The Valentino Study

Author

Pietrantonio, Filippo, primary, Morano, Federica, additional, Corallo, Salvatore, additional, Miceli, Rosalba, additional, Lonardi, Sara, additional, Raimondi, Alessandra, additional, Cremolini, Chiara, additional, Rimassa, Lorenza, additional, Bergamo, Francesca, additional, Sartore-Bianchi, Andrea, additional, Tampellini, Marco, additional, Racca, Patrizia, additional, Clavarezza, Matteo, additional, Berenato, Rosa, additional, Caporale, Marta, additional, Antista, Maria, additional, Niger, Monica, additional, Smiroldo, Valeria, additional, Murialdo, Roberto, additional, Zaniboni, Alberto, additional, Adamo, Vincenzo, additional, Tomasello, Gianluca, additional, Giordano, Monica, additional, Petrelli, Fausto, additional, Longarini, Raffaella, additional, Cinieri, Saverio, additional, Falcone, Alfredo, additional, Zagonel, Vittorina, additional, Di Bartolomeo, Maria, additional, and de Braud, Filippo, additional

Published
2018
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41. Abstract A089: Exploiting clonal evolution and liquid biopsy to overcome resistance to anti-EGFR treatment in metastatic colorectal cancer: the CHRONOS trial

Author

Siena, Salvatore, primary, Bardelli, Alberto, additional, Sartore-Bianchi, Andrea, additional, Lonardi, Sara, additional, Leone, Francesco, additional, Bergamo, Francesca, additional, Tonini, Giuseppe, additional, De Braud, Filippo, additional, Pietrantonio, Filippo, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Siravegna, Giulia, additional, Mussolin, Benedetta, additional, Rua, Francesco, additional, Bonazzina, Erica Francesca, additional, Amatu, Alessio, additional, Racca, Patrizia, additional, Ardizzoni, Andrea, additional, Zagonel, Vittorina, additional, and Marsoni, Silvia, additional

Published
2018
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42. Abstract A087: Empowering precision medicine in metastatic colorectal cancer: preliminary results from the FUNNEL platform

Author

Martino, Cosimo, primary, Berrino, Enrico, additional, Dell'Aglio, Carmine, additional, Casorzo, Laura, additional, Panero, Mara, additional, Siena, Salvatore, additional, Sartore-Bianchi, Andrea, additional, Cassingena, Andrea, additional, Zagonel, Vittorina, additional, Lonardi, Sara, additional, Loupakis, Fotios, additional, Tonini, Giuseppe, additional, Racca, Patrizia, additional, Trusolino, Livio, additional, Bertotti, Andrea, additional, Depetris, Ilaria, additional, Balsamo, Antonella, additional, Sapino, Anna, additional, and Marsoni, Silvia, additional

Published
2018
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43. DPYD and UGT1A1 genotyping to predict adverse events during first-line FOLFIRI or FOLFOXIRI plus bevacizumab in metastatic colorectal cancer

Author

Cremolini, Chiara, primary, Del Re, Marzia, additional, Antoniotti, Carlotta, additional, Lonardi, Sara, additional, Bergamo, Francesca, additional, Loupakis, Fotios, additional, Borelli, Beatrice, additional, Marmorino, Federica, additional, Citi, Valentina, additional, Cortesi, Enrico, additional, Moretto, Roberto, additional, Ronzoni, Monica, additional, Tomasello, Gianluca, additional, Zaniboni, Alberto, additional, Racca, Patrizia, additional, Buonadonna, Angela, additional, Allegrini, Giacomo, additional, Ricci, Vincenzo, additional, Di Donato, Samantha, additional, Zagonel, Vittorina, additional, Boni, Luca, additional, Falcone, Alfredo, additional, and Danesi, Romano, additional

Published
2017
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44. Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

Author

Barault, Ludovic, primary, Amatu, Alessio, additional, Siravegna, Giulia, additional, Ponzetti, Agostino, additional, Moran, Sebastian, additional, Cassingena, Andrea, additional, Mussolin, Benedetta, additional, Falcomatà, Chiara, additional, Binder, Alexandra M, additional, Cristiano, Carmen, additional, Oddo, Daniele, additional, Guarrera, Simonetta, additional, Cancelliere, Carlotta, additional, Bustreo, Sara, additional, Bencardino, Katia, additional, Maden, Sean, additional, Vanzati, Alice, additional, Zavattari, Patrizia, additional, Matullo, Giuseppe, additional, Truini, Mauro, additional, Grady, William M, additional, Racca, Patrizia, additional, Michels, Karin B, additional, Siena, Salvatore, additional, Esteller, Manel, additional, Bardelli, Alberto, additional, Sartore-Bianchi, Andrea, additional, and Di Nicolantonio, Federica, additional

Published
2017
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45. Image-guided IMRT with simultaneous integrated boost as per RTOG 0529 for the treatment of anal cancer

Author

Arcadipane, Francesca, primary, Franco, Pierfrancesco, additional, Ceccarelli, Manuela, additional, Furfaro, Gabriella, additional, Rondi, Nadia, additional, Trino, Elisabetta, additional, Martini, Stefania, additional, Iorio, Giuseppe Carlo, additional, Mistrangelo, Massimiliano, additional, Cassoni, Paola, additional, Racca, Patrizia, additional, Morino, Mario, additional, and Ricardi, Umberto, additional

Published
2017
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46. Abstract CT005: Final results of the HERACLES trial in HER2-amplified colorectal cancer

Author

Siena, Salvatore, primary, Sartore-Bianchi, Andrea, additional, Trusolino, Livio, additional, Martino, Cosimo, additional, Bencardino, Katia, additional, Lonardi, Sara, additional, Zagonel, Vittorina, additional, Leone, Francesco, additional, Martinelli, Erika, additional, Ciardiello, Fortunato, additional, Racca, Patrizia, additional, Amatu, Alessio, additional, Palmeri, Laura, additional, Valtorta, Emanuele, additional, Ghezzi, Silvia, additional, Vanzulli, Angelo, additional, Regge, Daniele, additional, Veronese, Silvio, additional, Bardelli, Alberto, additional, and Marsoni, Silvia, additional

Published
2017
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47. Prognostic and predictive role of neutrophils/lymphocytes ratio in metastatic colorectal cancer: A retrospective analysis of the TRIBE study by Gono

Author

Dell' Aquila, Emanuela, primary, Cremolini, Chiara, additional, Zeppola, Tea, additional, Lonardi, Sara, additional, Bergamo, Francesca, additional, Moretto, Roberto, additional, Stellato, Marco, additional, Marmorino, Federica, additional, Battaglin, Francesca, additional, Cortesi, Enrico, additional, Ronzoni, Monica, additional, Tomasello, Gianluca, additional, Zaniboni, Alberto, additional, Racca, Patrizia, additional, Buonadonna, Angela, additional, Allegrini, Giacomo, additional, Fea, Elena, additional, Di Donato, Samantha, additional, Chiara, Silvana, additional, Tonini, Giuseppe, additional, Falcone, Alfredo, additional, and Santini, Daniele, additional

Published
2017
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49. Tailoring chemotherapy supply according to patients' preferences: a quantitative method in colorectal cancer care.

Author

Rosato, Rosalba, Di Cuonzo, Daniela, Ritorto, Giuliana, Fanchini, Laura, Bustreo, Sara, Racca, Patrizia, and Pagano, Eva

Subjects
DISCRETE choice models, COLORECTAL cancer, QUANTITATIVE research, PHYSICIANS, PATIENT satisfaction, CANCER chemotherapy, FOCUS groups, QUALITY of life, DECISION making, LONGITUDINAL method
Abstract

Objectives: The aim of this study was to conduct a discrete choice experiment with patients affected by colorectal cancer to understand their preferences for different attributes of the chemotherapy supply. Our overall goal is to provide evidence on the relative importance of each attribute in order to tailor chemotherapy supply according to patients' priorities in the design or reorganization processes of cancer services.Methods: Focus groups were used to identify the attributes and levels for the discrete choice experiment. The attributes were: continuity of care, understanding, information, treatment choice, and time for therapy. Respondents were asked to choose between two mutually exclusive hypothetical alternatives of chemotherapy supply. Patients completed the discrete choice experiment along with the health-related quality of life and patients' satisfaction questions. Conditional and mixed logistic models were used to analyses the data.Results: Patients with colorectal cancer treated with chemotherapy (n = 76) completed the survey. The most important aspects of chemotherapy supply were: "Providing detailed and complete information" and "High ability in understanding" patients. Preferences were also influenced by the availability of a trusted doctor. Except for one attribute (waiting time for therapy), all other characteristics significantly influenced respondents' preferences.Conclusions: Results should support a policy of strengthening medical doctors' capabilities to communicate with patients, providing them complete information and involving them in the clinical decisions. Specifically, the findings should be used to improve the current provision of cancer care by identifying areas of preferred intervention from the perspectives of patients in order to tailor the service supply accordingly. [ABSTRACT FROM AUTHOR]

Published
2020
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