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1. Smartphone-Based Physical Activity Telecoaching in Chronic Obstructive Pulmonary Disease: Mixed-Methods Study on Patient Experiences and Lessons for Implementation

Author

Loeckx, Matthias, Rabinovich, Roberto A, Demeyer, Heleen, Louvaris, Zafeiris, Tanner, Rebecca, Rubio, Noah, Frei, Anja, De Jong, Corina, Gimeno-Santos, Elena, Rodrigues, Fernanda M, Buttery, Sara C, Hopkinson, Nicholas S, Büsching, Gilbert, Strassmann, Alexandra, Serra, Ignasi, Vogiatzis, Ioannis, Garcia-Aymerich, Judith, Polkey, Michael I, and Troosters, Thierry

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundTelecoaching approaches can enhance physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD). However, their effectiveness is likely to be influenced by intervention-specific characteristics. ObjectiveThis study aimed to assess the acceptability, actual usage, and feasibility of a complex PA telecoaching intervention from both patient and coach perspectives and link these to the effectiveness of the intervention. MethodsWe conducted a mixed-methods study based on the completers of the intervention group (N=159) included in an (effective) 12-week PA telecoaching intervention. This semiautomated telecoaching intervention consisted of a step counter and a smartphone app. Data from a project-tailored questionnaire (quantitative data) were combined with data from patient interviews and a coach focus group (qualitative data) to investigate patient and coach acceptability, actual usage, and feasibility of the intervention. The degree of actual usage of the smartphone and step counter was also derived from app data. Both actual usage and perception of feasibility were linked to objectively measured change in PA. ResultsThe intervention was well accepted and perceived as feasible by all coaches present in the focus group as well by patients, with 89.3% (142/159) of patients indicating that they enjoyed taking part. Only a minority of patients (8.2%; 13/159) reported that they found it difficult to use the smartphone. Actual usage of the step counter was excellent, with patients wearing it for a median (25th-75th percentiles) of 6.3 (5.8-6.8) days per week, which did not change over time (P=.98). The smartphone interface was used less frequently and actual usage of all daily tasks decreased significantly over time (P

Published
2018
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2. Greater male variability in daily energy expenditure develops through puberty.

Author

Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty, Kimura, Misaka, Kraus, William, Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert, Lambert, Estelle, Lanerolle, Pulani, Larsson, Christel, Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin, Morehen, James, Morton, James, Must, Aviva, Neuheuser, Marian, Nicklas, Theresa, Ojiambo, Robert, Pietilainen, Kirsi, Pitsiladis, Yannis, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross, Rabinovich, Roberto, Racette, Susan, Raichen, David, Ravussin, Eric, Redman, Leanne, Reilly, John, Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer, Samaranayake, Dulani, Sardinha, Luís, Scuitt, Albertine, Silva, Analiza, Sinha, Srishti, Sjödin, Anders, Stice, Eric, Stunkard, Albert, Urlacher, Samuel, Valencia, Mauro, Valenti, Giulio, van Etten, Ludo, Van Mil, Edgar, Verbunt, Jeanine, Wells, Jonathan, Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Sagayama, Hiroyuki, Westerterp, Klaas, Wong, William, Yamada, Yosuke, Speakman, John, Halsey, Lewis, Careau, Vincent, Ainslie, Philip, Alemán-Mateo, Heliodoro, Andersen, Lene, Anderson, Liam, Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn, Bovet, Pascal, Brage, Soren, Buchowski, Maciej, Butte, Nancy, Camps, Stephan, Casper, Regian, Close, Graeme, Colbert, Lisa, Cooper, Jamie, Cooper, Richard, Dabare, Prasangi, Das, Sai, Davies, Peter, Deb, Sanjoy, and Nyström, Christine

Subjects
age, height, inter-individual variation, morphometry, weight, Adolescent, Young Adult, Female, Humans, Male, Adult, Puberty, Sexual Behavior, Reproduction, Energy Metabolism, Phenotype
Abstract

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass. Total EE, and to some degree also activity EE, exhibit considerable greater male variation (GMV) in young adults, and then a decreasing GMV in progressively older individuals. Arguably, basal EE, and also morphometrics, do not exhibit this pattern. These findings suggest that single male sexual characteristics may not exhibit peak GMV in young adulthood, however total and perhaps also activity EE, associated with many morphological and physiological traits combined, do exhibit GMV most prominently during the reproductive life stages.

Published
2023

3. Variation in human water turnover associated with environmental and lifestyle factors

Author

Yamada, Yosuke, Zhang, Xueying, Henderson, Mary ET, Sagayama, Hiroyuki, Pontzer, Herman, Watanabe, Daiki, Yoshida, Tsukasa, Kimura, Misaka, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Close, Graeme L, Cooper, Jamie A, Cooper, Richard, Das, Sai Krupa, Dugas, Lara R, Eaton, Simon, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Halsey, Lewis G, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kraus, William E, Kriengsinyos, Wantanee, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Redman, Leanne M, Reilly, John J, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sardinha, Luis B, Silva, Analiza M, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack A, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Westerterp, Klaas R, Wong, William W, Miyachi, Motohiko, Schoeller, Dale A, Speakman, John R, and Consortium§, International Atomic Energy Agency Doubly Labeled Water Database

Subjects
Prevention, Clean Water and Sanitation, Female, Humans, Pregnancy, Exercise, Humidity, Life Style, Social Class, Water, Infant, Newborn, Infant, Child, Preschool, Child, Adolescent, Young Adult, Adult, Middle Aged, Aged, Aged, 80 and over, Drinking, International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium§, General Science & Technology
Abstract

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

Published
2022

4. Variability in energy expenditure is much greater in males than females

Author

Halsey, Lewis G, Careau, Vincent, Pontzer, Herman, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Yamada, Yosuke, and Speakman, John R

Subjects
Obesity, Behavioral and Social Science, Affordable and Clean Energy, Adult, Aged, Aging, Animals, Body Composition, Energy Metabolism, Female, Humans, Male, Mammals, Reproduction, Sex Characteristics, DLW, Energetics, Activity, Trait variability, Biological sex, Evolutionary Biology, Anthropology, Archaeology
Abstract

In mammals, trait variation is often reported to be greater among males than females. However, to date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behavioral traits. Energy expenditure could exhibit particularly high greater male variation through a cumulative effect if those traits mostly exhibit greater male variation, or a lack of greater male variation if many of them do not. Sex differences in energy expenditure variation have been little explored. We analyzed a large database on energy expenditure in adult humans (1494 males and 3108 females) to investigate whether humans have evolved sex differences in the degree of interindividual variation in energy expenditure. We found that, even when statistically comparing males and females of the same age, height, and body composition, there is much more variation in total, activity, and basal energy expenditure among males. However, with aging, variation in total energy expenditure decreases, and because this happens more rapidly in males, the magnitude of greater male variation, though still large, is attenuated in older age groups. Considerably greater male variation in both total and activity energy expenditure could be explained by greater male variation in levels of daily activity. The considerably greater male variation in basal energy expenditure is remarkable and may be explained, at least in part, by greater male variation in the size of energy-demanding organs. If energy expenditure is a trait that is of indirect interest to females when choosing a sexual partner, this would suggest that energy expenditure is under sexual selection. However, we present a novel energetics model demonstrating that it is also possible that females have been under stabilizing selection pressure for an intermediate basal energy expenditure to maximize energy available for reproduction.

Published
2022

5. Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Author

Zhang, Xueying, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Blaak, Ellen E, Buchowski, Maciej S, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Dugas, Lara R, Gurven, Michael, Hamdouchi, Asmaa El, Hu, Sumei, Joonas, Noorjehan, Katzmarzyk, Peter, Kraus, William E, Kushner, Robert F, Leonard, William R, Martin, Corby K, Meijer, Erwin P, Neuhouser, Marian L, Ojiambo, Robert M, Pitsiladis, Yannis P, Plasqui, Guy, Prentice, Ross L, Racette, Susan B, Ravussin, Eric, Redman, Leanne M, Reynolds, Rebecca M, Roberts, Susan B, Sardinha, Luis B, Silva, Analiza M, Stice, Eric, Urlacher, Samuel S, Van Mil, Edgar A, Wood, Brian M, Murphy-Alford, Alexia J, Loechl, Cornelia, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Pontzer, Herman, Speakman, John R, consortium, the IAEA DLW database, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Addo, Bedu, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn VC, Bovet, Pascal, Branth, Stefan, De Bruin, Niels C, Butte, Nancy F, Colbert, Lisa H, Camps, Stephan G, Dutman, Alice E, Eaton, Simon D, Ekelund, Ulf, Entringer, Sonja, Ebbeling, Cara, Elmståhl, Sölve, Fogelholm, Mikael, Forrester, Terrence, Fudge, Barry W, Harris, Tamara, Heijligenberg, Rik, Goris, Annelies H, Hambly, Catherine, Hoos, Marije B, Jorgensen, Hans U, Joosen, Annemiek M, Kempen, Kitty P, Kimura, Misaka, Kriengsinyos, Watanee, Lambert, Estelle V, Larsson, Christel L, Lessan, Nader, Ludwig, David S, McCloskey, Margaret, Medin, Anine C, Meijer, Gerwin A, Matsiko, Eric, Melse-Boonstra, Alida, Morehen, James C, Morton, James P, Nicklas, Theresa A, Pannemans, Daphne L, Pietiläinen, Kirsi H, Philippaerts, Renaat M, Rabinovich, Roberto A, Reilly, John J, Rothenberg, Elisabet M, Schuit, Albertine J, Schulz, Sabine, and Sjödin, Anders M

Subjects
Nutrition, IAEA DLW database consortium, Human Physiology, Human activity in medical context, Human metabolism
Abstract

Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW database for adults in the USA (n = 3213) to determine the effect of Ta (-10 to +30°C) on TEE, basal (BEE) and activity energy expenditure (AEE) and physical activity level (PAL). There were no significant relationships (p > 0.05) between maximum, minimum and average Ta and TEE, BEE, AEE and PAL. After adjustment for fat-free mass, fat mass and age, statistically significant (p

Published
2022

6. Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Author

Rimbach, Rebecca, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Anderson, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Speakman, John R, and Pontzer, Herman

Subjects
Nutrition, Pediatric, Clinical Research, Obesity, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Adipose Tissue, Adult, Bayes Theorem, Body Composition, Child, Databases, Factual, Energy Metabolism, Female, Humans, Isotope Labeling, Longitudinal Studies, Male, Middle Aged, Water, Weight Gain, IAEA DLW Database Consortium
Abstract

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.

Published
2022

7. Physical activity and fat-free mass during growth and in later life

Author

Westerterp, Klaas R, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai K, Cooper, Richard, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A, Wong, William W, Speakman, John R, Branth, Stefan, Colbert, Lisa H, De Bruin, Niels C, Dutman, Alice E, Elmståhl, Sölve, Fogelholm, Mikael, Harris, Tamara, Heijligenberg, Rik, Jorgensen, Hans U, Larsson, Christel L, Rothenberg, Elisabet M, McCloskey, Margaret, Meijer, Gerwin A, Pannemans, Daphne L, Schulz, Sabine, Van den Berg-Emons, Rita, Van Gemert, Wim G, and Wilhelmine, W

Subjects
Prevention, Aging, Clinical Research, Nutrition, Adipose Tissue, Adolescent, Adult, Aged, Aged, 80 and over, Body Composition, Child, Child, Preschool, Cross-Sectional Studies, Energy Metabolism, Exercise, Female, Humans, Male, Middle Aged, Young Adult, physical activity level, age, energy expenditure, body composition, doubly labeled water, International Atomic Energy Agency Doubly Labeled Water database group, Engineering, Medical and Health Sciences, Nutrition & Dietetics
Abstract

BackgroundPhysical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass.ObjectivesA study is presented of the association between FFM and physical activity in relation to age.MethodsIn a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution.ResultsPAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males

Published
2021

8. Energy compensation and adiposity in humans

Author

Careau, Vincent, Halsey, Lewis G, Pontzer, Herman, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Eaton, Simon D, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reilly, John J, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A, Wong, William W, Yamada, Yosuke, Speakman, John R, and group, the IAEA DLW database

Subjects
Nutrition, Obesity, Clinical Research, Oral and gastrointestinal, Stroke, Metabolic and endocrine, Cancer, Cardiovascular, Affordable and Clean Energy, Adiposity, Energy Intake, Energy Metabolism, Humans, IAEA DLW database group, Homo sapiens, activity, basal metabolic rate, daily energy expenditure, energy compensation, energy management models, exercise, trade-offs, weight loss, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology
Abstract

Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.1-3 This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response-energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories we burn from additional activity translates into extra calories burned that day. Moreover, the degree of energy compensation varied considerably between people of different body compositions. This association between compensation and adiposity could be due to among-individual differences in compensation: people who compensate more may be more likely to accumulate body fat. Alternatively, the process might occur within individuals: as we get fatter, our body might compensate more strongly for the calories burned during activity, making losing fat progressively more difficult. Determining the causality of the relationship between energy compensation and adiposity will be key to improving public health strategies regarding obesity.

Published
2021

9. Daily energy expenditure through the human life course

Author

Pontzer, Herman, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Close, Graeme L, Cooper, Jamie A, Cooper, Richard, Das, Sai Krupa, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marjije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Teresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia, Luke, Amy H, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, Speakman, John R, and Consortium§, IAEA DLW Database

Subjects
Aging, Nutrition, Adolescent, Adult, Aged, Aged, 80 and over, Basal Metabolism, Body Composition, Body Weight, Child, Child, Preschool, Energy Metabolism, Exercise, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Pregnancy, Young Adult, IAEA DLW Database Consortium, General Science & Technology
Abstract

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Published
2021

10. A standard calculation methodology for human doubly labeled water studies.

Author

Speakman, John R, Yamada, Yosuke, Sagayama, Hiroyuki, Berman, Elena SF, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan GJA, Close, Graeme L, Cooper, Jamie A, Creasy, Seth A, Das, Sai Krupa, Cooper, Richard, Dugas, Lara R, Ebbeling, Cara B, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Ludwig, David S, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan CK, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Melanson, Edward L, Luke, Amy H, Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A, Westerterp, Klaas R, Wong, William W, and IAEA DLW database group

Subjects
IAEA DLW database group, doubly labeled water, free-living, total energy expenditure, validation
Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (

Published
2021

12. ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases

Author

Radtke, Thomas, Crook, Sarah, Kaltsakas, Georgios, Louvaris, Zafeiris, Berton, Danilo, Urquhart, Don S, Kampouras, Asterios, Rabinovich, Roberto A, Verges, Samuel, Kontopidis, Dimitris, Boyd, Jeanette, Tonia, Thomy, Langer, Daniel, De Brandt, Jana, Goërtz, Yvonne MJ, Burtin, Chris, Spruit, Martijn A, Braeken, Dionne CW, Dacha, Sauwaluk, Franssen, Frits ME, Laveneziana, Pierantonio, Eber, Ernst, Troosters, Thierry, Neder, J Alberto, Puhan, Milo A, Casaburi, Richard, Vogiatzis, Ioannis, and Hebestreit, Helge

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Clinical Research, Respiratory, Chronic Disease, Clinical Protocols, Europe, Exercise Test, Humans, Lung Diseases, Medical Physiology, Respiratory System, Cardiovascular medicine and haematology
Abstract

The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects. This document: 1) summarises the protocols and procedures used in published studies focusing on incremental CPET in chronic lung conditions; 2) presents standard incremental protocols for CPET on a stationary cycle ergometer and a treadmill; and 3) provides patients' perspectives on CPET obtained through an online survey supported by the European Lung Foundation. We systematically reviewed published studies obtained from EMBASE, Medline, Scopus, Web of Science and the Cochrane Library from inception to January 2017. Of 7914 identified studies, 595 studies with 26 523 subjects were included. The literature supports a test protocol with a resting phase lasting at least 3 min, a 3-min unloaded phase, and an 8- to 12-min incremental phase with work rate increased linearly at least every minute, followed by a recovery phase of at least 2-3 min. Patients responding to the survey (n=295) perceived CPET as highly beneficial for their diagnostic assessment and informed the Task Force consensus. Future research should focus on the individualised estimation of optimal work rate increments across different lung diseases, and the collection of robust normative data.

Published
2019

13. Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Author

Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issad, Addo, Bedu, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn V.C., Bovet, Pascal, Branth, Stefan, De Bruin, Niels C., Butte, Nancy F., Colbert, Lisa H., Camps, Stephan G., Dutman, Alice E., Eaton, Simon D., Ekelund, Ulf, Entringer, Sonja, Ebbeling, Cara, Elmståhl, Sölve, Fogelholm, Mikael, Forrester, Terrence, Fudge, Barry W., Harris, Tamara, Heijligenberg, Rik, Goris, Annelies H., Hambly, Catherine, Hoos, Marije B., Jorgensen, Hans U., Joosen, Annemiek M., Kempen, Kitty P., Kimura, Misaka, Kriengsinyos, Watanee, Lambert, Estelle V., Larsson, Christel L., Lessan, Nader, Ludwig, David S., McCloskey, Margaret, Medin, Anine C., Meijer, Gerwin A., Matsiko, Eric, Melse-Boonstra, Alida, Morehen, James C., Morton, James P., Nicklas, Theresa A., Pannemans, Daphne L., Pietiläinen, Kirsi H., Philippaerts, Renaat M., Rabinovich, Roberto A., Reilly, John J., Rothenberg, Elisabet M., Schuit, Albertine J., Schulz, Sabine, Sjödin, Anders M., Subar, Amy, Tanskanen, Minna, Uauy, Ricardo, Valenti, Giulio, Van Etten, Ludo M., Berg-Emons, Rita Van den, Van Gemert, Wim G., Velthuis-te Wierik, Erica J., Verboeket-van de Venne, Wilhelmine W., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Zhang, Xueying, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N., Blaak, Ellen E., Buchowski, Maciej S., Close, Graeme L., Cooper, Jamie A., Das, Sai Krupa, Dugas, Lara R., Gurven, Michael, El Hamdouchi, Asmaa, Hu, Sumei, Joonas, Noorjehan, Katzmarzyk, Peter, Kraus, William E., Kushner, Robert F., Leonard, William R., Martin, Corby K., Meijer, Erwin P., Neuhouser, Marian L., Ojiambo, Robert M., Pitsiladis, Yannis P., Plasqui, Guy, Prentice, Ross L., Racette, Susan B., Ravussin, Eric, Redman, Leanne M., Reynolds, Rebecca M., Roberts, Susan B., Sardinha, Luis B., Silva, Analiza M., Stice, Eric, Urlacher, Samuel S., Van Mil, Edgar A., Wood, Brian M., Murphy-Alford, Alexia J., Loechl, Cornelia, Luke, Amy H., Rood, Jennifer, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W., Pontzer, Herman, and Speakman, John R.

Published
2022
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15. Patterns of Physical Activity Progression in Patients With COPD

Author

Arbillaga-Etxarri, Ane, Benet, Marta, Delgado, Anna, Garcia-Aymerich, Judith, Gimeno-Santos, Elena, Torrent-Pallicer, Jaume, Vilaró, Jordi, Barberan-Garcia, Anael, Rodriguez-Roisín, Robert, Balcells, Eva, Chiaradía, Diego A Rodríguez, Marín, Alicia, Ortega, Pilar, Celorrio, Nuria, Monteagudo, Mónica, Montellà, Nuria, Muñoz, Laura, Toran, Pere, Simonet, Pere, Janèc), Carme, Martín-Cantera, Carlos, Borrell, Eulàlia, Vall-Casas, Pere, Ivanoff, Nathalie, Karlsson, Niklas, Corriol-Rohou, Solange, Jarrod, Ian, Erzen, Damijen, Brindicci, Caterina, Higenbottam, Tim, Scuri, Mario, McBride, Paul, Kamel, Nadia, Tabberer, Margaret, Troosters, Thierry, Dobbels, Fabienne, de Boer, Pim, Kulich, Karoly, Glendenning, Alastair, Rudell, Katja, Wilson, Frederick J., Polkey, Michael I., Hopkinson, Nick S., Vogiatzis, Ioannis, Nikai, Enkeleida, van der Molen, Thys, De Jong, Corina, Rabinovich, Roberto A., MacNee, Bill, Puhan, Milo A., Frei, Anja, Koreny, Maria, Demeyer, Heleen, Hopkinson, Nicholas S., Louvaris, Zafeiris, and Rodríguez-Roisin, Robert

Published
2021
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16. Physiological response during activity programs using Wii-based video games in patients with cystic fibrosis (CF)

Author

Del Corral Núñez-Flores, Tamara, Percegona, Janaína, Seborga, Melisa, Rabinovich, Roberto A, Vilaró, Jordi, Del Corral Núñez-Flores, Tamara, Percegona, Janaína, Seborga, Melisa, Rabinovich, Roberto A, and Vilaró, Jordi

Abstract

Patients with cystic fibrosis (CF) are characterized by an abnormal ventilation response that limits the exercise capacity. Exercise training increases exercise capacity, decreases dyspnea and improves health-related quality of life in CF. Adherence to pulmonary rehabilitation programs is a key factor to guarantee optimal benefits and a difficult goal in this population. The aim of this study was to determine the physiological response during three Nintendo Wii™ video game activities (VGA) candidates to be used as training modalities in patients with CF. Method: 24 CF patients (age 12.6 ± 3.7 years; BMI 18.8 ± 2.9 kg m−2; FEV1 93.8 ± 18.8 %pred) were included. All participants performed, on two separate days, 3 different VGA: 1) Wii Fit Plus (Wii-Fit); 2) Wii Active (Wii-Acti), and 3) Wii Family Trainer (Wii-Train), in random order during 5 min. The obtained results were compared with the 6-min walk test (6MWT). The physiological variables [oxygen uptake (VO2), minute ventilation (VE), and heart rate (HR)] were recorded using a portable metabolic analyzer. Results: During all VGA and 6MWT, VO2 reached a plateau from the 3rd min. Compared with the 6MWT (1024.2 ± 282.2 mL m−1), Wii-Acti (1232.2 ± 427.2 mL m−1) and Wii-Train (1252.6 ± 360.2 mL m−1) reached higher VO2 levels during the last 3 min (p b 0.0001 in both cases), while Wii-Fit (553.8 ± 113.2 mL m−1) reached significantly lower levels of VO2 (p b 0.001). Similar effects were seen for the ventilatory volume (VE). No differences in dyspnea and oxygen saturation were seen between the different modalities. All patients were compliant with all three Wii™ modalities. Conclusion: Active video game are well tolerated by patients with CF. All the modalities evaluated imposed a constant load but were associated with different physiological responses reflecting the different intensities imposed. Wii-Acti and Wii-Train impose a significantly high metabolic demand comparable to the 6MWT. Further research is needed to evalu, Depto. de Radiología, Rehabilitación y Fisioterapia, Fac. de Enfermería, Fisioterapia y Podología, TRUE, pub

Published
2024

17. Real-world walking cadence in people with COPD

Author

Delgado-Ortiz, Laura, primary, Ranciati, Saverio, additional, Arbillaga-Etxarri, Ane, additional, Balcells, Eva, additional, Buekers, Joren, additional, Demeyer, Heleen, additional, Frei, Anja, additional, Gimeno-Santos, Elena, additional, Hopkinson, Nicholas S., additional, de Jong, Corina, additional, Karlsson, Niklas, additional, Louvaris, Zafeiris, additional, Palmerini, Luca, additional, Polkey, Michael I., additional, Puhan, Milo A., additional, Rabinovich, Roberto A., additional, Rodríguez Chiaradia, Diego A., additional, Rodriguez-Roisin, Robert, additional, Toran-Montserrat, Pere, additional, Vogiatzis, Ioannis, additional, Watz, Henrik, additional, Troosters, Thierry, additional, and Garcia-Aymerich, Judith, additional

Published
2024
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18. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement

Author

Puente-Maestu, Luis, Palange, Paolo, Casaburi, Richard, Laveneziana, Pierantonio, Maltais, François, Neder, J Alberto, O'Donnell, Denis E, Onorati, Paolo, Porszasz, Janos, Rabinovich, Roberto, Rossiter, Harry B, Singh, Sally, Troosters, Thierry, and Ward, Susan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Respiratory, Advisory Committees, Breath Tests, Carbon Dioxide, Dyspnea, Europe, Exercise Test, Exercise Tolerance, Humans, Hypertension, Pulmonary, Inspiratory Capacity, Outcome Assessment, Health Care, Oxygen Consumption, Pulmonary Disease, Chronic Obstructive, Pulmonary Medicine, Pulmonary Ventilation, Reproducibility of Results, Respiratory Tract Diseases, Societies, Medical, Walking, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology
Abstract

This document reviews 1) the measurement properties of commonly used exercise tests in patients with chronic respiratory diseases and 2) published studies on their utilty and/or evaluation obtained from MEDLINE and Cochrane Library searches between 1990 and March 2015.Exercise tests are reliable and consistently responsive to rehabilitative and pharmacological interventions. Thresholds for clinically important changes in performance are available for several tests. In pulmonary arterial hypertension, the 6-min walk test (6MWT), peak oxygen uptake and ventilation/carbon dioxide output indices appear to be the variables most responsive to vasodilators. While bronchodilators do not always show clinically relevant effects in chronic obstructive pulmonary disease, high-intensity constant work-rate (endurance) tests (CWRET) are considerably more responsive than incremental exercise tests and 6MWTs. High-intensity CWRETs need to be standardised to reduce interindividual variability. Additional physiological information and responsiveness can be obtained from isotime measurements, particularly of inspiratory capacity and dyspnoea. Less evidence is available for the endurance shuttle walk test. Although the incremental shuttle walk test and 6MWT are reliable and less expensive than cardiopulmonary exercise testing, two repetitions are needed at baseline. All exercise tests are safe when recommended precautions are followed, with evidence suggesting that no test is safer than others.

Published
2016

19. Assessment of Limb Muscle Function

Author

Rabinovich, Roberto A., Bui, Kim-Ly, Nyberg, André, Saey, Didier, Maltais, François, Clini, Enrico, editor, Holland, Anne E., editor, Pitta, Fabio, editor, and Troosters, Thierry, editor

Published
2018
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21. Clinical validation of real-world walking cadence in patients with COPD

Author

Delgado Ortiz, Laura, primary, Ranciati, Saverio, additional, Arbillaga-Etxarri, Ane, additional, Balcells, Eva, additional, Buekers, Joren, additional, Demeyer, Heleen, additional, Frei, Anja, additional, Gimeno-Santos, Elena, additional, Hopkinson, Nicholas S., additional, De Jong, Corina, additional, Karlsson, Niklas, additional, Palmerini, Luca, additional, Polkey, Michael I., additional, Puhan, Milo A., additional, Rabinovich, Roberto, additional, Rodríguez Chiaradia, Diego, additional, Rodriguez-Roisin, Robert, additional, Toran, Pere, additional, Vogiatzis, Ioannis, additional, Watz, Henrik, additional, Troosters, Thierry, additional, and Garcia-Aymerich, Judith, additional

Published
2023
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26. Pulmonary rehabilitation and physical interventions

Author

Troosters, Thierry, Janssens, Wim, Demeyer, Heleen, and Rabinovich, Roberto A

Subjects
Pulmonary Disease, Chronic Obstructive, Exercise Tolerance, Humans, Lung, Exercise, Exercise Therapy
Abstract

Pulmonary rehabilitation has established a status of evidence-based therapy for patients with symptomatic COPD in the stable phase and after acute exacerbations. Rehabilitation should have the possibility of including different disciplines and be offered in several formats and lines of healthcare. This review focusses on the cornerstone intervention, exercise training, and how training interventions can be adapted to the limitations of patients. These adaptations may lead to altered cardiovascular or muscular training effects and/or may improve movement efficiency. Optimising pharmacotherapy (not the focus of this review) and oxygen supplements, whole-body low- and high-intensity training or interval training, and resistance (or neuromuscular electrical stimulation) training are important training modalities for these patients in order to accommodate cardiovascular and ventilatory impairments. Inspiratory muscle training and whole-body vibration may also be worthwhile interventions in selected patients. Patients with stable but symptomatic COPD, those who have suffered exacerbations and patients waiting for or who have received lung volume reduction or lung transplantation are good candidates. The future surely holds promise to further personalise exercise training interventions and to tailor the format of rehabilitation to the individual patient's needs and preferences. ispartof: Eur Respir Rev vol:32 issue:168 pages:220222- ispartof: location:England status: Published online

Published
2023

27. Greater male variability in daily energy expenditure develops through puberty

Author

Halsey, Lewis G., Careau, Vincent, Ainslie, Philip N., Alemán-Mateo, Heliodoro, Andersen, Lene F., Anderson, Liam J., Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Brage, Soren, Buchowski, Maciej S., Butte, Nancy, Camps, Stephan G., Casper, Regian, Close, Graeme L., Colbert, Lisa H., Cooper, Jamie A., Cooper, Richard, Dabare, Prasangi, Das, Sai Krupa, Davies, Peter S.W., Deb, Sanjoy, Nyström, Christine Delisle, Dietz, William, Dugas, Lara R., Eaton, Simon, Ekelund, Ulf, Hamdouchi, Asmaa El, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Gillingham, Melanie, Goris, Annelies H., Gurven, Michael, Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert F., Lambert, Estelle V., Lanerolle, Pulani, Larsson, Christel L., Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin A., Morehen, James C., Morton, James P., Must, Aviva, Neuheuser, Marian, Nicklas, Theresa A., Ojiambo, Robert M., Pietilainen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto, Racette, Susan B., Raichen, David A., Ravussin, Eric, Redman, Leanne, Reilly, John J., Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer C., Samaranayake, Dulani, Sardinha, Luís B., Scuitt, Albertine J., Silva, Analiza M., Sinha, Srishti, Sjödin, Anders M., Stice, Eric, Stunkard, Albert, Urlacher, Samuel S., Valencia, Mauro Eduardo, Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Rood, Jennifer, Sagayama, Hiroyuki, Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, Speakman, John R., Halsey, Lewis G., Careau, Vincent, Ainslie, Philip N., Alemán-Mateo, Heliodoro, Andersen, Lene F., Anderson, Liam J., Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Brage, Soren, Buchowski, Maciej S., Butte, Nancy, Camps, Stephan G., Casper, Regian, Close, Graeme L., Colbert, Lisa H., Cooper, Jamie A., Cooper, Richard, Dabare, Prasangi, Das, Sai Krupa, Davies, Peter S.W., Deb, Sanjoy, Nyström, Christine Delisle, Dietz, William, Dugas, Lara R., Eaton, Simon, Ekelund, Ulf, Hamdouchi, Asmaa El, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Gillingham, Melanie, Goris, Annelies H., Gurven, Michael, Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert F., Lambert, Estelle V., Lanerolle, Pulani, Larsson, Christel L., Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin A., Morehen, James C., Morton, James P., Must, Aviva, Neuheuser, Marian, Nicklas, Theresa A., Ojiambo, Robert M., Pietilainen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto, Racette, Susan B., Raichen, David A., Ravussin, Eric, Redman, Leanne, Reilly, John J., Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer C., Samaranayake, Dulani, Sardinha, Luís B., Scuitt, Albertine J., Silva, Analiza M., Sinha, Srishti, Sjödin, Anders M., Stice, Eric, Stunkard, Albert, Urlacher, Samuel S., Valencia, Mauro Eduardo, Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Rood, Jennifer, Sagayama, Hiroyuki, Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, and Speakman, John R.

Abstract

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass. Total EE, and to some degree also activity EE, exhibit considerable greater male variation (GMV) in young adults, and then a decreasing GMV in progressively older individuals. Arguably, basal EE, and also morphometrics, do not exhibit this pattern. These findings suggest that single male sexual characteristics may not exhibit peak GMV in young adulthood, however total and perhaps also activity EE, associated with many morphological and physiological traits combined, do exhibit GMV most prominently during the reproductive life stages.

Published
2023

32. Variability in energy expenditure is much greater in males than females

Author

Halsey, Lewis G., primary, Careau, Vincent, additional, Pontzer, Herman, additional, Ainslie, Philip N., additional, Andersen, Lene F., additional, Anderson, Liam J., additional, Arab, Lenore, additional, Baddou, Issad, additional, Bedu-Addo, Kweku, additional, Blaak, Ellen E., additional, Blanc, Stephane, additional, Bonomi, Alberto G., additional, Bouten, Carlijn V.C., additional, Bovet, Pascal, additional, Buchowski, Maciej S., additional, Butte, Nancy F., additional, Camps, Stefan G.J.A., additional, Close, Graeme L., additional, Cooper, Jamie A., additional, Das, Sai Krupa, additional, Cooper, Richard, additional, Dugas, Lara R., additional, Ekelund, Ulf, additional, Entringer, Sonja, additional, Forrester, Terrence, additional, Fudge, Barry W., additional, Goris, Annelies H., additional, Gurven, Michael, additional, Hambly, Catherine, additional, Hamdouchi, Asmaa El, additional, Hoos, Marije B., additional, Hu, Sumei, additional, Joonas, Noorjehan, additional, Joosen, Annemiek M., additional, Katzmarzyk, Peter, additional, Kempen, Kitty P., additional, Kimura, Misaka, additional, Kraus, William E., additional, Kushner, Robert F., additional, Lambert, Estelle V., additional, Leonard, William R., additional, Lessan, Nader, additional, Martin, Corby K., additional, Medin, Anine C., additional, Meijer, Erwin P., additional, Morehen, James C., additional, Morton, James P., additional, Neuhouser, Marian L., additional, Nicklas, Theresa A., additional, Ojiambo, Robert M., additional, Pietiläinen, Kirsi H., additional, Pitsiladis, Yannis P., additional, Plange-Rhule, Jacob, additional, Plasqui, Guy, additional, Prentice, Ross L., additional, Rabinovich, Roberto A., additional, Racette, Susan B., additional, Raichlen, David A., additional, Ravussin, Eric, additional, Reynolds, Rebecca M., additional, Roberts, Susan B., additional, Schuit, Albertine J., additional, Sjödin, Anders M., additional, Stice, Eric, additional, Urlacher, Samuel S., additional, Valenti, Giulio, additional, Van Etten, Ludo M., additional, Van Mil, Edgar A., additional, Wilson, George, additional, Wood, Brian M., additional, Yanovski, Jack, additional, Yoshida, Tsukasa, additional, Zhang, Xueying, additional, Murphy-Alford, Alexia J., additional, Loechl, Cornelia U., additional, Luke, Amy H., additional, Rood, Jennifer, additional, Sagayama, Hiroyuki, additional, Schoeller, Dale A., additional, Westerterp, Klaas R., additional, Wong, William W., additional, Yamada, Yosuke, additional, and Speakman, John R., additional

Published
2022
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33. Effectiveness of home-based pulmonary rehabilitation: systematic review and meta-analysis

Author

Uzzaman, Md. Nazim, primary, Agarwal, Dhiraj, additional, Chan, Soo Chin, additional, Patrick Engkasan, Julia, additional, Habib, G.M. Monsur, additional, Hanafi, Nik Sherina, additional, Jackson, Tracy, additional, Jebaraj, Paul, additional, Khoo, Ee Ming, additional, Mirza, Fatim Tahirah, additional, Pinnock, Hilary, additional, Shunmugam, Ranita Hisham, additional, and Rabinovich, Roberto A., additional

Published
2022
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34. Evaluación de intervenciones durante la pandemia COVID-19: desarrollo de un modelo basado en subpoblaciones con distintas tasas de contacto

Author

Morando, Nicolás, Sanfilippo, Mauricio, Herrero, Francisco, Iturburu, Matías, Torti, Ariel, Gutson, Daniel, Pando, María A., and Rabinovich, Roberto Daniel

Subjects
Número básico dereproducción, SARS-CoV-2, Basic reproductionnumber, COVID-19, Argentina, Modelo, SEIR, Model
Abstract

Resumen Si bien se han realizado múltiples intentos de modelar matemáticamente la pande-mia de la enfermedad por coronavirus 2019 (COVID-19), causada por SARS-CoV-2, pocos modeloshan sido pensados como herramientas interactivas accesibles para usuarios de distintos ámbitos.El objetivo de este trabajo fue desarrollar un modelo que tuviera en cuenta la heterogeneidadde las tasas de contacto de la población e implementarlo en una aplicación accesible, que per-mitiera estimar el impacto de posibles intervenciones a partir de información disponible. Sedesarrolló una versión ampliada del modelo susceptible-expuesto-infectado-resistente (SEIR),denominada SEIR-HL, que asume una población dividida en dos subpoblaciones, con tasas decontacto diferentes. Asimismo, se desarrolló una fórmula para calcular el número básico dereproducción (R0) para una población dividida en n subpoblaciones, discriminando las tasas decontacto de cada subpoblación según el tipo o contexto de contacto. Se compararon las pre-dicciones del SEIR-HL con las del SEIR y se demostró que la heterogeneidad en las tasas decontacto puede afectar drásticamente la dinámica de las simulaciones, aun partiendo de lasmismas condiciones iniciales y los mismos parámetros. Se empleó el SEIR-HL para mostrar elefecto sobre la evolución de la pandemia del desplazamiento de individuos desde posiciones dealto contacto hacia posiciones de bajo contacto. Finalmente, a modo de ejemplo, se aplicó elSEIR-HL al análisis de la pandemia de COVID-19 en Argentina; también se desarrolló un ejemplode uso de la fórmula del R0. Tanto el SEIR-HL como una calculadora del R0fueron implementadosinformáticamente y puestos a disposición de la comunidad. Abstract Although multiple attempts have been made to mathematically model the currentepidemic of SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), fewmodels have been conceived as accessible interactive tools for users from various backgrounds.The goal of this study was to develop a model that took into account the heterogeneity incontact rates within the population and to implement it in an accessible application allowingto estimate the impact of possible interventions based on available information. An extendedversion of the Susceptible-Exposed-Infected-Resistant (SEIR) model, named SEIR-HL, was deve-loped, assuming a population divided into two subpopulations, with different contact rates.Additionally, a formula for the calculation of the basic reproduction number (R0) for a popula-tion divided into n subpopulations was proposed, where the contact rates for each subpopulationcan be distinguished according to contact type or context. The predictions made by SEIR-HLwere compared to those of SEIR, showing that the heterogeneity in contact rates can drama-tically affect the dynamics of simulations, even when run from the same initial conditions andwith the same parameters. SEIR-HL was used to predict the effect on the epidemic evolution ofthe displacement of individuals from high-contact positions to low-contact positions. Lastly, byway of example, SEIR-HL was applied to the analysis of the SARS-CoV-2 epidemic in Argentinaand an example of the application of the R0formula was also developed. Both the SEIR-HLmodel and an R0calculator were computerized and made available to the community.

Published
2022

35. Variability in energy expenditure is much greater in males than females

Author

Halsey, Lewis G., Careau, Vincent, Pontzer, Herman, Ainslie, Philip N., Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Buchowski, Maciej S., Butte, Nancy F., Camps, Stefan G.J.A., Close, Graeme L., Cooper, Jamie A., Das, Sai Krupa, Cooper, Richard, Dugas, Lara R., Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H., Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M., Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kushner, Robert F., Lambert, Estelle V., Leonard, William R., Lessan, Nader, Martin, Corby K., Medin, Anine C., Meijer, Erwin P., Morehen, James C., Morton, James P., Neuhouser, Marian L., Nicklas, Theresa A., Ojiambo, Robert M., Pietiläinen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto A., Racette, Susan B., Raichlen, David A., Ravussin, Eric, Reynolds, Rebecca M., Roberts, Susan B., Schuit, Albertine J., Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S., Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Wilson, George, Wood, Brian M., Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J., Loechl, Cornelia U., Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, Speakman, John R., Halsey, Lewis G., Careau, Vincent, Pontzer, Herman, Ainslie, Philip N., Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Buchowski, Maciej S., Butte, Nancy F., Camps, Stefan G.J.A., Close, Graeme L., Cooper, Jamie A., Das, Sai Krupa, Cooper, Richard, Dugas, Lara R., Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H., Gurven, Michael, Hambly, Catherine, Hamdouchi, Asmaa El, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M., Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kushner, Robert F., Lambert, Estelle V., Leonard, William R., Lessan, Nader, Martin, Corby K., Medin, Anine C., Meijer, Erwin P., Morehen, James C., Morton, James P., Neuhouser, Marian L., Nicklas, Theresa A., Ojiambo, Robert M., Pietiläinen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto A., Racette, Susan B., Raichlen, David A., Ravussin, Eric, Reynolds, Rebecca M., Roberts, Susan B., Schuit, Albertine J., Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S., Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Wilson, George, Wood, Brian M., Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J., Loechl, Cornelia U., Luke, Amy H, Rood, Jennifer, Sagayama, Hiroyuki, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, and Speakman, John R.

Abstract

In mammals, trait variation is often reported to be greater among males than females. However, to date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behavioral traits. Energy expenditure could exhibit particularly high greater male variation through a cumulative effect if those traits mostly exhibit greater male variation, or a lack of greater male variation if many of them do not. Sex differences in energy expenditure variation have been little explored. We analyzed a large database on energy expenditure in adult humans (1494 males and 3108 females) to investigate whether humans have evolved sex differences in the degree of interindividual variation in energy expenditure. We found that, even when statistically comparing males and females of the same age, height, and body composition, there is much more variation in total, activity, and basal energy expenditure among males. However, with aging, variation in total energy expenditure decreases, and because this happens more rapidly in males, the magnitude of greater male variation, though still large, is attenuated in older age groups. Considerably greater male variation in both total and activity energy expenditure could be explained by greater male variation in levels of daily activity. The considerably greater male variation in basal energy expenditure is remarkable and may be explained, at least in part, by greater male variation in the size of energy-demanding organs. If energy expenditure is a trait that is of indirect interest to females when choosing a sexual partner, this would suggest that energy expenditure is under sexual selection. However, we present a novel energetics model demonstrating that it is also possible that females have been under stabilizing selection pressure for an intermediate basal energy expenditure to maximize energy available for reproduction.

Published
2022

40. Clinical effectiveness and components of Home-pulmonary rehabilitation for people with chronic respiratory diseases: a systematic review protocol

Author

Uzzaman, Md Nazim, primary, Chan, Soo Chin, additional, Shunmugam, Ranita Hisham, additional, Engkasan, Julia Patrick, additional, Agarwal, Dhiraj, additional, Habib, G M Monsur, additional, Hanafi, Nik Sherina, additional, Jackson, Tracy, additional, Jebaraj, Paul, additional, Khoo, Ee Ming, additional, Liew, Su May, additional, Mirza, Fatim Tahirah, additional, Pinnock, Hilary, additional, and Rabinovich, Roberto A, additional

Published
2021
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42. Patterns of physical activity progression in patients with COPD

Author

Koreny, Maria, Demeyer, Heleen, Benet, Marta, Arbillaga-Etxarri, Ane, Balcells, Eva, Barberan-Garcia, Anael, Gimeno-Santos, Elena, Hopkinson, Nicholas S, De Jong, Corina, Karlsson, Niklas, Louvaris, Zafeiris, Polkey, Michael I, Puhan, Milo A, Rabinovich, Roberto A, Rodríguez-Roisin, Robert, Vall-Casas, Pere, Vogiatzis, Ioannis, Troosters, Thierry, Garcia-Aymerich, Judith, Delgado, Anna, Torrent-Pallicer, Jaume, Vilaró, Jordi, et al, University of Zurich, and Garcia-Aymerich, Judith

Subjects
2740 Pulmonary and Respiratory Medicine, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI)
Published
2021

44. A standard calculation methodology for human doubly labeled water studies

Author

Speakman, John R., Yamada, Yosuke, Sagayama, Hiroyuki, Berman, Elena S.f., Ainslie, Philip N., Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issaad, Bedu-addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.c., Bovet, Pascal, Buchowski, Maciej S., Butte, Nancy F., Camps, Stefan G.j.a., Close, Graeme L., Cooper, Jamie A., Creasy, Seth A., Das, Sai Krupa, Cooper, Richard, Dugas, Lara R., Ebbeling, Cara B., Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Goris, Annelies H., Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M., Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kushner, Robert F., Lambert, Estelle V., Leonard, William R., Lessan, Nader, Ludwig, David S., Martin, Corby K., Medin, Anine C., Meijer, Erwin P., Morehen, James C., Morton, James P., Neuhouser, Marian L., Nicklas, Theresa A., Ojiambo, Robert M., Pietiläinen, Kirsi H., Pitsiladis, Yannis P., Plange-rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto A., Racette, Susan B., Raichlen, David A., Ravussin, Eric, Reynolds, Rebecca M., Roberts, Susan B., Schuit, Albertine J., Sjödin, Anders M., Stice, Eric, Urlacher, Samuel S., Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Wells, Jonathan C.k., Wilson, George, Wood, Brian M., Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-alford, Alexia J., Loechl, Cornelia U., Melanson, Edward L., Luke, Amy H., Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W., Speakman, John R., Yamada, Yosuke, Sagayama, Hiroyuki, Berman, Elena S.f., Ainslie, Philip N., Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issaad, Bedu-addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.c., Bovet, Pascal, Buchowski, Maciej S., Butte, Nancy F., Camps, Stefan G.j.a., Close, Graeme L., Cooper, Jamie A., Creasy, Seth A., Das, Sai Krupa, Cooper, Richard, Dugas, Lara R., Ebbeling, Cara B., Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Goris, Annelies H., Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M., Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kushner, Robert F., Lambert, Estelle V., Leonard, William R., Lessan, Nader, Ludwig, David S., Martin, Corby K., Medin, Anine C., Meijer, Erwin P., Morehen, James C., Morton, James P., Neuhouser, Marian L., Nicklas, Theresa A., Ojiambo, Robert M., Pietiläinen, Kirsi H., Pitsiladis, Yannis P., Plange-rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto A., Racette, Susan B., Raichlen, David A., Ravussin, Eric, Reynolds, Rebecca M., Roberts, Susan B., Schuit, Albertine J., Sjödin, Anders M., Stice, Eric, Urlacher, Samuel S., Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Wells, Jonathan C.k., Wilson, George, Wood, Brian M., Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-alford, Alexia J., Loechl, Cornelia U., Melanson, Edward L., Luke, Amy H., Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A., Westerterp, Klaas R., and Wong, William W.

Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

Published
2021

46. Patterns of Physical Activity Progression in Patients With COPD

Author

Koreny, Maria, primary, Demeyer, Heleen, additional, Benet, Marta, additional, Arbillaga-Etxarri, Ane, additional, Balcells, Eva, additional, Barberan-Garcia, Anael, additional, Gimeno-Santos, Elena, additional, Hopkinson, Nicholas S., additional, De Jong, Corina, additional, Karlsson, Niklas, additional, Louvaris, Zafeiris, additional, Polkey, Michael I., additional, Puhan, Milo A., additional, Rabinovich, Roberto A., additional, Rodríguez-Roisin, Robert, additional, Vall-Casas, Pere, additional, Vogiatzis, Ioannis, additional, Troosters, Thierry, additional, Garcia-Aymerich, Judith, additional, Delgado, Anna, additional, Torrent-Pallicer, Jaume, additional, Vilaró, Jordi, additional, Rodriguez-Roisín, Robert, additional, Chiaradía, Diego A Rodríguez, additional, Marín, Alicia, additional, Ortega, Pilar, additional, Celorrio, Nuria, additional, Monteagudo, Mónica, additional, Montellà, Nuria, additional, Muñoz, Laura, additional, Toran, Pere, additional, Simonet, Pere, additional, Jané, Carme, additional, Martín-Cantera, Carlos, additional, Borrell, Eulàlia, additional, Ivanoff, Nathalie, additional, Corriol-Rohou, Solange, additional, Jarrod, Ian, additional, Erzen, Damijen, additional, Brindicci, Caterina, additional, Higenbottam, Tim, additional, Scuri, Mario, additional, McBride, Paul, additional, Kamel, Nadia, additional, Tabberer, Margaret, additional, Dobbels, Fabienne, additional, de Boer, Pim, additional, Kulich, Karoly, additional, Glendenning, Alastair, additional, Rudell, Katja, additional, Wilson, Frederick J., additional, Hopkinson, Nick S., additional, Nikai, Enkeleida, additional, van der Molen, Thys, additional, MacNee, Bill, additional, and Frei, Anja, additional

Published
2021
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47. Standardisation of cardiopulmonary exercise testing in chronic lung diseases: summary of key findings from the ERS task force

Author

Radtke, Thomas, Vogiatzis, Ioannis, Urquhart, Don S., Laveneziana, Pierantonio, Casaburi, Richard, Hebestreit, Helge, Crook, Sarah, Kaltsakas, Georgios, Louvaris, Zafeiris, Berton, Danilo C., Kampouras, Asterios, Rabinovich, Roberto A., Verges, Samuel, Kontopidis, Dimitris, Boyd, Jeanette, Tonia, Thomy, Langer, Daniel, De Brandt, Jana, Goertz, Yvonne M. J., Burtin, Chris, Spruit, Martijn A., Braeken, Dionne C. W., Dacha, Sauwaluk, Franssen, Frits M. E., Eber, Ernst, Troosters, Thierry, Neder, J. Alberto, Puhan, Milo A., University of Zurich, Hebestreit, Helge, Pulmonologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, and Afdeling Onderwijs FHML

Subjects
Lung Diseases, PROTOCOL, Pulmonary and Respiratory Medicine, medicine.medical_specialty, MEDLINE, 610 Medicine & health, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, 030212 general & internal medicine, Treadmill, Lung, RAMP, business.industry, Task force, Cardiopulmonary exercise, Cardiopulmonary exercise testing, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), C600, B900, Chronic disease, medicine.anatomical_structure, 030228 respiratory system, 2740 Pulmonary and Respiratory Medicine, Chronic Disease, Key (cryptography), Physical therapy, Exercise Test, business, TREADMILL
Abstract

The new ERS statement facilitates standardisation of conducting, reporting and interpreting cardiopulmonary exercise tests in chronic lung diseases. The conclusions are especially valuable for multicentre comparisons and for establishing global reference data.http://bit.ly/32Y0eO0

Published
2019

48. Validity and responsiveness of the Daily- and Clinical visit-PROactive Physical Activity in COPD (D-PPAC and C-PPAC) instruments

Author

Garcia-Aymerich, Judith, primary, Puhan, Milo A, additional, Corriol-Rohou, Solange, additional, de Jong, Corina, additional, Demeyer, Heleen, additional, Dobbels, Fabienne, additional, Erzen, Damijan, additional, Frei, Anja, additional, Gimeno-Santos, Elena, additional, Hopkinson, Nicholas S, additional, Ivanoff, Nathalie, additional, Karlsson, Niklas, additional, Louvaris, Zafeiris, additional, Polkey, Michael I, additional, Rabinovich, Roberto A, additional, Scuri, Mario, additional, Tabberer, Maggie, additional, Vogiatzis, Ioannis, additional, and Troosters, Thierry, additional

Published
2021
Full Text
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