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29 results on '"Ra, Y. -S."'

1. Central-moment description of polarization for quantum states of light

Author

Björk, G., Söderholm, J., Kim, Y. -S., Ra, Y. -S., Lim, H. -T., Kothe, C., Kim, Y. -H., Sánchez-Soto, L. L., and Klimov, A. B.

Subjects
Quantum Physics
Abstract

We present a moment expansion method for the systematic characterization of the polarization properties of quantum states of light. Specifically, we link the method to the measurements of the Stokes operator in different directions on the Poincar\'{e} sphere, and provide a method of polarization tomography without resorting to full state tomography. We apply these ideas to the experimental first- and second-order polarization characterization of some two-photon quantum states. In addition, we show that there are classes of states whose polarization characteristics are dominated not by their first-order moments (i.e., the Stokes vector) but by higher-order polarization moments., Comment: 11 pages, 7 figures, 4 tables, In version 2, Figs. 2 and 4 are replaced, Sec. IV extended, Sec. VIII revised, a few references added

Published
2011

2. CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

Author

Perry, Arie, Spence, T, Sin-Chan, P, Picard, D, Barszczyk, M, Hoss, K, Lu, M, Kim, S-K, Ra, Y-S, Nakamura, H, and Fangusaro, J

Abstract

Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought to evaluate the diagnostic specifici

Published
2014

3. First observation of the ΣN decay of the S = −2 system

Author

Watanabe, T., Ahn, J. K., Akikawa, H., Aoki, S., Arai, K., Bahk, S. Y., Baik, K. M., Bassalleck, B., Chung, J. H., Chung, M. S., Davis, D. H., Fukuda, T., Hayata, H., Hoshino, K., Ichikawa, A., Ieiri, M., Imai, K., Iwata, Y. H., Iwata, Y. S., Kakita, Y., Kanda, H., Kaneko, M., Kawai, T., Kawasaki, M., Kim, C. O., Kim, J. Y., Kim, S. J., Kim, S. H., Kondo, Y., Kouketsu, T., Lee, Y. L., McNabb, J. W. C., Mitsuhara, M., Nagase, Y., Nagoshi, C., Nakazawa, K., Noumi, H., Ogawa, S., Okabe, H., Oyama, K., Park, H. M., Park, I. G., Parker, J., Ra, Y. S., Rhee, J. T., Rusek, A., Shibuya, H., Sim, K. S., Saha, P. K., Seki, D., Sekimoto, M., Song, J. S., Takahashi, H., Takahashi, T., Takeutchi, F., Tanaka, H., Tanida, K., Tojo, J., Torii, H., Torikai, S., Tsunemi, T., Tovee, D. N., Ushida, N., Yamamoto, K., Yasuda, N., Yang, J. T., Yoon, C. J., Yoon, C. S., Yosoi, M., Yoshida, T., Zhu, L., Pochodzalla, Josef, editor, and Walcher, Thomas, editor

Published
2007
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4. First observation of the ΣN decay of the S = - 2 system

Author

Watanabe, T., Ahn, J. K., Akikawa, H., Aoki, S., Arai, K., Bahk, S. Y., Baik, K. M., Bassalleck, B., Chung, J. H., Chung, M. S., Davis, D. H., Fukuda, T., Hayata, H., Hoshino, K., Ichikawa, A., Ieiri, M., Imai, K., Iwata, Y. H., Iwata, Y. S., Kakita, Y., Kanda, H., Kaneko, M., Kawai, T., Kawasaki, M., Kim, C. O., Kim, J. Y., Kim, S. J., Kim, S. H., Kondo, Y., Kouketsu, T., Lee, Y. L., McNabb, J. W. C., Mitsuhara, M., Nagase, Y., Nagoshi, C., Nakazawa, K., Noumi, H., Ogawa, S., Okabe, H., Oyama, K., Park, H. M., Park, I. G., Parker, J., Ra, Y. S., Rhee, J. T., Rusek, A., Shibuya, H., Sim, K. S., Saha, P. K., Seki, D., Sekimoto, M., Song, J. S., Takahashi, H., Takahashi, T., Takeutchi, F., Tanaka, H., Tanida, K., Tojo, J., Torii, H., Torikai, S., Tsunemi, T., Tovee, D. N., Ushida, N., Yamamoto, K., Yasuda, N., Yang, J. T., Yoon, C. J., Yoon, C. S., Yosoi, M., Yoshida, T., and Zhu, L.

Published
2007
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5. Title: Defining the clinical and prognostic landscape of embryonal tumors with multi-layered rosettes (ETMRs), a rare brain tumor registry (RBTC) study.

Author

Gajjar A., Leary S., Mulcahy Levy J.M., Lassaletta A., Rivas E., Reddy A., Gillespie G.Y., Gupta N., Yalon-Oren M., Amariglio L., Nakamura H., Wu K.-S., Wong T.-T., Ra Y.-S., Spina M.L., Emanuele P.V., Massimi L., Buccoliero A.M., Hansford J.R., Grundy R.G., Adamek D., Fangusaro J., Scharnhorst D., Johnston D., Lafay-Cousin L., Camelo-Piragua S., Kabbara N., Boutarbouch M., Da Costa M.J.G., Hanson D., Wood P., Al-Hussaini M., Amayiri N., Wang Y., Catchpoole D., Michaud J., Bendel A.E., Ellezam B., Gerber N., Plant A., Jeffery R., Dunham C., Moertel C., Walter A., Ziegler D., Dodgshun A., Gottardo N., Demir A., Ramanujachar R., Raabe E., Mary S., Dirks P., Taylor M., Eugene H., Lindsey H., Tihan T., Mette J., Dahl C., Low S., Smith A., Hazrati L.-N., Kresak J., Gino S., Tan E., Morales A., Santa-Maria V., Hawkins C., Bartels U., Stephens D., Nobusawa S., Dufour C., Bourdeaut F., Andre N., Bouffet E., Huang A., Khan S., Solano-Paez P., Suwal T., Al-Karmi S., Lu M., Ho B., Fouladi M., Gajjar A., Leary S., Mulcahy Levy J.M., Lassaletta A., Rivas E., Reddy A., Gillespie G.Y., Gupta N., Yalon-Oren M., Amariglio L., Nakamura H., Wu K.-S., Wong T.-T., Ra Y.-S., Spina M.L., Emanuele P.V., Massimi L., Buccoliero A.M., Hansford J.R., Grundy R.G., Adamek D., Fangusaro J., Scharnhorst D., Johnston D., Lafay-Cousin L., Camelo-Piragua S., Kabbara N., Boutarbouch M., Da Costa M.J.G., Hanson D., Wood P., Al-Hussaini M., Amayiri N., Wang Y., Catchpoole D., Michaud J., Bendel A.E., Ellezam B., Gerber N., Plant A., Jeffery R., Dunham C., Moertel C., Walter A., Ziegler D., Dodgshun A., Gottardo N., Demir A., Ramanujachar R., Raabe E., Mary S., Dirks P., Taylor M., Eugene H., Lindsey H., Tihan T., Mette J., Dahl C., Low S., Smith A., Hazrati L.-N., Kresak J., Gino S., Tan E., Morales A., Santa-Maria V., Hawkins C., Bartels U., Stephens D., Nobusawa S., Dufour C., Bourdeaut F., Andre N., Bouffet E., Huang A., Khan S., Solano-Paez P., Suwal T., Al-Karmi S., Lu M., Ho B., and Fouladi M.

Abstract

ETMR, an aggressive disease characterised by C19MC alterations, were previously categorised as various histologic diagnoses. The clinical spectrum and impact of conventional multi-modal therapy on this new WHO diagnostic category remains poorly understood as a majority of ~200 cases reported to date lack molecular confirmation. We undertook comprehensive clinico-pathologic studies of a large molecularly confirmed cohort to improve disease recognition and treatment approaches. Amongst 623 CNSPNETs patients enrolled in the RBTC registry, 159 primary ETMRs were confirmed based on a combination of FISH (125), methylation analysis (88), SNP and RNAseq (32) analyses; 91% had C19MC amplification/gains/fusions, 9% lacked C19MC alterations but had global methylation features of ETMR NOS. ETMRs arose in young patients (median age 26 months) predominantly as localized disease (M0-72%, M2-3 -18%) at multiple locations including cerebrum (60%) cerebellum (18%), midline structures (6%); notably 10% were brainstem primaries mimicking DIPG. Uni-and multivariate analyses of clinical and treatment details of curative regimens available for 110 patients identified metastatic disease (p=0.002), brainstem locations(p=0.005), extent of surgery, receipt of multi-modal therapy including high dose chemotherapy and radiation (P<0.001) as significant treatment prognosticators, while C19MC status, age and gender were nonsignificant risk factors. Analyses of events in all patients showed respective EFS at 3 and 12 months of 84%(95%CI:77-91) and 37%(95%CI:20-41) and 4yr OS of 27%(95%CI:18-37) indicating despite intensified therapies ETMR is a rapidly progressive and fatal disease. Our comprehensive data on the largest cohort of molecularly-confirmed ETMRs provides a critical framework to guide current clinical management and development of clinical trials.

Published
2021

6. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

Author

Sin-Chan, P., Mumal, I., Suwal, T., Ho, B., Fan, X., Singh, I., Du, Y., Lu, M., Patel, N., Torchia, J., Popovski, D., Fouladi, M., Guilhamon, P., Hansford, J. R., Leary, S., Hoffman, L. M., Mulcahy Levy, J. M., Lassaletta, A., Solano-Paez, P., Rivas, E., Reddy, A., Gillespie, G. Y., Gupta, N., Van Meter, T. E., Nakamura, H., Wong, T. -T., Ra, Y. -S., Kim, S. -K., Massimi, Luca, Grundy, R. G., Fangusaro, J., Johnston, D., Chan, J., Lafay-Cousin, L., Hwang, E. I., Wang, Y., Catchpoole, D., Michaud, J., Ellezam, B., Ramanujachar, R., Lindsay, H., Taylor, M. D., Hawkins, C. E., Bouffet, E., Jabado, N., Singh, S. K., Kleinman, C. L., Barsyte-Lovejoy, D., Li, X. -N., Dirks, P. B., Lin, C. Y., Mack, S. C., Rich, J. N., Huang, A., Massimi L., Sin-Chan, P., Mumal, I., Suwal, T., Ho, B., Fan, X., Singh, I., Du, Y., Lu, M., Patel, N., Torchia, J., Popovski, D., Fouladi, M., Guilhamon, P., Hansford, J. R., Leary, S., Hoffman, L. M., Mulcahy Levy, J. M., Lassaletta, A., Solano-Paez, P., Rivas, E., Reddy, A., Gillespie, G. Y., Gupta, N., Van Meter, T. E., Nakamura, H., Wong, T. -T., Ra, Y. -S., Kim, S. -K., Massimi, Luca, Grundy, R. G., Fangusaro, J., Johnston, D., Chan, J., Lafay-Cousin, L., Hwang, E. I., Wang, Y., Catchpoole, D., Michaud, J., Ellezam, B., Ramanujachar, R., Lindsay, H., Taylor, M. D., Hawkins, C. E., Bouffet, E., Jabado, N., Singh, S. K., Kleinman, C. L., Barsyte-Lovejoy, D., Li, X. -N., Dirks, P. B., Lin, C. Y., Mack, S. C., Rich, J. N., Huang, A., and Massimi L.

Abstract

Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated C19MC oncogenic mechanisms and discovered a C19MC-LIN28A-MYCN circuit fueled by multiple complex regulatory loops including an MYCN core transcriptional network and super-enhancers resulting from long-range MYCN DNA interactions and C19MC gene fusions. Our data show that this powerful oncogenic circuit, which entraps an early neural lineage network, is potently abrogated by bromodomain inhibitor JQ1, leading to ETMR cell death. Sin-Chan et al. uncover a C19MC-LIN28A-MYCN super-enhancer-dependent oncogenic circuit in embryonal tumors with multilayered rosettes (ETMRs). The circuit entraps an early neural lineage network to sustain embryonic epigenetic programming and is vulnerable to bromodomain inhibition, which promotes ETMR cell death.

Published
2019

7. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Author

Torchia, J, Golbourn, B, Feng, S, Ho, KC, Sin-Chan, P, Vasiljevic, A, Norman, JD, Guilhamon, P, Garzia, L, Agamez, NR, Lu, M, Chan, TS, Picard, D, de Antonellis, P, Khuong-Quang, D-A, Planello, AC, Zeller, C, Barsyte-Lovejoy, D, Lafay-Cousin, L, Letourneau, L, Bourgey, M, Yu, M, Gendoo, DMA, Dzamba, M, Barszczyk, M, Medina, T, Riemenschneider, AN, Morrissy, AS, Ra, Y-S, Ramaswamy, V, Remke, M, Dunham, CP, Yip, S, Ng, H-K, Lu, J-Q, Mehta, V, Albrecht, S, Pimentel, J, Chan, JA, Somers, GR, Faria, CC, Roque, L, Fouladi, M, Hoffman, LM, Moore, AS, Wang, Y, Choi, SA, Hansford, JR, Catchpoole, D, Birks, DK, Foreman, NK, Strother, D, Klekner, A, Bognár, L, Garami, M, Hauser, P, Hortobágyi, T, Wilson, B, Hukin, J, Carret, A-S, Van Meter, TE, Hwang, EI, Gajjar, A, Chiou, S-H, Nakamura, H, Toledano, H, Fried, I, Fults, D, Wataya, T, Fryer, C, Eisenstat, DD, Scheinemann, K, Fleming, AJ, Johnston, DL, Michaud, J, Zelcer, S, Hammond, R, Afzal, S, Ramsay, DA, Sirachainan, N, Hongeng, S, Larbcharoensub, N, Grundy, RG, Lulla, RR, Fangusaro, JR, Druker, H, Bartels, U, Grant, R, Malkin, D, McGlade, CJ, Nicolaides, T, Tihan, T, Phillips, J, Majewski, J, Montpetit, A, Bourque, G, Bader, GD, Reddy, AT, Gillespie, GY, Warmuth-Metz, M, Rutkowski, S, Tabori, U, Lupien, M, Brudno, M, Schüller, U, Pietsch, T, Judkins, AR, Hawkins, CE, Bouffet, E, Kim, S-K, Dirks, PB, Taylor, MD, Erdreich-Epstein, A, Arrowsmith, CH, De Carvalho, DD, Rutka, JT, Jabado, N, Huang, A, Torchia, J, Golbourn, B, Feng, S, Ho, KC, Sin-Chan, P, Vasiljevic, A, Norman, JD, Guilhamon, P, Garzia, L, Agamez, NR, Lu, M, Chan, TS, Picard, D, de Antonellis, P, Khuong-Quang, D-A, Planello, AC, Zeller, C, Barsyte-Lovejoy, D, Lafay-Cousin, L, Letourneau, L, Bourgey, M, Yu, M, Gendoo, DMA, Dzamba, M, Barszczyk, M, Medina, T, Riemenschneider, AN, Morrissy, AS, Ra, Y-S, Ramaswamy, V, Remke, M, Dunham, CP, Yip, S, Ng, H-K, Lu, J-Q, Mehta, V, Albrecht, S, Pimentel, J, Chan, JA, Somers, GR, Faria, CC, Roque, L, Fouladi, M, Hoffman, LM, Moore, AS, Wang, Y, Choi, SA, Hansford, JR, Catchpoole, D, Birks, DK, Foreman, NK, Strother, D, Klekner, A, Bognár, L, Garami, M, Hauser, P, Hortobágyi, T, Wilson, B, Hukin, J, Carret, A-S, Van Meter, TE, Hwang, EI, Gajjar, A, Chiou, S-H, Nakamura, H, Toledano, H, Fried, I, Fults, D, Wataya, T, Fryer, C, Eisenstat, DD, Scheinemann, K, Fleming, AJ, Johnston, DL, Michaud, J, Zelcer, S, Hammond, R, Afzal, S, Ramsay, DA, Sirachainan, N, Hongeng, S, Larbcharoensub, N, Grundy, RG, Lulla, RR, Fangusaro, JR, Druker, H, Bartels, U, Grant, R, Malkin, D, McGlade, CJ, Nicolaides, T, Tihan, T, Phillips, J, Majewski, J, Montpetit, A, Bourque, G, Bader, GD, Reddy, AT, Gillespie, GY, Warmuth-Metz, M, Rutkowski, S, Tabori, U, Lupien, M, Brudno, M, Schüller, U, Pietsch, T, Judkins, AR, Hawkins, CE, Bouffet, E, Kim, S-K, Dirks, PB, Taylor, MD, Erdreich-Epstein, A, Arrowsmith, CH, De Carvalho, DD, Rutka, JT, Jabado, N, and Huang, A

Abstract

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.

Published
2016

9. First observation of the ΣN decay of the S = −2 system

Author

Watanabe, T., primary, Ahn, J. K., additional, Akikawa, H., additional, Aoki, S., additional, Arai, K., additional, Bahk, S. Y., additional, Baik, K. M., additional, Bassalleck, B., additional, Chung, J. H., additional, Chung, M. S., additional, Davis, D. H., additional, Fukuda, T., additional, Hayata, H., additional, Hoshino, K., additional, Ichikawa, A., additional, Ieiri, M., additional, Imai, K., additional, Iwata, Y. H., additional, Iwata, Y. S., additional, Kakita, Y., additional, Kanda, H., additional, Kaneko, M., additional, Kawai, T., additional, Kawasaki, M., additional, Kim, C. O., additional, Kim, J. Y., additional, Kim, S. J., additional, Kim, S. H., additional, Kondo, Y., additional, Kouketsu, T., additional, Lee, Y. L., additional, McNabb, J. W. C., additional, Mitsuhara, M., additional, Nagase, Y., additional, Nagoshi, C., additional, Nakazawa, K., additional, Noumi, H., additional, Ogawa, S., additional, Okabe, H., additional, Oyama, K., additional, Park, H. M., additional, Park, I. G., additional, Parker, J., additional, Ra, Y. S., additional, Rhee, J. T., additional, Rusek, A., additional, Shibuya, H., additional, Sim, K. S., additional, Saha, P. K., additional, Seki, D., additional, Sekimoto, M., additional, Song, J. S., additional, Takahashi, H., additional, Takahashi, T., additional, Takeutchi, F., additional, Tanaka, H., additional, Tanida, K., additional, Tojo, J., additional, Torii, H., additional, Torikai, S., additional, Tsunemi, T., additional, Tovee, D. N., additional, Ushida, N., additional, Yamamoto, K., additional, Yasuda, N., additional, Yang, J. T., additional, Yoon, C. J., additional, Yoon, C. S., additional, Yosoi, M., additional, Yoshida, T., additional, and Zhu, L., additional

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10. Central-moment description of polarization for quantum states of light

Author

Björk, Gunnar, Söderholm, J., Kim, Y-S, Ra, Y-S, Lim, H-T, Kothe, C., Kim, Y-H, Sánchez-Soto, L. L., Klimov, A. B., Björk, Gunnar, Söderholm, J., Kim, Y-S, Ra, Y-S, Lim, H-T, Kothe, C., Kim, Y-H, Sánchez-Soto, L. L., and Klimov, A. B.

Abstract

We present a moment expansion for the systematic characterization of the polarization properties of quantum states of light. Specifically, we link the method to the measurements of the Stokes operator in different directions on the Poincare sphere and provide a scheme for polarization tomography without resorting to full-state tomography. We apply these ideas to the experimental first-and second-order polarization characterization of some two-photon quantum states. In addition, we show that there are classes of states whose polarization characteristics are dominated not by their first-order moments (i.e., the Stokes vector) but by higher-order polarization moments., QC 20120625

Published
2012
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11. Central-moment description of polarization for quantum states of light

Author

Björk, G., Söderholm, J., Kim, Y.-S., Ra, Y.-S., Lim, H.-T., Kothe-Termén, Christian, Kim, Y.-H., Sánchez-Soto, L. L., Klimov, A. B., Björk, G., Söderholm, J., Kim, Y.-S., Ra, Y.-S., Lim, H.-T., Kothe-Termén, Christian, Kim, Y.-H., Sánchez-Soto, L. L., and Klimov, A. B.

Abstract

We present a moment expansion for the systematic characterization of the polarization properties of quantum states of light. Specifically,we link the method to themeasurements of the Stokes operator in different directions on the Poincar´e sphere and provide a scheme for polarization tomography without resorting to full-state tomography. We apply these ideas to the experimental first- and second-order polarization characterization of some two-photon quantum states. In addition, we show that there are classes of states whose polarization characteristics are dominated not by their first-order moments (i.e., the Stokes vector) but by higher-order polarization moments.

Published
2012

12. PEDIATRICS CLINICAL RESEARCH

Author

Antony, R., primary, Zagardo, M., additional, Gujrati, M., additional, Lin, J., additional, Antony, R., additional, Al-Rahawan, M., additional, Broniscer, A., additional, Bhardwaj, R., additional, Hampton, C., additional, Ozols, V., additional, Chakravadhanula, M., additional, Bouffet, E., additional, Hawkins, C., additional, Scheinemann, K., additional, Zelcer, S., additional, Johnston, D., additional, Lafay-Cousin, L., additional, Larouche, V., additional, Jabado, N., additional, Carret, A. S., additional, Hukin, J., additional, Eisenstat, D., additional, Pond, G., additional, Poskitt, K., additional, Wilson, B., additional, Bartels, U., additional, Tabori, U., additional, Dhall, G., additional, Haley, K., additional, Finlay, J., additional, Rushing, T., additional, Sposto, R., additional, Seeger, R., additional, Garvin, J., additional, Rupani, K., additional, Stark, E., additional, Anderson, R., additional, Feldstein, N., additional, Grill, J., additional, Hargrave, D., additional, Massimino, M., additional, Jaspan, T., additional, Varlet, P., additional, Jones, C., additional, Morgan, P., additional, Le Deley, M. C., additional, Azizi, A., additional, Canete, A., additional, Saran, F., additional, Bachir, J., additional, Bubuteishvili-Pacaud, L., additional, Rousseau, R., additional, Vassal, G., additional, Gupta, S., additional, Robinson, N., additional, Dhir, N., additional, Wong, K., additional, Zhou, S., additional, Kumabe, T., additional, Kawaguchi, T., additional, Saito, R., additional, Kanamori, M., additional, Yamashita, Y., additional, Sonoda, Y., additional, Tominaga, T., additional, Miyagawa, T., additional, Nwachukwu, C., additional, Youland, R., additional, Laack, N., additional, Filipek, I., additional, Drogosiewicz, M., additional, Polnik, M. P.-, additional, Swieszkowska, E., additional, Dembowska-Baginska, B., additional, Jurkiewicz, E., additional, Perek, D., additional, Grajkowska, W., additional, Roszkowski, M., additional, Sobol, G., additional, Musiol, K., additional, Wachowiak, J., additional, Kazmierczak, B., additional, Pogorzelski, J. P. -, additional, Mlynarski, W., additional, Szewczyk, B. Z.-, additional, Wysocki, M., additional, Niedzielska, E., additional, Kowalczyk, J., additional, Slusarz, H. W. -, additional, Balwierz, W., additional, Czepko, E. Z. -, additional, Szolkiewicz, A., additional, Perek-Polnik, M., additional, Lastowska, M., additional, Chojnacka, M., additional, Tarasinska, M., additional, Perreault, S., additional, Chao, K., additional, Ramaswamy, V., additional, Shih, D., additional, Remke, M., additional, Luu, B., additional, Schubert, S., additional, Fisher, P., additional, Partap, S., additional, Vogel, H., additional, Taylor, M., additional, Goumnerova, L., additional, Cho, Y.-J., additional, Robison, N., additional, Brown, R., additional, Cloughesy, T., additional, Davidson, T. B., additional, Krieger, M., additional, Berger, M., additional, Perry, A., additional, Gilles, F., additional, Finlay, J. L., additional, Khemani, J., additional, Britt, B., additional, Grimm, J., additional, Ruge, M. I., additional, Blau, T., additional, Hafkemeyer, V., additional, Hamisch, C., additional, Klinger, K., additional, Simon, T., additional, Sadighi, Z., additional, Ellezam, B., additional, Guindani, M., additional, Ater, J., additional, Shimizu, Y., additional, Arai, H., additional, Miyajima, M., additional, Shimoji, K., additional, Kondo, A., additional, Shinohara, E., additional, Perkins, S., additional, DeWees, T., additional, Slavc, I., additional, Chocholous, M., additional, Leiss, U., additional, Haberler, C., additional, Peyrl, A., additional, Azizi, A. A., additional, Dieckmann, K., additional, Woehrer, A., additional, Dorfer, C., additional, Czech, T., additional, Spence, T., additional, Picard, D., additional, Barszczyk, M., additional, Kim, S.-K., additional, Ra, Y.-S., additional, Fangusaro, J., additional, Toledano, H., additional, Nakamura, H., additional, Fan, X., additional, Muraszko, K. M., additional, Ng, H.-K., additional, Halliday, W., additional, Shago, M., additional, Hawkins, C. E., additional, Huang, A., additional, Suzuki, M., additional, van Zanten, S. V., additional, Jansen, M., additional, van Vuurden, D., additional, Hulleman, E., additional, Idema, S., additional, Noske, D., additional, Wolf, N., additional, Hendrikse, H., additional, Vandertop, P., additional, Kaspers, G. J., additional, Muller, K., additional, Schlamann, A., additional, Warmuth-Metz, M., additional, Pietsch, T., additional, Pietschmann, S., additional, Kortmann, R.-D., additional, Kramm, C. M., additional, von Bueren, A. O., additional, Walston, S., additional, Williams, T., additional, Hamstra, D., additional, Oh, K., additional, Pelloski, C., additional, Zhukova, N., additional, Pole, J., additional, Mistry, M., additional, Fried, I., additional, Lapperiere, N., additional, Dirks, P., additional, An, J., additional, Alon, N., additional, Nathan, P., additional, Greenberg, M., additional, and Malkin, D., additional

Published
2013
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13. Double-Λhypernuclei observed in a hybrid emulsion experiment

Author

Ahn, J. K., primary, Akikawa, H., additional, Aoki, S., additional, Arai, K., additional, Bahk, S. Y., additional, Baik, K. M., additional, Bassalleck, B., additional, Chung, J. H., additional, Chung, M. S., additional, Davis, D. H., additional, Fukuda, T., additional, Hoshino, K., additional, Ichikawa, A., additional, Ieiri, M., additional, Imai, K., additional, Itonaga, K., additional, Iwata, Y. H., additional, Iwata, Y. S., additional, Kanda, H., additional, Kaneko, M., additional, Kawai, T., additional, Kawasaki, M., additional, Kim, C. O., additional, Kim, J. Y., additional, Kim, S. H., additional, Kim, S. J., additional, Kondo, Y., additional, Kouketsu, T., additional, Kyaw, H. N., additional, Lee, Y. L., additional, McNabb, J. W. C., additional, Min, A. A., additional, Mitsuhara, M., additional, Miwa, K., additional, Nakazawa, K., additional, Nagase, Y., additional, Nagoshi, C., additional, Nakanishi, Y., additional, Noumi, H., additional, Ogawa, S., additional, Okabe, H., additional, Oyama, K., additional, Park, B. D., additional, Park, H. M., additional, Park, I. G., additional, Parker, J., additional, Ra, Y. S., additional, Rhee, J. T., additional, Rusek, A., additional, Sawa, A., additional, Shibuya, H., additional, Sim, K. S., additional, Saha, P. K., additional, Seki, D., additional, Sekimoto, M., additional, Song, J. S., additional, Takahashi, H., additional, Takahashi, T., additional, Takeutchi, F., additional, Tanaka, H., additional, Tanida, K., additional, Tint, K. T., additional, Tojo, J., additional, Torii, H., additional, Torikai, S., additional, Tovee, D. N., additional, Tsunemi, T., additional, Ukai, M., additional, Ushida, N., additional, Wint, T., additional, Yamamoto, K., additional, Yasuda, N., additional, Yang, J. T., additional, Yoon, C. J., additional, Yoon, C. S., additional, Yosoi, M., additional, Yoshida, T., additional, and Zhu, L., additional

Published
2013
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14. RARE TUMORS

Author

Kiyotani, C., primary, Uno, T., additional, Ogiwara, H., additional, Morota, N., additional, Nakazawa, A., additional, Tsutsumi, Y., additional, Masaki, H., additional, Mori, T., additional, Sanz, J. A. S., additional, Guibelalde, M., additional, Tavera, A., additional, Herandez, I., additional, Ibanez, J., additional, Brell, M., additional, Mas, A., additional, Muller, H. L., additional, Gebhardt, U., additional, Warmuth-Metz, M., additional, Pietsch, T., additional, Sorensen, N., additional, Kortmann, R.-D., additional, Stapleton, S., additional, Gonzalez, I., additional, Steinbrueck, S., additional, Rodriguez, L., additional, Tuite, G., additional, Krzyzankova, M., additional, Mertsch, S., additional, Jeibmann, A., additional, Kordes, U., additional, Wolff, J., additional, Paulus, W., additional, Hasselblatt, M., additional, Nonaka, Y., additional, Hara, S., additional, Fukazawa, S., additional, Shimizu, K., additional, Ben-Arush, M., additional, Postovsky, S., additional, Toledano, H., additional, Peretz-Nahum, M., additional, Fujimura, J., additional, Sakaguchi, S., additional, Kondo, A., additional, Saito, Y., additional, Shimoji, K., additional, Ohara, Y., additional, Arakawa, A., additional, Saito, M., additional, Shimizu, T., additional, Benesch, M., additional, von Bueren, A. O., additional, Dantonello, T., additional, von Hoff, K., additional, Leuschner, I., additional, Claviez, A., additional, Bierbach, U., additional, Kropshofer, G., additional, Korinthenberg, R., additional, Graf, N., additional, Suttorp, M., additional, Kortmann, R. D., additional, Friedrich, C., additional, Klingebiel, T., additional, Koscielniak, E., additional, Rutkowski, S., additional, Mesa, M., additional, Sanchez, M., additional, Mejia, J., additional, Pena, G., additional, Dussan, R., additional, Cabeza, M., additional, Storino, A., additional, Dincer, F., additional, Roffidal, T., additional, Powell, M., additional, Berrak, S., additional, Wolff, J. E., additional, Fouyssac, F., additional, Delaunay, C., additional, Vignaud, J.-M., additional, Schmitt, E., additional, Klein, O., additional, Mansuy, L., additional, Chastagner, P., additional, Cruz, O., additional, Guillen, A., additional, Garcia, G., additional, Alamar, M., additional, Candela, S., additional, Roussos, I., additional, Garzon, M., additional, Sunol, M., additional, Muchart, J., additional, Rebollo, M., additional, Mora, J., additional, Diez, B., additional, Muggeri, A., additional, Arakaki, N., additional, Meli, F., additional, Sevlever, G., additional, Tsitouras, V., additional, Pettorini, B., additional, Fellows, G., additional, Blair, J., additional, Didi, M., additional, Daousi, C., additional, Steele, C., additional, Javadpour, M., additional, Sinha, A., additional, Hishii, M., additional, Ishii, H., additional, Miyajima, M., additional, Arai, H., additional, Dvir, R., additional, Sayar, D., additional, Levin, D., additional, Ben-Sirah, L., additional, Constantini, S., additional, Elhasid, R., additional, Gertsch, E., additional, Foreman, N., additional, Valera, E. T., additional, Brassesco, M. S., additional, Machado, H. R., additional, Oliveira, R. S., additional, Santos, A. C., additional, Terra, V. C., additional, Barros, M. V., additional, Scrideli, C. A., additional, Tone, L. G., additional, Merino, D., additional, Pienkowska, M., additional, Shlien, A., additional, Tabori, U., additional, Gilbertson, R., additional, Malkin, D., additional, Jeeva, I., additional, Chang, B., additional, Long, V., additional, Picton, S., additional, Burton, D., additional, Clark, S., additional, Kwok, C., additional, Mokete, B., additional, Rafiq, O., additional, Simmons, I., additional, Shing, M. M. K., additional, Li, C. K., additional, Chan, G. C. F., additional, Ha, S. Y., additional, Yuen, H. L., additional, Luk, C. W., additional, Ling, S. C., additional, Li, R. C. H., additional, Yoon, J. H., additional, Park, H. J., additional, Shin, H. J., additional, Park, B.-K., additional, Kim, J.-Y., additional, Jung, H. L., additional, Ra, Y. S., additional, Ghim, T. T., additional, Hartung, S., additional, Garami, M., additional, Traunecker, H., additional, Thall, P., additional, Mahajan, A., additional, Sumerauer, D., additional, Grillner, P., additional, Orrego, A., additional, Mosskin, M., additional, Gustavsson, B., additional, Holm, S., additional, Peters, N., additional, Rogers, M., additional, Chowdry, S., additional, Selman, W., additional, Mitchell, A., additional, Bangert, B., additional, Ahuja, S., additional, Laschinger, K., additional, Gold, D., additional, Stearns, D., additional, Wright, K., additional, Gupta, K., additional, Klimo, P., additional, Ellison, D., additional, Keating, G., additional, Eckel, L., additional, Giannini, C., additional, Wetjen, N., additional, Patton, A., additional, Zaky, W., additional, McComb, G., additional, Finlay, J., additional, Grimm, J., additional, Wong, K., additional, Dhall, G., additional, Gilles, F., additional, Ormandy, D., additional, Alston, R., additional, Estlin, E., additional, Gattamaneni, R., additional, Birch, J., additional, Kamaly-Asl, I., additional, Hemenway, M., additional, Rush, S., additional, Reginald, Y. A., additional, Nicolin, G., additional, Bartel, U., additional, Buncic, J. R., additional, Aguilera, D., additional, Flamini, R., additional, Mazewski, C., additional, Schniederjan, M., additional, Hayes, L., additional, Boydston, W., additional, MacDonald, T., additional, Fleming, A., additional, Jabado, N., additional, Saint-Martin, C., additional, Albrecht, S., additional, Ramsay, D. A., additional, Farmer, J. P., additional, Bendel, A., additional, Hansen, M., additional, Dugan, S., additional, and Mendelsohn, N., additional

Published
2012
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16. PEDIATRICS CLINICAL RESEARCH

Author

Murray, J. C., primary, Rainusso, N., additional, Roberts, R. A., additional, Gomez, A. M., additional, Egler, R., additional, Russell, H., additional, Okcu, M. F., additional, Gururangan, S., additional, Fangusaro, J., additional, Young-Poussaint, T., additional, Lesh, S., additional, Onar, A., additional, Gilbertson, R., additional, Packer, R., additional, McLendon, R., additional, Friedman, H. S., additional, Boyett, J., additional, Kun, L. E., additional, Venkatramani, R., additional, Haley, K., additional, Gilles, F., additional, Sposto, R., additional, Ji, L., additional, Olshefski, R., additional, Garvin, J., additional, Tekautz, T., additional, Kennedy, G., additional, Rassekh, R., additional, Moore, T., additional, Gardner, S., additional, Allen, J., additional, Shore, R., additional, Moertel, C., additional, Atlas, M., additional, Lasky, J., additional, Finlay, J., additional, Valera, E. T., additional, Brassesco, M. S., additional, Scrideli, C. A., additional, Oliveira, R. S., additional, Machado, H. R., additional, Tone, L. G., additional, Finlay, J. L., additional, Kreimer, S., additional, Dagri, J., additional, Grimm, J., additional, Bluml, S., additional, Britt, B., additional, Dhall, G., additional, Brown, R. J., additional, Shah, A., additional, Kapoor, N., additional, Abdel-Azim, H., additional, Rao, A. A. N., additional, Wallace, D., additional, Gajjar, A., additional, Packer, R. J., additional, Pearlman, M. L., additional, Sadighi, Z., additional, Bingham, R., additional, Vats, T., additional, Khatua, S., additional, Ko, R. H., additional, O'Neil, S., additional, Lavey, R. S., additional, Davidson, T. B., additional, Tovar, J., additional, Wong, K., additional, Olch, A., additional, Murray, J. C., additional, Honeycutt, J. H., additional, Donahue, D. J., additional, Head, H. W., additional, Alles, A. J., additional, Ray, A., additional, Pearlman, M., additional, Baskin, J., additional, Qaddoumi, I., additional, Ahchu, M. S., additional, Alabi, S. F., additional, Arambu, I. C., additional, Castellanos, M., additional, Gamboa, Y., additional, Martinez, R., additional, Montero, M., additional, Ocampo, E., additional, Howard, S. C., additional, Broniscer, A., additional, Baker, S. D., additional, Baker, J. N., additional, Panandiker, A. P., additional, Onar-Thomas, A., additional, Chin, T. K., additional, Merchant, T. E., additional, Davidoff, A., additional, Kaste, S. C., additional, Stewart, C. F., additional, Espinoza, J., additional, Patel, N., additional, Jeffrey, A., additional, Torkildson, J., additional, Cornelius, A., additional, Bedros, A., additional, Etzl, M., additional, Pradhan, K., additional, Corbett, R., additional, Sullivan, M., additional, McGowage, G., additional, Puccetti, D., additional, Stein, D., additional, Jasty, R., additional, Antony, R., additional, Patel, M., additional, Wong, K. E., additional, Krieger, M., additional, McComb, G., additional, Sanchez-Lara, P. A., additional, Randolph, L. M., additional, Krieger, M. D., additional, Wu, S., additional, Panigrahy, A., additional, Shimada, H., additional, Erdreich-Epstein, A., additional, Puccetti, D. M., additional, Kennedy, T., additional, Salamat, S., additional, Bradfield, Y., additional, Park, H. J., additional, Yoon, J. H., additional, Ahn, H. S., additional, Shin, H. Y., additional, Kim, S. K., additional, Im, H. J., additional, Ra, Y. S., additional, Won, S. C., additional, Baek, H. J., additional, Sung, K. W., additional, Hah, J. O., additional, Lim, Y. T., additional, Lee, G. S., additional, Lee, Y. H., additional, Kim, H. S., additional, Park, J. K., additional, Kim, M. K., additional, Park, J. E., additional, Chung, N. G., additional, Choi, H. S., additional, Campen, C. J., additional, Fisher, P. G., additional, Ruge, M. I., additional, Simon, T., additional, Suchorska, B., additional, Lehrke, R., additional, Hamisch, C., additional, Koerber, F., additional, Treuer, H., additional, Berthold, F., additional, Sturm, V., additional, Voges, J., additional, Kirsch, M., additional, Lindner, C., additional, and Schackert, G., additional

Published
2011
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17. Observation of aHΛΛ6eDouble Hypernucleus

Author

Takahashi, H., primary, Ahn, J. K., additional, Akikawa, H., additional, Aoki, S., additional, Arai, K., additional, Bahk, S. Y., additional, Baik, K. M., additional, Bassalleck, B., additional, Chung, J. H., additional, Chung, M. S., additional, Davis, D. H., additional, Fukuda, T., additional, Hoshino, K., additional, Ichikawa, A., additional, Ieiri, M., additional, Imai, K., additional, Iwata, Y. H., additional, Iwata, Y. S., additional, Kanda, H., additional, Kaneko, M., additional, Kawai, T., additional, Kawasaki, M., additional, Kim, C. O., additional, Kim, J. Y., additional, Kim, S. J., additional, Kim, S. H., additional, Kondo, Y., additional, Kouketsu, T., additional, Lee, Y. L., additional, McNabb, J. W. C., additional, Mitsuhara, M., additional, Nagase, Y., additional, Nagoshi, C., additional, Nakazawa, K., additional, Noumi, H., additional, Ogawa, S., additional, Okabe, H., additional, Oyama, K., additional, Park, H. M., additional, Park, I. G., additional, Parker, J., additional, Ra, Y. S., additional, Rhee, J. T., additional, Rusek, A., additional, Shibuya, H., additional, Sim, K. S., additional, Saha, P. K., additional, Seki, D., additional, Sekimoto, M., additional, Song, J. S., additional, Takahashi, T., additional, Takeutchi, F., additional, Tanaka, H., additional, Tanida, K., additional, Tojo, J., additional, Torii, H., additional, Torikai, S., additional, Tovee, D. N., additional, Ushida, N., additional, Yamamoto, K., additional, Yasuda, N., additional, Yang, J. T., additional, Yoon, C. J., additional, Yoon, C. S., additional, Yosoi, M., additional, Yoshida, T., additional, and Zhu, L., additional

Published
2001
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19. STUDY OF DOUBLE-STRANGENESS NUCLEI WITH HYBRID-EMULSION METHOD (KEK-PS E373).

Author

ICHIKAWA, A., AHN, J. K., AKIKAWA, H., IMAI, K., KANDA, H., KONDO, Y., TAKAHASHI, H., TOJO, J., TORII, H., YAMAMOTO, K., YOSOI, Y., IWATA, Y., KANEKO, M., NAKAZAWA, K., PARK, H. M., RA, Y. S., TORIKAI, S., AKAISHI, Y., FUKUDA, T., and IEIRI, M.

Subjects
STRANGE particles, NUCLEAR reactions, SPECTROMETRY, SCINTILLATORS, HYPERFRAGMENTS
Published
2000

28. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Author

Constanze Zeller, Joseph D. Norman, Man Yu, Jian Qiang Lu, Doug Strother, Miklós Garami, C. Jane McGlade, Seung-Ki Kim, Misko Dzamba, Ronald Grant, David D. Eisenstat, Beverly Wilson, Anat Erdreich-Epstein, Almos Klekner, A. Sorana Morrissy, Richard Grundy, Young Shin Ra, Joanna J. Phillips, Alexandre Montpetit, Takafumi Wataya, Alexander R. Judkins, Shayna Zelcer, Nicholas K. Foreman, Rishi Lulla, Aline Cristiane Planello, Marc Remke, Harriet Druker, Annie Huang, Torsten Pietsch, José Pimentel, Jordan R. Hansford, Lindsey M. Hoffman, Mark Barszczyk, Tarik Tihan, Eugene Hwang, Vivek Mehta, László Bognár, Louis Letourneau, Donna L. Johnston, Stephen Yip, Lucie Lafay-Cousin, Mei Lu, Pasqualino De Antonellis, Katrin Scheinemann, Deena M.A. Gendoo, Shengrui Feng, James T. Rutka, G. Yancey Gillespie, Ho Keung Ng, Robert Hammond, David Malkin, Lúcia Roque, Anne Sophie Carret, King Ching Ho, Helen Toledano, Jennifer A. Chan, Monika Warmuth-Metz, Jacek Majewski, Jonathon Torchia, Livia Garzia, Stefan Rutkowski, Gino R. Somers, Tibor Hortobágyi, Ute Bartels, Peter Hauser, Ulrich Schüller, Cynthia Hawkins, Shih Hwa Chiou, Eric Bouffet, Adam Fleming, Alexandra N. Riemenschneider, Timothy E. Van Meter, Vijay Ramaswamy, Hideo Nakamura, Tiago Medina, Alexandre Vasiljevic, Noppadol Larbcharoensub, Patrick Sin-Chan, Christopher Dunham, Theodore Nicolaides, Iris Fried, Daniel Picard, Maryam Fouladi, Chris Fryer, Brian Golbourn, Mathieu Bourgey, Jean Michaud, Claudia C. Faria, Gary D. Bader, Mathieu Lupien, Amar Gajjar, Guillaume Bourque, Peter B. Dirks, Steffen Albrecht, Suradej Hongeng, Cheryl H. Arrowsmith, Uri Tabori, David A. Ramsay, Dalia Barsyte-Lovejoy, Paul Guilhamon, Michael Brudno, Nada Jabado, Juliette Hukin, Dong Anh Khuong-Quang, Michael D. Taylor, Tiffany Chan, Natalia R. Agamez, Daniel D. De Carvalho, Nongnuch Sirachainan, Samina Afzal, Seung Ah Choi, Diane K. Birks, Daniel W. Fults, Andrew S. Moore, Alyssa Reddy, Jason Fangusaro, Daniel Catchpoole, Yin Wang, Torchia, J., Golbourn, B., Feng, S., Ho, K. C., Sin-Chan, P., Vasiljevic, A., Norman, J. D., Guilhamon, P., Garzia, L., Agamez, N. R., Lu, M., Chan, T. S., Picard, D., de Antonellis, P., Khuong-Quang, D. -A., Planello, A. C., Zeller, C., Barsyte-Lovejoy, D., Lafay-Cousin, L., Letourneau, L., Bourgey, M., Yu, M., Gendoo, D. M. A., Dzamba, M., Barszczyk, M., Medina, T., Riemenschneider, A. N., Morrissy, A. S., Ra, Y. -S., Ramaswamy, V., Remke, M., Dunham, C. P., Yip, S., Ng, H. -K., Lu, J. -Q., Mehta, V., Albrecht, S., Pimentel, J., Chan, J. A., Somers, G. R., Faria, C. C., Roque, L., Fouladi, M., Hoffman, L. M., Moore, A. S., Wang, Y., Choi, S. A., Hansford, J. R., Catchpoole, D., Birks, D. K., Foreman, N. K., Strother, D., Klekner, A., Bognar, L., Garami, M., Hauser, P., Hortobagyi, T., Wilson, B., Hukin, J., Carret, A. -S., Van Meter, T. E., Hwang, E. I., Gajjar, A., Chiou, S. -H., Nakamura, H., Toledano, H., Fried, I., Fults, D., Wataya, T., Fryer, C., Eisenstat, D. D., Scheinemann, K., Fleming, A. J., Johnston, D. L., Michaud, J., Zelcer, S., Hammond, R., Afzal, S., Ramsay, D. A., Sirachainan, N., Hongeng, S., Larbcharoensub, N., Grundy, R. G., Lulla, R. R., Fangusaro, J. R., Druker, H., Bartels, U., Grant, R., Malkin, D., Mcglade, C. J., Nicolaides, T., Tihan, T., Phillips, J., Majewski, J., Montpetit, A., Bourque, G., Bader, G. D., Reddy, A. T., Gillespie, G. Y., Warmuth-Metz, M., Rutkowski, S., Tabori, U., Lupien, M., Brudno, M., Schuller, U., Pietsch, T., Judkins, A. R., Hawkins, C. E., Bouffet, E., Kim, S. -K., Dirks, P. B., Taylor, M. D., Erdreich-Epstein, A., Arrowsmith, C. H., De Carvalho, D. D., Rutka, J. T., Jabado, N., and Huang, A.

Subjects
Epigenomics, 0301 basic medicine, Cancer Research, Dasatinib, 1109 Neurosciences, 1112 Oncology and Carcinogenesis, ATRT, Epigenesis, Genetic, Central Nervous System Neoplasms, genomic, SMARCB1, Epigenesis, Central Nervous System Neoplasm, Teratoma, SMARCB1 Protein, Orvostudományok, Chromatin, 3. Good health, Oncology, DNA methylation, subgroup-specific therapeutic, Human, medicine.drug, Epigenomic, Cell Survival, Protein Kinase Inhibitor, Biology, Klinikai orvostudományok, Article, Receptor, Platelet-Derived Growth Factor beta, 03 medical and health sciences, Cell Line, Tumor, medicine, Humans, Oncology & Carcinogenesis, Epigenetics, Protein Kinase Inhibitors, rhabdoid tumor, Rhabdoid Tumor, Cell Proliferation, Cancer, DNA Methylation, medicine.disease, Pyrimidines, 030104 developmental biology, Pyrimidine, Mutation, Cancer research, enhancer
Abstract

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.

Published
2016

29. Observation of a (6)(LambdaLambda)He double hypernucleus.

Author

Takahashi H, Ahn JK, Akikawa H, Aoki S, Arai K, Bahk SY, Baik KM, Bassalleck B, Chung JH, Chung MS, Davis DH, Fukuda T, Hoshino K, Ichikawa A, Ieiri M, Imai K, Iwata YH, Iwata YS, Kanda H, Kaneko M, Kawai T, Kawasaki M, Kim CO, Kim JY, Kim SJ, Kim SH, Kondo Y, Kouketsu T, Lee YL, McNabb JW, Mitsuhara M, Nagase Y, Nagoshi C, Nakazawa K, Noumi H, Ogawa S, Okabe H, Oyama K, Park HM, Park IG, Parker J, Ra YS, Rhee JT, Rusek A, Shibuya H, Sim KS, Saha PK, Seki D, Sekimoto M, Song JS, Takahashi T, Takeutchi F, Tanaka H, Tanida K, Tojo J, Torii H, Torikai S, Tovee DN, Ushida N, Yamamoto K, Yasuda N, Yang JT, Yoon CJ, Yoon CS, Yosoi M, Yoshida T, and Zhu L

Abstract

A double-hyperfragment event has been found in a hybrid-emulsion experiment. It is identified uniquely as the sequential decay of ( 6)(LambdaLambda)He emitted from a Xi(-) hyperon nuclear capture at rest. The mass of ( 6)(LambdaLambda)He and the Lambda-Lambda interaction energy DeltaB(LambdaLambda) have been measured for the first time devoid of the ambiguities due to the possibilities of excited states. The value of DeltaB(LambdaLambda) is 1.01+/-0.20(+0.18)(-0.11) MeV. This demonstrates that the Lambda-Lambda interaction is weakly attractive.

Published
2001
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