42 results on '"Rabella, Nuria"'
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2. Titers of IgG and IgA against SARS-CoV-2 proteins and their association with symptoms in mild COVID-19 infection
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Abril, Andrés G., Alejandre, Jose, Mariscal, Anais, Alserawan, Leticia, Rabella, Nuria, Roman, Eva, Lopez-Contreras, Joaquin, Navarro, Ferran, Serrano, Elena, Nomdedeu, Josep F., and Vidal, Silvia
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- 2024
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3. Characteristics of enterovirus infection associated neurologic disease associated in a pediatric population in Spain
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Castillo, Fátima, Turón-Viñas, Eulàlia, Armendariz, Laura, Carbonell, Emma, Rabella, Nuria, del Cuerpo, Margarita, and Moliner, Elisenda
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- 2024
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4. Characteristics of enterovirus infection associated neurologic disease in a pediatric population in Spain
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Castillo, Fátima, Turón-Viñas, Eulàlia, Armendariz, Laura, Carbonell, Emma, Rabella, Nuria, del Cuerpo, Margarita, and Moliner, Elisenda
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- 2024
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5. Detection of reassortant influenza B strains from 2004 to 2015 seasons in Barcelona (Catalonia, Spain) by whole genome sequencing
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Andrés, Cristina, del Cuerpo, Margarita, Rabella, Núria, Piñana, Maria, Iglesias-Cabezas, Manuel Jesús, González-Sánchez, Alejandra, Esperalba, Juliana, Rando, Ariadna, Martín, Maria Carmen, Fuentes, Francisco, Rubio, Susana, Saubi, Narcís, Pumarola, Tomàs, and Antón, Andrés
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- 2023
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6. Viral culture and immunofluorescence for the detection of SARS-CoV-2 infectivity in RT-PCR positive respiratory samples
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Berengua, Carla, López, Marina, Esteban, Montserrat, Marín, Pilar, Ramos, Paula, Cuerpo, Margarita del, Gich, Ignasi, Navarro, Ferran, Miró, Elisenda, and Rabella, Núria
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- 2022
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7. Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study
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Simoes, Margarida Pires, primary, Hodcroft, Emma B, additional, Simmonds, Peter, additional, Albert, Jan, additional, Alidjinou, Enagon K, additional, Ambert-Balay, Katia, additional, Andrés, Cristina, additional, Antón, Andrés, additional, Auvray, Christelle, additional, Bailly, Jean-Luc, additional, Baldanti, Fausto, additional, Bastings, Capser, additional, Beard, Stuart, additional, Pereira, Carla Berengua, additional, Berginc, Natasa, additional, Bloemen, Mandy, additional, Blomqvist, Soile, additional, Bosma, Froukje, additional, Böttcher, Sindy, additional, Bubba, Laura, additional, Buderus, Stafan, additional, Cabrerizo, Maria, additional, Calvo, Christina, additional, Celma, Christina, additional, Ceriotti, Ferruccio, additional, Clark, Gemma, additional, Costa, Inës, additional, Coste-Burel, Marianne, additional, Couderé, Karen, additional, Cremer, Jeroen, additional, del Cuerpo Casas, Margarita, additional, Daehne, Theo, additional, de Beer, Jessica, additional, de Ceano-Vivas, Maria, additional, De Gascun, Cillian, additional, de Rougemont, Alexis, additional, Dean, Johnathan, additional, Dembinski, Jennifer L, additional, Diedrich, Sabine, additional, Diez-Domingo, Javier, additional, Dillner, Lena, additional, Dorenberg, Dagny H, additional, Ducancelle, Alexandra, additional, Dudman, Susanne, additional, Dyrdak, Robert, additional, Eis-Huebinger, Anna-Maria, additional, Falces-Romero, Iker, additional, Farkas, Agnes, additional, Feeney, Susan, additional, Fernandez-Garcia, Maria D, additional, Flipse, Jacky, additional, Franck, Kristina T, additional, Galli, Cristina, additional, Garrigue, Isabelle, additional, Geeraedts, Felix, additional, Georgieva, Irina, additional, Giardina, Federica, additional, Guiomar, Raquel, additional, Hauzenberger, Elenor, additional, Heikens, Esther, additional, Henquell, Cécille, additional, Hober, Didier, additional, Hönemann, Amrio, additional, Howson-Wells, Hannah, additional, Hruškar, Željka, additional, Ikonen, Niina, additional, Imbert, Berthemarie, additional, Jansz, Arjan R, additional, Jeannoël, Marion, additional, Jiřincová, Helena, additional, Josset, Laurence, additional, Keeren, Kathrin, additional, Kramer-Lindhout, Naomie, additional, Krokstad, Sidsel, additional, Lazrek, Mouna, additional, Le Guillou-Guillemette, Hélène, additional, Lefeuvre, Caroline, additional, Lind, Andreas, additional, Lunar, Maja M, additional, Maier, Melanie, additional, Marque-Juillet, Stéphanie, additional, McClure, C Patrick, additional, McKenna, James, additional, Meijer, Adam, additional, Menasalvas Ruiz, Ana, additional, Mengual-Chuliá, Beatriz, additional, Midgley, Sofie, additional, Mirand, Audrey, additional, Molenkamp, Richard, additional, Montes, Milagrosa, additional, Moreno-Docón, Antonio, additional, Morley, Ursula, additional, Murk, Jean-Luc, additional, Navascués-Ortega, Ana, additional, Nijhuis, Roel, additional, Nikolaeva-Glomb, Lubomira, additional, Nordbø, Svein A, additional, Numanovic, Sanela, additional, Oggioni, Massimo, additional, Oñate Vergara, Eider, additional, Pacaud, Jordi, additional, Pacreau, Marie L, additional, Panning, Marcus, additional, Pariani, Elena, additional, Pekova, Lili, additional, Pellegrinelli, Laura, additional, Petrovec, Miroslav, additional, Pietsch, Corinna, additional, Pilorge, Léa, additional, Piñeiro, Luis, additional, Piralla, Antonio, additional, Poljak, Mario, additional, Prochazka, Birgit, additional, Rabella, Nuria, additional, Rahamat-Langendoen, Janette C, additional, Rainetova, petra, additional, Reynders, Marijke, additional, Riezebos-Brilman, Annelies, additional, Roorda, Lieuwe, additional, Savolainen-Kopra, Carita, additional, Schuffenecker, Isabelle, additional, Smeets, Leo C, additional, Stoyanova, Ayse, additional, Stefic, Karl, additional, Swanink, Caroline, additional, Tabain, Irena, additional, Tjhie, Jeroen, additional, Thouault, Luc, additional, Tumiotto, Camille, additional, Uceda Renteria, Sara, additional, Uršič, Tina, additional, Vallet, Sophie, additional, Van Ranst, Marc, additional, Van Wunnik, Peter, additional, Verweij, Jaco J, additional, Vila, Jorgina, additional, Wintermans, Bas, additional, Wollants, Elke, additional, Wolthers, Katja C, additional, Xavier López-Labrado, F, additional, Fischer, Thea Kolsen, additional, Harvala, Heli, additional, and Benschop, Kimberley S M, additional
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- 2024
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8. Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation
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Guglieri-Lopez, Beatriz, Perez-Pitarch, Alejandro, Garcia-Cadenas, Irene, Gimenez, Estela, Barba, Pere, Rabella, Nuria, Hernandez-Boluda, Juan Carlos, Fox, Laura, Valcarcel, David, Esquirol, Albert, Ferriols-Lisart, Rafael, Sierra, Jorge, Solano, Carlos, Navarro, David, Martino, Rodrigo, and Piñana, José Luis
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- 2019
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9. Epidemiological and clinical characteristics of infants admitted to hospital due to human parechovirus infections: A prospective study in Spain
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Martín del Valle, Fernando, Calvo, Cristina, Martinez-Rienda, Inés, Cilla, Amaia, Romero, María P., Menasalvas, Ana Isabel, Reis-Iglesias, Leticia, Roda, Diana, Pena, María J., Rabella, Nuria, Portugués de la Red, María del Mar, Megías, Gregoria, Moreno-Docón, Antonio, Otero, Almudena, and Cabrerizo, María
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- 2018
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10. Características epidemiológicas y clínicas de los lactantes hospitalizados por infecciones por parechovirus humanos. Estudio prospectivo en España
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Martín del Valle, Fernando, Calvo, Cristina, Martinez-Rienda, Inés, Cilla, Amaia, Romero, María P., Menasalvas, Ana Isabel, Reis-Iglesias, Leticia, Roda, Diana, Pena, María J., Rabella, Nuria, Portugués de la Red, María del Mar, Megías, Gregoria, Moreno-Docón, Antonio, Otero, Almudena, and Cabrerizo, María
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- 2018
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11. Characteristics of enterovirus infection associated neurologic disease associated in a pediatric population in Spain
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Castillo, Fátima, primary, Turón-Viñas, Eulàlia, additional, Armendariz, Laura, additional, Carbonell, Emma, additional, Rabella, Nuria, additional, del Cuerpo, Margarita, additional, and Moliner, Elisenda, additional
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- 2023
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12. First Cases of Severe Flaccid Paralysis Associated With Enterovirus D68 Infection in Spain, 2015–2016
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Cabrerizo, María, García-Iñiguez, Juan Pablo, Munell, Francina, Amado, Alfonso, Madurga-Revilla, Paula, Rodrigo, Carlos, Pérez, Sonia, Martínez-Sapiña, Ana, Antón, Andrés, Suárez, Gerardo, Rabella, Nuria, del Campo, Víctor, Otero, Almudena, and Masa-Calles, Josefa
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- 2017
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13. Molecular epidemiology of coxsackievirus B3 infection in Spain, 2004-2014
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Calderón, Katherine I., Díaz-de Cerio, María, Otero, Almudena, Muñoz-Almagro, Carmen, Rabella, Nuria, Martínez-Rienda, Inés, Moreno-Docón, Antonio, Trallero, Gloria, and Cabrerizo, María
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- 2016
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14. Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life
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Cabrerizo, María, Trallero, Gloria, Pena, María José, Cilla, Amaia, Megias, Gregoria, Muñoz-Almagro, Carmen, Del Amo, Eva, Roda, Diana, Mensalvas, Ana Isabel, Moreno-Docón, Antonio, García-Costa, Juan, Rabella, Nuria, Omeñaca, Manuel, Romero, María Pilar, Sanbonmatsu-Gámez, Sara, Pérez-Ruiz, Mercedes, Santos-Muñoz, María José, Calvo, Cristina, and *And the study group of “Enterovirus and parechovirus infections in children under 3 years-old, Spain” PI12-00904
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- 2015
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15. Community Respiratory Viral Infections: An Overlooked Cause of Morbidity and Mortality in Transplant Recipients
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Rabella, Núria, Rello, Jordi, editor, Singh, Nina, editor, and Aguado, José M., editor
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- 2001
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16. A Prospective Study Comparing Human Metapneumovirus with Other Respiratory Viruses in Adults , with Hematologic Malignancies and Respiratory Tract Infections
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Williams, John V., Martino, Rodrigo, Rabella, Núria, Otegui, Magdalena, Parody, Rocio, Heck, Joshua M., and Crowe, James E.
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- 2005
17. Mapping of serological testing and SARS-CoV-2 seroprevalence studies performed in 20 European countries, March-June 2020
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Bubba, Laura, primary, Simmonds, Peter, additional, Fischer, Thea K, additional, Harvala, Heli, additional, Weseslindtner, Lukas, additional, Spuchhammer-Stockl, Elisabeth, additional, Marijke, Reynders, additional, Dedeic Ljubovic, Amela, additional, Aleksandrova, Dora, additional, Tabain, Irena, additional, Rainetova, Petra, additional, Jirincova, Helena, additional, Bang, Didi, additional, Fickenscher, Helmut, additional, Krumbholz, Andi, additional, Panning, Marcus, additional, Huzly, Daniela, additional, Eis-Hübinger, Anna M, additional, Papa, Anna, additional, Sourvinos, George, additional, Zafiropoulos, Alexandros, additional, Ásgeirsson, Asgeir Erlendur, additional, Connell, Jeff, additional, Percivalle, Elena, additional, Cassaniti, Irene, additional, Karen, Couderé, additional, Lind, Andreas, additional, Nordbo, Svein Arne, additional, de Sao Jose Nascimento, Maria, additional, Mesquita, Joao Rodrigo, additional, Brito, Maria, additional, Guiomar, Raquel, additional, Rodrigues, Ana Paula, additional, Fonseca e Silva, Daniela, additional, Abreu, Ana, additional, Dessa, Paulo, additional, Popescu, Corneliu Petru, additional, Berginc, Natasa, additional, ProsencTrilar, Katarina, additional, Poljak, Mario, additional, Rabella, Nuria, additional, Esperalba, Juliana, additional, Perez-Olmeda, Mayte, additional, Fernández-García, Aurora, additional, Bogdanovic, Gordana, additional, Muschiol, Sandra, additional, Bohn Christiansen, Claus, additional, Can Sarınoglu, Rabia, additional, Karahasan Yagci, Aysegul, additional, Zeytinoglu, Aysin, additional, Soylu, Mehmet, additional, Sener, Burcin, additional, and Alp, Alpaslan, additional
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- 2021
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18. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant
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López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodriguez, Paula, Bracho, Maria Alma, Cancino-Muñoz, Irving, D’Auria, Giuseppe, de Marco, Griselda, García-González, Neris, Goig, Galo Adrian, Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martinez-Priego, Llúcia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, Jose Antonio, Bordoy, Antoni E., Canut-Blasco, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, Maria Luz, Costa-Alcalde, José J., de Toro, María, de Toro Peinado, Inmaculada, del Pozo, Jose Luis, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno Cardona, Concepción, González Galán, Verónica, Gonzalo Jiménez, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José Antonio, López-Causapé, Carla, López-Hontangas, José Luis, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, Maria Carmen, Pérez-Lago, Laura, Pérez-Ruiz, Mercedes, Piñeiro Vázquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Soriano, Alex, Tirado Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Pérez-Tur, Jordi, Catalán-Alonso, Pilar, Suárez González, Julia, Muñoz, Patricia, Ruiz-Rodríguez, Paula, Bracho, María Alma, Martínez Priego, Llúcia, Galán-Vendrell, Inmaculada, De Marco, Griselda, Ferrús-Abad, María Loreto, Carbó-Ramírez, Sandra, Nogueira, Jose Miguel, Camarena, Juan José, Martínez Expósito, Óscar, Antona Urieta, Nerea, Castelló-Abietar, Cristian, Rojo-Alba, Susana, Álvarez-Argüelles, Marta Elena, Melón, Santiago, Antuori, Adrián, Fernández-Navarro, Anabel, Lecaroz Agara, Maria Concepción, Gómez-González, Carmen, Aguirre-Quiñonero, Amaia, López-Mirones, José Israel, Fernández-Torres, Marina, Almela-Ferrer, Maria Rosario, Fregeneda-Grandes, Juan Miguel, Argüello, Héctor, Sorarrain, Ane, Trastoy, Rocío, Barbeito Castiñeiras, Gema, Coira, Amparo, Pérez del Molino, María Luisa, Aguilera, Antonio, Mediavilla Gradolph, Maria Concepción, Fernández-Alonso, Mirian, González-Recio, Oscar, Gutiérrez-Rivas, Mónica, Jiménez Clavero, Miguel Ángel, Ocete Mochón, María Dolores, Medina-Gonzalez, Rafael, Reina, Jordi, Gómez-Ruiz, Maria Dolores, Gonzalez-Barbera, Eva M., Molina, Antonio J., Fernandez-Villa, Tania, Martínez-Cameo, Nieves Felisa, Gracia-Grataloup, Yolanda, Tirado Balaguer, Maria Dolores, Gómez Alonso, Bárbara, Arjona Zaragozí, Francisco José, Chamizo López, Francisco Javier, Bordes-Benítez, Ana, Rabella, Núria, Navarro, Ferran, Miró, Elisenda, Simarro Córdoba, Encarnación, Lozano-Serra, Julia, Soriano, Álex, Roig Sena, Francisco Javier, Vanaclocha Luna, Hermelinda, Sanmartín, Isabel, García-Souto, Daniel, Pequeño-Valtierra, Ana, Tubio, Jose M. C., Temes, Javier, Rodríguez-Castro, Jorge, Santamarina García, Martín, Rodríguez-Iglesias, Manuel, Galán-Sanchez, Fátima, Rodríguez-Pallares, Salud, Azcona-Gutiérrez, José Manuel, Blasco-Alberdi, Miriam, Mayor, Alfredo, García-Basteiro, Alberto L., Moncunill, Gemma, Dobaño, Carlota, Cisteró, Pau, Mitjà, Oriol, González-Beiras, Camila, Vall-Mayans, Martí, Corbacho-Monné, Marc, Alemany, Andrea, Muñoz-Cuevas, Cristina, Rodríguez-Rodríguez, Guadalupe, Benito, Rafael, Algarate, Sonia, Bueno, Jessica, Vergara-Gómez, Andrea, Martínez, Miguel J., Vila, Jordi, Rubio, Elisa, Peiró-Mestres, Aida, Navero-Castillejos, Jessica, Posada, David, Valverde, Diana, Estévez, Nuria, Fernández-Silva, Iria, de Chiara, Loretta, Gallego-García, Pilar, Varela, Nair, Gómez-Pinedo, Ulises, Gozalo-Margüello, Mónica, Cano García, Maria Eliecer, Méndez-Legaza, José Manuel, Rodríguez-Lozano, Jesus, Siller, María, Pablo-Marcos, Daniel, Ruiz-García, Maria Montserrat, Galiana, Antonio, Sánchez-Almendro, Judith, Gascón Ros, Maria Isabel, Torregrosa-Hetland, Cristina Juana, Pastor Boix, Eva María, Cascales Ramos, Paloma, Garcinuño Enríquez, Pedro Luis, Raga Borja, Salvador, González Cantó, Julia, Martínez Macias, Olalla, de Salazar, Adolfo, Viñuela González, Laura, Chueca, Natalia, García, Federico, Gómez-Camarasa, Cristina, Farga Martí, Amparo, Falcón, Rocío, Domínguez-Márquez, Victoria, Planas, Anna M., Fernández-Cádenas, Israel, Marcos, Maria Ángeles, Ezpeleta, Carmen, Navascués, Ana, Miqueleiz Zapatero, Ana, Segovia, Manuel, Moreno-Docón, Antonio, Viedma, Esther, Recio Martínez, Raúl, Muñoz-Gallego, Irene, Gonzalez-Bodi, Sara, Folgueira, Maria Dolores, Mingorance, Jesús, Dahdouh, Elias, Lázaro-Perona, Fernando, Rodríguez-Tejedor, María, Romero-Gómez, María Pilar, García-Rodríguez, Julio, Galán, Juan Carlos, Rodríguez-Dominguez, Mario, Martínez-García, Laura, Abreu Di Berardino, Melanie, Ponce-Alonso, Manuel, González-Alba, Jose Maria, Sanz-Muñoz, Ivan, Pérez San José, Diana, Gil Fortuño, Maria, Bellido-Blasco, Juan B., Yagüe Muñoz, Alberto, Hernández Pérez, Noelia, Buj Jordá, Helena, Pérez Olaso, Óscar, González Praetorius, Alejandro, Martínez Ramírez, Nora Mariela, Ramírez Marinero, Aida, Padilla León, Eduardo, Vilas Basil, Alba, Canal Aranda, Mireia, Bernet Sánchez, Albert, Bellés Bellés, Alba, López González, Eric, Prats Sánchez, Iván, García-González, Mercè, Martínez-Lirola, Miguel José, Rodríguez Maresca, Manuel Ángel, Cabezas Fernández, Maria Teresa, Carrillo Gil, María Eugenia, Ventero Martín, Maria Paz, Molina Pardines, Carmen, Orta Mira, Nieves, Navarro Cots, María, Vidal Catalá, Inmaculada, García Nava, Isabel, Illescas Fernández-Bermejo, Soledad, Martínez-Alarcón, José, Torres-Narbona, Marta, Colmenarejo, Cristina, García-Agudo, Lidia, Pérez García, Jorge A., Yago López, Martín, Goberna Bravo, María Ángeles, Simón García, Victoria, Llop Furquet, Gonzalo, Iranzo Tatay, Agustín, Moreno-Marro, Sandra, Lozano Rodríguez, Noelia, Broseta Tamarit, Amparo, Badiola Díez, Juan José, Martínez-Ramírez, Amparo, Dopazo, Ana, Callejas, Sergio, Benguría, Alberto, Aguado, Begoña, Alcamí, Antonio, Bermejo Bermejo, Marta, Ramos-Ruíz, Ricardo, Fernández Soria, Víctor Manuel, Simón Soria, Fernando, Roig Cardells, Mercedes, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Research Council, European Commission, Generalitat Valenciana, Chiner-Oms, Álvaro [0000-0002-0463-0101], Ruiz-Rodríguez, Paula [0000-0003-0727-5974], D'Auria, Giuseppe [0000-0003-0672-2541], Gómez-Navarro, Inmaculada [0000-0002-5235-7365], Jiménez Serrano, Santiago [0000-0003-2917-6053], Aranzamendi Zaldumbide, Maitane [0000-0003-2432-7078], Boga, José Antonio [0000-0002-5500-9972], Bordoy, Antoni E. [0000-0002-1165-542X], Costa-Alcalde, José J. [0000-0002-1916-2216], Toro Peinado, Inmaculada de [0000-0002-8151-3275], López-Causapé, Carla [0000-0003-2228-2005], Martín, Vicente [0000-0003-0552-2804], Moreno-Muñoz, Rosario [0000-0002-0185-5612], Parra Grande, Mónica [0000-0002-8330-7467], Balaguer, María Dolores [0000-0003-3808-7300], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], Ministerio de Ciencia (España), Generalitat Valenciana (España), Chiner-Oms, Álvaro, Ruiz-Rodríguez, Paula, D'Auria, Giuseppe, Gómez-Navarro, Inmaculada, Jiménez Serrano, Santiago, Aranzamendi Zaldumbide, Maitane, Boga, José Antonio, Bordoy, Antoni E., Costa-Alcalde, José J., Toro Peinado, Inmaculada de, López-Causapé, Carla, Martín, Vicente, Moreno-Muñoz, Rosario, Parra Grande, Mónica, Balaguer, María Dolores, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, and Marimon, Jose Maria
- Subjects
DYNAMICS ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Physical Distancing ,Biology ,Severity of Illness Index ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Pandemic ,Quarantine ,Genetics ,Humans ,Clade ,Phylogeny ,030304 developmental biology ,0303 health sciences ,Models, Statistical ,SARS-CoV-2 ,Incidence (epidemiology) ,Incidence ,Genetic variants ,COVID-19 ,Genomics ,New variant ,Dynamics ,Virus ,3. Good health ,Spain ,Communicable Disease Control ,VIRUS ,030217 neurology & neurosurgery ,Demography - Abstract
SeqCOVID-Spain consortium: Álvaro Chiner-Oms, Irving Cancino-Muñoz, Mariana G. López, Manuela Torres-Puente, Inmaculada Gómez-Navarro, Santiago Jiménez-Serrano, Jordi Pérez-Tur, Darío García de Viedma, Laura Pérez-Lago, Marta Herranz, Jon Sicilia, Pilar Catalán-Alonso, Julia Suárez González, Patricia Muñoz, Mireia Coscolla, Paula Ruiz-Rodríguez, Fernando González-Candelas, Iñaki Comas, Lidia Ruiz-Roldán, María Alma Bracho, Neris García-González, Llúcia Martínez Priego, Inmaculada Galán-Vendrell, Paula Ruiz-Hueso, Griselda De Marco, María Loreto Ferrús-Abad, Sandra Carbó-Ramírez, Giuseppe D’Auria, Galo Adrian Goig, Juan Alberola, Jose Miguel Nogueira, Juan José Camarena, David Navarro, Eliseo Albert, Ignacio Torres, Maitane Aranzamendi Zaldumbide, Óscar Martínez Expósito, Nerea Antona Urieta, María de Toro, María Pilar Bea-Escudero, Jose Antonio Boga, Cristian Castelló-Abietar, Susana Rojo-Alba, Marta Elena Álvarez-Argüelles, Santiago Melón, Elisa Martró, Antoni E. Bordoy, Anna Not, Adrián Antuori, Anabel Fernández-Navarro, Andrés Canut-Blasco, Silvia Hernáez Crespo, Maria Luz Cordón Rodríguez, Maria Concepción Lecaroz Agara, Carmen Gómez-González, Amaia Aguirre-Quiñonero, José Israel López-Mirones, Marina Fernández-Torres, Maria Rosario Almela-Ferrer, Ana Carvajal, Juan Miguel Fregeneda-Grandes, Héctor Argüello, Gustavo Cilla Eguiluz, Milagrosa Montes Ros, Luis Piñeiro Vázquez, Ane Sorarrain, José María Marimón, José J. Costa-Alcalde, Rocío Trastoy, Gema Barbeito Castiñeiras, Amparo Coira, María Luisa Pérez del Molino, Antonio Aguilera, Begoña Palop-Borrás, Inmaculada de Toro Peinado, Maria Concepción Mediavilla Gradolph, Mercedes Pérez-Ruiz, Mirian Fernández-Alonso, Jose Luis del Pozo, Oscar González-Recio, Mónica Gutiérrez-Rivas, Jovita Fernández-Pinero, Miguel Ángel Jiménez Clavero, Begoña Fuster Escrivá, Concepción Gimeno Cardona, María Dolores Ocete Mochón, Rafael Medina-Gonzalez, José Antonio Lepe, Verónica González Galán, Ángel Rodríguez-Villodres, Nieves Gonzalo Jiménez, Jordi Reina, Carla López-Causapé, Maria Dolores Gómez-Ruiz, Eva M. Gonzalez-Barbera, José Luis López-Hontangas, Vicente Martín, Antonio J. Molina, Tania Fernandez-Villa, Ana Milagro Beamonte, Nieves Felisa Martínez-Cameo, Yolanda Gracia-Grataloup, Rosario Moreno-Muñoz, Maria Dolores Tirado Balaguer, José María Navarro-Marí, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Antonio Oliver, Mónica Parra Grande, Bárbara Gómez Alonso, Francisco José Arjona Zaragozí, Maria Carmen Pérez González, Francisco Javier Chamizo López, Ana Bordes-Benítez, Núria Rabella, Ferran Navarro, Elisenda Miró, Antonio Rezusta, Alexander Tristancho, Encarnación Simarro Córdoba, Julia Lozano-Serra, Lorena Robles Fonseca, Álex Soriano, Francisco Javier Roig Sena, Hermelinda Vanaclocha Luna, Isabel Sanmartín, Daniel García-Souto, Ana Pequeño-Valtierra, Jose M. C. Tubio, Javier Temes, Jorge Rodríguez-Castro, Martín Santamarina García, Manuel Rodríguez-Iglesias, Fátima Galán-Sanchez, Salud Rodríguez-Pallares, José Manuel Azcona-Gutiérrez, Miriam Blasco-Alberdi, Alfredo Mayor, Alberto L. García-Basteiro, Gemma Moncunill, Carlota Dobaño, Pau Cisteró, Oriol Mitjà, Camila González-Beiras, Martí Vall-Mayans, Marc Corbacho-Monné, Andrea Alemany, Cristina Muñoz-Cuevas, Guadalupe Rodríguez-Rodríguez, Rafael Benito, Sonia Algarate, Jessica Bueno, Andrea Vergara-Gómez, Miguel J. Martínez, Jordi Vila, Elisa Rubio, Aida Peiró-Mestres, Jessica Navero-Castillejos, David Posada, Diana Valverde, Nuria Estévez, Iria Fernández-Silva, Loretta de Chiara, Pilar Gallego-García, Nair Varela, Ulises Gómez-Pinedo, Mónica Gozalo-Margüello, Maria Eliecer Cano García, José Manuel Méndez-Legaza, Jesus Rodríguez-Lozano, María Siller, Daniel Pablo-Marcos, Maria Montserrat Ruiz-García, Antonio Galiana, Judith Sánchez-Almendro, Maria Isabel Gascón Ros, Cristina Juana Torregrosa-Hetland, Eva María Pastor Boix, Paloma Cascales Ramos, Pedro Luis Garcinuño Enríquez, Salvador Raga Borja, Julia González Cantó, Olalla Martínez Macias, Adolfo de Salazar, Laura Viñuela González, Natalia Chueca, Federico García, Cristina Gómez-Camarasa, Amparo Farga Martí, Rocío Falcón, Victoria Domínguez-Márquez, Anna M. Planas, Israel Fernández-Cádenas, Maria Ángeles Marcos, Carmen Ezpeleta, Ana Navascués, Ana Miqueleiz Zapatero, Manuel Segovia, Antonio Moreno-Docón, Esther Viedma, Raúl Recio Martínez, Irene Muñoz-Gallego, Sara Gonzalez-Bodi, Maria Dolores Folgueira, Jesús Mingorance, Elias Dahdouh, Fernando Lázaro-Perona, María Rodríguez-Tejedor, María Pilar Romero-Gómez, Julio García-Rodríguez, Juan Carlos Galán, Mario Rodríguez-Dominguez, Laura Martínez-García, Melanie Abreu Di Berardino, Manuel Ponce-Alonso, Jose Maria González-Alba, Ivan Sanz-Muñoz, Diana Pérez San José, Maria Gil Fortuño, Juan B. Bellido-Blasco, Alberto Yagüe Muñoz, Noelia Hernández Pérez, Helena Buj Jordá, Óscar Pérez Olaso, Alejandro González Praetorius, Nora Mariela Martínez Ramírez, Aida Ramírez Marinero, Eduardo Padilla León, Alba Vilas Basil, Mireia Canal Aranda, Albert Bernet Sánchez, Alba Bellés Bellés, Eric López González, Iván Prats Sánchez, Mercè García-González, Miguel José Martínez-Lirola, Manuel Ángel Rodríguez Maresca, Maria Teresa Cabezas Fernández, María Eugenia Carrillo Gil, Maria Paz Ventero Martín, Carmen Molina Pardines, Nieves Orta Mira, María Navarro Cots, Inmaculada Vidal Catalá, Isabel García Nava, Soledad Illescas Fernández-Bermejo, José Martínez-Alarcón, Marta Torres-Narbona, Cristina Colmenarejo, Lidia García-Agudo, Jorge A. Pérez García, Martín Yago López, María Ángeles Goberna Bravo, Victoria Simón García, Gonzalo Llop Furquet, Agustín Iranzo Tatay, Sandra Moreno-Marro, Noelia Lozano Rodríguez, Amparo Broseta Tamarit, Juan José Badiola Díez, Amparo Martínez-Ramírez, Ana Dopazo, Sergio Callejas, Alberto Benguría, Begoña Aguado, Antonio Alcamí, Marta Bermejo Bermejo, Ricardo Ramos-Ruíz, Víctor Manuel Fernández Soria, Fernando Simón Soria & Mercedes Roig Cardells, The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re, This work was mainly funded by the Instituto de Salud Carlos III project COV20/00140, with additional funding by Spanish National Research Council project CSIC-COV19-021, Ministerio de Ciencia project PID2019-104477RB-100, ERC StG 638553 and ERC CoG 101001038 to I.C., and BFU2017-89594R to F.G.C. M.C. is supported by Ramón y Cajal program from Ministerio de Ciencia and grants RTI2018-094399-A-I00 and Generalitat Valenciana (Regional Government) project SEJI/2019/011. We gratefully acknowledge Hospital Universitari Vall d’Hebron, Instituto de Salud Carlos III, IrsiCaixa AIDS Research Lab and all the international researchers and institutions that submitted sequenced SARS-CoV-2 genomes to the GISAID’s EpiCov Database (Supplementary Table 1), as an important part of our analyses has been made possible by the sharing of their work. We also thank Unidad de Bioinformática y Estadística, Centro de Investigación Príncipe Felipe, for allowing us to use the Computer Cluster to perform some of the bioinformatic analysis.
- Published
- 2021
19. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant
- Author
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Marimon, Jose Maria, Fernández Pinero, Jovita, Lopez, Mariana G., Chiner-Oms, Alvaro, Garcia de Viedma, Dario, Ruiz-Rodriguez, Paula, Cancino-Munoz, Irving, D'Auria, Giuseppe, de Marco, Griselda, Garcia-Gonzalez, Neris, Goig, Galo Adrian, Gomez-Navarro, Inmaculada, Jimenez-Serrano, Santiago, Martinez-Priego, Llucia, Ruiz-Hueso, Paula, Ruiz-Roldan, Lidia, Torres-Puente, Manuela, Alma Bracho, Maria, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, Maria Pilar, Boga, Jose Antonio, Bordoy, Antoni E., Canut-Blasco, Andres, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordon Rodriguez, , Maria Luz, Costa-Alcalde, Jose J., de Toro, Maria, de Toro Peinado, Inmaculada, Luis del Pozo, Jose, Duchene, Sebastian, Fuster Escrivá, Begoña, Gimeno Cardona, Concepcion, Gonzalez Galan, Veronica, Gonzalo Jimenez, Nieves, Herranz, M, Antonio Lepe, , Jose, Lopez-Causape, Carla, Lopez-Hontangas, Jose Luis, Martin, Vicente, Martro, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Munoz, Rosario, Navarro, , David, Maria Navarro, Mari, Jose, Not, Anna, Oliver, Antonio, Palop-Borras, Begona, Grande, Monica Parra, Pedrosa-Corral, Irene, Perez Gonzalez, Maria Carmen, Perez-Lago, Laura, Perez-Ruiz, Mercedes, Pineiro Vazquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Sanbonmatsu-Gamez, Sara, Sicilia, Jon, Soriano, Alex, Tirado Balaguer, Maria Dolores, Torres, Ignacio, Tristancho, Alexander, Coscolla, Mireia, Gonzalez-Candelas, Fernando, Comas, Inaki, Marimon, Jose Maria, Fernández Pinero, Jovita, Lopez, Mariana G., Chiner-Oms, Alvaro, Garcia de Viedma, Dario, Ruiz-Rodriguez, Paula, Cancino-Munoz, Irving, D'Auria, Giuseppe, de Marco, Griselda, Garcia-Gonzalez, Neris, Goig, Galo Adrian, Gomez-Navarro, Inmaculada, Jimenez-Serrano, Santiago, Martinez-Priego, Llucia, Ruiz-Hueso, Paula, Ruiz-Roldan, Lidia, Torres-Puente, Manuela, Alma Bracho, Maria, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, Maria Pilar, Boga, Jose Antonio, Bordoy, Antoni E., Canut-Blasco, Andres, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordon Rodriguez, , Maria Luz, Costa-Alcalde, Jose J., de Toro, Maria, de Toro Peinado, Inmaculada, Luis del Pozo, Jose, Duchene, Sebastian, Fuster Escrivá, Begoña, Gimeno Cardona, Concepcion, Gonzalez Galan, Veronica, Gonzalo Jimenez, Nieves, Herranz, M, Antonio Lepe, , Jose, Lopez-Causape, Carla, Lopez-Hontangas, Jose Luis, Martin, Vicente, Martro, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Munoz, Rosario, Navarro, , David, Maria Navarro, Mari, Jose, Not, Anna, Oliver, Antonio, Palop-Borras, Begona, Grande, Monica Parra, Pedrosa-Corral, Irene, Perez Gonzalez, Maria Carmen, Perez-Lago, Laura, Perez-Ruiz, Mercedes, Pineiro Vazquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Sanbonmatsu-Gamez, Sara, Sicilia, Jon, Soriano, Alex, Tirado Balaguer, Maria Dolores, Torres, Ignacio, Tristancho, Alexander, Coscolla, Mireia, Gonzalez-Candelas, Fernando, and Comas, Inaki
- Abstract
The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (R-e < 1), also reflected in the replacement of SECs by a new variant over the summer of 2020. In summary, we reveal a notable difference in the initial genetic makeup of SARS-CoV-2 in Spain compared with other European countries and show evidence to support the effectiveness of lockdown measures in controlling virus spread, even for the most successful genetic variants. Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.
- Published
- 2021
20. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant
- Author
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Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Research Council, European Commission, Generalitat Valenciana, Chiner-Oms, Álvaro [0000-0002-0463-0101], Ruiz-Rodríguez, Paula [0000-0003-0727-5974], D'Auria, Giuseppe [0000-0003-0672-2541], Gómez-Navarro, Inmaculada [0000-0002-5235-7365], Jiménez Serrano, Santiago [0000-0003-2917-6053], Aranzamendi Zaldumbide, Maitane [0000-0003-2432-7078], Boga, José Antonio [0000-0002-5500-9972], Bordoy, Antoni E. [0000-0002-1165-542X], Costa-Alcalde, José J. [0000-0002-1916-2216], Toro Peinado, Inmaculada de [0000-0002-8151-3275], López-Causapé, Carla [0000-0003-2228-2005], Martín, Vicente [0000-0003-0552-2804], Moreno-Muñoz, Rosario [0000-0002-0185-5612], Parra Grande, Mónica [0000-0002-8330-7467], Balaguer, María Dolores [0000-0003-3808-7300], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodríguez, Paula, Bracho, María Alma, Cancino-Muñoz, Irving, D'Auria, Giuseppe, Marco, Griselda de, García-González, Neris, Goig, Galo A., Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martínez-Priego, Llucia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, José Antonio, Bordoy, Antoni E., Canut, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, María Luz, Costa-Alcalde, José J., Toro, María de, Toro Peinado, Inmaculada de, Pozo, José Luis del, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno, Concepción, González Galán, Verónica, Gonzalo Jimeno, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José A., López-Causapé, Carla, López-Hontangas, José Luis, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, María Carmen, Pérez-Lago, Laura, Pérez-Ruiz, Mercedes, Piñeiro Vázquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Soriano, Álex, Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Seqcovid-Spain Consortium, Coscollá, Mireia, González-Candelas, Fernando, Comas, Iñaki, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Research Council, European Commission, Generalitat Valenciana, Chiner-Oms, Álvaro [0000-0002-0463-0101], Ruiz-Rodríguez, Paula [0000-0003-0727-5974], D'Auria, Giuseppe [0000-0003-0672-2541], Gómez-Navarro, Inmaculada [0000-0002-5235-7365], Jiménez Serrano, Santiago [0000-0003-2917-6053], Aranzamendi Zaldumbide, Maitane [0000-0003-2432-7078], Boga, José Antonio [0000-0002-5500-9972], Bordoy, Antoni E. [0000-0002-1165-542X], Costa-Alcalde, José J. [0000-0002-1916-2216], Toro Peinado, Inmaculada de [0000-0002-8151-3275], López-Causapé, Carla [0000-0003-2228-2005], Martín, Vicente [0000-0003-0552-2804], Moreno-Muñoz, Rosario [0000-0002-0185-5612], Parra Grande, Mónica [0000-0002-8330-7467], Balaguer, María Dolores [0000-0003-3808-7300], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodríguez, Paula, Bracho, María Alma, Cancino-Muñoz, Irving, D'Auria, Giuseppe, Marco, Griselda de, García-González, Neris, Goig, Galo A., Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martínez-Priego, Llucia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, José Antonio, Bordoy, Antoni E., Canut, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, María Luz, Costa-Alcalde, José J., Toro, María de, Toro Peinado, Inmaculada de, Pozo, José Luis del, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno, Concepción, González Galán, Verónica, Gonzalo Jimeno, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José A., López-Causapé, Carla, López-Hontangas, José Luis, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, María Carmen, Pérez-Lago, Laura, Pérez-Ruiz, Mercedes, Piñeiro Vázquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Soriano, Álex, Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Seqcovid-Spain Consortium, Coscollá, Mireia, González-Candelas, Fernando, and Comas, Iñaki
- Abstract
The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re < 1), also reflected in the replacement of SECs by a new variant over the summer of 2020. In summary, we reveal a notable difference in the initial genetic makeup of SARS-CoV-2 in Spain compared with other European countries and show evidence to support the effectiveness of lockdown measures in controlling virus spread, even for the most successful genetic variants.
- Published
- 2021
21. Molecular identification of an enterovirus 99 strain in Spain
- Author
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Cabrerizo, Maria, Rabella, Nuria, Torner, Nuria, Castellanos, Teresa, Bustillo, Isidoro, Varela, Carlos, Colomer, Jaume, and Trallero, Gloria
- Published
- 2012
- Full Text
- View/download PDF
22. The first wave of the Spanish COVID-19 epidemic was associated with early introductions and fast spread of a dominating genetic variant
- Author
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Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), European Commission, European Research Council, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), López, Mariana G. [0000-0002-2216-9232], Chiner-Oms, Álvaro [0000-0002-0463-0101], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodríguez, Paula, Bracho, María Alma, Cancino-Muñoz, Irving, D’Auria, Giuseppe, Marco, Griselda de, García-González, Neris, Goig, Galo A., Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martínez-Priego, Llucia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, José Antonio, Bordoy, Antoni E., Canut, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, María Luz, Costa-Alcalde, José J., Toro, María de, Toro Peinado, Inmaculada de, Pozo, José Luis del, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno, Concepción, González Galán, Verónica, Gonzalo Jimeno, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José A., López-Hontangas, José Luis, Marcos, María Ángeles, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, María Carmen, Pérez-Lago, Laura, Piñeiro Vázquez, Luis, Rabella, Nuria, Reina, Jordi, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Tirado Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Coscollá, Mireia, González-Candelas, Fernando, Comas, Iñaki, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), European Commission, European Research Council, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), López, Mariana G. [0000-0002-2216-9232], Chiner-Oms, Álvaro [0000-0002-0463-0101], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodríguez, Paula, Bracho, María Alma, Cancino-Muñoz, Irving, D’Auria, Giuseppe, Marco, Griselda de, García-González, Neris, Goig, Galo A., Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martínez-Priego, Llucia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, José Antonio, Bordoy, Antoni E., Canut, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, María Luz, Costa-Alcalde, José J., Toro, María de, Toro Peinado, Inmaculada de, Pozo, José Luis del, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno, Concepción, González Galán, Verónica, Gonzalo Jimeno, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José A., López-Hontangas, José Luis, Marcos, María Ángeles, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, María Carmen, Pérez-Lago, Laura, Piñeiro Vázquez, Luis, Rabella, Nuria, Reina, Jordi, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Tirado Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Coscollá, Mireia, González-Candelas, Fernando, and Comas, Iñaki
- Abstract
The COVID-19 pandemic has shaken the world since the beginning of 2020. Spain is among the European countries with the highest incidence of the disease during the first pandemic wave. We established a multidisciplinar consortium to monitor and study the evolution of the epidemic, with the aim of contributing to decision making and stopping rapid spreading across the country. We present the results for 2170 sequences from the first wave of the SARS-Cov-2 epidemic in Spain and representing 12% of diagnosed cases until 14th March. This effort allows us to document at least 500 initial introductions, between early February-March from multiple international sources. Importantly, we document the early raise of two dominant genetic variants in Spain (Spanish Epidemic Clades), named SEC7 and SEC8, likely amplified by superspreading events. In sharp contrast to other non-Asian countries those two variants were closely related to the initial variants of SARS-CoV-2 described in Asia and represented 40% of the genome sequences analyzed. The two dominant SECs were widely spread across the country compared to other genetic variants with SEC8 reaching a 60% prevalence just before the lockdown. Employing Bayesian phylodynamic analysis, we inferred a reduction in the effective reproductive number of these two SECs from around 2.5 to below 0.5 after the implementation of strict public-health interventions in mid March. The effects of lockdown on the genetic variants of the virus are reflected in the general replacement of preexisting SECs by a new variant at the beginning of the summer season. Our results reveal a significant difference in the genetic makeup of the epidemic in Spain and support the effectiveness of lockdown measures in controlling virus spread even for the most successful genetic variants. Finally, earlier control of SEC7 and particularly SEC8 might have reduced the incidence and impact of COVID-19 in our country.
- Published
- 2020
23. The first wave of the Spanish COVID-19 epidemic was associated with early introductions and fast spread of a dominating genetic variant
- Author
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López, Mariana G., primary, Chiner-Oms, Álvaro, additional, de Viedma, Darío García, additional, Ruiz-Rodriguez, Paula, additional, Bracho, Maria Alma, additional, Cancino-Muñoz, Irving, additional, D’Auria, Giuseppe, additional, de Marco, Griselda, additional, García-González, Neris, additional, Goig, Galo Adrian, additional, Gómez-Navarro, Inmaculada, additional, Jiménez-Serrano, Santiago, additional, Martinez-Priego, Llúcia, additional, Ruiz-Hueso, Paula, additional, Ruiz-Roldán, Lidia, additional, Torres-Puente, Manuela, additional, Alberola, Juan, additional, Albert, Eliseo, additional, Zaldumbide, Maitane Aranzamendi, additional, Bea-Escudero, María Pilar, additional, Boga, Jose Antonio, additional, Bordoy, Antoni E., additional, Canut-Blasco, Andrés, additional, Carvajal, Ana, additional, Eguiluz, Gustavo Cilla, additional, Rodríguez, Maria Luz Cordón, additional, Costa-Alcalde, José J., additional, de Toro, María, additional, de Toro Peinado, Inmaculada, additional, del Pozo, Jose Luis, additional, Duchêne, Sebastián, additional, Fernández-Pinero, Jovita, additional, Escrivá, Begoña Fuster, additional, Cardona, Concepción Gimeno, additional, Galán, Verónica González, additional, Jiménez, Nieves Gonzalo, additional, Crespo, Silvia Hernáez, additional, Herranz, Marta, additional, Lepe, José Antonio, additional, López-Hontangas, José Luis, additional, Marcos, Maria Ángeles, additional, Martín, Vicente, additional, Martró, Elisa, additional, Beamonte, Ana Milagro, additional, Ros, Milagrosa Montes, additional, Moreno-Muñoz, Rosario, additional, Navarro, David, additional, Navarro-Marí, José María, additional, Not, Anna, additional, Oliver, Antonio, additional, Palop-Borrás, Begoña, additional, Grande, Mónica Parra, additional, Pedrosa-Corral, Irene, additional, Gonzalez, Maria Carmen Perez, additional, Pérez-Lago, Laura, additional, Vázquez, Luis Piñeiro, additional, Rabella, Nuria, additional, Reina, Jordi, additional, Rezusta, Antonio, additional, Fonseca, Lorena Robles, additional, Rodríguez-Villodres, Ángel, additional, Sanbonmatsu-Gámez, Sara, additional, Sicilia, Jon, additional, Balaguer, María Dolores Tirado, additional, Torres, Ignacio, additional, Tristancho, Alexander, additional, Marimón, José María, additional, Coscolla, Mireia, additional, González-Candelas, Fernando, additional, and Comas, Iñaki, additional
- Published
- 2020
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24. Respiratory virus infections in adults with hematologic malignancies: a prospective study. (Major Article)
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Martino, Rodrigo, Ramila, Elena, Rabella, Nuria, Munoz, Jose Manuel, Peyret, Merce, Portos, Jose Manuel, Laborda, Rosario, and Sierra, Jorge
- Subjects
Respiratory tract infections -- Patient outcomes ,Health ,Health care industry - Published
- 2003
25. COVID-19-associated ophthalmoparesis and hypothalamic involvement
- Author
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Pascual-Goñi, Elba, primary, Fortea, Juan, additional, Martínez-Domeño, Alejandro, additional, Rabella, Nuria, additional, Tecame, Mario, additional, Gómez-Oliva, Cristina, additional, Querol, Luis, additional, and Gómez-Ansón, Beatriz, additional
- Published
- 2020
- Full Text
- View/download PDF
26. Prospective Study of the Incidence, Clinical Features, and Outcome of Symptomatic Upper and Lower Respiratory Tract Infections by Respiratory Viruses in Adult Recipients of Hematopoietic Stem Cell Transplants for Hematologic Malignancies
- Author
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Martino, Rodrigo, Porras, Rocío Parody, Rabella, Nuria, Williams, John V., Rámila, Elena, Margall, Nuria, Labeaga, Rosa, Crowe, James E., Jr, Coll, Pedro, and Sierra, Jorge
- Published
- 2005
- Full Text
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27. Influence of Coinfection With Hepatitis Viruses on Human Immunodeficiency Plasma Viral Load
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Negredo, Eugenia, Domingo, Pere, Sambeat, M. Antonia, Rabella, Nuria, and Vázquez, Guillermo
- Published
- 1999
28. Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016
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González-Sanz, Rubén, primary, Casas-Alba, Didac, additional, Launes, Cristian, additional, Muñoz-Almagro, Carmen, additional, Ruiz-García, María Montserrat, additional, Alonso, Mercedes, additional, González-Abad, María José, additional, Megías, Gregoria, additional, Rabella, Nuria, additional, del Cuerpo, Margarita, additional, Gozalo-Margüello, Mónica, additional, González-Praetorius, Alejandro, additional, Martínez-Sapiña, Ana, additional, Goyanes-Galán, María José, additional, Romero, María Pilar, additional, Calvo, Cristina, additional, Antón, Andrés, additional, Imaz, Manuel, additional, Aranzamendi, Maitane, additional, Hernández-Rodríguez, Águeda, additional, Moreno-Docón, Antonio, additional, Rey-Cao, Sonia, additional, Navascués, Ana, additional, Otero, Almudena, additional, and Cabrerizo, María, additional
- Published
- 2019
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29. Enterovirus 75 and aseptic meningitis, Spain, 2005
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Avellon, Ana, Rubio, Gurutze, Palacios, Gustavo, Casas, Inmaculada, Rabella, Nuria, Reina, Gabriel, Perez, Carmen, Lipkin, W. Ian, and Trallero, Gloria
- Abstract
To the Editor: Although most human enterovirus (EV) (genus Enterovirus, family Picornaviridae) infections are asymptomatic, they can cause upper respiratory illness, febrile rash, aseptic meningitis, pleurodynia, encephalitis, acute flaccid paralysis, [...]
- Published
- 2006
30. Prevalence of Parvovirus B19 Infection Among Patients With Human Immunodeficiency Virus Infection in Barcelona, Spain
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Negredo, Eugenia, Domingo, Pere, Rabella, Nuria, Lopez-Contreras, Joaquin, Fontanet, Angels, and Orellana, Inmaculada
- Published
- 1998
31. Design and validation of a real-time RT-PCR for the simultaneous detection of enteroviruses and parechoviruses in clinical samples
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Cabrerizo, María, Calvo, Cristina, Rabella, Nuria, Muñoz-Almagro, Carmen, del Amo, Eva, Pérez-Ruiz, Mercedes, Sanbonmatsu-Gámez, Sara, Moreno-Docón, Antonio, Otero, Almudena, and Trallero, Gloria
- Published
- 2014
- Full Text
- View/download PDF
32. Características epidemiológicas y clínicas de los lactantes hospitalizados por infecciones por parechovirus humanos. Estudio prospectivo en España
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Martín del Valle, Fernando, Calvo, Cristina, Martinez-Rienda, Inés, Cilla, Amaia, Romero, María P., Menasalvas, Ana Isabel, Reis-Iglesias, Leticia, Roda, Diana, Pena, María J., Rabella, Nuria, Portugués de la Red, María del Mar, Megías, Gregoria, Moreno-Docón, Antonio, Otero, Almudena, and Cabrerizo, María
- Abstract
Los parechovirus humanos (HPeV) son virus de la familia Picornaviridae, recientemente descritos, a los que se atribuyen cuadros de fiebre sin foco (FSF), sepsis clínica, gastroenteritis, meningitis o encefalitis fundamentalmente en lactantes pequeños. Nuestro objetivo fue describir la epidemiología y las características clínicas de las infecciones por HPeV en nuestro medio.
- Published
- 2024
- Full Text
- View/download PDF
33. Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study)
- Author
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Boixeda,Ramon, Rabella,Nuria, Sauca,Goretti, Delgado,Maria, MartÃnez-Costa,Xavier, Mauri,Montserrat, Vicente,Vanessa, Palomera,Elisabet, Serra-Prat,Mateu, Capdevila,Josep Antón, Boixeda,Ramon, Rabella,Nuria, Sauca,Goretti, Delgado,Maria, MartÃnez-Costa,Xavier, Mauri,Montserrat, Vicente,Vanessa, Palomera,Elisabet, Serra-Prat,Mateu, and Capdevila,Josep Antón
- Abstract
Ramon Boixeda,1,5 Nuria Rabella,2 Goretti Sauca,3 Maria Delgado,1 Xavier Martinez-Costa1, Montserrat Mauri,1 Vanessa Vicente,1 Elisabet Palomera,4 Mateu Serra-Prat,4 Josep Antón Capdevila11Department of Internal Medicine, Hospital of Mataró, Barcelona, Spain; 2Department of Microbiology, Hospital of Santa Creu and Sant Pau, Barcelona, Spain; 3Department of Microbiology, Hospital of Mataró, Barcelona, Spain; 4Department of Research, Hospital of Mataró, Barcelona, Spain; 5Department of Medicine, Autonomous University of Barcelona, Barcelona, SpainPurpose: Respiratory infection is the most common cause for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD). The aim of this work was to study the etiology of the respiratory infection in order to assess the usefulness of the clinical and analytical parameters used for COPD identification.Patients and methods: We included 132 patients over a period of 2 years. The etiology of the respiratory infection was studied by conventional sputum, paired serology tests for atypical bacteria, and viral diagnostic techniques (immunochromatography, immunofluorescence, cell culture, and molecular biology techniques). We grouped the patients into four groups based on the pathogens isolated (bacterial versus. viral, known etiology versus unknown etiology) and compared the groups.Results: A pathogen was identified in 48 patients. The pathogen was identified through sputum culture in 34 patients, seroconversion in three patients, and a positive result from viral techniques in 14 patients. No significant differences in identifying etiology were observed in the clinical and analytical parameters within the different groups. The most cost-effective tests were the sputum test and the polymerase chain reaction.Conclusion: Based on our experience, clinical and analytical parameters are not useful for the etiological identification of COPD exacerbations. Diagnosing COPD exacerbation is
- Published
- 2012
34. Molecular identification of an enterovirus 99 strain in Spain
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Cabrerizo, Maria, primary, Rabella, Nuria, additional, Torner, Nuria, additional, Castellanos, Teresa, additional, Bustillo, Isidoro, additional, Varela, Carlos, additional, Colomer, Jaume, additional, and Trallero, Gloria, additional
- Published
- 2011
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35. Outbreaks of influenza A virus infection in neonatal intensive care units
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SAGRERA, XAVIER, primary, GINOVART, GEMMA, additional, RASPALL, FREDERIC, additional, RABELLA, NURIA, additional, SALA, PERE, additional, SIERRA, MONTSERRAT, additional, DEMESTRE, XAVIER, additional, and VILA, CLARA, additional
- Published
- 2002
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- View/download PDF
36. Molecular Epidemiology of Astrovirus Infection in Barcelona, Spain
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Guix, Susana, primary, Caballero, Santiago, additional, Villena, Cristina, additional, Bartolomé, Rosa, additional, Latorre, Cristina, additional, Rabella, Nuria, additional, Simó, Maria, additional, Bosch, Albert, additional, and Pintó, Rosa M., additional
- Published
- 2002
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- View/download PDF
37. SUCCESSFUL TRANSPLANTATION OF ORGANS RETRIEVED FROM A DONOR WITH SYPHILIS
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Caballero, Francisco, primary, Domingo, Pere, additional, Rabella, Nuria, additional, and L??pez-Navidad, Antonio, additional
- Published
- 1998
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- View/download PDF
38. Epstein-Barr Virus Infection Associated with Interstitial Nephritis and Chronic Fatigue
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Navidad, Antonio López, primary, Domingo, Pere, additional, Talavera, Juan C. López, additional, Rabella, Nuria, additional, and Verger, Guillem, additional
- Published
- 1996
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39. Disseminated Cytomegalovirus Infection in an Immunocompetent Adult Successfully Treated with Ganciclovir
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López-Contreras, Joaquin, primary, Ris, Josep, additional, Domingo, Pere, additional, Puig, Mireia, additional, Rabella, Nuria, additional, and Nolla, Joan, additional
- Published
- 1995
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- View/download PDF
40. Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study).
- Author
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Boixeda, Ramon, Rabella, Nuria, Sauca, Goretti, Delgado, Maria, Martínez-Costa, Xavier, Mauri, Montserrat, Vicente, Vanessa, Palomera, Elisabet, Serra-Prat, Mateu, and Capdevila, Josep Antón
- Published
- 2012
- Full Text
- View/download PDF
41. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant.
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López MG, Chiner-Oms Á, García de Viedma D, Ruiz-Rodriguez P, Bracho MA, Cancino-Muñoz I, D'Auria G, de Marco G, García-González N, Goig GA, Gómez-Navarro I, Jiménez-Serrano S, Martinez-Priego L, Ruiz-Hueso P, Ruiz-Roldán L, Torres-Puente M, Alberola J, Albert E, Aranzamendi Zaldumbide M, Bea-Escudero MP, Boga JA, Bordoy AE, Canut-Blasco A, Carvajal A, Cilla Eguiluz G, Cordón Rodríguez ML, Costa-Alcalde JJ, de Toro M, de Toro Peinado I, Del Pozo JL, Duchêne S, Fernández-Pinero J, Fuster Escrivá B, Gimeno Cardona C, González Galán V, Gonzalo Jiménez N, Hernáez Crespo S, Herranz M, Lepe JA, López-Causapé C, López-Hontangas JL, Martín V, Martró E, Milagro Beamonte A, Montes Ros M, Moreno-Muñoz R, Navarro D, Navarro-Marí JM, Not A, Oliver A, Palop-Borrás B, Parra Grande M, Pedrosa-Corral I, Pérez González MC, Pérez-Lago L, Pérez-Ruiz M, Piñeiro Vázquez L, Rabella N, Rezusta A, Robles Fonseca L, Rodríguez-Villodres Á, Sanbonmatsu-Gámez S, Sicilia J, Soriano A, Tirado Balaguer MD, Torres I, Tristancho A, Marimón JM, Coscolla M, González-Candelas F, and Comas I
- Subjects
- COVID-19 virology, Communicable Disease Control methods, Humans, Incidence, Phylogeny, Physical Distancing, Quarantine methods, Quarantine organization & administration, SARS-CoV-2 classification, SARS-CoV-2 pathogenicity, Severity of Illness Index, Spain epidemiology, COVID-19 epidemiology, COVID-19 transmission, Communicable Disease Control organization & administration, Models, Statistical, SARS-CoV-2 genetics
- Abstract
The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (R
e < 1), also reflected in the replacement of SECs by a new variant over the summer of 2020. In summary, we reveal a notable difference in the initial genetic makeup of SARS-CoV-2 in Spain compared with other European countries and show evidence to support the effectiveness of lockdown measures in controlling virus spread, even for the most successful genetic variants., (© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.)- Published
- 2021
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42. COVID-19-associated ophthalmoparesis and hypothalamic involvement.
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Pascual-Goñi E, Fortea J, Martínez-Domeño A, Rabella N, Tecame M, Gómez-Oliva C, Querol L, and Gómez-Ansón B
- Subjects
- Adult, COVID-19, Female, Humans, Middle Aged, Pandemics, SARS-CoV-2, Betacoronavirus, Coronavirus Infections complications, Coronavirus Infections diagnostic imaging, Hypothalamus diagnostic imaging, Ophthalmoplegia diagnostic imaging, Ophthalmoplegia etiology, Pneumonia, Viral complications, Pneumonia, Viral diagnostic imaging
- Published
- 2020
- Full Text
- View/download PDF
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