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186 results on '"Rabadi, Meheroz H."'

10. sj-pdf-1-cns-10.1177_11795735211028769 – Supplemental material for The Impact of Adherence to Disease-Modifying Therapies on Functional Outcomes in Veterans with Multiple Sclerosis

Author

Rabadi, Meheroz H, Just, Kimberly, and Xu, Chao

Subjects
FOS: Clinical medicine, health care economics and organizations, humanities, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-cns-10.1177_11795735211028769 for The Impact of Adherence to Disease-Modifying Therapies on Functional Outcomes in Veterans with Multiple Sclerosis by Meheroz H Rabadi, Kimberly Just and Chao Xu in Journal of Central Nervous System Disease

Published
2021
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13. Impact of adherence to disease-modifying therapies on employment among veterans with multiple sclerosis.

Author

Rabadi, Meheroz H., Just, Kimberly, and Xu, Chao

Subjects
*MULTIPLE sclerosis, *KRUSKAL-Wallis Test, *SCIENTIFIC observation, *ANALYSIS of variance, *RETROSPECTIVE studies, *FISHER exact test, *DRUGS, *EMPLOYMENT, *DESCRIPTIVE statistics, *CHI-squared test, *PATIENT compliance, *VETERANS, *LOGISTIC regression analysis, *DATA analysis software, *LONGITUDINAL method
Abstract

Patients who adhere to their disease-modifying therapies (DMTs) have a lower rate of MS-related relapses and disability. We sought to determine the adherence rate to DMTs and the association between adherence to DMTs and employment in patients with multiple sclerosis (MS). One hundred and forty-two patients with MS who were periodically followed in our clinic between January 2000 and January 2020. We compared three groups of patients, defined according to their adherence to DMTs (non-adherent; poorly adherent; adherent), on their obtaining paid employment. Forty-seven MS patients (33.1%) were non-adherent to any DMT medication, while 88 MS patients (62.0%) demonstrated good and 7 (4.9%) poor adherences. More patients in the good-adherence group were in paid employment 42.0% compared to 23.4% in the non-adherent group (p = 0.587) after controlling for potential co-founders. In this study veterans who adhered to their DMTs were 2.4 times more likely to be in paid-employment compared to non- or poorly-adherent patients. The clinical significance of this study is to encourage MS patients to adhere to their DMTs as a motivating factor of being in paid-employment. What is known about this subject? In the setting of a randomized controlled trial adherence rates reported for different injectable DMTs vary from 79–85% for once a week interferon beta-1a (IM IFNb-1a) to 49–78% for other injectable DMTs. •What are the new findings and/or impact on clinical practice? •Paid employment was more common among veterans whose adherence to DMTs was good (42.0% employed) or poor (42.9%) than among those who were non-adherent (23.4%). Veterans who adhered to DMTs were also younger, had less severe MS, and displayed less cognitive and physically impairment than those who did not adhere. •Being employed can act as a motivating factor to encourage adherence to treatment aimed at preventing accumulation of mental and physical disabilities. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Veterans with familial ALS and bulbar and respiratory presentations at onset had shorter survival

Author

Rabadi, Meheroz H, Russell, Kimberly A, and Xu, Chao

Abstract

Objective: We sought to characterize the clinical prognostic factors in veterans with amyotrophic lateral sclerosis (ALS) followed in our ALS clinic.Background: ALS is a rare, progressive neurodegenerative condition associated with decreased survival compared to that in the normal population.Method: The electronic medical records of 105 veterans diagnosed with ALS who are followed in our ALS clinic between 2010 and 2021 were reviewed. Approval from the institutional review board was obtained from the study protocol. Demographic and clinical variables included age at symptom onset, age at initial evaluation, survival (from symptom onset to death), gender, site of onset (appendicular, bulbar, and respiratory), initial amyotrophic lateral sclerosis functional-related score-revised (ALSFRS-R), total functional independence measure (TFIM) scores, initial forced vital capacity (FVC), and interventions (Riluzole, gastrostomy, noninvasive ventilation [NIV], and tracheostomy). Normally distributed data was expressed as mean ± standard deviation. Fischer's exact analysis of the distribution differences of categorical data. The Kaplan–Meier plot analyzed the time-to-event.Results: The mean (SD) age at symptom onset was 62.0 (11.1) years, age at diagnosis was 65 (11) years, with 72% of the patients being over 60 years at diagnosis. The median survival time from symptom onset was 4.12 (3) years. Limb-onset ALS (appendicular) was the most frequent (52%) followed by bulbar-onset ALS (43%). The mean ALSFRS-R and TFIM scores were 31 (8) and 91 (25), respectively. Family history (familial), bulbar, and respiratory presentation at diagnosis were associated with shorter survival times.Conclusion: This study suggests that of the clinical prognostic factors veterans with familial ALS, bulbar, and respiratory onset at presentations had shorter survival. The presence of Agent Orange, PEG placement, and NIV did not affect survival.

Published
2024
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21. Admission ambulation velocity predicts length of stay and discharge disposition following stroke in an acute rehabilitation hospital

Author

Rabadi, Meheroz H. and Blau, Alan

Subjects
Stroke (Disease) -- Care and treatment, Rehabilitation, Psychology and mental health, Care and treatment
Abstract

Background and Purpose. Poststroke functional outcome and discharge disposition are influenced by age, lesion location and size, severity of neurological insult, prior functional ability, and social support. The effect of [...]

Published
2005

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