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4. Respiratory support in patients with COVID-19 (outside intensive care unit). A position paper of the Respiratory Support and Chronic Care Group of the French Society of Respiratory Diseases

Author

Mercy, M., Grassion, L., Pontier, S., Patout, M., Luque, R., Delafosse, C., Raherison-Semjen, C., Maître, B., Duthoit, L., Mendoza, A., Jacquin, L., Borel, J.C., Cervantes, P., Janssens, J.-P., Chabot, J.-F., Morelot-Panzini, C., Jaffuel, D., Rabec, C., and Gonzalez-Bermejo, J.

Published
2020
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5. Est-il important de phénotyper les patients recevant une VNI à domicile ? Analyse des résultats des premiers 2052 patients inclus dans la Cohorte ANTADIR-GAVO2

Author

Rabec, C., primary, Cuvelier, A., additional, Cervantes, P., additional, Morelot, C., additional, Georges, M., additional, Patout, M., additional, Pontier, S., additional, Mercy, M., additional, Guillaumot, A., additional, Prigent, A., additional, Gagnadoux, F., additional, Perrin, C., additional, Lavergne, F., additional, Mallart, A., additional, Grassion, L., additional, Kessler, R., additional, Claude, F., additional, Goubert, L., additional, Jaffre, S., additional, Prigent, H., additional, Perel, A., additional, Duval, Y., additional, Sedkaoui, K., additional, Chabot, F., additional, Llontop, C., additional, Berrier, A., additional, Delrieu, J., additional, Mba, L., additional, Muir, J.F., additional, Melloni, B., additional, and Gonzalez, J., additional

Published
2024
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16. Typologie et gestion des alertes de télésurveillance des patients insuffisants respiratoires chroniques ventilés participant au programme de télésurveillance médicale ETAPES (Expérimentations de télémédecine pour l’amélioration des parcours en santé)–Étude TELVENT

Author

Pontier-Marchandise, S., primary, Letierce, A., additional, Prigent, A., additional, Rabec, C., additional, Gagnadoux, F., additional, Gonzalez-Bermejo, J., additional, and Texereau, J., additional

Published
2022
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18. Évolution du handicap respiratoire des patients insuffisants respiratoires chroniques ventilés au cours de leur participation au programme de télésurveillance médicale ETAPES (Expérimentations de télémédecine pour l’amélioration des parcours en santé) – Étude TELVENT

Author

Texereau, J., primary, Letierce, A., additional, Rabec, C., additional, Gagnadoux, F., additional, Gonzalez-Bermejo, J., additional, Prigent, A., additional, and Pontier-Marchandise, S., additional

Published
2022
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19. Observance et autres données de télésuivi des patients insuffisants respiratoires chroniques ventilés au cours de leur participation au programme ETAPES (expérimentations de télémédecine pour l’amélioration des parcours en santé) – Étude TELVENT

Author

Pontier-Marchandise, S., primary, Letierce, A., additional, Gagnadoux, F., additional, Gonzalez-Bermejo, J., additional, Prigent, A., additional, Rabec, C., additional, and Texereau, J., additional

Published
2022
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20. Impact de la mise en place d’un filtre sur les performances des pressions positives et de la ventilation non invasive

Author

Rabec, C., primary, Fresnel, E., additional, Retory, Y., additional, Zhu, K., additional, Joly, K., additional, Kerfourn, A., additional, Dudoignon, B., additional, Mendoza, A., additional, Cuvelier, A., additional, Muir, J.F., additional, Melloni, B., additional, Chabot, F., additional, Gonzalez-Bermejo, J., additional, and Patout, M., additional

Published
2022
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21. Home Mechanical Ventilation: Results of A National Program In Adults (2008 to 2017), Ministry of Health, Chile

Author

Rabec C, Torres Me, Canales K, Villalobos J, A Ma, Antolini M, Aguayo M, Maquilon C, Valdés N, Olave C, Matus Pr, Vilaro Ca, Cabrera O, Venegas A, and Zapata S

Subjects
Mechanical ventilation, Engineering, business.industry, medicine.medical_treatment, medicine, Christian ministry, Medical emergency, business, medicine.disease
Abstract

Background: Home mechanical ventilation (HMV) is a viable and effective strategy for patients with chronic respiratory failure (CRF) of different causes. The Chilean Ministry of Health started in 2006 a program for HMV in Children and in 2008 it began a program for HMV in adults. All belonged to the state health insurance.Methods: Prospective cohort of adult patients with CRF in 10 regions of Chile admitted to the national HMV program, their demographic, clinical and functional characteristics, mode of admission, time in the program and survival.Results: A total of 1,105 patients were included. Median age was 59 years (44-58, IQR1-IQR3). Women were 58.1%. The body mass index was 34.9 (26-46) kg/m2, and 942 (85.4%) belonged to low-income socioeconomic groups. The baseline score on the Severe Respiratory Insufficiency questionnaire (SRI) was 47 (35-62.1) points, 98.5% lived in urban areas, 76.2% initiated HMV in the stable chronic mode, 23.8% in the acute mode and 99 patients were transferred from the children's program. There were 1047 patients on noninvasive ventilation and 58 on invasive ventilation through tracheostomy. Baseline PaCO2 was 58.2 (52-65) mmHg. Device usage time was 7.3 h/d (5.8-8.8), the time in HMV was 21.6 (12.2-49.5) months. The diagnostic groups were COPD, 35%; obesity hypoventilation syndrome (OHS), 23.9%; neuromuscular disease (NMD) 16.3%; non-cystic fibrosis bronchiectasis or tuberculosis (non-CF BC or TBC) 8.3%; Scoliosis, 5.9%; and Amyotrophic Lateral Sclerosis (ALS) 5.24%. The lowest 1- and 3-year survival rates were observed in the ALS group, i.e., 67% and 26%, respectively, and the lowest 9-year survival was observed in the non-CF BC or TB and COPD, 27% and 30.9%, respectively. The best survival rates at 9 years were 57.7%, 57.2% and 50.9% for patients with OHS, Scoliosis and NMD, respectively.Conclusion: The most common diagnoses were COPD and OHS. Patients were hypercapnic and had poor quality of life at program admission. The best survival was observed in patients with OHS, Scoliosis and NMD.

Published
2021

23. Automated ventilator technology : More answers and some questions

Author

Rabec, C, Patout, Maxime, Gagnadoux, Frederic, Trzepizur, Wojciech, Georges, M, Perrin, C, Tamisier, Renaud, Pepin, Jean Louis, Llontop, Claudia, Attali, Valerie, Goutorbes, Frédéric, Pontier-Marchandise, Sandrine, Cervantes, Pierre, Bironneau, Vanessa, Portmann, Adriana, Delrieux, J., Cuvelier, A, Muir, Jf, and SALAS, Danielle

Subjects
[SDV] Life Sciences [q-bio]
Published
2021

24. Recommended Approaches to Minimize Aerosol Dispersion of SARS-CoV-2 During Noninvasive Ventilatory Support Can Cause Ventilator Performance Deterioration: A Benchmark Comparative Study

Author

Patout, M., Fresnel, E., Lujan, M., Rabec, C., Carlucci, A., Razakamanantsoa, L., Kerfourn, A., Nunes, H., Tandjaoui-Lambiotte, Y., Cuvelier, A., Muir, J. -F., Lalmoda, C., Langevin, B., Sayas, J., Gonzalez-Bermejo, J., Janssens, J. -P., Sayas-Catalan, J., Lujan-Torne, M., Lofaso, F., Carlo, J. W., and Lamolda, C.

Subjects
filter, CPAP, COVID-19, noninvasive ventilation, aerosolization
Published
2021

25. Precision Medicine Is Coming to Town: Personalising Home Ventilatory Equipment in COPD Patients With Chronic Hypercapnic Respiratory Failure

Author

Gonzalez-Bermejo J., Nava S., Rabec C., Vega M. L., Neurophysiologie Respiratoire Expérimentale et Clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Bologna, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Bologna/Università di Bologna, Gestionnaire, Hal Sorbonne Université, Gonzalez-Bermejo J., Nava S., Rabec C., and Vega M.L.

Subjects
lcsh:RC705-779, Male, Noninvasive Ventilation, Ventilators, Mechanical, lcsh:Diseases of the respiratory system, Middle Aged, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Hypercapnia, Pulmonary Disease, Chronic Obstructive, NONINVASIVE VENTILATION - COPD - PRECISION MEDICINE, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Humans, Precision Medicine, Respiratory Insufficiency
Abstract

International audience; Discharging a chronic critically ill patient is a risky procedure if the clinician does not have full control of his prescription. This is even more important when applying a machine to replace a failing organ, as is the case for home ventilation. Even if modern home ventilators fulfil quality and safety criteria and, 'on paper', ventilators and masks look very similar, performance and scenarios of applicability are not always equivalent. In the case of ventilators, the type of circuit, accessories provided and available modes vary between devices. Bench studies comparing ventilators have shown large differences in triggering, rise time, pressurisation capacities, maximal flow provided, cycling and level of authorised expiratory positive airway pressure. Automated algorithms to deal with leaks also vary and have not been sufficiently evaluated. In the case of interfaces, the choice of mask requires careful evaluation of the underlying disease and of the type of ventilator and circuit, which could have a potentially major impact on patient compliance and clinical effectiveness. This could explain different results in the same clinical situation. The choice of ventilator and type of mask represents a medical prescription and should be respected by the provider and not subject to financial constraints.

Published
2019

26. Respiratory support in COPD patients after acute exacerbation with monitoring the quality of support (Rescue2-monitor): an open-label, prospective randomized, controlled, superiority clinical trial comparing hospital- versus home-based acute non-invasive ventilation for patients with hypercapnic chronic obstructive pulmonary disease

Author

Gonzalez-Bermejo J, Hajage D, Durand-Zaleski I, Arnal J, Cuvelier A, Grassion L, Jaffre S, Lamia B, Pontier S, Prigent A, Rabec C, Raherison-Semjen C, Saint Raymond C, Soler J, Trzepizur W, Winck J, Aguiar M, Chaves H, Conde B, Guimaraes M, Lopes P, Mineiro A, Moreira S, Pamplona P, Rodrigues C, Sousa S, Anton A, Cordoba-Izquierdo A, Embid C, Gonzalez C, Ezzine F, Garcia P, Gonzalez M, Guerassimova I, Lopez D, Lujan M, Beltran S, Martinez J, Masa F, Pascual N, Penacoba N, Resano P, Rey L, Jerez F, Roncero A, Chinesta J, Catalan J, and On behalf of the Rescue2

Subjects
Targeted treatment, Hypercapnic respiratory failure, Chronic obstructive pulmonary disease (COPD), Non-invasive ventilation (NIV), Hypoventilation
Abstract

Chronic obstructive pulmonary disease (COPD) is expected to be the 3(rd)leading cause of death worldwide by 2020. Despite improvements in survival by using acute non-invasive ventilation (NIV) to treat patients with exacerbations of COPD complicated by acute hypercapnic respiratory failure (AHRF), these patients are at high risk of readmission and further life-threatening events, including death. Recent studies suggested that NIV at home can reduce readmissions, but in a small proportion of patients, and with a high level of expertise. Other studies, however, do not show any benefit of home NIV. This could be related to the fact that respiratory failure in patients with stable COPD and their response to mechanical ventilation are influenced by several pathophysiological factors which frequently coexist in the same patient to varying degrees. These pathophysiological factors might influence the success of home NIV in stable COPD, thus long-term NIV specifically adapted to a patient's "phenotype" is likely to improve prognosis, reduce readmission to hospital, and prevent death. In view of this conundrum, Rescue2-monitor (R2M), an open-label, prospective randomized, controlled study performed in patients with hypercapnic COPD post-AHRF, will investigate the impact of the quality of nocturnal NIV on the readmission-free survival. The primary objective is to show that any of 3 home NIV strategies ("rescue," "non-targeted," and "targeted") will improve readmission-free survival in comparison to no-home NIV. The "targeted" group of patients will receive a treatment with personalized (targeted) ventilation settings and extensive monitoring. Furthermore, the influence of comorbidities typical for COPD patients, such as cardiac insufficiency, OSA, or associated asthma, on ventilation outcomes will be taken into consideration and reasons for non-inclusion of patients will be recorded in order to evaluate the percentage of ventilated COPD patients that are screening failures. ClinicalTrials.gov. Registered on March 26, 2019.

Published
2020

28. EvalClin: évaluation clinique des concentrateurs d’oxygène portatif : impact de l’oxygénothérapie pulsé à l’effort

Author

Maris, J., primary, Melloni, B., additional, Rabec, C., additional, Delrieu, J., additional, Mba Mintsa, L., additional, Bonnevie, T., additional, Gravier, F.E., additional, Herengt, F., additional, Al Chikahanie, Y., additional, Foret, D., additional, Cuvelier, A., additional, Chambellan, A., additional, Gonzalez-Bermejo, J., additional, Muir, J.F., additional, and Patout, M., additional

Published
2021
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29. Impact sur l’efficacité de la ventilation de l’ajout de filtres minimisant la dispersion des aérosols chez les patients atteints d’une infection virale: étude de 8 configurations de circuits sur banc test

Author

Patout, M., primary, Fresnel, E., additional, Lujan, M., additional, Rabec, C., additional, Carlucci, A., additional, Razakamanantsoa, L., additional, Kerfourn, A., additional, Nunes, H., additional, Tandjaoui-Lambiotte, Y., additional, Cuvelier, A., additional, Muir, J.F., additional, Lalmoda, C., additional, Langevin, B., additional, Sayas, J., additional, Gonzalez-Bermejo, J., additional, and Janssens, J.P., additional

Published
2021
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32. Respiratory support in patients with COVID-19 (outside intensive care unit). A position paper of the Respiratory Support and Chronic Care Group of the French Society of Respiratory Diseases

Author

Rabec, C., primary, Gonzalez-Bermejo, J., additional, Mercy, M., additional, Grassion, L., additional, Pontier, S., additional, Patout, M., additional, Luque, R., additional, Delafosse, C., additional, Raherison-Semjen, C., additional, Maître, B., additional, Duthoit, L., additional, Mendoza, A., additional, Jacquin, L., additional, Borel, J.C., additional, Cervantes, P., additional, Janssens, J.-P., additional, Chabot, J.-F., additional, Morelot-Panzini, C., additional, and Jaffuel, D., additional

Published
2020
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34. Ventilation non invasive (VNI) à domicile : que faire des données de télé-suivi ?

Author

El Husseini, K., primary, Dantoing, E., additional, Kerfourn, A., additional, Fresnel, E., additional, Borel, J.C., additional, Dupuis, J., additional, Gagnadoux, F., additional, Gonzalez-Bermejo, J., additional, Muir, J.F., additional, Murphy, P., additional, Prigent, A., additional, Rabec, C., additional, Trzepizur, W., additional, Winck, J.C., additional, Cuvelier, A., additional, and Patout, M., additional

Published
2020
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36. Sleep Quality Using AVAPS-AE Versus ST Mode: A Randomized Controlled Trial in Patients with Obesity Hypoventilation Syndrome

Author

Patout, M., primary, Gagnadoux, F., additional, Rabec, C., additional, Trzepizur, W., additional, Georges, M., additional, Perrin, C., additional, Tamisier, R., additional, Llontop, C., additional, Goutorbe, F., additional, Gounane, C., additional, Marchandise, S., additional, Cervantes, P., additional, Bironneau, V., additional, Portmann, A., additional, Delrieu, J., additional, Muir, J.-F., additional, and Cuvelier, A., additional

Published
2019
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39. Comparaison des modes AVAPS-AE et mode ST chez les patients atteints d’un syndrome obésité hypoventilation : une étude contrôlée randomisée

Author

Patout, M., primary, Gagnadoux, F., additional, Rabec, C., additional, Trzepizur, W., additional, Georges, M., additional, Perrin, C., additional, Tamisier, R., additional, Llontop, C., additional, Goutorbe, F., additional, Gounane, C., additional, Pontier-Marchandise, S., additional, Cervantes, P., additional, Bironneau, V., additional, Portmann, A., additional, Delrieu, J., additional, Muir, J.F., additional, and Cuvelier, A., additional

Published
2019
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41. Cohorte ANTADIR-GAV de patients insuffisants respiratoires nouvellement traités par ventilation non invasive à domicile en France. Résultats à 18 mois

Author

Rabec, C., primary, Cuvelier, A., additional, Melloni, B., additional, Cervantes, P., additional, Morelot, C., additional, Georges, M., additional, Pontier, S., additional, Guillaumot, A., additional, Mercy, M., additional, Gagnadoux, F., additional, Perrin, C., additional, Lavergne, F., additional, Prigent, A., additional, Mallart, A., additional, Hilbert, G., additional, Kessler, R., additional, Claude, F., additional, Goubert, L., additional, Prigent, H., additional, Jaffre, S., additional, Perel, A., additional, Llontop, C., additional, Sedkaoui, K., additional, Foret, D., additional, Mounier, L., additional, Muir, F., additional, and Gonzalez, J., additional

Published
2018
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44. Et s’il était possible de prédire le type d’appareil de PPC (constant ou autopiloté) à utiliser dans le traitement du SAHOS ?

Author

Bironneau, V., primary, Loustonneau, E., additional, Pontier, S., additional, Gagnadoux, F., additional, Iamandi, C., additional, Portel, L., additional, Martin, F., additional, Mallart, A., additional, Lerousseau, L., additional, Alfandary, D., additional, Levrat, V., additional, Portier, F., additional, Tamisier, R., additional, Goutorbe, F., additional, Rabec, C., additional, Codron, F., additional, Auregan, G., additional, Mercy, M., additional, Attali, V., additional, Soyez, F., additional, Launois, C., additional, Recart, D., additional, Vecchierini, F., additional, and Meurice, J.C., additional

Published
2016
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49. Hot Topics in Noninvasive Ventilation: Report of a Working Group at the International Symposium on Sleep-Disordered Breathing in Leuven, Belgium

Author

Vrijsen, B., primary, Chatwin, M., additional, Contal, O., additional, Derom, E., additional, Janssens, J.-P., additional, Kampelmacher, M. J., additional, Muir, J.-F., additional, Pinto, S., additional, Rabec, C., additional, Ramsay, M., additional, Randerath, W. J., additional, Storre, J. H., additional, Wijkstra, P. J., additional, Windisch, W., additional, and Testelmans, D., additional

Published
2015
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