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1. Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele

Author

Jaffey, J.A., Pavlick, M., Webster, C.R., Moore, G.E., McDaniel, K.A., Blois, S.L., Brand, E.M., Reich, C.F., Motschenbacher, L., Hostnik, E.T., Su, D., Lidbury, J.A., Raab, O., Carr, S.V., Mabry, K.E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., Ohno, K., VanEerde, E., Fieten, H., Hulsman, A.H., Cooley-Lock, K., Dunning, M., Kisielewicz, C., Zoia, A., Caldin, M., Conti-Patara, A., Ross, L., Mansfield, C., Lynn, O., Claus, M.A., Watson, P.J., Swallow, A., Yool, D.A., Gommeren, K., Knops, M., Ceplecha, V., de Rooster, H., Lobetti, R., Dossin, O., Jolivet, F., Papazoglou, L.G., Pappalardo, M.C.F., Manczur, F., Dudás-Györki, Z., O’Neill, E.J., Martinez, C., Gal, A., Owen, R.L., Gunn, E., Brown, K., Harder, L.K., Griebsch, C., Anfinsen, K.P., Gron, T.K., Marchetti, V., Heilmann, R.M., Pazzi, P., and DeClue, A.E.

Published
2019
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3. Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele

Author

Jaffey, J. A., Pavlick, M., Webster, C. R., Moore, G. E., McDaniel, K. A., Blois, S. L., Brand, E. M., Reich, C. F., Motschenbacher, L., Hostnik, E. T., Su, D., Lidbury, J. A., Raab, O., Carr, S. V., Mabry, K. E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., Ohno, K., VanEerde, E., Fieten, H., Hulsman, A. H., Cooley-Lock, K., Dunning, M., Kisielewicz, C., Zoia, A., Caldin, M., Conti-Patara, A., Ross, L., Mansfield, C., Lynn, O., Claus, M. A., Watson, P. J., Swallow, A., Yool, D. A., Gommeren, K., Knops, M., Ceplecha, V., de Rooster, H., Lobetti, R., Dossin, O., Jolivet, F., Papazoglou, L. G., Pappalardo, M. C.F., Manczur, F., Dudás-Györki, Z., O'Neill, E. J., Martinez, C., Gal, A., Owen, R. L., Gunn, E., Brown, K., Harder, L. K., Griebsch, C., Anfinsen, K. P., Gron, T. K., Marchetti, V., Heilmann, R. M., Pazzi, P., DeClue, A. E., Jaffey, J. A., Pavlick, M., Webster, C. R., Moore, G. E., McDaniel, K. A., Blois, S. L., Brand, E. M., Reich, C. F., Motschenbacher, L., Hostnik, E. T., Su, D., Lidbury, J. A., Raab, O., Carr, S. V., Mabry, K. E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., Ohno, K., VanEerde, E., Fieten, H., Hulsman, A. H., Cooley-Lock, K., Dunning, M., Kisielewicz, C., Zoia, A., Caldin, M., Conti-Patara, A., Ross, L., Mansfield, C., Lynn, O., Claus, M. A., Watson, P. J., Swallow, A., Yool, D. A., Gommeren, K., Knops, M., Ceplecha, V., de Rooster, H., Lobetti, R., Dossin, O., Jolivet, F., Papazoglou, L. G., Pappalardo, M. C.F., Manczur, F., Dudás-Györki, Z., O'Neill, E. J., Martinez, C., Gal, A., Owen, R. L., Gunn, E., Brown, K., Harder, L. K., Griebsch, C., Anfinsen, K. P., Gron, T. K., Marchetti, V., Heilmann, R. M., Pazzi, P., and DeClue, A. E.

Abstract

Gallbladder mucocele (GBM) is a common extra-hepatic biliary syndrome in dogs with death rates ranging from 7 to 45%. Therefore, the aim of this study was to identify the association of survival with variables that could be utilized to improve clinical decisions. A total of 1194 dogs with a gross and histopathological diagnosis of GBM were included from 41 veterinary referral hospitals in this retrospective study. Dogs with GBM that demonstrated abnormal clinical signs had significantly greater odds of death than subclinical dogs in a univariable analysis (OR, 4.2; 95% CI, 2.14–8.23; P < 0.001). The multivariable model indicated that categorical variables including owner recognition of jaundice (OR, 2.12; 95% CI, 1.19–3.77; P = 0.011), concurrent hyperadrenocorticism (OR 1.94; 95% CI, 1.08–3.47; P = 0.026), and Pomeranian breed (OR, 2.46; 95% CI 1.10–5.50; P = 0.029) were associated with increased odds of death, and vomiting was associated with decreased odds of death (OR, 0.48; 95% CI, 0.30–0.72; P = 0.001). Continuous variables in the multivariable model, total serum/plasma bilirubin concentration (OR, 1.03; 95% CI, 1.01–1.04; P < 0.001) and age (OR, 1.17; 95% CI, 1.08–1.26; P < 0.001), were associated with increased odds of death. The clinical utility of total serum/plasma bilirubin concentration as a biomarker to predict death was poor with a sensitivity of 0.61 (95% CI, 0.54–0.69) and a specificity of 0.63 (95% CI, 0.59–0.66). This study identified several prognostic variables in dogs with GBM including total serum/plasma bilirubin concentration, age, clinical signs, concurrent hyperadrenocorticism, and the Pomeranian breed. The presence of hypothyroidism or diabetes mellitus did not impact outcome in this study.

Published
2019

4. Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele

Author

dCSCA RMSC-1, dCSCA AVR, LS Interne geneeskunde, Jaffey, J. A., Pavlick, M., Webster, C. R., Moore, G. E., McDaniel, K. A., Blois, S. L., Brand, E. M., Reich, C. F., Motschenbacher, L., Hostnik, E. T., Su, D., Lidbury, J. A., Raab, O., Carr, S. V., Mabry, K. E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., Ohno, K., VanEerde, E., Fieten, H., Hulsman, A. H., Cooley-Lock, K., Dunning, M., Kisielewicz, C., Zoia, A., Caldin, M., Conti-Patara, A., Ross, L., Mansfield, C., Lynn, O., Claus, M. A., Watson, P. J., Swallow, A., Yool, D. A., Gommeren, K., Knops, M., Ceplecha, V., de Rooster, H., Lobetti, R., Dossin, O., Jolivet, F., Papazoglou, L. G., Pappalardo, M. C.F., Manczur, F., Dudás-Györki, Z., O'Neill, E. J., Martinez, C., Gal, A., Owen, R. L., Gunn, E., Brown, K., Harder, L. K., Griebsch, C., Anfinsen, K. P., Gron, T. K., Marchetti, V., Heilmann, R. M., Pazzi, P., DeClue, A. E., dCSCA RMSC-1, dCSCA AVR, LS Interne geneeskunde, Jaffey, J. A., Pavlick, M., Webster, C. R., Moore, G. E., McDaniel, K. A., Blois, S. L., Brand, E. M., Reich, C. F., Motschenbacher, L., Hostnik, E. T., Su, D., Lidbury, J. A., Raab, O., Carr, S. V., Mabry, K. E., Fox-Alvarez, W., Townsend, S., Palermo, S., Nakazono, Y., Ohno, K., VanEerde, E., Fieten, H., Hulsman, A. H., Cooley-Lock, K., Dunning, M., Kisielewicz, C., Zoia, A., Caldin, M., Conti-Patara, A., Ross, L., Mansfield, C., Lynn, O., Claus, M. A., Watson, P. J., Swallow, A., Yool, D. A., Gommeren, K., Knops, M., Ceplecha, V., de Rooster, H., Lobetti, R., Dossin, O., Jolivet, F., Papazoglou, L. G., Pappalardo, M. C.F., Manczur, F., Dudás-Györki, Z., O'Neill, E. J., Martinez, C., Gal, A., Owen, R. L., Gunn, E., Brown, K., Harder, L. K., Griebsch, C., Anfinsen, K. P., Gron, T. K., Marchetti, V., Heilmann, R. M., Pazzi, P., and DeClue, A. E.

Published
2019

5. Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele

Author

Jaffey, JA, Pavlick, M, Webster, CR, Moore, GE, McDaniel, KA, Blois, SL, Brand, EM, Reich, CF, Motschenbacher, L, Hostnik, ET, Su, D, Lidbury, JA, Raab, O, Carr, SV, Mabry, KE, Fox-Alvarez, W, Townsend, S, Palermo, S, Nakazono, Y, Ohno, K, VanEerde, E, Fieten, H, Hulsman, AH, Cooley-Lock, K, Dunning, M, Kisielewicz, C, Zoia, A, Caldin, M, Conti-Patara, A, Ross, L, Mansfield, C, Lynn, O, Claus, MA, Watson, PJ, Swallow, A, Yool, DA, Gommeren, K, Knops, M, Ceplecha, V, De Rooster, H, Lobetti, R, Dossin, O, Jolivet, F, Papazoglou, LG, Pappalardo, MCF, Manczur, F, Dudás-Györki, Z, O'Neill, EJ, Martinez, C, Gal, A, Owen, RL, Gunn, E, Brown, K, Harder, LK, Griebsch, C, Anfinsen, KP, Gron, TK, Marchetti, V, Heilmann, RM, Pazzi, P, and DeClue, AE

Subjects
Adrenocortical Hyperfunction, Survival, Gallbladder mucocoele, Mucocele, Bilirubin, Hyperlipidemias, Canine Cushing’s, Gallbladder Diseases, 3. Good health, Dogs, Treatment Outcome, Hypothyroidism, Animals, Cholecystectomy, Genetic Predisposition to Disease, Dog Diseases, Biomarkers, Hyperbilirubinemia, Retrospective Studies
Abstract

Gallbladder mucocele (GBM) is a common extra-hepatic biliary syndrome in dogs with death rates ranging from 7 to 45%. Therefore, the aim of this study was to identify the association of survival with variables that could be utilized to improve clinical decisions. A total of 1194 dogs with a gross and histopathological diagnosis of GBM were included from 41 veterinary referral hospitals in this retrospective study. Dogs with GBM that demonstrated abnormal clinical signs had significantly greater odds of death than subclinical dogs in a univariable analysis (OR, 4.2; 95% CI, 2.14-8.23; P

7. Pathology in Practice.

Author

Gilroy C, Raab O, and Hanna P

Subjects
Animals, Dogs, Male, Cystitis diagnosis, Cystitis microbiology, Cystitis veterinary, Dog Diseases diagnosis, Peritonitis diagnosis, Peritonitis microbiology, Peritonitis veterinary
Published
2020
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8. A cross-sectional study of Tritrichomonas foetus infection in feral and shelter cats in Prince Edward Island, Canada.

Author

Raab O, Greenwood S, Vanderstichel R, and Gelens H

Subjects
Animals, Animals, Wild parasitology, Cat Diseases epidemiology, Cats, Cross-Sectional Studies, Disease Reservoirs veterinary, Feces parasitology, Female, Housing, Animal, Male, Prince Edward Island epidemiology, Prospective Studies, Toxocara, Toxocariasis epidemiology, Cat Diseases parasitology, Intestinal Diseases, Parasitic veterinary, Protozoan Infections, Animal epidemiology, Tritrichomonas foetus
Abstract

A cross-sectional study examined the occurrence of Tritrichomonas foetus, and other intestinal parasites, in feral and shelter cats in Prince Edward Island (PEI). Fecal samples were collected from 100 feral cats, 100 cats from the PEI Humane Society, and 5 cats from a private residence. The occurrence of T. foetus, based on fecal culture, was 0% in feral and shelter cats. A single positive sample was obtained from an owned Abyssinian cat that was imported to PEI. Intestinal parasites were identified via fecal flotation in 76% of feral cats and 39% of cats from the humane society. Feral cats had a higher incidence of Toxocara cati than cats from the humane society (P < 0.001), conversely, shelter cats had a higher incidence of Cystoisospora spp. (P < 0.001). These results suggest that while T. foetus is not of importance in feral and shelter cats in PEI, imported cats could serve as reservoirs.

Published
2016

9. Successful treatment of Corynebacterium urealyticum encrusting cystitis with systemic and intravesical antimicrobial therapy.

Author

Raab O, Béraud R, Tefft KM, and Muckle CA

Subjects
Animals, Corynebacterium Infections microbiology, Cystitis microbiology, Cystitis surgery, Dog Diseases drug therapy, Dog Diseases surgery, Dogs, Male, Anti-Bacterial Agents therapeutic use, Corynebacterium isolation & purification, Corynebacterium Infections veterinary, Cystitis veterinary, Dog Diseases microbiology
Abstract

A 6-year-old Saint Bernard dog was diagnosed with encrusting cystitis caused by Corynebacterium urealyticum. The infection persisted despite the prolonged use of antimicrobials and surgical debridement of the urinary bladder. Resolution occurred following intravenous vancomycin, urine acidification, and intravesical gentamicin. The challenges involved in the treatment of encrusting cystitis are described.

Published
2015

10. Deposition of inhaled monodisperse aerosols in small rodents.

Author

Raab OG, Yeh HC, Newton GJ, Phalen RF, and Velasquez DJ

Subjects
Animals, Cricetinae, Female, Male, Mesocricetus, Particle Size, Pulmonary Ventilation, Rats, Aerosols, Respiration, Respiratory System
Abstract

Aerosols of five different sizes varying from about 0.05 micron to 3 micron in aerodynamic equivalent diameter were prepared from spherical aluminosilicate particles (p=2.2 g/cm3) labelled with 169Yb. Fifty hamsters and fifty rats were exposed, while anaesthetized, to these monodisperse aerosols under controlled laboratory conditions to determine quantitatively deposition in the respiratory airways with respect to particle size and volume of air inhaled. Ten animals of each species were exposed to each of the particle sizes. Five animals were exposed simultaneously for 20 min in an inhalation exposure apparatus which provided automatic recordings of respiratory rates and volumes using individual whole-body plethymographs; three were sacrificed immediately after exposure and the remaining two after 20 h had elapsed for radioanalysis of selected tissues to determine deposition quantities and organ distribution. Detailed results are given for the observed deposition fractions for the different aerosols in the various parts of the respiratory tract. The lowest fractional total deposition occurred for particles between 0.5 micron and 1 micron in aerodynamic equivalent diameter. Relative deposition among the various lung lobes showed remarkable consistency with respect to particle size. Based upon the results of morphometric measurements of replica casts of lungs of the two species, interpretations are made relating the observed deposition phenomena to tracheobronchial anatomy.

Published
1975

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